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11. 发明申请

US20120012472A1 NOVEL CHEMISTRY USED IN BIOSENSORS 有权
标题翻译：生物传感器中使用的新化学物质
公开(公告)号：US20120012472A1
公开(公告)日：2012-01-19
申请号：US13187142
申请日：2011-07-20
申请人： Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
发明人： Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
IPC分类号： G01N27/30 , H01R43/00 , G01N27/26 , C07F15/00 , G01N33/50
CPC分类号： G01N27/327 , C07F15/002 , C12Q1/003 , G01N33/54353 , G01N33/5438 , Y10T29/49117 , Y10T29/49204
摘要： The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
摘要翻译：本发明涉及可用于合成标记蛋白质，核酸和用于电极修饰的二取代联吡啶锇络合物的新组合物。

12. 发明申请

US20100222226A1 Biochip 审中-公开
标题翻译：生物芯片
公开(公告)号：US20100222226A1
公开(公告)日：2010-09-02
申请号：US10572332
申请日：2004-09-17
申请人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
发明人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
IPC分类号： C40B30/04 , C40B99/00 , C40B60/12 , C40B40/08 , C40B40/10 , C40B40/12 , C40B50/18
CPC分类号： C12Q1/003
摘要： To provide an electronic component mounting system and an electronic component mounting method which can prevent a mounting failure due to positional error in a height direction of a substrate and ensure mounting quality. The electronic component mounting system includes a plurality of electronic component mounting devices connected to one another and mounts an electronic component on a substrate to manufacture a mounting substrate. A print test device for testing the substrate after solder printing measures a height position of a height measurement point set on the upper surface of the substrate 4 by a height measuring machine 22 and outputs a measurement result as substrate height data. In a component placing step using an electronic component placing device, a control parameter for controlling a component placing operation of the placing head 32 is updated. Accordingly, it is possible to correct a variation of the height position of an individual substrate and to prevent a mounting failure due to positional error in the height direction of the substrate.
摘要翻译：提供一种能够防止由于基板的高度方向上的位置误差引起的安装故障并确保安装质量的电子部件安装系统和电子部件安装方法。电子部件安装系统包括彼此连接的多个电子部件安装装置，并将电子部件安装在基板上以制造安装基板。用于在焊接印刷之后测试基板的印刷测试装置通过高度测量机22测量设置在基板4的上表面上的高度测量点的高度位置，并输出测量结果作为基板高度数据。在使用电子部件放置装置的部件放置步骤中，更新用于控制放置头32的部件放置操作的控制参数。因此，可以校正单个基板的高度位置的变化，并且可以防止由于基板的高度方向上的位置误差引起的安装故障。

13. 发明申请

US20100219072A1 ENZYME ELECTRODE AND METHOD FOR PRODUCING THE SAME 失效
标题翻译：酶电极及其制造方法
公开(公告)号：US20100219072A1
公开(公告)日：2010-09-02
申请号：US12421565
申请日：2009-04-09
申请人： Chean-Yeh Cheng , Kuo-Chung Chang
发明人： Chean-Yeh Cheng , Kuo-Chung Chang
IPC分类号： C12Q1/54 , B05D5/12 , C25D3/48 , G01N27/26 , G01N33/50
CPC分类号： C25D7/00 , C12Q1/003 , C12Q1/004 , C12Q1/006 , C25D3/48
摘要： An enzyme electrode and its producing method are disclosed. The method includes providing a substrate having a carbon surface; forming a gold surface on the carbon surface and forming an electrode; modifying the gold surface by L-cysteine; modifying the gold surface by N,N′-dicyclohexylcarbodiimide; and chemically bonding the modified gold surface with a glucose oxidase.
摘要翻译：公开了一种酶电极及其制造方法。该方法包括提供具有碳表面的基底; 在碳表面上形成金表面并形成电极; 通过L-半胱氨酸改性金表面; 用N，N'-二环己基碳二亚胺改性金表面; 并将改性金表面与葡萄糖氧化酶化学键合。

14. 发明申请

US20090253149A1 Novel Chemistry Used in Biosensors 有权
标题翻译：用于生物传感器的新型化学品
公开(公告)号：US20090253149A1
公开(公告)日：2009-10-08
申请号：US12253875
申请日：2008-10-17
申请人： Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人： Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号： G01N33/573 , B32B9/00
CPC分类号： G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要： The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译：本发明涉及使用电子转移过程的核重组能量λ检测分析物的新型组合物和方法。

15. 发明授权

US07270850B2 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US07270850B2
公开(公告)日：2007-09-18
申请号：US11082325
申请日：2005-03-16
申请人： Jainamma Krotz , Daniel J. Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
发明人： Jainamma Krotz , Daniel J. Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
IPC分类号： C23C16/00 , B01D29/00
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括以下步骤：通过气相沉积用接头处理该表面，并提供包含至少一种具有至少一个单体的聚合溶液，将接头连接到阵列的表面上可聚合部分，修饰的链霉抗生物素蛋白，表面活性剂或致孔剂和交联剂。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。

16. 发明申请

US20060030028A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20060030028A1
公开(公告)日：2006-02-09
申请号：US10312034
申请日：2002-06-14
申请人： Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka
发明人： Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： C12Q1/003 , C12Q1/004
摘要： A simple-structured biosensor is provided for measuring a substrate in a sample rapidly and highly precisely, without significant influence of a peptide included in the sample. A biosensor for measuring the substrate contained in a sample solution includes one or a plurality of insulating base plate(s) 1; a pair of electrodes including a working electrode 2 and a counter electrode 3 provided on the base plate 1; and a reagent 11 for measurement including a redox enzyme and an electron mediator. The sample solution contains a peptide, and the working electrode 2 includes a metal, and at least a part of a surface of the working electrode 2 is covered with a film 10 of an organic compound containing at least one sulfur atom.
摘要翻译：提供了一种简单结构的生物传感器，用于在样品中包含的肽的显着影响下快速高度精确地测量样品中的底物。用于测量包含在样品溶液中的基底的生物传感器包括一个或多个绝缘基板1; 包括设置在基板1上的工作电极2和对置电极3的一对电极; 和包含氧化还原酶和电子介体的测定用试剂11。样品溶液含有肽，工作电极2包括金属，工作电极2的至少一部分表面被含有至少一个硫原子的有机化合物的膜10覆盖。

17. 发明申请

US20050164283A1 Mesoporous permeation layers for use on active electronic matrix devices 有权
标题翻译：用于有源电子矩阵器件的介孔渗透层
公开(公告)号：US20050164283A1
公开(公告)日：2005-07-28
申请号：US11082325
申请日：2005-03-16
申请人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
发明人： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
IPC分类号： G01N33/53 , A61K20060101 , B01D29/00 , B01D39/14 , B01D63/08 , B01J19/00 , C08J5/12 , C12M1/34 , C12Q1/68 , G01N27/26 , G01N27/30 , G01N27/447 , G01N33/543 , G01N33/547 , G01N33/566
CPC分类号： C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
摘要： The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array by treating the surface with a linker by vapor deposition and providing a polymerization solution that includes at least one monomer having a polymerizable moiety, a modified streptavidin, a surfactant or porogen, and a cross-linking agent. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker.
摘要翻译：本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。本发明包括在微电极阵列上形成渗透层的方法，包括以下步骤：通过气相沉积用接头处理该表面，并提供包含至少一种具有至少一个单体的聚合溶液，将接头连接到阵列的表面上可聚合部分，修饰的链霉抗生物素蛋白，表面活性剂或致孔剂和交联剂。然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。

18. 发明申请

US20040182719A1 Methods for producing highly sensitive potentiometric sensors 有权
标题翻译：生产高灵敏度电位传感器的方法
公开(公告)号：US20040182719A1
公开(公告)日：2004-09-23
申请号：US10486840
申请日：2004-02-23
发明人： Duncan Ross Purvis , Olga Leonardova , Dmitri Alexandrovich Farmakovski , Vladimir Rurikovich Tcherkassov
IPC分类号： C25B003/00 , G01N027/26
CPC分类号： C12Q1/003 , G01N27/3276 , G01N33/5438
摘要： The invention relates to methods of preparation of highly sensitive potentiometric sensors with an electroconductive polymer film as a sensing element.
摘要翻译：本发明涉及制备具有导电聚合物膜作为感测元件的高灵敏度电位传感器的方法。

19. 发明申请

US20040023253A1 Device structure for closely spaced electrodes 审中-公开
标题翻译：紧密间隔电极的器件结构
公开(公告)号：US20040023253A1
公开(公告)日：2004-02-05
申请号：US10335482
申请日：2002-12-26
发明人： Sandeep Kunwar , George T. Mathai
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： C12Q1/003 , B82Y10/00 , C12Q1/6825 , F41H11/12 , G01N27/27 , G01N27/3276 , G01N33/5438 , G11C13/0014 , G11C13/0019 , C12Q2565/607
摘要： A biosensor comprising a plurality of devices on a substrate. Each device in the plurality of devices occupying a different region on the substrate. Each device in the plurality of devices comprises a first electrically conducting material, a spacer, and a second electrically conducting material. The first electrically conducting material is overlaid on a first portion of the different region on the substrate occupied by a device and the spacer is overlaid on a second portion of the different region on the substrate that is occupied by the device. The first electrically conducting material and the spacer abut each other. The second electrically conducting material is overlaid on a portion of the spacer.
摘要翻译：一种生物传感器，包括在基板上的多个装置。多个装置中的每个装置占据基板上的不同区域。多个装置中的每个装置包括第一导电材料，间隔物和第二导电材料。第一导电材料覆盖在由器件占据的衬底上的不同区域的第一部分上，并且间隔物覆盖在被器件占据的衬底上的不同区域的第二部分上。第一导电材料和间隔物彼此邻接。第二导电材料覆盖在间隔件的一部分上。

20. 发明申请

US20030148169A1 Biosensor carrying redox enzymes 失效
标题翻译：携带氧化还原酶的生物传感器
公开(公告)号：US20030148169A1
公开(公告)日：2003-08-07
申请号：US10133635
申请日：2002-04-29
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： Itamar Willner , Eugenii Katz , Maya Zayats
IPC分类号： H01M004/90 , G01N027/26 , H01M004/60
CPC分类号： H01M8/16 , C12Q1/003 , H01M4/9008 , Y02E60/527
摘要： The present invention concerns an electrode carrying immobilized redox enzymes such that electric charge can flow between an electron mediator group to the enzyme cofactor by the use of boronic acid or a boronic acid derivative that acts as a linker moiety between the cofactor and the electron mediator group. The invention also concerns devices and systems that make use of the electrode of the invention, such as bio-sensors and fuel cells, the electrode being one of the components thereof.
摘要翻译：本发明涉及携带固定化氧化还原酶的电极，使得电荷可以通过使用硼酸或作为辅因子和电子介体基团之间的连接体部分的硼酸衍生物在电子介体基团与酶辅因子之间流动。本发明还涉及利用本发明的电极，例如生物传感器和燃料电池的电极是其组成部分之一的装置和系统。

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