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11. 发明授权

US5260056A Composition for enhancing biosynthesis of interferon 失效
标题翻译：用于增强干扰素生物合成的组合物
公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
IPC分类号： A61K31/28 , A61K31/70 , A61K37/66 , A61K31/79 , A61K59/16
CPC分类号： A61K31/28 , A61K31/70
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译：有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。

12. 发明授权

US5180739A Use of 3-oxygermylpropionic acid to treat and prevent diabetes-dependent type of autoimmune diseases 失效
标题翻译：使用3-甲氧基丙酸治疗并预防糖尿病依赖型自身免疫性疾病
公开(公告)号：US5180739A
公开(公告)日：1993-01-19
申请号：US659649
申请日：1991-02-23
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Masanori Nagabuchi , Keizo Anzai
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Masanori Nagabuchi , Keizo Anzai
IPC分类号： A61K31/28 , A61K31/80 , A61P3/08 , A61P3/10 , A61P37/00
CPC分类号： A61K31/28 , A61K31/80
摘要： A pharmaceutical composition is used to treat and prevent a diabetes-dependent type of autoimmune diseases, said pharmaceutical composition comprising a therapeutically effective amount of 3-oxygermylpropionic acid represented by the following formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 CO.sub.2 H].sub.nwherein n stands for an integer of 1 or more, optionally with an activating carrier.

13. 发明授权

US4970088A Liquid food for supplying protein 失效
标题翻译：用于提供蛋白质的液体食品
公开(公告)号：US4970088A
公开(公告)日：1990-11-13
申请号：US427276
申请日：1989-10-24
申请人： Yoshinaru Tanaka , Sadaaki Iwamura , Naoko Sugiura , Hiromoto Asai , Tadashi Kurachi , Masayasu Kurono , Bunichiro Yasui , Kiichi Sawai
发明人： Yoshinaru Tanaka , Sadaaki Iwamura , Naoko Sugiura , Hiromoto Asai , Tadashi Kurachi , Masayasu Kurono , Bunichiro Yasui , Kiichi Sawai
IPC分类号： A23J3/00 , A23J3/08 , A23L1/09 , A23L1/305
CPC分类号： A23J3/08 , A23L29/30 , A23L33/19 , Y10S426/80 , Y10S426/801
摘要： The invention is a liquid food for supplying protein principally containing protein, seasonings, flavoring materials and water, wherein it contains 5 to 15% by weight of lactalbumin as the protein. The lactalbumin is obtained by heating to denature under conditions so as to form a cloudy solution. The food is useful for undernourished patients who suffer from hypoproteinemia, hypoalbuminemia or common healthy men who need protein so as to desire to supply nutritious food and develop their muscles.

14. 发明授权

US4897495A Process for the preparation of pyrrolizine derivatives 失效
标题翻译：吡咯啉衍生物的制备方法
公开(公告)号：US4897495A
公开(公告)日：1990-01-30
申请号：US351006
申请日：1989-05-12
申请人： Masayasu Kurono , Yasuaki Kondo , Ryoichi Unno , Yukiharu Matsumoto , Hiromoto Kimura , Mitsuru Oka , Kiichi Sawai
发明人： Masayasu Kurono , Yasuaki Kondo , Ryoichi Unno , Yukiharu Matsumoto , Hiromoto Kimura , Mitsuru Oka , Kiichi Sawai
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A process for the preparation of pyrrolizine derivatives of the formula ##STR1## wherein R is --CN or --CH.sub.2 NH.sub.2, and salts thereof.

15. 发明授权

US5474908A Method of enzymatically measuring hydrogen peroxide and reagent therefor 失效
标题翻译：酶法测定过氧化氢及其试剂的方法
公开(公告)号：US5474908A
公开(公告)日：1995-12-12
申请号：US797011
申请日：1991-11-25
申请人： Masayasu Kurono , Shizuo Uno , Osamu Takehiro , Kiichi Sawai
发明人： Masayasu Kurono , Shizuo Uno , Osamu Takehiro , Kiichi Sawai
IPC分类号： C12Q1/28 , C12Q1/30 , C12Q1/00 , C12Q1/26
CPC分类号： C12Q1/28 , C12Q1/30 , C12Q2326/32
摘要： A method of enzymatically measuring hydrogen peroxide by developing a color with use of 3-methyl-2-benzothiazolinoehydrazone as a coupler and in combination with an oxidative color developing reagent with peroxidase, and a reagent therefor is described. Catalase is added to the 3-methyl-2-benzothiazolinonehydrazone reagent as a stabilizer and the reaction is carried out in the presence of ethylenediaminetetraacetic acid or an analogue thereof. The color developing reaction may be carried out in neutral or weak alkali conditions. A reagent is described which comprises a buffer, 3-methyl-2-benzothiazolinohydrazone, and catalase.
摘要翻译：描述了使用3-甲基-2-苯并噻唑腙腙作为偶联剂并与具有过氧化物酶的氧化显色剂组合的显色测定过氧化氢的方法及其试剂。将过氧化氢酶作为稳定剂加入到3-甲基-2-苯并噻唑啉酮腙试剂中，反应在乙二胺四乙酸或其类似物的存在下进行。显色反应可以在中性或弱碱性条件下进行。描述了包含缓冲剂，3-甲基-2-苯并噻唑腙和过氧化氢酶的试剂。

16. 发明授权

US5434082A Early diagnosis of mastitis or garget 失效
标题翻译：乳腺炎或靶标的早期诊断
公开(公告)号：US5434082A
公开(公告)日：1995-07-18
申请号：US1413
申请日：1993-01-07
申请人： Hideo Yamamoto , Eiji Furukawa , Hiromoto Asai , Masayasu Kurono , Kiichi Sawai
发明人： Hideo Yamamoto , Eiji Furukawa , Hiromoto Asai , Masayasu Kurono , Kiichi Sawai
IPC分类号： G01N33/50 , A61B10/00 , C12Q1/00 , C12Q1/32 , C12Q1/34 , G01N33/04 , C07C49/00 , C12Q1/25
CPC分类号： A01J5/0131 , C12Q1/32 , C12Q1/34 , G01N33/04 , C12Q2326/92
摘要： Early diagnosis of mastitis or garget is carried out by measuring the concentration of 3-hydroxybutyric acid in milk. Used to this end is a reagent reacting with 3-hydroxybutyric acid to show a color at a concentration of 100 .mu.mol/l or higher.
摘要翻译：通过测量牛奶中3-羟基丁酸的浓度来进行乳腺炎或靶标的早期诊断。为此目的是与3-羟基丁酸反应以显示浓度为100微摩尔/升或更高的颜色的试剂。

17. 发明授权

US5432261A Motlin-like polypeptide and use thereof 失效
标题翻译： Motlin样多肽及其用途
公开(公告)号：US5432261A
公开(公告)日：1995-07-11
申请号：US943992
申请日：1992-09-11
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/63 , C12N15/16 , C07K14/00
CPC分类号： C07K14/63 , A61K38/00 , C07K2319/02
摘要： A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.3 are each an amino acid residue having a side-chain with an aromatic ring, C is Gln, Glu or Asp, D is Asn, Glu or Asp, X' is an amino acid residue other than Met, E is Gln, Lys or Arg, and Y is homoserine, homoserine-lactone or a peptide chain having amino acid residues not exceeding 10 and containing homoserine or homoserine-lactone at the C-terminal where the first amino acid of said peptide chain is other than Lys, Arg or Pro.
摘要翻译：一种用于刺激肠道蠕动收缩的药物组合物，其含有药学上可接受的载体或赋形剂和有效量的具有与胃动素相似的药理活性的多肽或其盐。该多肽具有式B1-Z1-A1-Z2-B2-Thr-B3-A2-Glu-Z3-C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-EY， Z 1，Z 2和Z 3各自为具有疏水侧链的氨基酸残基，A1和A2各自为氨基酸残基，例如Pro，Gly，Asn和Ser，B1，B2和B3各自为具有具有芳环的侧链，C是Gln，Glu或Asp，D是Asn，Glu或Asp，X'是Met以外的氨基酸残基，E是Gln，Lys或Arg，Y是高丝氨酸，高丝氨酸 β-内酯或氨基酸残基不超过10的肽链，并且在所述肽链的第一个氨基酸不是Lys，Arg或Pro的C末端含有高丝氨酸或高丝氨酸 - 内酯。

18. 发明授权

US5428015A Vasoactive intestinal polypeptide analogues and use thereof 失效
标题翻译：血管活性肠多肽类似物及其用途
公开(公告)号：US5428015A
公开(公告)日：1995-06-27
申请号：US201092
申请日：1994-02-24
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/575 , C07K7/08
CPC分类号： C07K14/57563 , A61K38/00
摘要： Vasoactive intestinal polypeptide (VIP) analogues and use thereof are disclosed. The VIP analogues are shown by the formula ofHis-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Ywherein X is a residue of amino acid other than methionine (Met); and Y is homoserine, homoserine-lactone, amidized homoserine, a residue reacted homoserine-lactone with a primary alkyl amine having carbon atoms not exceeding 20, or an optional polypeptide chain and containing an amidized homoserine at C-terminal.Each of the VIP analogues is employed as an effective ingredient for various medicines and a hair tonic, and more particularly curing an asthma and impotence.
摘要翻译：公开了血管活性肠肽（VIP）类似物及其用途。 VIP类似物以His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys -Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Y其中X是甲硫氨酸以外的氨基酸残基（Met）; 并且Y是高丝氨酸，高丝氨酸 - 内酯，酰胺化高丝氨酸，残基与高丝氨酸 - 内酯与碳原子数不超过20的伯烷基胺反应，或任选的多肽链，并且在C-末端含有酰胺化的高丝氨酸。每种VIP类似物被用作各种药物和头发补品的有效成分，更特别地治疗哮喘和阳。。

19. 发明授权

US5290679A Method of predicting threatened premature delivery in a pregnant woman 失效
标题翻译：孕妇威胁性早产的预测方法
公开(公告)号：US5290679A
公开(公告)日：1994-03-01
申请号：US898681
申请日：1992-06-15
申请人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
发明人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
IPC分类号： A61K49/00 , G01N33/573 , C12Q1/00 , C12Q1/37
CPC分类号： G01N33/573
摘要： Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex. It is thus possible to predict and prevent threatened premature delivery, premature delivery or premature rupture of membranes by immunoassay of mucus collected from the cervical canal of a pregnant woman, to make a diagnosis of chronic or repetitive airway infections and pulmonary emphysema based on chronic respiratory diseases by immunoassay of sputum and a rinsed solution of bronchovesicular lavage and to make a diagnosis of urinary tract infections by immunoassay of urine.
摘要翻译：即使样品含有游离弹性蛋白酶与弹性蛋白酶抑制剂复合物或复合物的混合物形式的人粒细胞弹性蛋白酶，本发明能够精确地检测该样本中弹性蛋白酶的总量。将抑制剂加入到游离弹性蛋白酶中以将其转化成弹性蛋白酶抑制剂复合物，由此弹性蛋白酶的量可以通过免疫测定来测量，包括先前存在的弹性蛋白酶抑制剂复合物的总量。可以精确测量从孕妇，痰液或冲洗的支气管泡灌洗液的宫颈管中收集的弹性蛋白酶的总量，其中游离弹性蛋白酶与弹性蛋白酶抑制剂复合物混合。因此，可以通过从孕妇的宫颈管收集的粘液的免疫测定来预测和预防受威胁的早产，早产或过早破裂，以诊断慢性或重复性气道感染和基于慢性呼吸的肺气肿通过免疫测定痰液的疾病和支气管泡灌洗液的清洗溶液，并通过免疫测定尿液来诊断尿路感染。

20. 发明授权

US5211956A Pharmaceutical compositions containing phytic acid or its salts 失效
标题翻译：含有植物酸或其盐的药物组合物
公开(公告)号：US5211956A
公开(公告)日：1993-05-18
申请号：US346852
申请日：1989-05-03
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Pharmaceutical compositions for oral administration used for the treatment and prevention of hyperlipemia, obesity and obesity-related diseases contain phytic acid or its salt as a pharmaceutically effective component.

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