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211. 发明申请

US20140364649A1 METHOD FOR PRODUCING HIGH-PURITY CERAMIDE 有权
标题翻译：生产高纯度CERAMIDE的方法
公开(公告)号：US20140364649A1
公开(公告)日：2014-12-11
申请号：US14366883
申请日：2012-11-07
申请人： Takasago International Corporation
发明人： Kenya Ishida , Kenji Yagi
IPC分类号： C07C231/02 , C07C235/08 , C07C231/24
CPC分类号： C07C231/02 , C07B2200/07 , C07C231/22 , C07C231/24 , C07C233/18 , C07C235/08
摘要： Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate. (In the formula, R1 represents an alkyl group which has 13-17 carbon atoms and optionally has a carbon-carbon unsaturated bond; R2 represents an alkyl group which has 11-23 carbon atoms and optionally has a hydroxyl group; and represents an optically active state.)
摘要翻译：提供了通过光学活性氨基二醇的N-酰化（酰胺化）反应制备光学活性神经酰胺的方法，其中通过工业上有利的方法纯化其中产生的粗制神经酰胺。即，提供高纯度的高纯度神经酰胺的制造方法。高纯度神经酰胺是通过以下步骤生产的：其中由通式（1）表示的神经酰胺通过氨基二醇与具有12-24个碳原子的脂族羧酸的具有1-5个碳原子的烷基酯反应来制备，所述任选具有羟基的脂族羧酸，在具有5-10个碳原子的烃溶剂中; 并将其中将具有1-3个碳原子的醇加入到前述步骤中获得的反应混合物中，从而使晶体沉淀。（式中，R 1表示碳原子数为13〜17的烷基，可以具有碳 - 碳不饱和键; R 2表示碳原子数为11〜23的烷基，可以具有羟基，活跃状态）

212. 发明申请

US20140296582A1 METHOD FOR PREVENTING DECREASE IN OPTICAL PURITY 有权
标题翻译：防止光学降解的方法
公开(公告)号：US20140296582A1
公开(公告)日：2014-10-02
申请号：US14355895
申请日：2011-11-04
申请人： Hideki Nara , Yoshiki Hasegawa
发明人： Hideki Nara , Yoshiki Hasegawa
IPC分类号： C07C29/94
CPC分类号： C07C29/94 , C07B53/00 , C07C29/74 , C07C253/32 , C07C33/22 , C07C255/53
摘要： The present invention provides a method for producing a reduction reaction product, wherein recovery of the reaction solvent and/or distillation is carried out after adding a nitrogen-containing compound into a reaction liquid of a reduction reaction that has been conducted using a transition metal complex. The present invention is capable of suppressing decrease in the optical purity of the reduction reaction product due to the transition metal complex used as a catalyst.
摘要翻译：本发明提供一种还原反应产物的制备方法，其中在将含氮化合物加入到使用过渡金属络合物进行的还原反应的反应液中进行反应溶剂和/或蒸馏的回收。本发明能够抑制由于用作催化剂的过渡金属络合物引起的还原反应产物的光学纯度的降低。

213. 发明申请

US20140296562A1 METHOD FOR PRODUCING OPTICALLY ACTIVE BETA-HYDROXY-ALPHA-AMINOCARBOXYLIC ACID ESTER 审中-公开
标题翻译：用于生产光学活性的β-羟基-α-氨基甲酰氧基酸酯的方法
公开(公告)号：US20140296562A1
公开(公告)日：2014-10-02
申请号：US14352920
申请日：2012-10-31
申请人： TAKASAGO INTERNATIONAL CORPORATION
发明人： Shigeru Tanaka , Taichiro Touge , Hideki Nara , Kenya Ishida
IPC分类号： C07C67/31
CPC分类号： C07C67/31 , C07B53/00 , C07C231/12 , C07C231/18 , C07F15/0046 , C07C233/47
摘要： The present invention relates to a novel method for producing an optically active β-hydroxy-α-aminocarboxylic acid ester, the method comprising performing an asymmetric reduction reaction of a β-keto-α-aminocarboxylic acid ester by use of a ruthenium complex as a catalyst.
摘要翻译：本发明涉及一种制备光学活性的α-羟基-α-氨基羧酸酯的新方法，该方法包括使用钌络合物进行α-酮-α-氨基羧酸酯的不对称还原反应作为催化剂。

214. 发明授权

US08846983B2 Method for reducing halogenobenzoic acid ester using ruthenium carbonyl complex 有权
标题翻译：使用钌羰基络合物还原卤代苯甲酸酯的方法
公开(公告)号：US08846983B2
公开(公告)日：2014-09-30
申请号：US14100163
申请日：2013-12-09
申请人： Takasago International Corporation
发明人： Kiyoto Hori , Osamu Ogata , Wataru Kuriyama
IPC分类号： C07C29/149 , C07C51/60
CPC分类号： C07C51/60 , C07C29/149 , C07C33/46
摘要： An object of the present invention is to provide a method for reducing a halogenobenzoic acid ester, in which dehalogenation is inhibited, by using a readily available catalyst. The method comprises reducing an ester with hydrogen gas by using an aromatic hydrocarbon as a solvent in the presence of a ruthenium complex represented by the following general formula (1): RuXY(CO)(L) (1) where X and Y represent monovalent anionic ligands, and L represents a tridentate aminodiphosphine ligand represented by the following general formula (2): where RZ1 represents an alkyl group having 1 to 4 carbon atoms, each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4.
摘要翻译：本发明的目的是提供一种通过使用容易获得的催化剂来还原其中脱卤被抑制的卤代苯甲酸酯的方法。该方法包括在由以下通式（1）表示的钌络合物存在下，通过使用芳族烃作为溶剂，用氢气还原酯：RuXY（CO）（L）（1）其中X和Y表示一价阴离子配位体，L表示由以下通式（2）表示的三齿氨基二膦配体：其中RZ1表示碳原子数1〜4的烷基，各RZ2表示碳原子数为1〜4的烷基或卤素原子，任何相邻的两个RZ2可以形成环，Hal表示卤素原子，n表示0至4。

215. 发明授权

US08846651B2 Lipid composition having excellent shape retention property and product 有权
标题翻译：脂肪组合物具有优异的形状保持性和产品
公开(公告)号：US08846651B2
公开(公告)日：2014-09-30
申请号：US12529272
申请日：2008-02-27
申请人： Kenya Ishida , Chiyomi Birou , Tetsuya Yamamoto
发明人： Kenya Ishida , Chiyomi Birou , Tetsuya Yamamoto
IPC分类号： A61K31/568 , A61Q19/00 , A24B15/10 , A61K8/18 , C11D3/20 , C09K3/00 , A61K8/63 , A23L1/30 , A24B15/30 , A61K47/28 , A23L1/226 , A61K8/34
CPC分类号： A61K47/28 , A23L27/203 , A23L33/11 , A23V2002/00 , A24B15/30 , A61K8/34 , A61K8/63 , A61Q19/00 , A23V2200/208 , A23V2250/21 , A23V2250/18
摘要： It is to provide a technique for preventing aggregation or caking of menthol at the time of its keeping. In addition, it is to provide a lipid composition, which can show excellent thermal stability even in the case of high temperature at the time of keeping menthol and at the time of blending in a product, does not cause mutual aggregation of powders, particles, flakes, pellets, sticks and the like of menthol, and can maintain its shape retention property. From 10 to 50% by mass of sterols are added to and mixed with from 50 to 90% by mass of menthol, and the resultant is melted with heating. Paraffins may be further added and mixed in an amount of 20% by mass or less, based on the lipid composition.
摘要翻译：它是提供一种防止薄荷醇保留时聚集或结块的技术。此外，提供一种脂质组合物，即使在保持薄荷醇时的高温的情况下也能显示优异的热稳定性，并且在产品中混合时，不会引起粉末，颗粒，片，丸，棒等，并能保持其形状保持性。加入10〜50质量％的甾醇并与50〜90质量％的薄荷醇混合，加热熔融。基于脂质组成，石蜡可以进一步添加并混合20质量％以下。

216. 发明申请

US20140219931A1 P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COOLING SENSATION COMPOSITION COMPRISING THE SAME, AND PRODUCT COMPRISING THE COOLING SENSATION COMPOSITION 审中-公开
标题翻译： P-MENTHANE-3,8-DIOL异构体混合物，包含其的冷却感测组合物和包含冷却感测组合物的产品
公开(公告)号：US20140219931A1
公开(公告)日：2014-08-07
申请号：US14239831
申请日：2012-08-31
申请人： Yasuhiro Komatsuki , Shigeru Tanaka , Kenya Ishida
发明人： Yasuhiro Komatsuki , Shigeru Tanaka , Kenya Ishida
IPC分类号： A61K31/047 , A61Q11/00 , A23G4/06 , A61Q5/02 , A23L1/226 , A61K8/34 , A61K31/085
CPC分类号： A61K31/047 , A23G1/32 , A23G4/06 , A23L2/52 , A23L27/203 , A61K8/34 , A61K8/345 , A61K31/085 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q13/00 , C11B9/0034
摘要： The present invention relates to a p-menthane-3,8-diol isomer mixture 50% by mass or more of which is constituted of (1S)-isomers and a cooling sensation composition containing this mixture. The present invention also relates to a flavor and/or fragrance composition, food, beverage, cosmetic, daily use product, oral cavity composition, or pharmaceutical containing the p-menthane-3,8-diol isomer mixture in an amount of 0.0001 to 90% by mass.
摘要翻译：本发明涉及由（1S） - 异构体构成的50质量％以上的对薄荷烷-3,8-二醇异构体混合物和含有该混合物的冷却感组合物。本发明还涉及一种风味剂和/或香料组合物，食品，饮料，化妆品，日用品，口腔组合物或含有对数薄荷烷-3,8-二醇异构体混合物的药物，其量为0.0001至90 质量％。

217. 发明申请

US20140213792A1 METHOD FOR PRODUCING OPTICALLY ACTIVE 2-ARYLPIPERIDINIUM SALT 有权
标题翻译：用于生产光学活性的2-亚氨基哌啶盐的方法
公开(公告)号：US20140213792A1
公开(公告)日：2014-07-31
申请号：US14168101
申请日：2014-01-30
申请人： TAKASAGO INTERNATIONAL CORPORATION
发明人： Kazushi MASHIMA , Yusuke KITA , Takuto NAGANO , Atsuhiro IIMURO , Kenta YAMAJI , Shoji HIDA , Kiyoto HORI , Hideki NARA
IPC分类号： C07D213/26
CPC分类号： C07D213/26 , C07B53/00 , C07D211/12
摘要： Disclosed is a method for producing an optically active 2-arylpiperidinium salt, comprising asymmetrically hydrogenating a pyridinium salt in the presence of an iridium complex and hydrogen, the 2-arylpiperidinium salt being represented by the following general formula (1): wherein R1, R2, X, *, and m are as described in Description, the pyridinium salt being represented by the following general formula (2): wherein R1, R2, X, and m are as described in Description, and the iridium complex being represented by the following general formula (3): IrH(Z)(Q)(PP*) (3), wherein Z, PP*, and Q are as described in Description, or the following general formula (4): [{IrH(PP*)}2(μ-Z)3]Z (4), wherein Z and PP* are as described in Description.
摘要翻译：公开了一种制备光学活性2-芳基哌啶鎓盐的方法，包括在铱络合物和氢存在下不对称氢化吡啶鎓盐，2-芳基哌啶鎓盐由以下通式（1）表示：其中R1，R2 ，X，*和m如描述中所述，吡啶鎓盐由以下通式（2）表示：其中R1，R2，X和m如描述中所述，并且铱络合物由以下通式（3）：IrH（Z）（Q）（PP *）（3）其中Z，PP *和Q如描述中所述，或以下通式（4）：[{IrH *）} 2（μ-Z）3] Z（4）其中Z和PP *如描述中所述。

218. 发明申请

US20140205688A1 STIMULATING AGENT AND STIMULATING COMPOSITION 审中-公开
标题翻译：刺激剂和刺激组合物
公开(公告)号：US20140205688A1
公开(公告)日：2014-07-24
申请号：US14123040
申请日：2012-05-29
申请人： Kaori Takahashi , Miyuki Takayanagi
发明人： Kaori Takahashi , Miyuki Takayanagi
IPC分类号： A61K36/758 , A61K36/28 , A61K31/164 , A23L1/30 , A61K31/357 , A61K36/67 , A61K36/75 , A61K31/16 , A61K31/4525
CPC分类号： A61K31/357 , A23L2/56 , A23L27/10 , A23L27/202 , A23L27/204 , A23L27/2054 , A23L33/10 , A23L33/105 , A61K8/42 , A61K8/4926 , A61K8/4973 , A61K8/922 , A61K8/97 , A61K31/16 , A61K31/164 , A61K31/36 , A61K31/4525 , A61K36/28 , A61K36/67 , A61K36/75 , A61K36/758 , A61Q11/00 , A61Q13/00 , A61Q19/00 , A61K2300/00
摘要： The present invention relates to a stimulating agent comprising a pungent component having astringency, a stimulating composition including the agent, as well as a flavor or fragrance composition, a food, a drink, an oral care product and an external skin preparation containing the agent or the composition, and also relates to the use of a pungent component having astringency as a stimulating agent. Examples of the pungent component having astringency include a plant extract of Asteraceae Spilanthes, Rutaceae Zanthoxyium, Rutaceae Fagara, or Piperaceae Piper, or an amide derivative represented by general formula (1) (where R1 represents an alkenyl group having 2 to 12 carbon atoms which may be substituted by a methylenedioxyphenyl at the end, R2 and R3 may be the same or different from each other and each are a hydrogen atom or a lower alkyl group in which a hydroxyl group may be substituted, and R2 and R3, together with the nitrogen atom adjacent thereto, may form a heterocyclic ring).
摘要翻译：本发明涉及包含具有涩味的刺激性成分的刺激剂，包含该试剂的刺激性组合物，以及风味剂或香料组合物，食品，饮料，口腔护理产品和含有所述药剂的外用皮肤制剂，该组合物，还涉及使用具有涩味的刺激性成分作为刺激剂。具有涩味的刺激性成分的实例包括菊科植物提取物，菊科植物提取物，芸香科镰刀菌或Pi菜Pi子，或由通式（1）表示的酰胺衍生物（其中R 1表示具有2至12个碳原子的链烯基，可以在末端被亚甲二氧基苯基取代，R2和R3可以相同或不同，各自为氢原子或羟基可以被取代的低级烷基，R2和R3与与其相邻的氮原子可以形成杂环）。

219. 发明授权

US08741958B2 Synthetic spilanthol and use thereof 有权
标题翻译：合成稀释剂及其用途
公开(公告)号：US08741958B2
公开(公告)日：2014-06-03
申请号：US12505283
申请日：2009-07-17
申请人： Louis Lombardo , Michael E. Lankin , Kenya Ishida , Shigeru Tanaka , Hideo Ujihara , Kenji Yagi , Jennifer B. Mei , Carter B. Green , Amrit S. Mankoo
发明人： Louis Lombardo , Michael E. Lankin , Kenya Ishida , Shigeru Tanaka , Hideo Ujihara , Kenji Yagi , Jennifer B. Mei , Carter B. Green , Amrit S. Mankoo
IPC分类号： A23L1/221
CPC分类号： A61K8/42 , A23G1/32 , A23G3/36 , A23G4/06 , A23L27/202 , A61Q5/00 , A61Q11/00 , A61Q15/00 , C07C43/303 , C07C45/41 , C07C57/66 , C07C231/12 , C07C233/09 , C07C235/28 , C07C309/66 , C12P13/02 , C07C47/21
摘要： The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.
摘要翻译：本申请提供了包括（2E，6Z，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺的合成稀释剂风味组合物。（2E，6E，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺和（2E，6Z，8Z）-N-（2- 甲基丙基）-2,6,8-十一三烯酰胺，（N-（2-甲基丙基）-2,6,8-癸三酰胺以有效赋予唾液或叮咬效果同时减少脱落感觉的量存在，相比之下在消费口服消耗品时，增加唾液分泌和/或提供刺痛感的方法包括向产品中加入合成的稀释剂风味组合物的方法也是合成的稀释剂风味组合物可以添加到口服食品中，例如但不限于食品，饮料，药物，营养保健品或治疗组合物，口腔个人护理产品，牙龈（例如口香糖或泡泡糖），糖果或锭剂。

220. 发明授权

US08680302B2 Method for producing alcohol compound 有权
标题翻译：醇化合物的制备方法
公开(公告)号：US08680302B2
公开(公告)日：2014-03-25
申请号：US13126289
申请日：2008-12-11
申请人： Hideo Shimizu
发明人： Hideo Shimizu
IPC分类号： C07C45/00 , C07C29/14 , C07D307/00
CPC分类号： C07D213/30 , C07C29/141 , C07D307/40 , C07D317/54 , C07D333/16 , C07C33/28 , C07C33/03 , C07C33/32 , C07C31/135 , C07C33/14 , C07C33/12
摘要： Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.
摘要翻译：公开了通过使用易于获得的低成本金属种类的均匀铜催化剂氢化醛来有效生产醇化合物的实用方法。具体公开了一种醇化合物的制造方法，其特征在于，在均匀的铜催化剂和二膦化合物的存在下进行醛化合物的氢化反应。

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