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1. 发明授权

US5750351A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5750351A
公开(公告)日：1998-05-12
申请号：US474530
申请日：1995-06-07
申请人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
发明人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
IPC分类号： G01N33/50 , A61K31/10 , A61K31/105 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/26 , A61K31/27 , A61K31/28 , A61K31/325 , A61K31/365 , A61K31/40 , A61K31/455 , A61K31/55 , A61K38/00 , A61K45/00 , A61K45/06 , A61K49/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/15 , G01N33/68 , G01N33/92 , G01N33/53 , A61K31/54 , A61K31/265
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

2. 发明授权

US5877203A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5877203A
公开(公告)日：1999-03-02
申请号：US722438
申请日：1996-10-17
申请人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander
发明人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander
IPC分类号： C07D295/10 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/27 , A61K31/325 , A61K31/40 , A61K31/445 , A61K45/06 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P29/00 , C07C333/04 , C07C333/06 , G01N33/68 , A61K31/10 , A61K31/16 , A61K31/55
CPC分类号： G01N33/6872 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , G01N2333/70503 , G01N2333/7056 , G01N2800/323
摘要： Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.

3. 发明授权

US5807884A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5807884A
公开(公告)日：1998-09-15
申请号：US317399
申请日：1994-10-04
申请人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
发明人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
IPC分类号： G01N33/50 , A61K31/10 , A61K31/105 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/26 , A61K31/27 , A61K31/28 , A61K31/325 , A61K31/365 , A61K31/40 , A61K31/455 , A61K31/55 , A61K38/00 , A61K45/00 , A61K45/06 , A61K49/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/15 , G01N33/68 , G01N33/92 , A61K31/54 , A61K31/265
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

4. 发明授权

US5792787A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5792787A
公开(公告)日：1998-08-11
申请号：US486239
申请日：1995-06-07
申请人： Russell M. Medford , R. Wayne Alexander , Margaret K. Offermann
发明人： Russell M. Medford , R. Wayne Alexander , Margaret K. Offermann
IPC分类号： A61K31/325 , A61K31/40 , A61K31/4453 , A61K31/55 , A61K31/445 , A61K31/395
CPC分类号： A61K31/40 , A61K31/325 , A61K31/4453 , A61K31/55 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863
摘要： Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.

5. 发明授权

US5498539A Bovine endothelial nitric oxide synthase nucleic acids 失效
标题翻译：牛内皮一氧化氮合酶核酸
公开(公告)号：US5498539A
公开(公告)日：1996-03-12
申请号：US908245
申请日：1992-07-02
申请人： David G. Harrison , R. Wayne Alexander , Murphy T. J. , Ken'ichi Nishida
发明人： David G. Harrison , R. Wayne Alexander , Murphy T. J. , Ken'ichi Nishida
IPC分类号： C12N9/02 , C12N5/10 , C07H21/04 , C12N1/21
CPC分类号： C12N9/0075
摘要： The cloning, nucleotide and deduced amino acid sequences of the gene encoding endothelial nitric oxide synthase are described. The sequence contains binding domains for calcium/calmodulin, FMN, FAD and NADPH. The enzyme has a molecular weight of 133,413 M.sub.r. The amino terminal portion of the enzyme exhibits a proline-rich region and several sites for proline-directed phosphorylation as well as a potential substrate site for acyl transferase. DNA probes prepared from the nucleic acid sequence are useful in research and diagnostically to determine the level of nitric oxide synthase mRNA expressed by endothelial cells both in cell culture and in intact tissues. These probes are also useful for detecting genetic abnormalities. The nitric oxide synthase gene is transfected into blood vessels in vivo for enhanced synthesis of nitric oxide synthase, resulting in increased production of nitric oxide. The gene is also transfected into host cells that do not normally express the enzyme for production of endothelial nitric oxide synthase in large volumes.
摘要翻译：描述了编码内皮一氧化氮合酶的基因的克隆，核苷酸和推定的氨基酸序列。该序列含有钙/钙调蛋白，FMN，FAD和NADPH的结合结构域。酶的分子量为133,413。酶的氨基末端部分表现出富含脯氨酸的区域和脯氨酸定向磷酸化的几个位点以及酰基转移酶的潜在底物位点。从核酸序列制备的DNA探针在研究和诊断上可用于确定细胞培养和完整组织中内皮细胞表达的一氧化氮合成酶mRNA的水平。这些探针也可用于检测遗传异常。一氧化氮合酶基因在体内转染到血管中以增强一氧化氮合成酶的合成，导致一氧化氮的产生增加。该基因也被转染到宿主细胞中，该细胞通常不表达用于大量生产内皮一氧化氮合成酶的酶。

6. 发明授权

US5773209A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
标题翻译：治疗动脉粥样硬化和其他心血管和炎症疾病
公开(公告)号：US5773209A
公开(公告)日：1998-06-30
申请号：US484059
申请日：1995-06-07
申请人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
发明人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
IPC分类号： G01N33/50 , A61K31/10 , A61K31/105 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/26 , A61K31/27 , A61K31/28 , A61K31/325 , A61K31/365 , A61K31/40 , A61K31/455 , A61K31/55 , A61K38/00 , A61K45/00 , A61K45/06 , A61K49/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/15 , G01N33/68 , G01N33/92 , G01N33/53
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
摘要翻译：提供了一种治疗由VCAM-1介导的心血管疾病和非心血管炎性疾病的方法，其包括去除，降低浓度或预防氧化的多不饱和脂肪酸的形成，或干扰形成多不饱和脂肪酸或氧化多不饱和脂肪酸和介导VCAM-1表达的蛋白质或肽。还提供了抑制氧化还原敏感基因表达或激活通过氧化还原敏感途径抑制的基因的方法，其包括施用有效量的防止氧化信号氧化的物质，通常，多不饱和脂肪酸的氧化，或干扰氧化信号与介导氧化还原基因表达的蛋白质或肽之间形成的复合物。

7. 发明授权

US5380747A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
标题翻译：治疗动脉粥样硬化和其他心血管和炎症疾病
公开(公告)号：US5380747A
公开(公告)日：1995-01-10
申请号：US969934
申请日：1992-10-30
申请人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander
发明人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander
IPC分类号： C07D295/10 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/27 , A61K31/325 , A61K31/40 , A61K31/445 , A61K45/06 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P29/00 , C07C333/04 , C07C333/06 , G01N33/68
CPC分类号： G01N33/6872 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , G01N2333/70503 , G01N2333/7056 , G01N2800/323
摘要： Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
摘要翻译：二硫代羧酸盐，特别是二硫代氨基甲酸盐阻断内皮细胞表面粘附分子VCAM-1的诱导表达，并且可用于治疗心血管疾病，包括动脉粥样硬化，血管成形术后再狭窄，冠状动脉疾病和心绞痛，作为以及由VCAM-1介导的非心血管炎性疾病。

8. 发明授权

US5821260A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5821260A
公开(公告)日：1998-10-13
申请号：US485307
申请日：1995-06-07
申请人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander , Sampath Parthasarathy
发明人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander , Sampath Parthasarathy
IPC分类号： A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/68 , G01N33/92 , A61K31/54 , A61K31/265
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.

9. 发明授权

US5783596A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5783596A
公开(公告)日：1998-07-21
申请号：US477881
申请日：1995-06-07
申请人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander , Sampath Parthasarathy
发明人： Russell M. Medford , Margaret K. Offermann , R. Wayne Alexander , Sampath Parthasarathy
IPC分类号： A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/68 , G01N33/92 , A61K31/54 , A61K31/265
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.

10. 发明授权

US5773231A Treatment for atherosclerosis and other cardiovascular and inflammatory diseases 失效
公开(公告)号：US5773231A
公开(公告)日：1998-06-30
申请号：US473272
申请日：1995-06-07
申请人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
发明人： Russell M. Medford , R. Wayne Alexander , Sampath Parthasarathy , Bobby V. Khan
IPC分类号： G01N33/50 , A61K31/10 , A61K31/105 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/26 , A61K31/27 , A61K31/28 , A61K31/325 , A61K31/365 , A61K31/40 , A61K31/455 , A61K31/55 , A61K38/00 , A61K45/00 , A61K45/06 , A61K49/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C333/04 , C07C333/08 , C07C333/16 , C07D295/21 , G01N33/15 , G01N33/68 , G01N33/92 , G01N33/53
CPC分类号： C07D295/21 , A61K31/145 , A61K31/185 , A61K31/198 , A61K31/325 , A61K31/40 , A61K45/06 , C07C333/04 , C07C333/08 , C07C333/16 , G01N33/68 , G01N33/92 , G01N2333/70503 , G01N2333/7056 , G01N2500/00 , G01N2800/323 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10T436/201666
摘要： A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.

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