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11. 发明授权

US5770758A 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 失效
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US5770758A
公开(公告)日：1998-06-23
申请号：US770353
申请日：1996-12-20
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C323/62 , C07C20060101 , C07C319/02 , C07C319/12 , C07C323/33 , C07C323/34 , C07C323/47 , C07C323/49 , C07C323/63 , C07C323/64 , C07C327/26 , C07C335/16 , C07C335/22 , C07D20060101 , C07D277/82 , C07D285/00 , C07D285/01 , C07D285/06 , C07D285/14 , C07D417/04 , C07C255/07 , C07C321/08 , C07C327/16
CPC分类号： C07D285/14 , C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen, n is 0,1,2 or 3; Z is CN, CO-A or CS-A, A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ; R.sub.1 to R .sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O,S and/or N. Processes for the preparation of compounds of the formula I are described.
摘要翻译：式I的化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要的中间产物。在式I和III的化合物中 X为卤素，n为0,1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。用于制备描述了式I。

12. 发明授权

US5151540A Thio carbamates and their derivatives 失效
标题翻译： THIO碳水化合物及其衍生物
公开(公告)号：US5151540A
公开(公告)日：1992-09-29
申请号：US935461
申请日：1986-11-26
申请人： Mohammad Aslam , Kenneth G. Davenport
发明人： Mohammad Aslam , Kenneth G. Davenport
IPC分类号： B01J27/06 , B01J27/00 , C07C67/00 , C07C313/00 , C07C319/02 , C07C323/34 , C07C325/00 , C07C333/02 , C07C333/04
CPC分类号： C07C333/02
摘要： A method is provided for preparing N-acylaminothiophenols, e.g., N-acetyl-para-aminothiophenol, or aminothiophenols, e.g., para-aminothiophenol, or N,S-diacylaminothiophenols, e.g., N,S-diacetyl-para-aminothiophenol, by reacting any of certain sulfur-containing ketones, viz., an S-(acylaryl) N,N-di(organo)thiocarbamate, e.g., S-(4'-acetophenyl)-N,N-dimethylthiocarbamate, an acylthiophenol acylate ester, e.g., 4-acetothiophenol acetate, or a free acylthiophenol, e.g., 4-acetothiophenol with hydroxylamine or a hydroxylamine salt, to form the oxime of the ketone, subjecting the oxime to a Beckmann rearrangement in the presence of a catalyst to form an S-(N-acyl-aminoaryl) N,N-di(organo)thiocarbamate, e.g., S-(N-acetyl-para-aminophenyl) N,N-dimethylthiocarbamate, an N,S-diacylaminothiophenol, e.g., N,S-diacetyl-paraaminothiophenol, or an N-acyl aminothiophenol, e.g., N-acetyl-para-aminothiophenol, respectively. The S-(N-acyl-aminoaryl) N,N-di(organo)thiocarbamate may be hydrolyzed to the N-acyl aminothiophenol or aminothiophenol. The S-(acylaryl) N,N-di(organo)thiocarbamate may be produced by reacting a hydroxy aromatic ketone, e.g., 4-hydroxyacetophenone (4-HAP) with an N,N-di(organo)thiocarbamoyl halide, e.g., N,N-dimethylthiocarbamoyl chloride (DMTC) to form an O-(acylaryl) N,N-di(organo)thiocarbamate, e.g., O-(4'-acetophenyl) N,N-dimethylthiocarbamate, and pyrolytically rearranging the latter compound. The acylthiophenol may be produced by hydrolyzing the S-(acylaryl) N,N-di(organo)thiocarbamate.

13. 发明申请

US20070060649A1 NOVEL LYSINE SALTS OF 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACID DERIVATIVES 有权
标题翻译： 4 - （（苯甲基）硫代） - 氧化戊酸衍生物的新型赖氨酸盐
公开(公告)号：US20070060649A1
公开(公告)日：2007-03-15
申请号：US11531464
申请日：2006-09-13
申请人： Ahmed Abdel-Magid , Steven Mehrman , Armin Roessier
发明人： Ahmed Abdel-Magid , Steven Mehrman , Armin Roessier
IPC分类号： A61K31/205 , C07C323/34
CPC分类号： C07C323/20
摘要： The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts,
摘要翻译：本发明涉及含有它们的新型赖氨酸盐，药物组合物及其用于治疗由PPARδ调节的病症和状况的用途。本发明进一步涉及制备所述赖氨酸盐的新方法，

14. 发明授权

US5750763A Process for production of thioaryl compound 失效
标题翻译：硫代芳基化合物的制备方法
公开(公告)号：US5750763A
公开(公告)日：1998-05-12
申请号：US532801
申请日：1995-11-08
申请人： Tatsuo Sugiyama , Tadashi Nakayama
发明人： Tatsuo Sugiyama , Tadashi Nakayama
IPC分类号： C07C319/06 , C07C319/14 , C07C319/20 , C07C321/24 , C07C321/26 , C07C323/20 , C07C323/22 , C07C323/33 , C07C323/34 , C07C323/37 , C07C323/39 , C07C323/52 , C07C321/28
CPC分类号： C07C319/14 , C07C319/06
摘要： The present invention provides: a process for producing an alkali metal salt of an arylmercaptan compound, represented by general formula (3): ##STR1## which process comprises reacting a disulfide compound represented by general formula: ##STR2## with a hydroxide of an alkali metal M.sup.1 in the presence of a sulfur compound represented by general formula (2): H.sub.(2-i) S(M.sup.1).sub.i (2) a process for producing an alkoxycarbonylalkylthioaryl compound represented by general formula (5): ##STR3## which process comprises reacting the above-mentioned alkalimetal salt of an arylmercaptan compound with a halogenofattyacid ester compound represented by general formula (4): X.sup.1 R.sup.2 COOR.sup.3 (4) at pH 7-10; and a process for producing the above-mentioned alkoxycarbonylalkylthioaryl compound, which process comprises reacting the above-mentioned disulfide compound with the above-mentioned hydroxide of an alkali metal M.sup.1 in the presence of the above-mentioned sulfur compound to obtain an alkali metal salt of an arylmercaptan compound, and reacting said alkali metal salt, without isolating it, with the above-mentioned halogenofatty acid ester compound under the same condition as mentioned above.
摘要翻译： PCT No.PCT / JP95 / 00455 Sec。 371日期：1995年11月8日 102（e）日期1995年11月8日PCT 1995年3月17日PCT公布。 WO95 / 25089 PCT公开日期1995年9月21日本发明提供一种由通式（3）表示的芳基硫醇化合物的碱金属盐的制造方法：在通式（3）表示的硫化合物的存在下，由通式：tal M1表示的二硫化物式（2）：H（2-i）S（M1）i（2）制备由通式（5）表示的烷氧基羰基烷基硫代芳基化合物的方法：该方法包括使上述碱金属盐的通式（4）表示的卤代酯酸酯化合物：X1R2COOR3（4），pH7-10的芳基硫醇化合物; 以及制备上述烷氧基羰基烷基硫代芳基化合物的方法，该方法包括使上述二硫化物与上述碱金属M1的氢氧化物在上述硫化合物的存在下反应，得到碱金属盐在与上述相同的条件下，使所述碱金属盐与上述卤代酯酸酯化合物分离而使其与所述碱金属盐反应。

15. 发明授权

US5739374A Processes of preparing diphenylheteroalkyl derivatives 失效
标题翻译：制备二苯基杂烷基衍生物的方法
公开(公告)号：US5739374A
公开(公告)日：1998-04-14
申请号：US800623
申请日：1997-02-14
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/67 , A61K31/195 , A61Q19/00 , C07C37/11 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C59/70 , C07C65/21 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/51 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07D263/58 , C07D311/72 , C07F9/38 , C07F9/40 , C07C255/49 , C07C69/02
CPC分类号： A61K8/46 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/671 , A61Q19/00 , C07C205/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/48 , C07C233/75 , C07C235/42 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C37/18 , C07C39/17 , C07C41/26 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C51/367 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07D263/58 , C07D311/58 , C07D311/70 , C07D311/72 , C07D317/22 , C07F9/3834 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

16. 发明授权

US5688872A Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same 失效
标题翻译：二氨基苯硫酚化合物，其制造方法以及含有它们的含氟弹性体的固化剂
公开(公告)号：US5688872A
公开(公告)日：1997-11-18
申请号：US753407
申请日：1996-11-25
申请人： Takehiro Sonoi , Haruyoshi Tatsu , Lev Solomonovich German, deceased , Valerii Romanovich Polishchuk, deceased
发明人： Takehiro Sonoi , Haruyoshi Tatsu , Lev Solomonovich German, deceased , Valerii Romanovich Polishchuk, deceased
IPC分类号： C07C319/02 , C07C323/34 , C07D277/82 , C08K5/37 , C08K5/46 , C08L27/12 , C08C19/18
CPC分类号： C07D277/82 , C07C323/34 , C08K5/37
摘要： 2,2-bis(4-aminophenyl)hexafluoropropane is allowed to react with potassium thiocyanate and bromine to obtain 2,2-bis(5-amino-4,6-benzothiazolyl)hexafluoropropaneo which is allowed to further react successively with potassium hydroxide and hydrochloric acid to obtain 2,2-bis(4-amino-3-mercapto-phenyl)hexafluoropropane, which is a novel compound applicable as a curing agent for a fluorine-containing elastomer having CN groups as cross-linkable groups.
摘要翻译：使2,2-双（4-氨基苯基）六氟丙烷与硫氰酸钾和溴反应，得到2,2-双（5-氨基-4,6-苯并噻唑基）六氟丙烷，使其进一步与氢氧化钾反应，得到2,2-双（4-氨基-3-巯基 - 苯基）六氟丙烷，它是可用作具有CN基团作为可交联基团的含氟弹性体的固化剂的新型化合物。

17. 发明授权

US5217964A Polyamine thiols as radioprotective agents 失效
标题翻译：聚氨酯作为放射防护剂
公开(公告)号：US5217964A
公开(公告)日：1993-06-08
申请号：US644810
申请日：1991-01-23
申请人： Michael L. Edwards , Ronald D. Snyder
发明人： Michael L. Edwards , Ronald D. Snyder
IPC分类号： A61K31/135 , A61K31/66 , A61P39/02 , A61P43/00 , C07C319/08 , C07C319/12 , C07C323/25 , C07C323/32 , C07C323/34 , C07F9/165 , C07F9/18
CPC分类号： C07C323/25 , C07C323/32 , C07C323/34 , C07F9/1651
摘要： The present invention relates to certain polyamine thiols which are useful as radioprotective agents.

18. 发明授权

US5036064A Cephalosporins with sulfur-containing oxyimino side chain 失效
标题翻译：含硫氧基亚氨基侧链的头孢菌素
公开(公告)号：US5036064A
公开(公告)日：1991-07-30
申请号：US229960
申请日：1988-08-09
申请人： Erwin Gotschi
发明人： Erwin Gotschi
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C67/00 , C07C313/00 , C07C317/22 , C07C317/24 , C07C317/46 , C07C323/22 , C07C323/34 , C07C323/35 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/62 , C07C323/65 , C07C323/66 , C07D277/40 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号： C07D501/20 , C07D277/40
摘要： Antibacterial compounds of the formula ##STR1## wherein R is a mononuclear carbocyclic aromatic group, a 5-membered aromatic heterocyclic group which contains as the hetero (non-carbon) ring member(s) an oxygen or sulphur atom or an imino or lower alkylimino group and, optionally, one or two nitrogen atoms, or a 6-membered aromatic heterocyclic group which contains one to three nitrogen atoms as the hetero ring member(s); R.sup.1 is hydrogen or a 3-substituent which is usable in cephalosporin chemistry; A is lower alkylene or C.sub.3-7 -cycloalkylene which is optionally substituted with carboxy, carbamoyl, lower alkylcarbamoyl or di(lower alkyl)carbamoyl; Q is lower alkylene or C.sub.3-7 -cycloalkylene which is optionally substituted with carboxy, carbamoyl, lower alkylcarbamoyl or di(lower alkyl)carbamoyl, or the group --NR.sup.2 -- or --NR.sup.2 NR.sup.3 --; R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl; p and m are the zero or 1, n is zero, 1 or 2; R.sup.4 is hydrogen, lower alkanoyl or tri(lower alkyl)silyl; two R.sup.4 groups together represent diphenylmethylene; R.sup.5 is hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, --OCOR.sup.7, --OCOOR.sup.71, --N(R.sup.7).sub.2, --NHCOR.sup.7, --NHCOOR.sup.71, --COR.sup.7, --SR.sup.7, --SOR.sup.7, --SO.sub.2 R.sup.7, --SO.sub.3 H, --COOR.sup.7 or --CON(R.sup.7).sub.2 ; R.sup.6 is hydrogen, lower alkyl or halogen, R.sup.7 is hydrogen or lower alkyl; R.sup.71 is lower alkyl, and the two --OR.sup.4 groups are attached to the phenyl ring via adjacent carbon atoms, as well as readily hydrolyzable esters and pharmaceutically acceptable salts of these compounds and hydrates of compounds of formula I and of their esters and salts.
摘要翻译：其中R是单核碳环芳族基团，含有作为杂（非碳）环成员的氧或硫原子的亚烷基或低级的5元芳族杂环基的抗菌化合物烷基亚氨基和任选的一个或两个氮原子，或含有1-3个氮原子作为杂环成员的6元芳族杂环基; R1是氢或可用于头孢菌素化学的3-取代基; A是低级亚烷基或任选被羧基，氨基甲酰基，低级烷基氨基甲酰基或二（低级烷基）氨基甲酰基取代的C 3-7 - 亚环烷基; Q是低级亚烷基或任选被羧基，氨基甲酰基，低级烷基氨基甲酰基或二（低级烷基）氨基甲酰基取代的C 3-7 - 亚环烷基，或-NR2-或-NR2NR3-基团。 R2和R3独立地是氢或低级烷基; p和m为零或1，n为零，1或2; R4是氢，低级烷酰基或三（低级烷基）甲硅烷基; 两个R 4基团一起表示二苯基亚甲基; R5是氢，低级烷基，羟基，低级烷氧基，卤素，硝基，-OCOR7，-OCOOR71，-N（R7）2，-NHCOR7，-NHCOOR71，-COR7，-SR7，-SOR7，-SO2R7，-SO3H， -COOR7或-CON（R7）2; R6是氢，低级烷基或卤素，R7是氢或低级烷基; R71是低级烷基，并且两个-OR4基团通过相邻的碳原子连接到苯环上，以及这些化合物的易水解的酯和药学上可接受的盐以及式I化合物及其酯和盐的水合物。

19. 发明授权

US4902832A 2-Substituted phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-diones, and their production and use 失效
标题翻译： 2-取代的苯基-4,5,6,7-四氢-2H-异吲哚-1,3-二酮及其制备和用途
公开(公告)号：US4902832A
公开(公告)日：1990-02-20
申请号：US817667
申请日：1986-01-10
申请人： Toru Haga , Eiki Nagano , Ryo Yoshida , Shunichi Hashimoto
发明人： Toru Haga , Eiki Nagano , Ryo Yoshida , Shunichi Hashimoto
IPC分类号： A01N39/00 , C07C323/34 , C07D209/48
CPC分类号： C07D209/48 , A01N39/00 , C07C323/34
摘要： A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a fluorine atom or a methyl group and R.sub.2 is as C.sub.1 -C.sub.3 alkyl group, a C.sub.1 -C.sub.5 alkoxy group, a chloro(C.sub.2 -C.sub.4)alkoxy group, a dichloro(C.sub.2 -C.sub.4)alkoxy group, a cyclo(C.sub.3 -C.sub.7)alkoxy group, a phenoxy group, a C.sub.1 -C.sub.5 alkylthio group or a di(C.sub.1 -C.sub.5)alkylamino group, which is useful as a herbicide.
摘要翻译：下式的化合物，其中R 1是氢原子，氟原子或甲基，R 2是C 1 -C 3烷基，C 1 -C 5烷氧基，氯（C 2 -C 4）烷氧基，可用作除草剂的二氯（C 2 -C 4）烷氧基，环（C 3 -C 7）烷氧基，苯氧基，C 1 -C 5烷硫基或二（C 1 -C 5）烷基氨基）。

20. 发明授权

US4585460A Reactive dyes, process for their preparation and use thereof: bis-vinyl or substituted ethyl sulphenyl azo reactive dyes for textiles 失效
标题翻译：活性染料及其制备方法及用途：用于纺织品的双乙烯基或取代的苯磺酸偶氮活性染料
公开(公告)号：US4585460A
公开(公告)日：1986-04-29
申请号：US537661
申请日：1983-09-30
申请人： Hansrudolf Schwander , Jurgen Markert , Peter Aeschlimann
发明人： Hansrudolf Schwander , Jurgen Markert , Peter Aeschlimann
IPC分类号： C09B62/503 , C07C67/00 , C07C313/00 , C07C317/32 , C07C317/36 , C07C323/34 , C07C323/48 , C09B62/44 , C09B62/51 , D06P1/38 , D06P3/66
CPC分类号： C09B62/51 , C09B62/4413 , D06P1/38 , Y10S8/918
摘要： Reactive dyes of the formula ##STR1## wherein Y is a --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 --X radical, in which X is a leaving group, and Z is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or carboxy, and K is the radical of a coupling component which couples at pH.ltoreq.7, are suitable for dyeing and printing textile fibre material and give dyeings and prints of good fastness properties.
摘要翻译：式（1）的反应性染料其中Y是-CH = CH 2或-CH 2 CH 2 -X基团，其中X是离去基团，Z是氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基或羧基，而K是在pH值为7的情况下结合的耦合组分的基团，适用于纺织纤维材料的染色和印花，并赋予染色和印花的良好牢度。

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