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11. 发明授权

US07807403B2 Device and direct method for detection of antibiotic-inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和直接方法
公开(公告)号：US07807403B2
公开(公告)日：2010-10-05
申请号：US11904254
申请日：2007-09-26
申请人： Jennifer A. Black , Kenneth S. Thomson
发明人： Jennifer A. Black , Kenneth S. Thomson
IPC分类号： C12Q1/00 , C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/986
摘要： A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of i) a β-lactam-containing antibiotic, ii) a β-lactamase inhibitor to which AmpC β-lactamase is resistant, and iii) a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing amount to form an assay culture. That assay culture in maintained under appropriate culture conditions and for a time period sufficient to determine the interaction of the microorganism with the AmpC β-lactamase resistant inhibitor and antibacterial compound, and thereby determine the presence of an AmpC β-lactamase, wherein a positive test indicates the presence of an AmpC β-lactamase.
摘要翻译：公开了一种用于确定微生物是否产生AmpC和β-内酰胺酶的方法，其中将怀疑产生含有β-内酰胺的抗生素的β-内酰胺酶的微生物培养物与有效量的每种 i）含有β-内酰胺的抗生素，ii）AmpC和β-内酰胺酶具有抗性的β-内酰胺酶抑制剂，和iii）以非生长抑制性微生物渗透量存在的微生物的渗透剂以形成测定培养物。该测定培养物在合适的培养条件下保持足够的时间以确定微生物与AmpC和β-内酰胺酶抗性抑制剂和抗菌化合物的相互作用，从而确定AmpC和β-内酰胺酶的存在，其中a 阳性试验表明存在AmpC＆bgr。 - 内酰胺酶。

12. 发明授权

US07452691B2 Device and method for detecting antibiotic inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和方法
公开(公告)号：US07452691B2
公开(公告)日：2008-11-18
申请号：US11713884
申请日：2007-03-05
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/16
CPC分类号： C12Q1/18
摘要： The present invention provides a method of detecting production of antibiotic-inactivating factor and for determining the antibiotic susceptibility of a microorganism comprising the following steps, a culture of the microorganism suspected of producing inactivating factors and/or whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. The assay culture is incubated under appropriate culture conditions and for a time sufficient to determine production of antibiotic-inactivating factors and/or the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供检测抗生素失活因子的产生和测定微生物的抗生素易感性的方法，包括以下步骤：将怀疑产生灭活因子的微生物培养物和/或其易感性确定的培养物与要测定敏感性的抗生素，以及存在于非生长抑制性微生物透化有效量中的微生物渗透剂，以形成测定培养物。将测定培养物在合适的培养条件下孵育足够长的时间以确定抗生素灭活因子的产生和/或微生物对抗生素的敏感性。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

13. 发明申请

US20080125119A1 MOBILE REGISTRATION SYSTEM 审中-公开
标题翻译：移动注册系统
公开(公告)号：US20080125119A1
公开(公告)日：2008-05-29
申请号：US11941679
申请日：2007-11-16
申请人： Cindy Corritore , Nate Rempe
发明人： Cindy Corritore , Nate Rempe
IPC分类号： H04Q7/20 , H04M1/66
CPC分类号： G06Q10/02 , G06Q50/20 , H04L67/04 , H04L67/306
摘要： A method and system for registering for a course of an educational institution with a telecommunication device via a mobile registration system being executed on a server is disclosed. The server sends registration notifications to the telecommunication devices of a student eligible to participate the mobile registration system. A student operates their telecommunication device to send a registration request to the server to receive registration data. The mobile registration system then retrieves the requested registration data, and based on an infinite number of business rules, performs a smart interpretation convenient when accessing the information via a mobile telecommunications device.
摘要翻译：公开了一种通过在服务器上执行的移动登记系统来注册具有电信设备的教育机构课程的方法和系统。服务器向有资格参与移动注册系统的学生的电信设备发送注册通知。学生操作其电信设备向服务器发送注册请求以接收注册数据。然后，移动注册系统检索所请求的注册数据，并且基于无限数量的业务规则，当通过移动电信设备访问信息时执行智能解释。

14. 发明申请

US20080091261A1 IMPLANTABLE VALVE PROSTHESIS 审中-公开
标题翻译：可植入阀门
公开(公告)号：US20080091261A1
公开(公告)日：2008-04-17
申请号：US11872504
申请日：2007-10-15
申请人： Andrew Long , Attila Csordas
发明人： Andrew Long , Attila Csordas
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2230/0067 , A61F2230/0078 , A61F2230/008
摘要： An implantable valve prosthesis (10) having a deformable body (12) defining an upstream opening in fluid communication with a downstream opening wherein the deformable body (12) has a first configuration that permits fluid flow in one direction only and a second configuration that prevents retrograde fluid flow in the opposite direction is disclosed.
摘要翻译：一种可植入瓣膜假体（10），其具有限定与下游开口流体连通的上游开口的可变形体（12），其中所述可变形体（12）具有允许流体仅在一个方向上流动的第一构造和防止公开了相反方向的逆行流体流动。

15. 发明授权

US07335485B2 Device and method for determining antibiotic susceptibility 有权
标题翻译：用于测定抗生素敏感性的装置和方法
公开(公告)号：US07335485B2
公开(公告)日：2008-02-26
申请号：US11636103
申请日：2006-12-08
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定所述培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

16. 发明申请

US20070082376A1 Device and method for determining antibiotic susceptibility 有权
标题翻译：用于测定抗生素敏感性的装置和方法
公开(公告)号：US20070082376A1
公开(公告)日：2007-04-12
申请号：US11636103
申请日：2006-12-08
申请人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
发明人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
IPC分类号： C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定所述培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

17. 发明授权

US06905848B2 Primers for use in detecting beta-lactamases 有权
标题翻译：用于检测β-内酰胺酶的底漆
公开(公告)号：US06905848B2
公开(公告)日：2005-06-14
申请号：US09814257
申请日：2001-03-21
申请人： Nancy D. Hanson , Christine C. Sanders , Anton F. Ehrhardt
发明人： Nancy D. Hanson , Christine C. Sanders , Anton F. Ehrhardt
IPC分类号： C07H21/04 , C12N9/78 , C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02
CPC分类号： C12N9/78 , C12Q1/689
摘要： Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.
摘要翻译：提供了对某些β-内酰胺酶的核酸特征特异的寡核苷酸引物。引物可用于鉴定样品中家族特异性β-内酰胺酶的核酸特征的方法，特别是在革兰氏阴性细菌的临床分离物中。

18. 发明申请

US20040176582A1 High bone mass gene of 11q13.3 失效
标题翻译： 11q13.3高骨质量基因
公开(公告)号：US20040176582A1
公开(公告)日：2004-09-09
申请号：US10731739
申请日：2003-12-10
申请人： Genome Therapeutics Corporation , Creighton University
发明人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/64 , A61K048/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译：本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。本发明还涉及高骨量基因，相应的野生型基因及其突变体。在本发明中鉴定的基因涉及骨发育。本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法在骨发育。在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

19. 发明授权

US5354674A Method of gene transfer using retrotransposons 失效
标题翻译：使用反转录转座子的基因转移方法
公开(公告)号：US5354674A
公开(公告)日：1994-10-11
申请号：US968259
申请日：1992-10-29
申请人： Clague P. Hodgson
发明人： Clague P. Hodgson
IPC分类号： A61K39/12 , A61K39/395 , C12N7/00 , C12N15/09 , C12N15/63 , C12N15/85 , C12P21/00 , C12R1/91 , C12N15/00 , C12N5/00
CPC分类号： C12N15/63 , C12N15/85 , C12N2800/90 , C12N2830/00 , C12N2830/85
摘要： A process for the transfer and/or expression of any gene into cells, organisms or species is disclosed. The process involves isolating the gene, introducing the gene into a vector comprised of at least one retrotransposon genetic element to provide a hybrid gene. The hybrid gene is introduced into a donor cell capable of packaging and transmitting the retrotransposon to other cells, organisms or species. The hybrid gene is transferred to a recipient cell wherein the hybrid gene replicates by reverse transcription and is inserted into the recipient cell's genome. The gene is preferably expressed as RNA and/or protein, giving the phenotype of the gene.
摘要翻译：公开了将任何基因转移和/或表达到细胞，生物或物种中的方法。该方法包括分离基因，将该基因导入由至少一个反转录转座子遗传元件组成的载体中以提供杂交基因。将杂交基因导入能够将反转录转座子包装并传递到其他细胞，生物或物种的供体细胞中。将杂交基因转移到受体细胞，其中杂交基因通过逆转录复制并插入受体细胞的基因组。该基因优选表达为RNA和/或蛋白质，得到该基因的表型。

20. 发明公开

US20230312645A1 14-3-3 TARGETING PEPTIDES FOR CANCER TREATMENT 审中-公开
公开(公告)号：US20230312645A1
公开(公告)日：2023-10-05
申请号：US18076033
申请日：2022-12-06
申请人： Creighton University , The Board of Regents of the University of Nebraska
发明人： Laura Hansen , Sandor Lovas , Nicholas Palermo
IPC分类号： C07K5/117 , A61P35/00 , A61K9/06 , A61K9/107 , C07K7/08
CPC分类号： C07K5/1024 , A61P35/00 , A61K9/06 , A61K9/107 , C07K7/08 , A61K38/00
摘要： Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3ε heterodimerization or CDC25A binding to 14-3-3ε. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Trp-Tyr-Trp-Lys-NH2 (SEQ ID NO: 1), a second targeting peptide comprising a structure of phospho-Ser178; Ac-Thr-Gln-Arg-Gln-Asn-Ser-(PO32−)-Ala-Pro-Arg-Met-Leu-Ser-Ser-Asn-NH2 (SEQ ID NO: 2), and a third targeting peptide comprising a structure of phospho-Thr507 residue; Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32−)-Trp-Ala-Gly-Glu-Lys-Ser-Lys-Arg-NH2 (SEQ ID NO: 3).

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