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11. 发明申请

US20030004125A1 Inducible gene 审中-公开
标题翻译：诱导基因
公开(公告)号：US20030004125A1
公开(公告)日：2003-01-02
申请号：US10177093
申请日：2002-06-21
发明人： David G. Hirst , Tracey Robson , Jenny Isobel Worthington
IPC分类号： A61K048/00 , C12N015/01
CPC分类号： C12N9/0075 , A61K48/00 , C07K14/4738
摘要： A method to regulate the expression of a sequence encoding a gene using ionising radiation, wherein said method comprises the steps of: a. constructing a vector including the promoter of the X-ray inducible gene WAF1 and a sequence encoding an inducible gene the expression of which is regulated by the promoter of the X-ray inducible gene WAF1, b. delivering said vector to the target cells, tissue or organ, c. modulating the level of expression of the inducible gene(s) by providing ionising radiation suitable to cause the promoter of WAF1 to effect the expression of the sequence encoding the inducible gene. The method can be used in the treatment of tumours.
摘要翻译：一种使用电离辐射调节编码基因的序列的表达的方法，其中所述方法包括以下步骤：a。构建包含X射线诱导型基因WAF1的启动子和编码可诱导基因的载体的载体，其表达由X射线诱导型基因WAF1的启动子调节b。将所述载体递送至靶细胞，组织或器官，c。通过提供适于引起WAF1启动子的电离辐射来影响编码可诱导基因的序列的表达来调节可诱导基因的表达水平。该方法可用于治疗肿瘤。

12. 发明授权

US6051559A Cloning and characterizing of genes associated with long-term memory 失效
标题翻译：与长期记忆相关的基因的克隆和表征
公开(公告)号：US6051559A
公开(公告)日：2000-04-18
申请号：US361063
申请日：1994-12-21
申请人： Timothy P. Tully , Jerry Chi-Ping Yin
发明人： Timothy P. Tully , Jerry Chi-Ping Yin
IPC分类号： G01N33/15 , A61K38/00 , A61P25/28 , A61P37/02 , C07K7/08 , C07K14/435 , C07K14/47 , C12N9/02 , C12N15/09 , C12N15/12 , A61K39/395 , A01N37/18 , A01N43/04
CPC分类号： C12N9/0075 , C07K14/435 , C07K14/4703 , C07K14/4705 , A01K2217/05 , A61K38/00 , C07K2319/00 , Y10T436/105831
摘要： A method of regulating long term memory is disclosed. Also disclosed is isolated DNA encoding a cyclic 3',5'-adenosine monophosphate responsive transcriptional activator, isolated DNA encoding an antagonist of cyclic 3',5'-adenosine monophosphate-inducible transcription, isolated DNA encoding an enhancer-specific activator, and isolated DNA encoding a nitric oxide synthase. A method for assessing the effect of a drug on long term memory formation is also disclosed.
摘要翻译：公开了一种调节长期记忆的方法。还公开了编码环状3'，5'-腺苷单磷酸应答转录活化剂的分离的DNA，编码环状3'，5'-腺苷一磷酸诱导型转录的拮抗剂的分离的DNA，编码增强子特异性激活物的分离的DNA，编码一氧化氮合酶的DNA。还公开了评估药物对长期记忆形成的影响的方法。

13. 发明授权

US5498539A Bovine endothelial nitric oxide synthase nucleic acids 失效
标题翻译：牛内皮一氧化氮合酶核酸
公开(公告)号：US5498539A
公开(公告)日：1996-03-12
申请号：US908245
申请日：1992-07-02
申请人： David G. Harrison , R. Wayne Alexander , Murphy T. J. , Ken'ichi Nishida
发明人： David G. Harrison , R. Wayne Alexander , Murphy T. J. , Ken'ichi Nishida
IPC分类号： C12N9/02 , C12N5/10 , C07H21/04 , C12N1/21
CPC分类号： C12N9/0075
摘要： The cloning, nucleotide and deduced amino acid sequences of the gene encoding endothelial nitric oxide synthase are described. The sequence contains binding domains for calcium/calmodulin, FMN, FAD and NADPH. The enzyme has a molecular weight of 133,413 M.sub.r. The amino terminal portion of the enzyme exhibits a proline-rich region and several sites for proline-directed phosphorylation as well as a potential substrate site for acyl transferase. DNA probes prepared from the nucleic acid sequence are useful in research and diagnostically to determine the level of nitric oxide synthase mRNA expressed by endothelial cells both in cell culture and in intact tissues. These probes are also useful for detecting genetic abnormalities. The nitric oxide synthase gene is transfected into blood vessels in vivo for enhanced synthesis of nitric oxide synthase, resulting in increased production of nitric oxide. The gene is also transfected into host cells that do not normally express the enzyme for production of endothelial nitric oxide synthase in large volumes.
摘要翻译：描述了编码内皮一氧化氮合酶的基因的克隆，核苷酸和推定的氨基酸序列。该序列含有钙/钙调蛋白，FMN，FAD和NADPH的结合结构域。酶的分子量为133,413。酶的氨基末端部分表现出富含脯氨酸的区域和脯氨酸定向磷酸化的几个位点以及酰基转移酶的潜在底物位点。从核酸序列制备的DNA探针在研究和诊断上可用于确定细胞培养和完整组织中内皮细胞表达的一氧化氮合成酶mRNA的水平。这些探针也可用于检测遗传异常。一氧化氮合酶基因在体内转染到血管中以增强一氧化氮合成酶的合成，导致一氧化氮的产生增加。该基因也被转染到宿主细胞中，该细胞通常不表达用于大量生产内皮一氧化氮合成酶的酶。

14. 发明授权

US11739300B2 RNA preparations comprising purified modified RNA for reprogramming cells 有权
公开(公告)号：US11739300B2
公开(公告)日：2023-08-29
申请号：US16827098
申请日：2020-03-23
申请人： The Trustees of the University of Pennsylvania
发明人： Katalin Kariko , Drew Weissman , Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
IPC分类号： C12N5/074 , C12N15/87 , C12N15/85 , A61K38/17 , A61K38/18 , A61K38/44 , A61K38/46 , A61K38/50 , A61K48/00 , C07K14/47 , C07K14/505 , C12N9/02 , C12N9/22 , C12N9/78 , C12N15/117
CPC分类号： C12N5/0696 , A61K38/1709 , A61K38/1816 , A61K38/44 , A61K38/465 , A61K38/50 , A61K48/005 , A61K48/0075 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N9/0075 , C12N9/22 , C12N9/78 , C12N15/117 , C12N15/85 , C12N15/87 , C12N2310/17 , C12N2310/335 , C12N2320/30 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/02 , C12Y114/13039 , C12Y301/04012 , C12Y305/04004
摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.

15. 发明申请

US20170112136A1 BIOFILMS, COMPONENTS AND METHODS OF USE TO REDUCE BIOFOULING AND CONTAMINATION 审中-公开
公开(公告)号：US20170112136A1
公开(公告)日：2017-04-27
申请号：US15334168
申请日：2016-10-25
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： Thomas K. Wood , Manish Kumar , Thammajun L. Wood
IPC分类号： A01N63/02 , C12N9/14 , C07K14/245 , C12N9/02 , C12N9/10 , C07K14/21
CPC分类号： A01N63/02 , C07K14/21 , C07K14/245 , C12N1/20 , C12N9/0075 , C12N9/1029 , C12N9/14 , C12Y114/13039 , C12Y203/01184 , C12Y303/02003
摘要： Biofilms are provided which are capable of regulating their own thickness, reducing contamination and preventing biofouling. Constructs are introduced into bacteria that comprise nucleic acid molecules encoding an autoinducer synthase polypeptide, a transcriptional regulator and a biofilm dispersal protein. Nucleic acid molecules may also be introduced which encode a nitric oxide synthase, an epoxide hydrolase, or both. Biofilms of the bacteria may be used to reduce biofouling and contamination of a surface.

16. 发明申请

US20170087175A1 NITRIC OXIDE-MODULATING BONE-TARGETING COMPLEXES 审中-公开
公开(公告)号：US20170087175A1
公开(公告)日：2017-03-30
申请号：US14870432
申请日：2015-09-30
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Lowell L. Wood, JR.
IPC分类号： A61K31/7076 , A61K47/48 , A61K31/519
CPC分类号： A61K31/7076 , A61K31/519 , A61K47/548 , A61K47/64 , A61K47/645 , C12N9/0075 , C12Y114/13039
摘要： Compositions and methods are described herein for treating a bone disorder, including a bone-targeting complex including an activator of nitric oxide synthase; a bone-targeting agent; and a linker coupling the activator of nitric oxide synthase to the bone-targeting agent.

17. 发明授权

US08932842B2 Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition 有权
标题翻译：氨基吡啶二聚体化合物，组合物和神经元一氧化氮合酶抑制的相关方法
公开(公告)号：US08932842B2
公开(公告)日：2015-01-13
申请号：US13573654
申请日：2012-10-01
申请人： Northwestern University
发明人： Richard B. Silverman , Fengtian Xue , He Huang
IPC分类号： C07D401/12 , C07D401/10 , C07D401/14 , C12N9/99 , C12N9/02
CPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C12N9/0075 , C12Y114/13039
摘要： Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
摘要翻译：包含双末端芳环部分的一氧化氮合酶（NOS）抑制剂化合物和NOS抑制的相关方法。

18. 发明申请

US20130040359A1 Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition 有权
公开(公告)号：US20130040359A1
公开(公告)日：2013-02-14
申请号：US13573654
申请日：2012-10-01
申请人： Northwestern University
发明人： Richard B. Silverman , Fengtian Xue , He Huang
IPC分类号： C07D401/12 , C07D401/10 , C12N9/99 , C07D401/14
CPC分类号： C07D401/10 , C07D401/12 , C07D401/14 , C12N9/0075 , C12Y114/13039
摘要： Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.

19. 发明申请

US20100029920A1 METHOD FOR ASSESSING THE EFFECT OF A DRUG ON LONG TERM MEMORY FORMATION 审中-公开
标题翻译：评估药物对长期记忆形成的影响的方法
公开(公告)号：US20100029920A1
公开(公告)日：2010-02-04
申请号：US12504514
申请日：2009-07-16
申请人： Timothy P Tully , Jerry Chi-Ping Yin
发明人： Timothy P Tully , Jerry Chi-Ping Yin
IPC分类号： C07H21/04 , C07K14/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/00 , A01K2267/0356 , A61C9/0026 , A61K38/00 , A61K49/0008 , C07K14/435 , C07K14/4703 , C07K14/4705 , C07K2319/00 , C12N9/0075 , Y10T436/105831
摘要： Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.
摘要翻译：公开了评估药物对长期记忆和用于筛选药剂以调节长期记忆能力的影响的方法。

20. 发明申请

US20090246183A1 eNOS mutations useful for gene therapy and therapeutic screening 有权
标题翻译： eNOS突变可用于基因治疗和治疗筛选
公开(公告)号：US20090246183A1
公开(公告)日：2009-10-01
申请号：US12316128
申请日：2008-12-09
申请人： William C. Sessa
发明人： William C. Sessa
IPC分类号： A61K35/12 , C07H21/00 , C12N9/00 , A61K31/7052 , A61K35/74 , A01K67/027 , C12Q1/48 , C12Q1/00 , A61K48/00 , A61P15/10 , A61P9/00
CPC分类号： C12N9/0075 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules are useful as gene therapy agents for the treatment of diseases including post angioplasty restenosis, hypertension, atherosclerosis, heart failure, diabetes and diseases with defective angiogenesis. NOS proteins and peptides are also useful in methods of screening for agents which modulate NOS activity.
摘要翻译：本发明涉及新的NOS变体或突变体，其包含Akt依赖性磷酸化位点的结构改变。改变的NOS蛋白质或肽，特别是人eNOS蛋白质或肽，Akt蛋白质或多肽及其编码核酸分子可用作治疗包括血管成形术后再狭窄，高血压，动脉粥样硬化，心力衰竭，糖尿病等疾病的基因治疗剂具有血管生成不良的疾病 NOS蛋白质和肽也可用于筛选调节NOS活性的试剂的方法。

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