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11. 发明申请

US20090018154A1 OPIOID AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：制备和使用它的方法和方法
公开(公告)号：US20090018154A1
公开(公告)日：2009-01-15
申请号：US12119841
申请日：2008-05-13
申请人： Huai-Hung Danny Kao , Yadi Zeng , Debashis Das
发明人： Huai-Hung Danny Kao , Yadi Zeng , Debashis Das
IPC分类号： A61K31/439 , C07D489/00 , A61P29/00
CPC分类号： C07D489/08
摘要： An opioid derivative of oxymorphol, called 8-hydroxy-6-α-oxymorphol, has been discovered. This opioid is believed to bind at least to mu-opioid receptors and produce an analgesic or anti-tussive effect. Pharmaceutically acceptable salts of 8-hydroxy-6-α-oxymorphol, and pharmaceutical compositions comprising 8-hydroxy-6-α-oxymorphol or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carrier, are also provided.
摘要翻译：已经发现称为8-羟基-6-α-羟基吗啡的羟吗啡的阿片样物质衍生物。据信这种阿片样物质至少与μ-阿片样物质受体结合并产生止痛或抗咳嗽作用。还提供了8-羟基-6-α-羟基吗啡的药学上可接受的盐，以及包含8-羟基-6-α-羟基吗啡喃或其药学上可接受的盐和药学上可接受的载体的药物组合物。

12. 发明申请

US20080226702A1 Transdermal Delivery Form Disposal Systems and Methods 审中-公开
标题翻译：透皮递送形式处置系统和方法
公开(公告)号：US20080226702A1
公开(公告)日：2008-09-18
申请号：US12048771
申请日：2008-03-14
申请人： Alan Philip Goldberg
发明人： Alan Philip Goldberg
IPC分类号： A61F13/02 , A61K31/4535 , A61K31/445
CPC分类号： A61K9/7023 , A61K31/445 , A61K31/4535 , B09B3/0075 , B09B2220/14
摘要： The extraction and use of residual opioids from transdermal dosage forms can be reduced by placement and fixation of used dosage forms onto a surface. The used dosage form can be fixed to the surface such that it cannot be removed without at least partially destroying the matrix containing the opioid, or such that the matrix containing the opioid is rendered at least partially inaccessible to opioid extraction methods. The disposal system for one or more opioid-containing transdermal delivery forms comprises at least one disposal surface for receiving the transdermal delivery form. The at least one disposal surface can comprise one or more structures for fixing a transdermal delivery form to the at least one surface. Alternatively, the transdermal delivery form comprises one or more structures for permanently fixing the transdermal delivery form to the surface. The disposal system can also be used for preventing or reducing diversion of opioids from transdermal delivery forms.
摘要翻译：可以通过将使用的剂型放置并固定在表面上来减少透皮剂型的残留阿片样物质的提取和使用。使用的剂型可以固定在表面上，使得其不能在不至少部分地破坏含有阿片样物质的基质的情况下被除去，或者使含有阿片样物质的基质至少部分地不能用于阿片样物质提取方法。用于一种或多种含阿片样物质的透皮递送形式的处置系统包括至少一个用于接受透皮递送形式的处置表面。所述至少一个处置表面可以包括用于将透皮递送形式固定到所述至少一个表面的一个或多个结构。或者，透皮递送形式包括用于将透皮递送形式永久固定到表面的一种或多种结构。处置系统也可用于预防或减少阿片类药物从透皮给药形式的转移。

13. 发明申请

US20070281016A1 Sustained release oxycodone composition with acrylic polymer and surfactant 审中-公开
标题翻译：具有丙烯酸聚合物和表面活性剂的缓释羟考酮组合物
公开(公告)号：US20070281016A1
公开(公告)日：2007-12-06
申请号：US11447560
申请日：2006-06-06
申请人： Huai-Hung Kao , Sou-Chan Chang , Yadi Zeng , Fai Jim
发明人： Huai-Hung Kao , Sou-Chan Chang , Yadi Zeng , Fai Jim
IPC分类号： A61K31/485 , A61K9/22
CPC分类号： A61K31/485 , A61K9/2013 , A61K9/2027 , A61K9/2054
摘要： The invention is a controlled release composition comprising a therapeutic amount of an active ingredient in a controlled release matrix. The matrix comprises a combination of a pharmaceutically acceptable acrylic polymer and a metal hydroxide. The amount of surfactant, relative to a given amount of acrylic polymer, is selected for and corresponds to a predetermined release rate for said active ingredient. The compound is preferably used to provide controlled release dosage of oxycodone through a matrix of ammonio methacrylic polymer and sodium lauryl sulfate.
摘要翻译：本发明是一种控释组合物，其包含治疗量的受控释放基质中的活性成分。基质包含药学上可接受的丙烯酸类聚合物和金属氢氧化物的组合。选择相对于给定量的丙烯酸类聚合物的表面活性剂的量并且对应于所述活性成分的预定释放速率。该化合物优选用于通过氨基甲基丙烯酸聚合物和月桂基硫酸钠的基质提供羟考酮的控制释放剂量。

14. 发明授权

US07087619B2 Method for the treatment of urinary incontinence 失效
公开(公告)号：US07087619B2
公开(公告)日：2006-08-08
申请号：US10394038
申请日：2003-03-21
申请人： Frank S. Caruso
发明人： Frank S. Caruso
IPC分类号： A61P3/00 , A61K31/485
CPC分类号： A61K31/00 , A61K31/485 , A61K31/565 , Y10S514/963 , Y10S514/964 , A61K31/46 , A61K31/445 , A61K31/35 , A61K31/335 , A61K31/215 , A61K31/135 , A61K2300/00
摘要： Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and/or pharmaceutically acceptable salts, alone or in combination with a pharmacologically active agent such as an anticholinergic, sympathomimetic, tricyclic antidepressant, antispasmodic, direct-acting smooth muscle relaxant, estrogen, compound having estrogen-like activity, or any combination of the foregoing.

15. 发明申请

US20050026956A1 Carbinols for the treatment of neuropathic dysfunction 审中-公开
标题翻译： Carbinols用于治疗神经性功能障碍
公开(公告)号：US20050026956A1
公开(公告)日：2005-02-03
申请号：US10923621
申请日：2004-08-20
申请人： Richard Carliss , David Lee
发明人： Richard Carliss , David Lee
IPC分类号： C07D215/14 , A61K31/40 , A61K31/435 , A61K31/451 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/55 , A61P3/00 , A61P3/10 , A61P5/00 , A61P7/00 , A61P9/00 , A61P17/02 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P37/06 , A61P39/02 , A61P43/00 , C07D207/08 , C07D211/22 , C07D223/04 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/453
CPC分类号： C07D207/08 , A61K31/40 , A61K31/451 , A61K31/4535 , A61K31/55 , C07D211/22 , C07D223/04 , C07D401/04 , C07D405/04 , C07D409/04
摘要： Compositions and methods are provided for treating neuropathic pain or neuropathic dysfunction that include the administration of an effective amount of a defined carbinol or a pharmaceutically acceptable salt or prodrug thereof.
摘要翻译：提供用于治疗神经性疼痛或神经性功能障碍的组合物和方法，其包括施用有效量的定义的甲醇或其药学上可接受的盐或前药。

16. 发明授权

US6166211A Sequential benzylic oxidations of the naloxone ring system 有权
标题翻译：纳洛酮环体系的连续苄基氧化
公开(公告)号：US6166211A
公开(公告)日：2000-12-26
申请号：US520099
申请日：2000-03-07
申请人： Gary A. Cain , Spencer Drummond, Jr.
发明人： Gary A. Cain , Spencer Drummond, Jr.
IPC分类号： C07D489/02 , C07D489/08
CPC分类号： C07D489/08 , C07D489/02 , Y02P20/55
摘要： The present invention pertains to a process for the preparation of the 10-keto analogs of morphinan compounds. In the case of compounds having a 3-hydroxyl group, the 3-methyl ether protected analog is synthesized by selective phenolic methylation in the presence of the basic amino group. When nalbuphine, morphine, or codeine is used as the starting material, the additional 6-hydroxyl group is protected using acetylation. The protected analog is selectively oxidized by treatment with cerium ammonium nitrate to provide the 10-(S)-hydroxy adduct. The 10-(S)-hydroxy adduct is further oxidized to the 10-keto analog. Any protecting groups that were added prior to oxidation are cleaved subsequent to oxidation to form the desired 10-ketomorphinan.
摘要翻译：本发明涉及制备吗啡喃化合物的10-酮类似物的方法。在具有3-羟基的化合物的情况下，3-甲基醚保护的类似物在碱性氨基存在下通过选择性酚甲基化合成。当使用纳布啡，吗啡或可待因作为起始原料时，使用乙酰化保护额外的6-羟基。通过用硝酸铈铵处理选择性地氧化受保护的类似物以提供10-（S） - 羟基加合物。将10-（S） - 羟基加合物进一步氧化成10-酮类似物。在氧化之前加入的任何保护基在氧化后被切割以形成所需的10-酮吗啡喃。

17. 发明申请

US20220313688A1 METHOD OF TREATING PAIN UTILIZING CONTROLLED RELEASE OXYMORPHONE PHARMACEUTICAL COMPOSITIONS AND INSTRUCTION ON DOSING FOR RENAL IMPAIRMENT 有权
公开(公告)号：US20220313688A1
公开(公告)日：2022-10-06
申请号：US17838636
申请日：2022-06-13
申请人： ENDO PHARMACEUTICALS INC.
发明人： Harry Ahdieh
IPC分类号： A61K31/485 , A61K9/20 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/38
摘要： The invention pertains to a method of using oxymorphone in the treatment of pain by providing a patient with an oxymorphone dosage form and informing the patient or prescribing physician that the bioavailability of oxymorphone is increased in patients with renal impairment.

18. 发明授权

US10052344B2 Vitamin B12 nasal spray and method of use 有权
公开(公告)号：US10052344B2
公开(公告)日：2018-08-21
申请号：US14878430
申请日：2015-10-08
申请人： ENDO PHARMACEUTICALS INC.
发明人： Theodore H. Feller , Angela Sutterer , Thomas E. Fleming
IPC分类号： A61K31/714 , A61K9/00 , A61M15/08 , A61M11/00 , A61K47/18 , A61K47/12 , A61K47/10 , A61K47/02
CPC分类号： A61K31/714 , A61K9/0043 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61M11/006 , A61M15/08
摘要： The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

19. 发明授权

US09926328B2 Crystalline, anhydrous forms of oxymorphone hydrochloride 有权
公开(公告)号：US09926328B2
公开(公告)日：2018-03-27
申请号：US15263175
申请日：2016-09-12
申请人： Endo Pharmaceuticals Inc.
发明人： Andreas Fischer , Dagmar Peters-Groth , Dagmar Lischke
IPC分类号： C07D489/08 , A61K31/485
CPC分类号： C07D489/08 , C07B2200/13
摘要： Crystalline, anhydrous hydrochloride salts of 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt as a medicament and for the treatment and/or prevention of pain.

20. 发明授权

US09789103B2 Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment 有权
公开(公告)号：US09789103B2
公开(公告)日：2017-10-17
申请号：US14336753
申请日：2014-07-21
申请人： Endo Pharmaceuticals Inc.
发明人： Harry Ahdieh
IPC分类号： A61K31/485 , A61K47/38 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/02 , A61K9/20
CPC分类号： A61K31/485 , A61K9/2054 , A61K9/2059 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/38
摘要： The invention pertains to a method of using oxymorphone in the treatment of pain by providing a patient with an oxymorphone dosage form and informing the patient or prescribing physician that the bioavailability of oxymorphone is increased in patients with renal impairment.

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