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1. 发明授权

US07718392B2 Device and direct method for detecting antibiotic-inactivating factors 有权
标题翻译：用于检测抗生素失活因子的装置和直接方法
公开(公告)号：US07718392B2
公开(公告)日：2010-05-18
申请号：US11880768
申请日：2007-07-24
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

2. 发明授权

US07166442B2 Device and method for detecting antibiotic inactivating enzymes 有权
公开(公告)号：US07166442B2
公开(公告)日：2007-01-23
申请号：US11177714
申请日：2005-07-08
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.

3. 发明授权

US07452691B2 Device and method for detecting antibiotic inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和方法
公开(公告)号：US07452691B2
公开(公告)日：2008-11-18
申请号：US11713884
申请日：2007-03-05
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/16
CPC分类号： C12Q1/18
摘要： The present invention provides a method of detecting production of antibiotic-inactivating factor and for determining the antibiotic susceptibility of a microorganism comprising the following steps, a culture of the microorganism suspected of producing inactivating factors and/or whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. The assay culture is incubated under appropriate culture conditions and for a time sufficient to determine production of antibiotic-inactivating factors and/or the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供检测抗生素失活因子的产生和测定微生物的抗生素易感性的方法，包括以下步骤：将怀疑产生灭活因子的微生物培养物和/或其易感性确定的培养物与要测定敏感性的抗生素，以及存在于非生长抑制性微生物透化有效量中的微生物渗透剂，以形成测定培养物。将测定培养物在合适的培养条件下孵育足够长的时间以确定抗生素灭活因子的产生和/或微生物对抗生素的敏感性。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

4. 发明授权

US07335485B2 Device and method for determining antibiotic susceptibility 有权
标题翻译：用于测定抗生素敏感性的装置和方法
公开(公告)号：US07335485B2
公开(公告)日：2008-02-26
申请号：US11636103
申请日：2006-12-08
申请人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
发明人： Jennifer A. Black , Ellen S. Moland , Kenneth Thomson
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定所述培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

5. 发明申请

US20070087592A1 Two circuit board housing integrated interconnect 审中-公开
标题翻译：两个电路板外壳集成互连
公开(公告)号：US20070087592A1
公开(公告)日：2007-04-19
申请号：US11580600
申请日：2006-10-13
申请人： Kenneth Thomson , Karl Laue
发明人： Kenneth Thomson , Karl Laue
IPC分类号： H01R12/00
CPC分类号： H05K5/0247 , H01R12/52 , H01R12/523 , H01R12/585 , H01R13/405 , H05K3/308 , H05K3/368 , H05K5/0043
摘要： An electrical device includes terminals encased within a housing and having distal ends connectable to two different circuit boards to provide a reliable electrical connection between the circuit boards. The first circuit board and the second circuit board are electrically connected through terminals that are embedded within the housing. Openings within the two circuit boards provide for electrical communication and continuity between the two circuit boards by a mating interference fit with the terminals. The electric contact provided by the interference fit between the terminal and the opening is dependable through extreme temperature ranges.
摘要翻译：电气设备包括封装在壳体内的端子，并且具有可连接到两个不同电路板的远端以在电路板之间提供可靠的电连接。第一电路板和第二电路板通过嵌入在壳体内的端子电连接。两个电路板中的开口通过与端子的配合过盈配合来提供两个电路板之间的电通信和连续性。通过端子和开口之间的过盈配合提供的电接触可以通过极端温度范围来确定。

6. 发明申请

US20050089947A1 Device and method for detecting antibiotic-inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和方法
公开(公告)号：US20050089947A1
公开(公告)日：2005-04-28
申请号：US10941132
申请日：2004-09-15
申请人： Jennifer Black , Kenneth Thomson
发明人： Jennifer Black , Kenneth Thomson
IPC分类号： C12Q1/18
CPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/986
摘要： A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of i) a β-lactam-containing antibiotic, ii) a β-lactamase inhibitor to which AmpC β-lactamase is resistant, and iii) a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing amount to form an assay culture. That assay culture in maintained under appropriate culture conditions and for a time period sufficient to determine the interaction of the microorganism with the AmpC β-lactamase resistant inhibitor and antibacterial compound, and thereby determine the presence of an AmpC β-lactamase, wherein a positive test indicates the presence of an AmpC β-lactamase.
摘要翻译：公开了一种用于确定微生物是否产生AmpCβ-内酰胺酶的方法，其中将怀疑产生含β-内酰胺抗生素灭活的β-内酰胺酶的微生物培养物与有效量的i）含有β-内酰胺的抗生素，ii）AmpCβ-内酰胺酶具有抗性的β-内酰胺酶抑制剂，和iii）以非生长抑制微生物渗透量存在的微生物渗透剂，以形成测定培养物。该测定培养物在适当的培养条件下保持足够的时间以确定微生物与AmpCβ-内酰胺酶抗性抑制剂和抗菌化合物的相互作用，从而确定AmpCβ-内酰胺酶的存在，其中阳性测试表示AmpCβ-内酰胺酶的存在。

7. 发明申请

US20080026418A1 Device and direct method for detecting antibiotic-inactivating factors 有权
标题翻译：用于检测抗生素失活因子的装置和直接方法
公开(公告)号：US20080026418A1
公开(公告)日：2008-01-31
申请号：US11880768
申请日：2007-07-24
申请人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
发明人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
IPC分类号： C12Q1/34 , C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

8. 发明申请

US20050277170A1 Device and method for detecting antibiotic inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和方法
公开(公告)号：US20050277170A1
公开(公告)日：2005-12-15
申请号：US11176420
申请日：2005-07-07
申请人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
发明人： Jennifer Black , Ellen Smith Moland , Kenneth Thomson
IPC分类号： C12Q1/18
CPC分类号： C12Q1/34 , C12Q1/18
摘要： The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic. In another aspect, the present invention provides an improved method for antibiotic susceptibility testing of a microorganism in a culture by admixing the culture with an antibiotic to which susceptibility is to be assayed, and incubating the culture for a time sufficient to determine the susceptibility of the microorganism to the antibiotic, the improvement comprising admixing the culture with a permeabilizing agent for the microorganism present in a non-growth inhibiting microorganism-permeabilizing effective amount.
摘要翻译：本发明提供了确定微生物的抗生素敏感性的方法，包括以下步骤。首先，将要测定其易感性的微生物的培养物与要测定易感性的抗生素混合，以及存在于非生长抑制性微生物透化有效量的微生物渗透剂以形成测定文化。接下来，将测定培养物在合适的培养条件下温育足以确定微生物对抗生素的敏感性的时间。另一方面，本发明提供了一种用于通过将培养物与待测定易感性的抗生素混合培养的培养物中的微生物的抗生素敏感性测试的改进方法，并将培养物温育足以确定培养物的易感性微生物对抗生素的改善，其包括将培养物与以非生长抑制性微生物渗透有效量存在的微生物渗透剂混合。

9. 发明授权

US5725056A Wellhead assembly with removable bowl adapter 失效
标题翻译：井口组件与可移动碗适配器
公开(公告)号：US5725056A
公开(公告)日：1998-03-10
申请号：US534436
申请日：1995-09-27
申请人： Kenneth Thomson
发明人： Kenneth Thomson
IPC分类号： E21B33/03 , E21B33/04
CPC分类号： E21B33/03 , E21B33/04
摘要： A wellhead assembly has provisions for emergency and nonemergency installation of oversized casing. The wellhead assembly includes a wellhead housing which has counterbore. An adapter sleeve fits within the counterbore. The adapter sleeve has an inner diameter with a profile. A casing hanger is installed during nonemergency conditions. A portion of the casing hanger seal assembly engages the inner diameter of the adapter sleeve. For an emergency when the casing hanger seal and casing hanger cannot be employed, the adapter sleeve is removed. An emergency slips is installed to support the casing. A casing hanger seal is then installed between the counterbore and casing.
摘要翻译：井口总成规定了超大型套管的紧急和非紧急安装。井口组件包括具有沉孔的井口壳体。适配器套筒装在沉孔内。适配器套筒具有具有轮廓的内径。在非紧急情况下安装套管吊架。套管衣架密封组件的一部分接合适配器套筒的内径。对于不能使用套管吊架密封件和套管吊架的紧急情况，拆卸紧固套管。安装紧急滑动件来支撑外壳。然后将套管衣架密封件安装在沉孔和套管之间。

10. 发明申请

US20080102483A1 Device and direct method for detection of antibiotic-inactivating enzymes 有权
标题翻译：用于检测抗生素失活酶的装置和直接方法
公开(公告)号：US20080102483A1
公开(公告)日：2008-05-01
申请号：US11904254
申请日：2007-09-26
申请人： Jennifer Black , Kenneth Thomson
发明人： Jennifer Black , Kenneth Thomson
IPC分类号： C12Q1/34
CPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/986
摘要： A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of i) a β-lactam-containing antibiotic, ii) a β-lactamase inhibitor to which AmpC β-lactamase is resistant, and iii) a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing amount to form an assay culture. That assay culture in maintained under appropriate culture conditions and for a time period sufficient to determine the interaction of the microorganism with the AmpC β-lactamase resistant inhibitor and antibacterial compound, and thereby determine the presence of an AmpC β-lactamase, wherein a positive test indicates the presence of an AmpC β-lactamase.
摘要翻译：公开了一种用于确定微生物是否产生AmpCβ-内酰胺酶的方法，其中将疑似产生含β-内酰胺抗生素灭活的β-内酰胺酶的微生物培养物与有效量的i）含有β-内酰胺的抗生素，ii）AmpCβ-内酰胺酶具有抗性的β-内酰胺酶抑制剂，和iii）以非生长抑制微生物渗透量存在的微生物渗透剂，以形成测定培养物。该测定培养物在适当的培养条件下保持足够的时间以确定微生物与AmpCβ-内酰胺酶抗性抑制剂和抗菌化合物的相互作用，从而确定AmpCβ-内酰胺酶的存在，其中阳性测试表示AmpCβ-内酰胺酶的存在。

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