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11. 发明授权

US09927346B2 Flow cytometer system including flow cytometer, autosampler and system integration structure 有权
公开(公告)号：US09927346B2
公开(公告)日：2018-03-27
申请号：US15715464
申请日：2017-09-26
申请人： IntelliCyt Corporation
发明人： Garrett S. Wilson , Braden L. Smith , Michael A. Artinger , Francis Kevin Kohlmeier , Christopher H. Converse
IPC分类号： B01L9/00 , G01N33/00 , C12Q1/68 , G01N15/14 , G01N35/10 , B01L3/00
CPC分类号： G01N15/1404 , B01L3/502 , B01L2200/026 , B01L2300/0609 , B01L2300/0858 , B01L2300/0867 , B01L2300/123 , G01N1/10 , G01N15/1459 , G01N35/00 , G01N35/1095 , G01N2015/1409
摘要： A flow cytometer system includes a flow cytometer, an autosampler and a system integration structure to accommodate interconnection and interface of the flow cytometer and autosampler for operation together and providing for convenient interface with equipment for handling process liquids.

12. 外观设计

USD787701S1 Flow cytometer system shelf unit 有权
公开(公告)号：USD787701S1
公开(公告)日：2017-05-23
申请号：US29485766
申请日：2014-03-21
申请人： Intellicyt Corporation
设计人： Garrett S. Wilson , Braden L. Smith , Michael A. Artinger

13. 发明授权

US08823943B2 System and method for separating samples in a continuous flow 有权
标题翻译：在连续流中分离样品的系统和方法
公开(公告)号：US08823943B2
公开(公告)日：2014-09-02
申请号：US13321809
申请日：2010-05-21
申请人： Linda Trinkle , Thomas Duensing
发明人： Linda Trinkle , Thomas Duensing
IPC分类号： G01N35/08 , G01N35/00
CPC分类号： G01N15/0211 , G01N15/1012 , G01N15/1459 , G01N35/00 , G01N35/08 , G01N2015/1006
摘要： One embodiment of the present invention provides for a method for identifying within a single record the location of each of a plurality of samples suspected of containing particles of interest wherein the single record is obtained from a flowing stream of the plurality of samples passing through a particle analyzer. The method comprises introducing into a conduit the plurality of samples suspected of containing particles of interest wherein each ones of the plurality of samples are separated by fluid gaps to produce a plurality of samples separated by fluid gaps and wherein each of the plurality of samples further comprises marker particles. The plurality of samples separated by fluid gaps are flowed through the conduit as a flowing sample stream to a detector of a particle analyzer, which may be a flow cytometer. The particles of interest are detected as the samples pass the detector of the particle analyzer.
摘要翻译：本发明的一个实施例提供了一种用于在单个记录中识别怀疑含有感兴趣的颗粒的多个样品中的每一个的位置的方法，其中单个记录是从多个样品通过颗粒的流动流获得的分析仪该方法包括将许多怀疑含有感兴趣颗粒的样品引入导管中，其中多个样品中的每一个样品由流体间隙分离以产生由流体间隙分离的多个样品，并且其中多个样品中的每一个进一步包含标记颗粒。通过流体间隙分离的多个样品作为流动的样品流流过导管，进入可以是流式细胞仪的颗粒分析仪的检测器。当样品通过粒子分析仪的检测器时，检测到感兴趣的颗粒。

14. 发明授权

US10101262B2 Evaluating biological material for unassociated virus-size particles with adeno-associated virus epitope 有权
公开(公告)号：US10101262B2
公开(公告)日：2018-10-16
申请号：US15713154
申请日：2017-09-22
申请人： Intellicyt Corporation
发明人： Michael A. Artinger , Francis Kevin Kohlmeier , Michael W. Olszowy , Tyler Donald Gates
IPC分类号： G01N15/14 , C12N7/00 , G01N15/06 , G01N33/58 , G01N33/569 , G01N15/00
摘要： A method for evaluating a biological material for unassociated virus-size particles having a particular epitope indicative of an adeno-associated virus viral type or an adenovirus viral type uses a fluorescent antibody stain specific for binding with the epitope and a fluid sample with the virus-size particles and fluorescent antibody stain is subjected to flow cytometry with identification of fluorescent emission detection events indicative of passage through a flow cell of a flow cytometer of unassociated labeled particles of virus size including such a virus-size particle and fluorescent antibody stain.

15. 发明授权

US10031061B2 Flow measurement and control for improved quantification of particles in flow cytometry 有权
公开(公告)号：US10031061B2
公开(公告)日：2018-07-24
申请号：US13319662
申请日：2009-05-13
申请人： Kathy L. Rowlen , Matthew Ferris
发明人： Kathy L. Rowlen , Matthew Ferris
IPC分类号： G01N15/10 , G01N15/14
摘要： The present invention relates to methods that enable improved accuracy for quantitative particle counting in a flowing liquid stream. The methods of the present invention utilize the real-time measurement of flow rates and flow rate control through feedback mechanisms to improve quantification, and this improved quantification translates to more accurate particle counting. In certain embodiments, particles being counted are biological particles in a liquid sample, such as viruses.

16. 发明授权

US09850979B2 Flow cytometer with optical system assembly having vibration isolation and shear protection structures 有权
公开(公告)号：US09850979B2
公开(公告)日：2017-12-26
申请号：US15316093
申请日：2015-06-02
申请人： IntelliCyt Corporation
发明人： Kathy L. Rowlen , Erica Dawson Tenent , Garrett S. Wilson , Christopher H. Converse
IPC分类号： G01N15/14 , F16F15/08 , G01N15/00 , G01N15/10
CPC分类号： F16F15/08 , F16F2224/025 , G01N15/1436 , G01N15/1459 , G01N2015/0065 , G01N2015/1006 , G01N2035/00306
摘要： A flow cytometer may include a vibration isolation structure on which a flow cytometer optical system assembly is supported when the flow cytometer is in an operational configuration. A shear protection structure may be positioned to protect a vibration isolation structure from damage during handling and shipping. A flow cytometer optical system assembly may include optical component units fixed in position on a support platform with adjustability of one or more optical features in the optical component units. A light-tight dichroic mirror unit may include a rotatably mounted dichroic mirror with a locking mechanism to permit re-setting angular positioning of a dichroic mirror.

17. 发明授权

US09816912B2 Evaluating biological material for unassociated virus-size particles having an adenovirus hexon protein epitope 有权
公开(公告)号：US09816912B2
公开(公告)日：2017-11-14
申请号：US15123544
申请日：2016-03-23
申请人： IntelliCyt Corporation
发明人： Michael A. Artinger , Francis Kevin Kohlmeier , Michael W. Olszowy , Tyler Donald Gates
IPC分类号： G01N15/14 , C12N7/00 , G01N33/569 , G01N33/58 , G01N15/06 , G01N15/00
CPC分类号： G01N15/1436 , C12N7/00 , G01N15/06 , G01N15/14 , G01N15/1459 , G01N21/6428 , G01N33/56983 , G01N33/582 , G01N2015/0065 , G01N2015/0687 , G01N2015/0693 , G01N2015/1486 , G01N2015/1488 , G01N2015/1493 , G01N2021/6439 , G01N2021/6441 , G01N2333/11 , G01N2469/10
摘要： A method for evaluating a biological material for unassociated virus-size particles having a particular epitope indicative of an adeno-associated virus viral type or an adenovirus viral type uses a fluorescent antibody stain specific for binding with the epitope and a fluid sample with the virus-size particles and fluorescent antibody stain is subjected to flow cytometry with identification of fluorescent emission detection events indicative of passage through a flow cell of a flow cytometer of unassociated labeled particles of virus size including such a virus-size particle and fluorescent antibody stain.

18. 发明申请

US20140152987A1 System and Method for Separating Samples in a Continuous Flow 审中-公开
标题翻译：在连续流中分离样品的系统和方法
公开(公告)号：US20140152987A1
公开(公告)日：2014-06-05
申请号：US14175032
申请日：2014-02-07
申请人： Intellicyt Corporation
发明人： Linda Trinkle , Thomas Duensing
IPC分类号： G01N15/02
CPC分类号： G01N15/0211 , G01N15/1012 , G01N15/1459 , G01N35/00 , G01N35/08 , G01N2015/1006
摘要： One embodiment of the present invention provides for a method for identifying within a single record the location of each of a plurality of samples suspected of containing particles of interest wherein the single record is obtained from a flowing stream of the plurality of samples passing through a particle analyzer. The method comprises introducing into a conduit the plurality of samples suspected of containing particles of interest wherein each ones of the plurality of samples are separated by fluid gaps to produce a plurality of samples separated by fluid gaps and wherein each of the plurality of samples further comprises marker particles. The plurality of samples separated by fluid gaps are flowed through the conduit as a flowing sample stream to a detector of a particle analyzer. The particle analyzer is for example a flow cytometer. The particles of interest when present and/or marker particles are detected as the plurality of samples pass the detector of the particle analyzer. A record over time for the particles of interest when present and/or marker particles in each of the plurality of samples are obtained in the single file once the plurality of samples pass the incident beam of light of the particle analyzer. A time position in the record is identified where particles of interest within any one of the plurality of samples would be located if present based upon the detection of marker particles present within each combined sample from the flowing stream of the plurality of samples.
摘要翻译：本发明的一个实施例提供了一种用于在单个记录中识别怀疑含有感兴趣的颗粒的多个样品中的每一个的位置的方法，其中单个记录是从多个样品通过颗粒的流动流获得的分析仪该方法包括将许多怀疑含有感兴趣颗粒的样品引入导管中，其中多个样品中的每一个样品由流体间隙分离以产生由流体间隙分离的多个样品，并且其中多个样品中的每一个进一步包含标记颗粒。通过流体间隙分离的多个样品作为流动的样品流流过导管至颗粒分析仪的检测器。颗粒分析仪例如是流式细胞仪。存在的感兴趣的颗粒和/或标记颗粒被检测为多个样品通过粒子分析仪的检测器。一旦多个样品通过了粒子分析仪的入射光束，则在单个文件中获得当存在时感兴趣的颗粒和/或多个样品中的每一个中的标记颗粒的时间记录。基于从多个样品的流动流中检测出每个组合样品内的标记物颗粒的检测，识别记录中的时间位置，其中如果存在多个样品中任何一个样品中的感兴趣的颗粒将被定位。

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