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11. 发明申请

US20140046054A1 PROCESS FOR PREPARING AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION IN THE PRESENCE OF A COMPLEX CATALYST COMPRISING IRIDIUM AND AN AMINO ACID 审中-公开
标题翻译：在含有IRIDI和氨基酸的复合催化剂存在下通过均相催化的乙醇胺化制备胺的方法
公开(公告)号：US20140046054A1
公开(公告)日：2014-02-13
申请号：US13961345
申请日：2013-08-07
申请人： BASF SE
发明人： Alexander WETZEL , Michael Limbach , Marion Brinks , Mathias Schelwies
IPC分类号： C07C209/16 , C07C227/18 , C07D295/023 , C07C209/18
CPC分类号： C07C209/16 , C07C209/18 , C07C227/18 , C07C2601/14 , C07D295/023 , C07D295/03 , C07C211/48 , C07C211/08 , C07C211/27 , C07C211/35
摘要： The invention relates to a process for preparing amines (A) by alcohol amination of alcohols (Al) by means of an aminating agent (Am) with elimination of water, wherein the alcohol amination is carried out in the presence of a complex catalyst comprising iridium and an amino acid.
摘要翻译：本发明涉及通过胺化剂（Am）通过醇的胺化来制备胺（A）的方法，其中除去水，其中醇胺化在包含铱的复合催化剂存在下进行和氨基酸。

12. 发明授权

US08637668B2 Process for preparing a cyclic tertiary methylamine 有权
标题翻译：制备环状叔甲胺的方法
公开(公告)号：US08637668B2
公开(公告)日：2014-01-28
申请号：US13158667
申请日：2011-06-13
申请人： Christof Wilhelm Wigbers , Johann-Peter Melder , Bernd Stein , Harald Meiβner
发明人： Christof Wilhelm Wigbers , Johann-Peter Melder , Bernd Stein , Harald Meiβner
IPC分类号： C07D295/03
CPC分类号： C07D295/03
摘要： Process for preparing a cyclic tertiary methylamine of the formula I where A is a C4-alkylene group, a C5-alkylene group or a —(CH2)2—B—(CH2)2— group, where B is oxygen (O) or an N—R1 radical and R1 is C1-C5-alkyl, aryl or C5-C7-cycloalkyl, wherein an amino alcohol II from the group consisting of 1,4-aminobutanol, 1,5-aminopentanol, aminodiglycol (ADG) or aminoethylethanolamine of the formula IIa where R1 is as defined above or is hydrogen (H), in which case R1═CH3 in the amine I, is reacted with methanol in a reactor at a temperature in the range from 150 to 270° C. in the liquid phase in the presence of a copper-comprising heterogeneous catalyst.
摘要翻译：制备式I的环状叔甲胺的方法，其中A是C 4 - 亚烷基，C 5-亚烷基或 - （CH 2）2 -B-（CH 2）2 - 基，其中B是氧（O）或 R 1是C 1 -C 5 - 烷基，芳基或C 5 -C 7 - 环烷基，其中由1,4-氨基丁醇，1,5-氨基戊醇，氨基二甘醇（ADG）或氨基乙基乙醇胺组成的组中的氨基醇II 其中R 1如上定义或是氢（H），在这种情况下，胺I中的R 1 = CH 3在反应器中在150-270℃的温度下与甲醇反应，在在含铜的非均相催化剂存在下的液相。

13. 发明申请

US20130338208A1 FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS 有权
标题翻译： FULVENE和FULVALENE模拟及其在治疗癌症中的应用
公开(公告)号：US20130338208A1
公开(公告)日：2013-12-19
申请号：US13970639
申请日：2013-08-20
申请人： U.S. GOVERNMANET AS REPRESENTED BY UNITED STATES DEPARTMENT OF VETERANS AFFAIR , EMORY UNIVERSITY
发明人： Jack L. Arbiser
IPC分类号： C07D209/14
CPC分类号： C07D209/14 , A61K31/015 , A61K31/045 , A61K31/167 , A61K31/341 , A61K31/357 , A61K31/403 , A61K31/4164 , A61K31/444 , A61K31/5375 , A61K31/573 , C07C13/28 , C07C13/40 , C07C13/465 , C07C13/58 , C07C13/66 , C07C25/18 , C07C35/32 , C07C39/23 , C07C43/215 , C07C43/23 , C07C69/608 , C07C211/50 , C07C215/46 , C07C233/44 , C07C237/26 , C07C251/28 , C07C275/64 , C07C2601/10 , C07C2602/08 , C07C2602/42 , C07C2603/24 , C07C2603/40 , C07C2603/46 , C07D209/82 , C07D209/86 , C07D213/53 , C07D233/58 , C07D233/68 , C07D261/08 , C07D277/40 , C07D295/03 , C07D295/135 , C07D307/58 , C07D309/38 , C07D311/58 , C07D311/60 , C07D311/82 , C07D407/04 , C07D471/10 , C07D473/34
摘要： Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, as well as numerous inflammatory, degenerative and vascular diseases, including various ocular diseases. Representative fulvene and/or fulvalene analogs include fulvene and fulvalene analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function, at least, by inhibiting Nox or ROS. In some embodiments, the Nox is one that is selectively expressed in cancer cells over normal cells, or one that is expressed in higher amounts in cancer cells over normal cells. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
摘要翻译：公开了化合物，包括该化合物的药物组合物，及其制备和使用方法。化合物是富烯和/或富瓦烯类似物。化合物和组合物可用于治疗和/或预防多种癌症，包括耐药性癌症，以及许多炎性，退行性和血管性疾病，包括各种眼部疾病。代表性的富烯和/或富瓦烯类似物包括各种染料，激素，糖，肽，寡核苷酸，氨基酸，核苷酸，核苷和多元醇的富烯和富瓦烯类似物。据信这些化合物至少通过抑制Nox或ROS起作用。在一些实施方案中，Nox是在癌细胞中在正常细胞上选择性表达的，或在癌细胞中以比正常细胞更高量表达的那些。因此，这些化合物是用于各种癌症和其它疾病的新型治疗剂。

14. 发明授权

US08287627B2 Piperazinium trifluoroacetate compound and carbon dioxide absorbent using the same 有权
标题翻译：三氟醋酸哌嗪化合物和使用其的二氧化碳吸收剂
公开(公告)号：US08287627B2
公开(公告)日：2012-10-16
申请号：US12612309
申请日：2009-11-04
申请人： Sung Yeup Chung , Ki Chun Lee , Seok Jin Choi , Hoon Sik Kim , Jelliarko Palgunadi , Je Eun Kang
发明人： Sung Yeup Chung , Ki Chun Lee , Seok Jin Choi , Hoon Sik Kim , Jelliarko Palgunadi , Je Eun Kang
IPC分类号： B01D53/14
CPC分类号： C07D295/03 , B01D53/1475 , B01D53/1493 , B01D2251/80 , C07C53/18 , Y02C10/06 , Y02P20/152 , Y02P20/542
摘要： The present invention provides a novel piperazinium trifluoroacetate compound prepared by reacting piperazine with trifluoroacetic acid and a carbon dioxide absorbent prepared by dissolving the compound in an ionic liquid or organic solvent. According to the present invention, the carbon dioxide absorbent has excellent carbon dioxide absorption capacity and low solvent loss, and the energy consumption required for the carbon dioxide absorption and desorption is significantly reduced.
摘要翻译：本发明提供了一种通过哌嗪与三氟乙酸反应制备的新型哌嗪鎓三氟乙酸盐化合物和通过将化合物溶解在离子液体或有机溶剂中制备的二氧化碳吸收剂。根据本发明，二氧化碳吸收剂具有优异的二氧化碳吸收能力和低溶剂损失，并且二氧化碳吸收和解吸所需的能量消耗显着降低。

15. 发明申请

US20120130147A1 METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS 审中-公开
标题翻译：用吲哚化合物治疗肿瘤的方法
公开(公告)号：US20120130147A1
公开(公告)日：2012-05-24
申请号：US13358191
申请日：2012-01-25
申请人： Dirk FINSINGER , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
发明人： Dirk FINSINGER , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
IPC分类号： A61N5/00 , A61K31/451 , A61K31/435 , A61K31/5375 , A61P35/02 , A61K31/122 , A61K31/4525 , A61K31/4545 , A61K31/496 , A61P35/00 , A61K31/137 , A61K31/495
CPC分类号： C07D405/08 , C07C45/46 , C07C49/67 , C07C49/747 , C07C49/755 , C07C225/22 , C07C255/56 , C07D211/14 , C07D211/70 , C07D221/16 , C07D295/03
摘要： Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译：其中R1，R2，R3，R4和q具有权利要求1所示含义的式（I）化合物可特别用于治疗肿瘤。

16. 发明申请

US20120095221A1 PROCESS FOR PREPARING A CYCLIC TERTIARY AMINE 有权
标题翻译：制备循环胺的方法
公开(公告)号：US20120095221A1
公开(公告)日：2012-04-19
申请号：US13273784
申请日：2011-10-14
申请人： Christof Wilhelm Wigbers , Johann-Peter Melder , Bernd Stein , Harald Meißner
发明人： Christof Wilhelm Wigbers , Johann-Peter Melder , Bernd Stein , Harald Meißner
IPC分类号： C07D295/03
CPC分类号： C07D295/03 , C07D295/023
摘要： A process for preparing a cyclic tertiary amine of the formula I where A is a C4-alkylene group, a C5-alkylene group or a —(CH2)2—B—(CH2)2— group, where B is oxygen (O) or an N—R1 radical and R1 is C1-C5-alkyl, aryl or C5-C7-cycloalkyl, and the radical R2 is a linear or branched C2-C16-alkyl, C5-C7-cycloalkyl or C7-C20-aralkyl, in which (i) an amino alcohol II from the group consisting of 1,4-aminobutanol, 1,5-aminopentanol, aminodiglycol (ADG) and aminoethylethanolamine of the formula IIa where R1 is as defined above or hydrogen (H), in which case R1═R2 in the amine I, is reacted with a primary or secondary alcohol R2OH (III) at a temperature in the range from 150 to 270° C. in the liquid phase in the presence of a copper-comprising heterogeneous catalyst in a reactor.
摘要翻译：其中A是C 4 - 亚烷基，C 5 - 亚烷基或 - （CH 2）2 -B-（CH 2）2 - 基团，其中B是氧（O））的式I的环状叔胺的方法，或N-R 1基团，并且R 1是C 1 -C 5 - 烷基，芳基或C 5 -C 7 - 环烷基，并且基团R 2是直链或支链C 2 -C 16 - 烷基，C 5 -C 7 - 环烷基或C 7 -C 20 - 芳烷基，其中（i）由式IIa的其中R1如上所定义的氢原子（H）的1,4-氨基丁醇，1,5-氨基戊醇，氨基二甘醇（ADG）和氨基乙基乙醇胺组成的组中的氨基醇II，其中在胺I中的情况R1 = R2在初级醇或仲醇R 2 OH（III）中，在含有铜的非均相催化剂的存在下，在液相中在150-270℃的温度下反应反应堆。

17. 发明申请

US20100311967A1 PRODUCTION OF BEPROMOLINE 有权
标题翻译：生产苯酚
公开(公告)号：US20100311967A1
公开(公告)日：2010-12-09
申请号：US12858273
申请日：2010-08-17
申请人： Beat Weber , Stefan Rosenberger
发明人： Beat Weber , Stefan Rosenberger
IPC分类号： C07D265/30
CPC分类号： C07D295/023 , C07D295/03
摘要： A process for the preparation of a compound of formula (Ib): including contacting a compound of formula (Ia): with toluene and HCl gas to provide the compound of formula (Ib).
摘要翻译：制备式（Ib）化合物的方法：包括使式（Ia）化合物与甲苯和HCl气体接触以提供式（Ib）化合物。

18. 发明申请

US20090118267A1 INDANES 审中-公开
标题翻译：印度
公开(公告)号：US20090118267A1
公开(公告)日：2009-05-07
申请号：US11817757
申请日：2006-02-13
申请人： Dirk Finsinger , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
发明人： Dirk Finsinger , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Kai Schiemann , Wolfgang Staehle , Christiane Amendt , Nina Heiss , Frank Zenke
IPC分类号： A61K31/5375 , C07C211/28 , C07D211/70 , C07D221/16 , C07D265/30 , C07D241/04 , A61K31/4525 , A61K31/496 , A61K31/4545 , A61K31/4965 , C07D405/02 , C07D401/06 , A61K31/135 , A61K31/445
CPC分类号： C07D405/08 , C07C45/46 , C07C49/67 , C07C49/747 , C07C49/755 , C07C225/22 , C07C255/56 , C07D211/14 , C07D211/70 , C07D221/16 , C07D295/03
摘要： Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译：其中R1，R2，R3，R4和q具有权利要求1所述含义的式（I）化合物可用于治疗肿瘤。

19. 发明授权

US07482364B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US07482364B2
公开(公告)日：2009-01-27
申请号：US11874321
申请日：2007-10-18
申请人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号： A61K31/54 , A61K31/445 , C07D239/02 , C07D401/02
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：取代的式（I）的苯炔基，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

20. 发明申请

US20080269483A1 Production of bepromoline 有权
标题翻译：生产甲基溴
公开(公告)号：US20080269483A1
公开(公告)日：2008-10-30
申请号：US12010635
申请日：2008-01-28
申请人： Beat Weber , Stefan Rosenberger
发明人： Beat Weber , Stefan Rosenberger
IPC分类号： C07D265/30
CPC分类号： C07D295/023 , C07D295/03
摘要： A process for the preparation of a compound of formula (Ia): includes: (i) contacting a compound of formula (III): with a compound of formula (IV): in the presence of a palladium catalyst, methanol and hydrogen gas, the step (i) preferably being conducted under basic conditions with acetic acid being added to the medium of reaction once the consumption of the hydrogen gas has ceased.
摘要翻译：制备式（Ia）化合物的方法包括：（i）使式（III）化合物与式（IV）化合物在钯催化剂，甲醇和氢气存在下接触，步骤（i）优选在碱性条件下进行，一旦氢气的消耗停止，将乙酸加入到反应介质中。

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