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11. 发明授权

US08822707B2 Nucleophile assisting leaving groups 有权
标题翻译：亲核试剂帮助离群
公开(公告)号：US08822707B2
公开(公告)日：2014-09-02
申请号：US11667414
申请日：2005-11-14
申请人： Salvatore Lepore
发明人： Salvatore Lepore
IPC分类号： C07C309/77 , C07C309/89 , C07D323/00 , C07H11/00
CPC分类号： C07H11/00 , C07C309/77 , C07C309/89 , C07C2603/74 , C07D323/00
摘要： Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.
摘要翻译：磺酸盐离去基团包括阳离子螯合部分，例如聚醚或冠醚。螯合部分通过与阳离子 - 亲核试剂组合的阳离子形成络合物来稳定磺酸根离去基团。稳定的离去基团在许多条件下比标准芳基磺酸盐离去基团如甲苯磺酰基更容易置换。取决于部分的同一性，螯合部分也有利于某些阳离子，从而增强与含有优选阳离子的亲核盐的反应速率。使用本发明的离去基团导致产率提高，反应时间缩短，产物纯度提高。

12. 发明申请

US20060004198A1 Method for producing substituted phenylsulfonyl urea 审中-公开
标题翻译：取代苯磺酰脲的制备方法
公开(公告)号：US20060004198A1
公开(公告)日：2006-01-05
申请号：US10511968
申请日：2003-04-16
申请人： Jan Vermehren , Mark Ford , Gunter Schlegel , Iswald Ort , Boerries Kuebel
发明人： Jan Vermehren , Mark Ford , Gunter Schlegel , Iswald Ort , Boerries Kuebel
IPC分类号： C07D43/02
CPC分类号： C07D251/42 , C07C303/22 , C07C309/89
摘要： The invention relates to a preparation process for the compound (I) or a salt thereof where Q, X*, Y, Z, R, R1, R2 and R3 are as defined in claim 1, which comprises a) monoesterifying a compound (II) where Hal=a halogen atom, giving (III), b) either b1) ammonolysing and phosgenating this compound to give (V) or b2) converting this compound with cyanate into (V) and c) converting the resulting compound (V) with the aminoheterocycle H2N-Het (Het=heterocycle as in (I)) into the compound (I) or a salt thereof. Some compounds (II) and some intermediates (VIII), stabilized with N-heteroaromatic compounds, of the compounds (V) are novel. The compounds (II) can be obtained from the corresponding sulfobenzoic acids by reaction with acid halides of sulfur or phosphorus in nonpolar organic solvents.
摘要翻译：本发明涉及其中Q，X *，Y，Z，R，R 1，R 2和R 2的化合物（I）或其盐的制备方法其中包括a）其中Hal =卤素原子的化合物（II）的单酯化，得到（III），b）b1）氨解和光气化该化合物，得到（ V）或b2）将该化合物与氰酸酯转化为（V），和c）将所得化合物（V）与氨基杂环H 2 N-Het（Het =如（I）中的杂环））转化成化合物（I）或其盐。化合物（V）的一些化合物（II）和一些由N-杂芳族化合物稳定的中间体（VIII））是新颖的。化合物（II）可以通过在非极性有机溶剂中与硫或磷的酰卤反应从相应的磺基苯甲酸获得。

13. 发明授权

US06548702B1 Method for the preparation of 2-methoxy-4-(N-t-butylamino-carbonyl)-benzenesulfonyl chloride 失效
标题翻译： 2-甲氧基-4-（N-叔丁基氨基 - 羰基） - 苯磺酰氯的制备方法
公开(公告)号：US06548702B1
公开(公告)日：2003-04-15
申请号：US10030655
申请日：2002-04-26
申请人： Csaba Gönczi , Éva Csikós , Félix Hajdú , István Hermecz , Gergely Héja , Gergelyné Héja , Lajos Nagy , Andrea Sántáné Csutor , Kálmán Simon , Ágota Smelkóné Esek , Tiborné Szomor , Györgyné Szvoboda
发明人： Csaba Gönczi , Éva Csikós , Félix Hajdú , István Hermecz , Gergely Héja , Gergelyné Héja , Lajos Nagy , Andrea Sántáné Csutor , Kálmán Simon , Ágota Smelkóné Esek , Tiborné Szomor , Györgyné Szvoboda
IPC分类号： C07C30306
CPC分类号： C07C303/32 , C07C303/06 , C07C303/22 , C07C309/60 , C07C309/89
摘要： The invention relates to a process for the preparation of 2-methoxy-4-(N-t-butylaminocarbonyl)benzenesulfonyl chloride by sulfonating m-hydroxybenzoic acid, methylating the hydroxy group of the resulting sulfonic acid or its salt, transforming the carboxylic acid group and the sulfonic acid group to acid chloride groups and reacting the 4-chlorosulfonyl-3-methoxy-benzoyl chloride with t-butylamine, which comprises carrying out the sulfonation of the 3-methoxy-benzoic acid of general formula (II) with 96% sulfuric acid, separating the resulting 3-hydroxy-4-sulfobenzoic acid of general formula (III) in the form of its salt of general formula (IV), wherein Z stands for alkali metal or ammonium group, methylating the compound of general formula (IV) in the presence of a phase transfer catalyst at a pH value of about 11.5, transforming the 3-methoxy-4-sulfobenzoic acid mono salt of general formula (V), wherein the meaning of Z is as defined above, to the acid chloride of general formula (VI), and reacting the compound of general formula (VI) with t-butylamine used in equimolar amount or in a small excess, in the presence of an acid binding agent, in aprotic solvent, at low temperature.
摘要翻译：本发明涉及通过磺化间羟基苯甲酸制备2-甲氧基-4-（N叔丁基氨基羰基）苯磺酰氯的方法，甲基化所得磺酸或其盐的羟基，转化羧酸基团和磺酸基团与酰氯基团反应，并使4-氯磺酰基-3-甲氧基苯甲酰氯与叔丁胺反应，其中包括用96％硫酸进行磺化通式（II）的3-甲氧基 - 苯甲酸将通式（III）的3-羟基-4-磺基苯甲酸以通式（Ⅳ）的盐形式分离，其中Z代表碱金属或铵基，甲基化通式（Ⅳ）的化合物，在pH值为约11.5的相转移催化剂的存在下，将Z的含义如上定义的通式（Ⅴ）的3-甲氧基-4-磺基苯甲酸单盐转化为通式（六），并且在非质子传递溶剂中在低温下使通式（VI）的化合物与等摩尔量或少量过量的叔丁胺在酸结合剂的存在下反应。

14. 发明授权

US5001163A Organic polymeric material and ion-exchange membrane with pendant carbocyclic exchanging groups produced 失效
标题翻译：生产有机聚合物材料和具有侧链碳环交换基团的离子交换膜
公开(公告)号：US5001163A
公开(公告)日：1991-03-19
申请号：US317369
申请日：1989-03-01
申请人： Harold C. Fielding , Philip H. Gamlen , Ian M. Shirley
发明人： Harold C. Fielding , Philip H. Gamlen , Ian M. Shirley
IPC分类号： B01J47/12 , C07C309/25 , C07C309/58 , C07C309/89 , C08F14/18 , C08F16/14 , C08F16/30 , C08F214/18 , C08F214/26 , C08F216/14 , C08F230/02 , C08F299/02 , C08J5/22 , C25B13/08 , H01M8/02
CPC分类号： C08J5/225 , C07C309/25 , C07C309/58 , C07C309/89 , C08F16/30 , H01M8/0289 , C07C2101/14 , C08J2327/18 , Y02P70/56
摘要： An organic polymeric material, which is preferably perfluorinated and which comprises a polymeric chain and at least one group pendant from the chain, in which the group pendant from the chain comprises a saturated cyclic group and at least one ion-exchange group or group convertible thereto, and in which the ion-exchange group or group convertible thereto is linked to the polymeric chain through the cyclic group. Also an ion-exchange membrane produced from the polymeric material, an electrolytic cell containing the membrane, vinyl monomers from which the organic polymeric material may be produced and intermediates useful in production of the monomers.

15. 发明授权

US4877442A Herbicidal sulfonamides 失效
标题翻译：除草磺酰胺
公开(公告)号：US4877442A
公开(公告)日：1989-10-31
申请号：US257143
申请日：1988-10-07
申请人： Craig L. Hillemann
发明人： Craig L. Hillemann
IPC分类号： A01N47/36 , C07D239/69 , C07D521/00
CPC分类号： C07C311/65 , A01N47/36 , C07C309/89 , C07C323/00 , C07D521/00
摘要： The invention relates to certain herbicidal sulfonamides, agriculturally suitable compositions thereof and a method for their use as a general or selective preemergent or postemergent herbicide or as a plant growth regulant.
摘要翻译：本发明涉及某些除草磺酰胺，其农业上合适的组合物，以及它们用作一般或选择性前兆或芽后除草剂或作为植物生长调节剂的方法。

16. 发明授权

US4678500A Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates 失效
标题翻译：除草2,6-二取代苄基磺酰胺和苯磺酰胺
公开(公告)号：US4678500A
公开(公告)日：1987-07-07
申请号：US768109
申请日：1985-08-21
申请人： James V. Hay , George Levitt
发明人： James V. Hay , George Levitt
IPC分类号： A01N47/36 , C07C205/58 , C07C311/55 , C07C335/32 , C07D205/04 , C07D239/47 , C07D521/00
CPC分类号： C07C309/81 , A01N47/36 , C07C205/58 , C07C309/89 , C07C311/55 , C07C311/65 , C07C335/32 , C07D205/04 , C07D521/00
摘要： This invention relates to novel disubstituted benzylsulfonamides and benzenesulfamates, agriculturally suitable compositions thereof and a method of their use as preemergent or postemergent herbicides or plant growth regulants.
摘要翻译：本发明涉及新的二取代的苄基磺酰胺和苯磺酸盐，其农业上合适的组合物和它们用作前兆或芽后除草剂或植物生长调节剂的方法。

17. 发明授权

US4632693A Herbicidal sulfonamides 失效
标题翻译：除草磺酰胺
公开(公告)号：US4632693A
公开(公告)日：1986-12-30
申请号：US699869
申请日：1985-02-14
申请人： Craig L. Hillemann
发明人： Craig L. Hillemann
IPC分类号： A01N47/36 , C07D251/42 , C07D521/00 , A01N43/66 , C07D251/16
CPC分类号： C07C309/89 , A01N47/36 , C07C311/65 , C07C323/00 , C07D521/00
摘要： This invention relates to a novel herbicidal sulfonamide, agriculturally suitable compositions and a method for using it as an herbicide.
摘要翻译：本发明涉及一种新颖的除草磺酰胺，农业上合适的组合物及其用作除草剂的方法。

18. 发明授权

US4602942A Herbicidal sulfonamides 失效
标题翻译：除草磺酰胺
公开(公告)号：US4602942A
公开(公告)日：1986-07-29
申请号：US697960
申请日：1985-02-04
申请人： William T. Zimmerman
发明人： William T. Zimmerman
IPC分类号： A01N47/36 , C07D239/46 , C07D239/52 , C07D251/16 , C07D263/10 , C07D263/12 , C07D521/00
CPC分类号： C07C309/89 , A01N47/36 , C07C311/65 , C07C323/00 , C07D239/52 , C07D251/16 , C07D263/10 , C07D263/12 , C07D521/00
摘要： Novel benzenesulfonylurea compounds containing phenyl or phenoxy substituents such as 2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-4-phenylbenzoic acid, methyl ester, and 2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-4-phenylbenzoic acid, methyl ester, herbicidal compositions containing these compounds, and their method of use as general or selective pre-emergent or post-emergent herbicides.
摘要翻译：含有苯基或苯氧基取代基的新型苯磺酰脲化合物如2 - [[（4,6-二甲氧基嘧啶-2-基）氨基羰基]氨基磺酰基] -4-苯基苯甲酸甲酯和2 - [[（4-甲氧基-6- - 甲基-1,3,5-三嗪-2-基）氨基羰基]氨基磺酰基] -4-苯基苯甲酸甲酯，含有这些化合物的除草组合物及其作为一般或选择性的出苗前或出苗后的方法除草剂。

19. 发明授权

US4486589A Herbicidal N-(heterocyclicaminocarbonyl)-ortho-haloalkylbenzenesulfonamides 失效
标题翻译：除草剂N-（杂环氨基羰基） - 对 - 卤代烷基苯磺酰胺
公开(公告)号：US4486589A
公开(公告)日：1984-12-04
申请号：US435711
申请日：1982-10-21
申请人： William B. Farnham
发明人： William B. Farnham
IPC分类号： A01N43/54 , A01N47/36 , C07D239/69 , C07D295/096 , C07D521/00 , C07D239/34 , A01N43/02
CPC分类号： C07C309/89 , A01N47/36 , C07C309/00 , C07C311/65 , C07C323/00 , C07D295/096 , C07D521/00
摘要： N-(heterocyclicaminocarbonyl)-ortho-haloalkylbenzenesulfonamides, such as 2-(dichloromethyl)-N-[(4-methoxy-6-methylprimidin-2-yl) aminocarbonyl]-benzenesulfonamide, are useful as preemergent or postemergent herbicides or as plant growth regulants.
摘要翻译： N-（杂环氨基羰基） - 叔 - 卤代烷基苯磺酰胺，例如2-（二氯甲基）-N - [（4-甲氧基-6-甲基嘧啶-2-基）氨基羰基] - 苯磺酰胺，可用作前期或出芽后除草剂或作为植物生长调节者

20. 发明申请

US20160024004A1 NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION 有权
标题翻译：抗HBV感染的新型抗病毒药物
公开(公告)号：US20160024004A1
公开(公告)日：2016-01-28
申请号：US14759385
申请日：2013-12-27
申请人： DREXEL UNIVERSITY , BARUCH S. BLUMBERG INSTITUTE , ENANTIGEN THERAPEUTICS, INC.
发明人： XIAODONG XU , JU-TAO GUO , TONG XIAO , YANMING DU , TIMOTHY BLOCK , SIMON DAVID PETER BAUGH , HONG YE
IPC分类号： C07C311/16 , C07C317/14 , C07D319/16 , C07C311/20 , C07D213/76 , C07D205/04 , C07D231/42 , C07D277/52 , C07D211/96 , C07D239/26 , C07D295/32 , C07C311/17 , C07D263/50
CPC分类号： C07C311/16 , C07B2200/07 , C07C233/66 , C07C309/89 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/48 , C07C317/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D203/26 , C07D205/04 , C07D211/96 , C07D213/40 , C07D213/75 , C07D213/76 , C07D215/38 , C07D215/42 , C07D217/24 , C07D231/40 , C07D231/42 , C07D239/26 , C07D261/14 , C07D263/48 , C07D263/50 , C07D263/58 , C07D277/46 , C07D277/52 , C07D295/26 , C07D295/30 , C07D295/32 , C07D305/08 , C07D309/04 , C07D319/16 , C07D319/18
摘要： The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
摘要翻译：本发明提供新的式（I）化合物及其使用方法。在某些实施方案中，本发明的化合物可用作核衣壳组装抑制剂。在其它实施方案中，本发明的化合物可用作乙型肝炎病毒（HBV）的前基因组RNA包封抑制剂。在其它实施方案中，本发明的化合物可用于治疗病毒感染，包括HBV和相关病毒感染。

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