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1. 发明申请

US20120015440A1 SPHEROID COMPOSITE, SPHEROID-CONTAINING HYDROGEL AND PROCESSES FOR PRODUCTION OF SAME 审中-公开
标题翻译： SPHEROID COMPOSITE，含SPHEROID的水凝胶及其制造方法
公开(公告)号：US20120015440A1
公开(公告)日：2012-01-19
申请号：US13060693
申请日：2009-09-08
申请人： Hidenori Otsuka , Tomomi Satomi , Koji Ueno , Masashi Yamamoto , Yuichi Nakasone , Kyoko Akashi
发明人： Hidenori Otsuka , Tomomi Satomi , Koji Ueno , Masashi Yamamoto , Yuichi Nakasone , Kyoko Akashi
IPC分类号： C12N5/071
CPC分类号： C12N5/0068 , C12N2533/30 , C12N2533/32 , C12N2533/70
摘要： A spheroid composite includes: a substrate including a cell-adhesive porous base material and plural hydrophilic regions and hydrophobic regions that are disposed on the porous base material and formed by curing a photosensitive composition, wherein the photosensitive composition includes a branched polyalkylene glycol derivative having three or more polyalkylene glycol groups, each having a polymerizable substituent at a terminal thereof, and a tri- or higher-valent linking group that binds to the polyalkylene glycol groups; and spheroids formed in the hydrophobic regions on the substrate, the plural spheroids having a uniform size. A spheroid-containing hydrogel, which includes a hydrogel and two or more spheroids having a uniform size with a diameter of from 70 μm to 400 μm that are disposed in the hydrogel in such a manner that the two or more spheroids do not contact each other, can favorably maintain the function of the plural spheroids contained within the hydrogel.
摘要翻译：球状复合体包括：基材，其包含细胞粘合剂多孔基材和多个亲水区域和疏水区域，其设置在所述多孔基材上并通过固化光敏组合物形成，其中所述光敏组合物包含具有三个基团的支链聚亚烷基二醇衍生物或更多个在其末端具有可聚合取代基的聚亚烷基二醇基团和与聚亚烷基二醇基团结合的三价或更高价的连接基团; 并且在基底上的疏水区域中形成球状体，所述多个球体具有均匀的尺寸。一种含球状体的水凝胶，其包含水凝胶和两个或更多个具有均匀尺寸的直径为70μm至400μm的球体，其以这样的方式设置在水凝胶中，使得两个或更多个球体不彼此接触可以有利地保持包含在水凝胶内的多个球体的功能。

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