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    • 11. 发明申请
    • SPHEROID COMPOSITE, SPHEROID-CONTAINING HYDROGEL AND PROCESSES FOR PRODUCTION OF SAME
    • SPHEROID COMPOSITE,含SPHEROID的水凝胶及其制造方法
    • US20120015440A1
    • 2012-01-19
    • US13060693
    • 2009-09-08
    • Hidenori OtsukaTomomi SatomiKoji UenoMasashi YamamotoYuichi NakasoneKyoko Akashi
    • Hidenori OtsukaTomomi SatomiKoji UenoMasashi YamamotoYuichi NakasoneKyoko Akashi
    • C12N5/071
    • C12N5/0068C12N2533/30C12N2533/32C12N2533/70
    • A spheroid composite includes: a substrate including a cell-adhesive porous base material and plural hydrophilic regions and hydrophobic regions that are disposed on the porous base material and formed by curing a photosensitive composition, wherein the photosensitive composition includes a branched polyalkylene glycol derivative having three or more polyalkylene glycol groups, each having a polymerizable substituent at a terminal thereof, and a tri- or higher-valent linking group that binds to the polyalkylene glycol groups; and spheroids formed in the hydrophobic regions on the substrate, the plural spheroids having a uniform size. A spheroid-containing hydrogel, which includes a hydrogel and two or more spheroids having a uniform size with a diameter of from 70 μm to 400 μm that are disposed in the hydrogel in such a manner that the two or more spheroids do not contact each other, can favorably maintain the function of the plural spheroids contained within the hydrogel.
    • 球状复合体包括:基材,其包含细胞粘合剂多孔基材和多个亲水区域和疏水区域,其设置在所述多孔基材上并通过固化光敏组合物形成,其中所述光敏组合物包含具有三个基团的支链聚亚烷基二醇衍生物 或更多个在其末端具有可聚合取代基的聚亚烷基二醇基团和与聚亚烷基二醇基团结合的三价或更高价的连接基团; 并且在基底上的疏水区域中形成球状体,所述多个球体具有均匀的尺寸。 一种含球状体的水凝胶,其包含水凝胶和两个或更多个具有均匀尺寸的直径为70μm至400μm的球体,其以这样的方式设置在水凝胶中,使得两个或更多个球体不彼此接触 可以有利地保持包含在水凝胶内的多个球体的功能。
    • 12. 发明申请
    • IMAGE RESTORING DEVICE AND IMAGE RESTORING METHOD
    • 图像恢复装置和图像恢复方法
    • US20110135214A1
    • 2011-06-09
    • US13057059
    • 2009-08-06
    • Nari TanabeToshihiro FurukawaShunichi Kitahara
    • Nari TanabeToshihiro FurukawaShunichi Kitahara
    • G06K9/40
    • G06T5/20G06T5/002G06T5/003
    • A simple and practical image restoring device capable of improving the performance of image restoration. An image restoring device (100) is provided with a first restoration processing unit (160a) and estimates original image information from the degraded image information into which information unnecessary for the original image information is incorporated. A correlation calculating section (164) calculates the correlation value of the estimation error of when the state amount of a system at time n+1 including the original image information is estimated by information up to time n or the time n+1 with respect to the degraded image information of only the time n. A weighting factor calculating section (166) calculates a weighting factor to define the relationship of the optimum estimated value of the state amount at the time n+1 by the information up to the time n+1, the optimum estimated value of the state amount at the time n+1 by the information up to the time n, and an estimation error of an observed amount including the degraded image information by using the correlation value with respect to the degraded image information of only the time n. An optimum estimated value calculating section (168) calculates the optimum estimated value of the state amount at the time n+1 by the information up to the time n+1 by using the weighting factor with respect to the degraded image information of only the time n.
    • 一种能够提高图像恢复性能的简单实用的图像恢复装置。 图像恢复装置(100)设置有第一恢复处理单元(160a),并且从包含原始图像信息所不需要的信息的劣化图像信息中估计原始图像信息。 相关计算部(164)计算当包括原始图像信息在内的时刻n + 1的系统的状态量通过直到时刻n或时间n + 1的信息来估计的估计误差的相关值相对于 退化的图像信息只有时间n。 加权系数计算部(166)计算加权系数,以确定在时刻n + 1的状态量的最佳估计值与直到时刻n + 1的信息,状态量的最佳推定值 在时刻n + 1处的信息,以及通过使用相对于劣化图像信息仅与时间n相关的值的包含劣化图像信息的观测量的估计误差。 最佳估计值计算部分(168)通过使用相对于劣化图像信息的加权因子来计算直到时间n + 1的信息在时间n + 1处的状态量的最佳估计值 n。
    • 15. 发明申请
    • NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF
    • 新型二氢萘酚化合物及其用途
    • US20100249400A1
    • 2010-09-30
    • US12675331
    • 2008-09-11
    • Isamu Shiina
    • Isamu Shiina
    • C07D403/12C07D413/12C07C211/09C07D401/12
    • C07D295/088C07C217/24C07C2602/10
    • Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two —(CH2)l—N(R1) (R2) groups represent a same substituent; R1 and R2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R1 and R2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R3, R4 and R5 each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; l represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)
    • 公开了下述式(I)表示的化合物,其具有与拉索昔芬和nafoxidine相比具有优异的生产效率的化学结构的二氢化合物。 该化合物可用作蛋白酶体抑制剂和/或抗肿瘤剂。 (式中,二 - (CH 2)1 -N(R 1)(R 2)基团表示相同的取代基; R 1和R 2各自表示氢原子或相同或不同的烷基;或者,R 1和R 2可以组合 一起形成具有氮原子的单环杂环,或者另外与一个或多个选自氧原子,硫原子和氮原子的原子一起形成; R3,R4和R5各自表示一个或多个选自氢的取代基 原子,烷基,酰基,脂环族基团,芳香族基团,卤素原子,酰氧基,氰基和硝基; l表示2-5的整数; n表示1- 4; m表示1-5的整数,q表示1-3的整数。)
    • 18. 发明申请
    • Anti-Reflection Structure Body, Method Of Producing The Same And Method Of Producing Optical Member
    • 防反射结构体及其制造方法及其制造方法
    • US20090323189A1
    • 2009-12-31
    • US12310016
    • 2007-08-09
    • Jun Taniguchi
    • Jun Taniguchi
    • G02B1/11C23C14/48
    • G02B1/118
    • An anti-reflection structure body comprises a base member which is made of glassy carbon and at a surface of which is formed an anti-reflection structure including a cluster of minute projections each having a diameter that contracts towards a tip thereof. The minute projections preferably have an average height of from 200 nm to 3000 nm and an average maximum diameter of from 50 nm to 300 nm, and an average pitch of from 50 nm to 300 nm. An anti-reflection structure body which is easily produced, capable of achieving an anti-reflection effect near to non-reflection, and capable of providing the minute structure even to a member having a high melting point such as quartz glass or the like by transfer or the like can be provided.
    • 防反射结构体包括由玻璃碳制成的基底构件,其表面形成有防反射结构,该防反射结构包括具有朝向其尖端收缩的直径的微小突起簇。 微小突起的平均高度优选为200nm〜3000nm,平均最大直径为50nm〜300nm,平均间距为50nm〜300nm。 一种抗反射结构体,其易于制造,能够实现接近无反射的抗反射效果,并且能够通过转印对具有高熔点的构件(例如石英玻璃等)提供均匀的微小结构 或类似物。