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11. 发明申请

US20070232690A1 Composition for inducing differentiation of leukemic cells and application thereof 审中-公开
标题翻译：用于诱导白血病细胞分化的组合物及其应用
公开(公告)号：US20070232690A1
公开(公告)日：2007-10-04
申请号：US11391581
申请日：2006-03-28
申请人： Yu-Jen Chen , Hui-Fen Liao , Yueh-Hsiung Kuo
发明人： Yu-Jen Chen , Hui-Fen Liao , Yueh-Hsiung Kuo
IPC分类号： A61K31/343
CPC分类号： A61K31/343
摘要： Disclosed is a medical composition for inducing differentiation of leukemic cells, which can induce leukemic cells to differentiate into monocytes and macrophages, and block the abnormal proliferation of leukemic cells through a PKC-independent pathway. In addition, the medical composition cans also downregulate c-myc gene expression in the leukemic cells, and upnregulate c-fms, c-fos and c-jun gene. The medical composition comprises a compound represented by the general formula (I) shown below: wherein R1, R2, and R3 represent —H, a linear or branched alkyl group with 1 to 3 carbon atoms, and R4 represents —H or a benzyl group.
摘要翻译：公开了用于诱导白血病细胞分化的医药组合物，其可以诱导白血病细胞分化成单核细胞和巨噬细胞，并通过PKC非依赖性途径阻断白血病细胞的异常增殖。另外，该药物组合物也可以下调白血病细胞中的c-myc基因表达，并调节c-fms，c-fos和c-jun基因。医药组合物包含由下列通式（I）表示的化合物：其中R 1，R 2和R 3表示 - H，具有1至3个碳原子的直链或支链烷基，R 4代表-H或苄基。

12. 发明授权

US10745370B2 Farnesyl transferase inhibitors and uses thereof 有权
公开(公告)号：US10745370B2
公开(公告)日：2020-08-18
申请号：US16087103
申请日：2017-03-20
申请人： Yu-Jen Chen
发明人： Yu-Jen Chen , Lie-Chwen Lin
IPC分类号： C07D311/22 , A61P37/06 , A61P25/28 , A61P35/00
摘要： Disclosed herein are novel compounds and uses thereof. The present compounds may suppress the activity of farnesyl transferase and thus, may act as modulators of immune cells; therefor, they are useful for the development of a medicament for treating diseases that are associated with or caused by excessive levels of farnesyl transferase or immune response. Also disclosed herein are pharmaceutical compositions containing the present compounds.

13. 发明授权

US09572545B2 Radiotherapy system adapted to monitor a target location in real time 有权
标题翻译：适用于实时监控目标位置的放射治疗系统
公开(公告)号：US09572545B2
公开(公告)日：2017-02-21
申请号：US13466142
申请日：2012-05-08
申请人： Yu-Jen Chen , Chia-Yuan Liu , Wen-Chung Chang , Chin-Sheng Chen
发明人： Yu-Jen Chen , Chia-Yuan Liu , Wen-Chung Chang , Chin-Sheng Chen
IPC分类号： A61B8/08 , A61B8/00 , A61N5/10
CPC分类号： A61B8/085 , A61B8/4218 , A61B8/4263 , A61B8/523 , A61B8/5261 , A61B8/565 , A61B8/587 , A61N5/1037 , A61N5/1067 , A61N2005/1058 , G06T7/187 , G06T7/33 , G06T2207/10081 , G06T2207/10132 , G06T2207/20032 , G06T2207/20061 , G06T2207/30056
摘要： The present invention provides a radiotherapy system that can monitor a target location in real time. The radiotherapy system includes a remote control system operable to actuate a real-time image capturing device to acquire images in real time for monitoring the target location. The system also includes an image registration system that can register the acquired image with an image previously captured for the treatment plan, whereby it can be determined whether the patient's tumor is in the beam's eye view of the treatment plan. By confirming that the tumor is in the range of the beam's eye view, the accuracy of the treatment can be improved, and the irradiated area can be reduced, which makes the radiation treatment safer.
摘要翻译：本发明提供了可以实时监视目标位置的放射治疗系统。放射治疗系统包括可操作以致动实时图像捕获装置以实时获取图像的遥控系统，用于监视目标位置。该系统还包括一个图像配准系统，其可以用先前为治疗计划拍摄的图像来注册所获取的图像，从而可以确定患者的肿瘤是否处于治疗计划的眼睛视图中。通过确认肿瘤在眼睛的视野范围内，可以提高治疗的准确性，并且可以减少照射面积，这使得放射治疗更安全。

14. 发明授权

US08846768B2 Use of compounds isolated from Euphorbia neriifolia for treating cancer and/or thrombocytopenia 有权
标题翻译：使用从大戟属分离的化合物治疗癌症和/或血小板减少症
公开(公告)号：US08846768B2
公开(公告)日：2014-09-30
申请号：US13595170
申请日：2012-08-27
申请人： Yu-Jen Chen , Lie-Chwn Lin , Ching-Pin Lin
发明人： Yu-Jen Chen , Lie-Chwn Lin , Ching-Pin Lin
IPC分类号： A61K31/015 , A61K33/24 , A61K31/336 , A61K31/045
CPC分类号： A61K31/336 , A61K31/045 , A61K31/575 , A61K33/24 , A61K2300/00
摘要： Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.
摘要翻译：本文公开了小分子特别是分离自大戟属的三萜类化合物和多糖二萜类的新型用途。三萜类化合物可用作制备用于治疗癌症的药物或药物组合物的铅化合物; 而二醇二萜可用作制备用于治疗血小板减少症的药物或药物组合物的铅化合物。

15. 发明授权

US08691870B2 Use of isothiocyanates for treating cancer 有权
标题翻译：使用异硫氰酸酯治疗癌症
公开(公告)号：US08691870B2
公开(公告)日：2014-04-08
申请号：US13243128
申请日：2011-09-23
申请人： Yu-Jen Chen , Hui-Fen Liao
发明人： Yu-Jen Chen , Hui-Fen Liao
IPC分类号： A61K31/26 , C07C331/00
CPC分类号： A61K31/26
摘要： Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
摘要翻译：本文公开了小分子，特别是异硫氰酸6-甲基亚磺酰基己酯和异硫氰酸6-甲基磺酰基己酯的新用途。两种异硫氰酸酯可用作制造用于治疗患者中的癌症，特别是耐药性癌症的药物或药物组合物的铅化合物。

16. 发明授权

US08546366B2 Method for inhibition of tumor cell growth using (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol 有权
标题翻译：（22R）-5alpha-lanosta-8,24-二烯-3β，15α，21-三醇抑制肿瘤细胞生长的方法
公开(公告)号：US08546366B2
公开(公告)日：2013-10-01
申请号：US13483620
申请日：2012-05-30
申请人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
发明人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
IPC分类号： A61K31/56 , A61K38/00 , A61P35/00
CPC分类号： A61K31/575
摘要： In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.
摘要翻译：在这项专利中，我们从番茄子实体中分离出一种新的化合物，即（22R）-5α-羊毛甾-8,24-二烯-3β，15α，21-三醇。该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

17. 发明申请

US20120309732A1 METHOD FOR INHIBITION OF TUMOR CELL GROWTH USING (22R)-5alpha-LANOSTA-8,24-DIEN-3Beta,15alpha,21-TRIOL 有权
标题翻译：使用（22R）-5alpha-LANOSTA-8,24-DIEN-3Beta，15α，21-TRIOL抑制肿瘤细胞生长的方法
公开(公告)号：US20120309732A1
公开(公告)日：2012-12-06
申请号：US13483620
申请日：2012-05-30
申请人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
发明人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
IPC分类号： A61K31/56 , A61P35/04 , A61P35/02 , C12N5/09
CPC分类号： A61K31/575
摘要： In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.
摘要翻译：在该专利中，我们分离出了一种新型的化合物，即，（22R）-5α-lanosta-8,24-二烯-3和bgr，15α，21-三醇的子实体。该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

18. 发明授权

US08310215B2 Linear modulation voltage transformer circuitry 有权
标题翻译：线性调制电压互感器电路
公开(公告)号：US08310215B2
公开(公告)日：2012-11-13
申请号：US12777437
申请日：2010-05-11
申请人： Chen-Kun Chou , Zhan-Yi Lin , Ting-Kuan Li , Yu-Jen Chen , Chi-Bin Wu
发明人： Chen-Kun Chou , Zhan-Yi Lin , Ting-Kuan Li , Yu-Jen Chen , Chi-Bin Wu
IPC分类号： G05F1/70
CPC分类号： G05F1/575
摘要： A linear modulation voltage transformer circuitry includes a power stage unit, a voltage division unit, a linear modulation unit, an error amplifier, and a recursive controller. The power stage unit adapts an input voltage and outputs a first voltage to the voltage division unit, which outputs a divided voltage. The linear modulation unit receives the divided voltage, compares it with a control voltage, and outputs an error voltage signal to the error amplifier, which amplifies the error voltage signal as an error gain control signal. The recursive controller receives and modulates the error gain control signal and outputs the modulation error gain control signal to the power stage unit as a reference signal so as for the power stage unit to modulate the first voltage. Thus, the first voltage can be varied in real time via the linear modulation unit to meet load demands.
摘要翻译：线性调制电压互感器电路包括功率级单元，分压单元，线性调制单元，误差放大器和递归控制器。功率级单元适应输入电压，并向分压单元输出第一电压，分压单元输出分压。线性调制单元接收分压，将其与控制电压进行比较，并将误差电压信号输出到误差放大器，该误差放大器将误差电压信号放大为误差增益控制信号。递归控制器接收并调制误差增益控制信号，并将调制误差增益控制信号输出到功率级单元作为参考信号，以使功率级单元调制第一电压。因此，可以经由线性调制单元实时地改变第一电压以满足负载需求。

19. 发明申请

US20120278724A1 CONTROL METHOD OF A TERMINAL DISPLAY DEVICE 审中-公开
标题翻译：终端显示设备的控制方法
公开(公告)号：US20120278724A1
公开(公告)日：2012-11-01
申请号：US13178515
申请日：2011-07-08
申请人： Yu-Jen Chen
发明人： Yu-Jen Chen
IPC分类号： G06F3/048 , G06F15/16
CPC分类号： H04N21/4222 , H04M1/72533
摘要： A method for controlling a terminal display device is disclosed and includes the following steps. An electronic device couples to a web server of the terminal display device via a network. The electronic device displays a web page transmitted from the web server. A user selects a function option of the web page shown on the electronic device. The web server of the terminal display device generates a command according to the selected function option. A control system of the terminal display device controls an operation of the terminal display device according to the command.
摘要翻译：公开了一种用于控制终端显示设备的方法，包括以下步骤。电子设备通过网络耦合到终端显示设备的web服务器。电子设备显示从web服务器发送的网页。用户选择电子设备上显示的网页的功能选项。终端显示设备的Web服务器根据所选择的功能选项生成命令。终端显示装置的控制系统根据该命令控制终端显示装置的动作。

20. 发明申请

US20090318400A1 METHOD FOR INHIBITING TUMOR GROWTH WITH DEHYDROSULPHURENIC ACID EXTRACTED FROM ANTRODIA CINNAMOMEA 有权
标题翻译：用于从ANTRODIA CINNAMOMEA中提取的脱氢赖氨酸抑制肿瘤生长的方法
公开(公告)号：US20090318400A1
公开(公告)日：2009-12-24
申请号：US12265599
申请日：2008-11-05
申请人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
发明人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
IPC分类号： A61K31/575 , A61P35/00
CPC分类号： A61K31/575
摘要： The present invention relates to a method for inhibiting tumor growth, in particular to the method using dehydrosulphurenic acid to inhibit the growth of leukemia cell or pancreatic cancer cell by a compound extracted and purified from Antrodia cinnamomea. Dehydrosulphurenic acid of the invention can be used as a pharmaceutical composition to inhibit the tumor growth of leukemia or pancreatic cancer.
摘要翻译：本发明涉及一种抑制肿瘤生长的方法，特别是涉及使用脱氢硫代酸通过从番茄红素提取和纯化的化合物抑制白血病细胞或胰腺癌细胞生长的方法。本发明的脱氢硫酸可以用作抑制白血病或胰腺癌肿瘤生长的药物组合物。

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