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11. 发明授权

US09233205B2 Injection device having injection volume adjustment 有权
标题翻译：注射装置具有进样量调节
公开(公告)号：US09233205B2
公开(公告)日：2016-01-12
申请号：US13254919
申请日：2010-01-22
申请人： Andreas Renz , Wilfried Weber
发明人： Andreas Renz , Wilfried Weber
IPC分类号： A61M5/20 , A61M5/24 , A61M5/315 , A61M5/46
CPC分类号： A61M5/2033 , A61M5/24 , A61M5/31546 , A61M5/31553 , A61M5/31563 , A61M5/31573 , A61M5/31591 , A61M5/46 , A61M2005/2006 , A61M2005/206 , A61M2005/2414
摘要： An injection device (2) comprises a housing (4) in which a receiving chamber (6) is provided for an injection mechanism (8) having an injection fluid container (10) that can be pressed out by means of an injection plunger (12). The injection device (2) further comprises an actuating device (18) that can be driven for automatically pressing out the injection fluid container (10), wherein said actuating device can be displaced between an insertion/removal position outside of the receiving chamber (6) and an injection position within the receiving chamber (6), wherein the actuating device (18) is spaced by a release distance (d) from the receiving chamber (6) in the insertion/removal position. A contact mechanism (22) is provided, by means of which the actuating device (18) can be brought into a stop position in which an actuating stop (26) of the actuating device (18) contacts the injection plunger (12) and in which an injection volume adjustment (28) is automatically actuated.
摘要翻译：注射装置（2）包括壳体（4），其中设置有用于注射机构（8）的接收室（6），该注射机构具有可以通过注射柱塞（12）压出的注射流体容器（10））。注射装置（2）还包括致动装置（18），其可被驱动以自动挤出注射流体容器（10），其中所述致动装置可以在接收室（6）外部的插入/取出位置之间移位）和所述接收室（6）内的注射位置，其中所述致动装置（18）在所述插入/取出位置处与所述容纳室（6）间隔开释放距离（d）。提供接触机构（22），通过该接触机构，致动装置（18）能够进入停止位置，致动装置（18）的致动止动件（26）接触到注射柱塞（12）自动启动进样量调节（28）。

12. 发明授权

US09220845B2 Medication injector apparatus with drive assembly that facilitates reset 有权
标题翻译：具有驱动组件的药物注射器装置便于复位
公开(公告)号：US09220845B2
公开(公告)日：2015-12-29
申请号：US14163498
申请日：2014-01-24
申请人： Eli Lilly and Company
发明人： William Godwin Atterbury , Mark Gerard Diller , Shannon Marie-Lynn Hoste , Bobby Lee Walters , Steven Michael Madland
IPC分类号： A61M5/315 , G01D5/249 , G01D5/25 , A61B17/00 , A61M5/24 , A61M5/31
CPC分类号： A61M5/31535 , A61B2017/00482 , A61M5/24 , A61M5/3129 , A61M5/31543 , A61M5/31551 , A61M5/31556 , A61M5/31558 , A61M5/31566 , A61M5/31568 , A61M5/31573 , A61M5/31575 , A61M5/31585 , A61M5/31593 , A61M2005/2407 , A61M2005/2488 , A61M2005/3125 , A61M2205/50 , A61M2205/581 , A61M2205/583 , A61M2205/585 , A61M2205/60 , A61M2205/6027 , G01D5/2497 , G01D5/25
摘要： A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.
摘要翻译：药剂注射器装置，例如注射笔。注射笔包括可重置的柱塞驱动组件，其包括轴向浮动的螺母，柱塞接合螺钉和可与螺母一起移动的驱动离合器，并且当旋转时，螺杆通过螺母旋紧。当墨盒组件安装到笔底座时，浮动螺母和驱动离合器向近侧移动，使得驱动离合器与笔的可旋转驱动构件扭转传递接合，使得该驱动构件的旋转导致驱动螺钉通过螺母在远端方向前进。当墨盒组件没有安装到笔底座上时，浮动螺母和驱动离合器被向远侧偏压以使驱动离合器与可旋转驱动构件的扭矩传递接合脱离，从而允许驱动螺钉通过螺母向近侧复位到在笔底座内更缩进的位置。注射笔还可以包括具有同轴地布置在驱动套筒上并在驱动套筒上轴向振动的注射打印机组件，其在药物分配期间旋转以提供指示注射使用笔的可听到的咔嗒声。注射笔还可以包括使用旋转矩阵和用于电感测笔的剂量设定机构的布置的传感器的剂量量标识符，该标识符可以是利用盒识别器识别的治疗剂量指示系统的一部分药物浓度以允许治疗剂量的自动测定。注射笔还可以包括用于选择性地旋转笔的驱动套筒的组件，该组件具有在剂量设定期间旋转并且在剂量注射期间不转动的转盘。

13. 发明申请

US20140249410A1 INFORMATION SENSING SYRINGE 有权
标题翻译：信息传感器
公开(公告)号：US20140249410A1
公开(公告)日：2014-09-04
申请号：US13783226
申请日：2013-03-01
申请人： MEDRAD, INC.
发明人： Arthur E. UBER, III , Charles MARSH
IPC分类号： A61M5/315 , A61M5/00 , A61M5/168
CPC分类号： A61M5/31573 , A61M5/007 , A61M5/1452 , A61M5/16831 , A61M5/16877 , A61M5/20 , A61M5/31513 , A61M2205/33
摘要： Syringe systems and flow control systems configured to detect information associated with a liquid material are described. The syringe systems may include a syringe body for housing the liquid material and an injector piston for expelling the liquid material out of the syringe through a discharge outlet at a distal end of the syringe body. Components of the syringe, such as an injector piston, may include sensors configured to measure and/or detect a property of the liquid material, such as concentration, pH, or radioactivity. The flow control system may include a pinch valve and a platen arranged about a fluid delivery channel. Flow within the fluid delivery channel may be controlled by increasing (squeezing the fluid delivery channel) or decreasing the distance between the pinch valve and the platen. Components of the flow control system may include detectors configured to detect properties of fluid in the fluid control channel.
摘要翻译：描述了配置成检测与液体材料相关联的信息的注射器系统和流量控制系统。注射器系统可以包括用于容纳液体材料的注射器主体和用于通过注射器主体的远端处的排出口将液体材料排出注射器的注射器活塞。注射器的诸如注射器活塞的部件可以包括被配置为测量和/或检测液体材料的性质（例如浓度，pH或放射性）的传感器。流量控制系统可以包括夹紧阀和围绕流体输送通道布置的压板。可以通过增加（挤压流体输送通道）或减小夹紧阀和压板之间的距离来控制流体输送通道内的流动。流量控制系统的组件可以包括被配置为检测流体控制通道中的流体的性质的检测器。

14. 发明申请

US20120116349A1 Medicated Module with Premix Medicament 有权
标题翻译：具有预混药物的药物模块
公开(公告)号：US20120116349A1
公开(公告)日：2012-05-10
申请号：US13375720
申请日：2010-06-01
申请人： Michael James David Heald , Christopher James Smith
发明人： Michael James David Heald , Christopher James Smith
IPC分类号： A61M5/31
CPC分类号： A61M5/2448 , A61M5/2466 , A61M5/31525 , A61M5/31573 , A61M5/32 , A61M5/3294 , A61M5/347 , A61M2005/1787 , A61M2206/20
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments (1, 2) is disclosed where a primary delivery device (7) contains a first drug agent and accepts a medicated module (4) containing a single dose of a secondary premix medicament (2) containing the first drug agent and at least a second drug agent, where both the primary medicament (1) and the secondary premix medicament (2) are delivered through a single hollow needle (3, 16, 21, 31).
摘要翻译：公开了一种用于共同递送至少两种药物（1,2）的注射系统的药物模块（4），其中主要递送装置（7）包含第一药剂并且接受含有单一剂量的药物模块（4）包含第一药剂和至少第二药物的次级预混合药物（2），其中主药物（1）和次预混药物（2）都通过单个中空针（3,16,21 ，31）。

15. 发明授权

US07896850B2 Device for delivering medicament 有权
标题翻译：用于输送药物的装置
公开(公告)号：US07896850B2
公开(公告)日：2011-03-01
申请号：US11916078
申请日：2006-05-22
申请人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson
发明人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson
IPC分类号： A61M5/00 , A61M5/20 , A61M5/315
CPC分类号： A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/3146 , A61M5/31535 , A61M5/31551 , A61M5/31556 , A61M5/3156 , A61M5/31568 , A61M5/31573 , A61M5/31583 , A61M5/31593 , A61M15/0045 , A61M15/0066 , A61M15/0068 , A61M15/007 , A61M15/0071 , A61M15/0073 , A61M15/0076 , A61M15/0091 , A61M2005/2013 , A61M2005/202 , A61M2005/2488
摘要： The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a predetermined force value. The device is designed and arranged to ensure that the predetermined dose of medicament expelled from the cartridge has a high degree of accuracy and to show the user in a simple manner how much medicament is remaining in the cartridge after a dose or several doses has/have been expelled and at the same time offering a shorter device, which is more convenient for the user when he/she has to carry it with him/her.
摘要翻译：本发明涉及一种用于将预定剂量的液体药物递送到患者的装置，该药物旨在被患者吸入或者想要注射到患者体内。该装置适于处于药物输送状态并且处于药物不输送状态。当装置处于药物递送状态时，所述装置适于以预定的力值将活塞驱动到容纳要输送的液体药物的药筒中。该装置被设计和布置成确保从药筒排出的预定剂量的药物具有高度的准确性并且以简单的方式向用户显示在剂量或数个剂量之后药盒中剩余多少药物被驱逐，同时提供较短的设备，当用户必须携带时，用户便于使用。

16. 发明授权

US07780635B2 Apparatus and methods for delivering fluid and material to a subject 有权
标题翻译：将流体和材料输送到受试者的装置和方法
公开(公告)号：US07780635B2
公开(公告)日：2010-08-24
申请号：US11672675
申请日：2007-02-08
申请人： Terrell Pruitt , Stephen A. Cochran , Bryan Marshall , Yandong Su , Kurt Stricker Stenn , Kenneth Justin Washenik , John DePiano , Gary F. Prokop , Martin Rathgeber
发明人： Terrell Pruitt , Stephen A. Cochran , Bryan Marshall , Yandong Su , Kurt Stricker Stenn , Kenneth Justin Washenik , John DePiano , Gary F. Prokop , Martin Rathgeber
IPC分类号： A61M31/00 , A61M5/00
CPC分类号： A61M37/00 , A61M5/3148 , A61M5/31551 , A61M5/31573 , A61M5/31586 , A61M2005/2411 , A61M2005/2414 , A61M2005/341 , A61M2005/342
摘要： The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
摘要翻译：本发明提供了用于实施该方法的流体和材料输送方法和装置。本发明提供递送细胞材料的方法，包括将细胞材料注射到受试者中，使得注射的细胞在注射时保持其固有的形态特征。该方法包括将多孔材料吸入包含注射器装置的流体递送装置中的步骤。将细胞材料吸入注射器的主体中，直到所需量的材料填充注射器体。然后将流体输送装置的针以与皮肤平行的角度插入受试者的皮肤中，直到达到所需的深度。然后将细胞材料注射到受试者中，直到注入了所需体积的材料。然后将装置的针旋转约45度至90度，并将针从注射部位移除。

17. 发明申请

US20100186739A1 Device for Delivering Medicament 有权
标题翻译：送药设备
公开(公告)号：US20100186739A1
公开(公告)日：2010-07-29
申请号：US11916082
申请日：2006-05-22
申请人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson , Tomas Deurrell , Anders Karlsson
发明人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson , Tomas Deurrell , Anders Karlsson
IPC分类号： A61M5/20 , A61M15/00 , A61F9/00 , A61M35/00
CPC分类号： A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/3146 , A61M5/31535 , A61M5/31551 , A61M5/31553 , A61M5/31556 , A61M5/3156 , A61M5/31573 , A61M5/31583 , A61M5/31593 , A61M5/484 , A61M15/0045 , A61M15/0065 , A61M15/0066 , A61M15/0073 , A61M15/0076 , A61M15/0081 , A61M15/0083 , A61M15/0091 , A61M2005/2013 , A61M2005/202 , A61M2005/3125 , A61M2205/585
摘要： The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a force that is above or equal to a predetermined minimum force value and below a predetermined maximum force value. The minimum force value is the lowest force value needed to deliver the predetermined dose and the maximum force value is the first force value at which it exists a risk of damaging the cartridge or the components of the device. Further, more of the spring force is brought to an efficient output torque ensuring that a predetermined volume of medicament is expelled from a cartridge.
摘要翻译：本发明涉及一种用于将预定剂量的液体药物递送到患者的装置，该药物旨在被患者吸入或者想要注射到患者体内。该装置适于处于药物输送状态并且处于药物不输送状态。当装置处于药物输送状态时，所述装置适于将活塞驱动到包含要输送的液体药物的药筒中，其中力大于或等于预定的最小力值并低于预定的最大力值。最小力值是递送预定剂量所需的最小力值，最大力值是其存在损坏药筒或装置部件的危险的第一力值。此外，更多的弹簧力被带到有效的输出扭矩，确保预定体积的药物从药筒中排出。

18. 发明申请

US20090308386A1 Device for Delivering Medicament 有权
标题翻译：送药设备
公开(公告)号：US20090308386A1
公开(公告)日：2009-12-17
申请号：US11916078
申请日：2006-05-22
申请人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson
发明人： Victor Kronestedt , Lennart Brunnberg , Stephan Olson
IPC分类号： A61M5/20 , A61M15/00 , A61M35/00 , A61F9/00
CPC分类号： A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/3146 , A61M5/31535 , A61M5/31551 , A61M5/31556 , A61M5/3156 , A61M5/31568 , A61M5/31573 , A61M5/31583 , A61M5/31593 , A61M15/0045 , A61M15/0066 , A61M15/0068 , A61M15/007 , A61M15/0071 , A61M15/0073 , A61M15/0076 , A61M15/0091 , A61M2005/2013 , A61M2005/202 , A61M2005/2488
摘要： The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a predetermined force value. The device is designed and arranged to ensure that the predetermined dose of medicament expelled from the cartridge has a high degree of accuracy and to show the user in a simple manner how much medicament is remaining in the cartridge after a dose or several doses has/have been expelled and at the same time offering a shorter device, which is more convenient for the user when he/she has to carry it with him/her.
摘要翻译：本发明涉及一种用于将预定剂量的液体药物递送到患者的装置，该药物旨在被患者吸入或者想要注射到患者体内。该装置适于处于药物输送状态并且处于药物不输送状态。当装置处于药物递送状态时，所述装置适于以预定的力值将活塞驱动到容纳要输送的液体药物的药筒中。该装置被设计和布置成确保从药筒排出的预定剂量的药物具有高度的准确性并且以简单的方式向用户显示在剂量或数个剂量之后药盒中剩余多少药物被驱逐，同时提供较短的设备，当用户必须携带时，用户便于使用。

19. 发明申请

US20090069756A1 Determination of Cartridge Content by Capacitive Means 审中-公开
标题翻译：通过电容方式确定滤芯内容
公开(公告)号：US20090069756A1
公开(公告)日：2009-03-12
申请号：US12293247
申请日：2007-03-20
申请人： Andre Larsen
发明人： Andre Larsen
IPC分类号： A61M5/00 , G01R27/26 , G01F22/00
CPC分类号： G01F11/027 , A61M5/14566 , A61M5/1782 , A61M5/24 , A61M5/31566 , A61M5/31573 , A61M2205/3317 , A61M2205/3379 , A61M2205/3389 , G01F23/268
摘要： The present invention relates to a replaceable cartridge (4) for a medication delivery device (1), the cartridge being adapted to contain a medicament to be expelled from the medication delivery device, the cartridge comprising a sidewall (2, 3) portion being made of an essentially electrical non-conducting material, a first electrically conducting layer (+) forming part of a first part of the sidewall portion, and a first electrically non-conducting intermediate layer arranged on the first electrically conducting layer, and a first electrically conducting shield layer arranged on the first electrically non-conducting layer.
摘要翻译：本发明涉及一种用于药物输送装置（1）的可替换的药筒（4），该药筒适于容纳从药物输送装置排出的药物，药筒包括制成的侧壁（2,3）部分的基本上不导电的材料，形成侧壁部分的第一部分的一部分的第一导电层（+）和布置在第一导电层上的第一非导电中间层，以及第一导电层屏蔽层布置在第一不导电层上。

20. 发明申请

US20080308580A1 ACCURATE METERING SYSTEM 有权
标题翻译：精确计量系统
公开(公告)号：US20080308580A1
公开(公告)日：2008-12-18
申请号：US11560540
申请日：2006-11-16
申请人： Peter A. Gaydos , Brian A. Lipp , Bruce D. Mcveety , George C. Proicou
发明人： Peter A. Gaydos , Brian A. Lipp , Bruce D. Mcveety , George C. Proicou
IPC分类号： B65D88/54
CPC分类号： A61M5/31525 , A61M5/14566 , A61M5/20 , A61M5/31556 , A61M5/31573 , A61M11/00 , A61M11/001 , A61M15/0065 , A61M2005/1402 , A61M2005/14264 , A61M2005/14506 , A61M2005/3128 , A61M2005/31588 , A61M2202/04 , A61M2205/106 , A61M2205/128 , A61M2205/3306 , A61M2205/3372 , A61M2205/3375 , A61M2205/50 , A61M2205/702 , A61M2205/8206 , B05C17/0103 , G01F11/029
摘要： The present invention is directed to metering devices, systems, and methods that mitigate differential thermal expansion/contraction for the efficient, accurate, and reproducible metered delivery of fluids. The present invention allows the net fluid volume and a plunger location within a fluid dispensing container to automatically adjust under the influence of differential thermal expansion/contraction between the fluid and the fluid dispensing container that the fluid is contained within. Further, the present invention allows the metering system drive to sense the adjusted plunger location and allows the metering system drive to re-zero itself to produce an accurate volumetric delivery of fluid from the fluid dispensing container. The metering system includes means for controlling the travel of the metering system drive, and hence the travel of the plunger into the fluid dispensing container, for delivering accurate/precise amounts of the fluid from the fluid dispensing container. The metering system may also mitigate dead volume in the metering system.
摘要翻译：本发明涉及用于减少不同热膨胀/收缩的计量装置，系统和方法，用于有效，精确和可再现的计量输送流体。本发明允许流体分配容器内的净流体体积和柱塞位置在流体和流体分配容器之间的不同热膨胀/收缩的影响下自动调节，流体分配容器内部包含有流体。此外，本发明允许计量系统驱动器感测经调节的柱塞位置，并且允许计量系统驱动器自身重新定位以产生来自流体分配容器的流体的精确的体积输送。计量系统包括用于控制计量系统驱动器的行程以及因此柱塞进入流体分配容器的行程的装置，用于从流体分配容器输送精确/精确量的流体。计量系统还可以减轻计量系统中的死体积。

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