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11. 发明授权

US09211548B2 Apparatus for sample introduction, chip for sample introduction, and method for sample introduction 有权
标题翻译：样品引入装置，样品引入芯片和样品引入方法
公开(公告)号：US09211548B2
公开(公告)日：2015-12-15
申请号：US13277699
申请日：2011-10-20
申请人： Yoichi Katsumoto
发明人： Yoichi Katsumoto
IPC分类号： G01N27/447 , G01N27/26 , B03C5/00 , B03C5/02 , G01N15/10
CPC分类号： B03C5/005 , B03C5/026 , G01N15/1031 , G01N15/1056
摘要： The present disclosure provides an apparatus for sample introduction including a flow channel, a sample inlet, a metering unit, a separating unit, cell dischargers and, and a pressure controlling unit. The sample inlet is given a sample fluid such as blood. The sample inlet has a constricting hole that communicates with the flow channel for passage of a carrier fluid. The constricting hole has a diameter large enough for passage of a single cell contained in the sample fluid. The sample fluid is introduced into the flow channel through the constricting hole, and the cells in the sample fluid pass one by one through the constricting hole. The constricting hole does not exist inside the flow channel for passage of the carrier fluid, so that the diameter of the constricting hole does not affect the flow rate of the carrier fluid passing through the flow channel.
摘要翻译：本公开提供了一种用于样品引入的装置，包括流动通道，样品入口，计量单元，分离单元，电池放电器和压力控制单元。样品入口被给予样品流体，如血液。样品入口具有与流动通道连通的收缩孔，用于载运流体的通过。收缩孔具有足够大的直径以容纳在样品流体中的单个细胞的通过。将样品流体通过收缩孔引入流动通道，并且样品流体中的细胞通过收缩孔逐个通过。收缩孔不存在于用于载体流体通过的流动通道内，使得收缩孔的直径不影响通过流动通道的载体流体的流量。

12. 发明授权

US09164023B2 Cell sorting apparatus, cell sorting chip and cell sorting method 有权
标题翻译：细胞分选装置，细胞分选芯片和细胞分选方法
公开(公告)号：US09164023B2
公开(公告)日：2015-10-20
申请号：US13279033
申请日：2011-10-21
申请人： Yoichi Katsumoto , Kazumasa Sato , Héloïse Cockenpot
发明人： Yoichi Katsumoto , Kazumasa Sato , Héloïse Cockenpot
IPC分类号： B03C5/02 , G01N15/14 , C12M3/06 , C12M1/00 , B01L3/00 , B03C5/00 , C12N13/00 , G01N15/10
CPC分类号： B03C5/005 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B03C5/026 , C12M23/16 , C12M47/04 , C12N13/00 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/149
摘要： A cell sorting apparatus includes a flow channel through which fluid including cells flows, an electric-field application section capable of applying an electric field having a gradient in a direction different from the flowing direction of the fluid at a first position on the flow channel in accordance with a cell sorting signal requesting an operation to sort the cells, and a flow splitting section configured to split the cells changing their flowing directions due to a dielectrophoretic force caused by application of the electric field at a second position on the downstream side of the first position on the flow channel.
摘要翻译：细胞分选装置包括：流路，包括细胞的流体流过的流路;电场施加部，其能够在流路的第一位置处施加与流体的流动方向不同的方向的梯度的电场根据要求对单元进行分类的操作的单元排序信号，以及分流单元，被配置为将由于施加电场而引起的介电电泳力改变其流动方向的单元分割在第二位置流通道上的第一个位置。

13. 发明申请

US20120273357A1 CELL SORTING APPARATUS, CELL SORTING CHIP AND CELL SORTING METHOD 有权
标题翻译：细胞分选装置，细胞分选芯片和细胞分选方法
公开(公告)号：US20120273357A1
公开(公告)日：2012-11-01
申请号：US13279033
申请日：2011-10-21
申请人： Yoichi Katsumoto , Kazumasa Sato , Héloïse Cockenpot
发明人： Yoichi Katsumoto , Kazumasa Sato , Héloïse Cockenpot
IPC分类号： G01N27/447
CPC分类号： B03C5/005 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B03C5/026 , C12M23/16 , C12M47/04 , C12N13/00 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/149
摘要： A cell sorting apparatus includes a flow channel through which fluid including cells flows, an electric-field application section capable of applying an electric field having a gradient in a direction different from the flowing direction of the fluid at a first position on the flow channel in accordance with a cell sorting signal requesting an operation to sort the cells, and a flow splitting section configured to split the cells changing their flowing directions due to a dielectrophoretic force caused by application of the electric field at a second position on the downstream side of the first position on the flow channel.
摘要翻译：细胞分选装置包括：流路，包括细胞的流体流过的流路;电场施加部，其能够在流路的第一位置处施加与流体的流动方向不同的方向的梯度的电场根据要求对单元进行分类的操作的单元排序信号，以及分流单元，被配置为将由于施加电场而引起的介电电泳力改变其流动方向的单元分割在第二位置流通道上的第一个位置。

14. 发明申请

US20120107860A1 CELL SORTING APPARATUS, CELL SORTING CHIP, AND CELL SORTING METHOD 审中-公开
标题翻译：细胞分选装置，细胞分选芯片和细胞分选方法
公开(公告)号：US20120107860A1
公开(公告)日：2012-05-03
申请号：US13272942
申请日：2011-10-13
申请人： Yoichi Katsumoto
发明人： Yoichi Katsumoto
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12M47/04 , B01L3/502761 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N15/1056 , G01N2015/1081
摘要： Disclosed herein is a cell sorting apparatus, including: a branch portion branching a flow path in which a fluid containing therein cells flows into a first branch flow path, and a second branch flow path; a coupling portion coupling the first branch flow path and the second branch flow path to each other; and a flowing-out portion causing liquids flowing in the first branch flow path and the second branch flow path coupled to each other by the coupling portion, respectively, to flow out to an outside.
摘要翻译：本发明公开了一种细胞分选装置，其特征在于，包括：分支流路，其中含有细胞的流体流入第一分支流路的分支部和第二分支流路; 将所述第一分支流路和所述第二分支流路相互连接的联接部; 以及流出部分，其分别使通过所述联接部分彼此耦合的所述第一分支流动路径和所述第二分支流动路径中的液体流出到外部。

15. 发明申请

US20120103814A1 APPARATUS FOR SAMPLE INTRODUCTION, CHIP FOR SAMPLE INTRODUCTION, AND METHOD FOR SAMPLE INTRODUCTION 有权
标题翻译：样品介绍的装置，样品介绍的芯片和样品介绍的方法
公开(公告)号：US20120103814A1
公开(公告)日：2012-05-03
申请号：US13277699
申请日：2011-10-20
申请人： Yoichi Katsumoto
发明人： Yoichi Katsumoto
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： B03C5/005 , B03C5/026 , G01N15/1031 , G01N15/1056
摘要： The present disclosure provides an apparatus for sample introduction including a flow channel, a sample inlet, a metering unit, a separating unit, cell dischargers and, and a pressure controlling unit. The sample inlet is given a sample fluid such as blood. The sample inlet has a constricting hole that communicates with the flow channel for passage of a carrier fluid. The constricting hole has a diameter large enough for passage of a single cell contained in the sample fluid. The sample fluid is introduced into the flow channel through the constricting hole, and the cells in the sample fluid pass one by one through the constricting hole. The constricting hole does not exist inside the flow channel for passage of the carrier fluid, so that the diameter of the constricting hole does not affect the flow rate of the carrier fluid passing through the flow channel.
摘要翻译：本公开提供了一种用于样品引入的装置，包括流动通道，样品入口，计量单元，分离单元，电池放电器和压力控制单元。样品入口被给予样品流体，如血液。样品入口具有与流动通道连通的收缩孔，用于载运流体的通过。收缩孔具有足够大的直径以容纳在样品流体中的单个细胞的通过。将样品流体通过收缩孔引入流动通道，并且样品流体中的细胞通过收缩孔逐个通过。收缩孔不存在于用于载体流体通过的流动通道内，使得收缩孔的直径不影响通过流动通道的载体流体的流量。

16. 发明申请

US20120103813A1 CELL SORTER AND CELL SORTING METHOD 有权
标题翻译：细胞分离器和细胞分选方法
公开(公告)号：US20120103813A1
公开(公告)日：2012-05-03
申请号：US13272906
申请日：2011-10-13
申请人： Kazumasa Sato , Yoichi Katsumoto
发明人： Kazumasa Sato , Yoichi Katsumoto
IPC分类号： B03C5/02 , B01D43/00
CPC分类号： B03C5/026 , B03C5/005
摘要： Disclosed herein is a cell sorter including a measuring electrode, working electrode, detection electrode, and output section. The measuring electrode forms a measuring electric field in a flow path to measure a complex dielectric constant of each cells flowing through the flow path. The working electrode forms, in the flow path, a working electric field to sort the cells by imparting a dielectrophoretic force to the cells and using the flow path. The detection electrode detects the presence of the cell in the fluid flowing through the flow path. The output section acquires a sorting signal based on information about the measured complex dielectric constant and a detection signal indicating the detection of the cell by the detection electrode. The output section outputs a working signal adapted to form the working electric field to the working electrode when the detection signal is acquired if the sorting signal is acquired.
摘要翻译：本文公开了一种电池分选器，包括测量电极，工作电极，检测电极和输出部分。测量电极在流路中形成测量电场，以测量流经流路的每个单元的复介电常数。工作电极在流动路径中形成工作电场，以通过向细胞施加介电电泳力并使用流动路径对细胞进行分类。检测电极检测流过流路的流体中的电池的存在。输出部根据测定的复介电常数的信息和表示检测电极对电池的检测的检测信号，取得分选信号。如果获取分选信号，则当获取检测信号时，输出部分输出适于形成工作电场的工作信号到工作电极。

17. 发明申请

US20110269221A1 FLOW CHANNEL DEVICE, COMPLEX PERMITTIVITY MEASURING APPARATUS, AND DIELECTRIC CYTOMETRY SYSTEM 审中-公开
标题翻译：流通道装置，复合容许度测量装置和电介质细胞计数系统
公开(公告)号：US20110269221A1
公开(公告)日：2011-11-03
申请号：US13142701
申请日：2010-01-07
申请人： Yoichi Katsumoto , Shinji Omori
发明人： Yoichi Katsumoto , Shinji Omori
IPC分类号： C12M1/42
CPC分类号： G01N15/12 , G01N15/1031 , G01N15/1056 , G01N2015/1006 , G01N2015/1254
摘要： A flow channel device, a complex permittivity measuring apparatus, and a dielectric cytometry system are provided which can improve the measurement accuracy. A constriction portion having a constricted space is disposed between an inflow port and an outflow port of a flow channel. Electrodes are arranged between the inflow port and the constriction portion and between the outflow port and the constriction portion. The conductance of the constriction portion at a low-limit frequency is less than the combined conductance of an inflow channel portion and an outflow channel portion. The capacitance of the constriction portion at a high-limit frequency is less than the combined capacitance of the inflow channel portion and the outflow channel portion.
摘要翻译：提供流路装置，复介电常数测定装置和介电细胞计数系统，能够提高测定精度。具有收缩空间的收缩部分设置在流动通道的流入口和流出口之间。电极布置在流入口和收缩部之间以及流出口和收缩部之间。收缩部分在低限频率处的电导小于流入通道部分和流出通道部分的组合电导率。收缩部在高限频率下的电容小于流入通道部分和流出通道部分的组合电容。

18. 发明申请

US20100213056A1 Interaction Detecting Portion with Electrode Having the Same Potential, Sensor Chip Using the Same, and Interaction Detector 审中-公开
标题翻译：具有相同电位的电极的相互作用检测部分，使用其的传感器芯片和相互作用检测器
公开(公告)号：US20100213056A1
公开(公告)日：2010-08-26
申请号：US11916206
申请日：2006-05-12
申请人： Yuji Segawa , Yoichi Katsumoto
发明人： Yuji Segawa , Yoichi Katsumoto
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N33/5438 , B01L3/5027 , G01N27/4473
摘要： There are provided an interaction detecting portion including an interaction region in the whole of which an electrodynamic effect is obtained, and which has a simpler structure, and the like. There is provided an interaction detecting portion 1 including at least: a reaction region 2 which provides a field for an interaction between materials, and an electrode E1 (or a group of electrodes), having the same potential, which is provided so as to face the reaction region 2. In addition, there are provided a sensor chip, such as a DNA chip or a protein chip, including the interaction detecting portion 1, and an interaction detector using the detection portion 1.
摘要翻译：提供了一种相互作用检测部分，其包括整体中获得电动势效应并具有更简单结构的相互作用区域等。提供了一种相互作用检测部分1，其至少包括：提供用于材料之间的相互作用的场的反应区域2和具有相同电位的电极E1（或一组电极），其被设置为面对反应区域2.此外，还提供了包括相互作用检测部分1的诸如DNA芯片或蛋白质芯片的传感器芯片以及使用检测部分1的相互作用检测器。

19. 发明申请

US20100203504A1 Substance-Information Acquisition Method Using Evanescent Light Beam, Substance-Information Measurement Apparatus, Base-Sequence Determination Method and Base-Sequence Determination Apparatus 审中-公开
标题翻译：物质信息采集方法，使用渐近光束，物质信息测量装置，基本序列确定方法和基本序列确定装置
公开(公告)号：US20100203504A1
公开(公告)日：2010-08-12
申请号：US11993786
申请日：2006-06-20
申请人： Yoichi Katsumoto , Noriyuki Kishii
发明人： Yoichi Katsumoto , Noriyuki Kishii
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/648 , G01B11/026 , G01N21/6428 , G01Q60/20
摘要： Information on the position and displacement of a detection-subject substance T can be presented by adoption an evanescent light illumination technology. An evanescent light beam PE has a property that the intensity thereof abruptly attenuates in accordance with an exponential function with increases in distance Z from a boundary surface S capable of generating the evanescent light beam PE. The detection-subject substance T fixed on the boundary surface S is excited by the evanescent light beam PE having the property described, generating the original fluorescent light beam f of the detection-subject substance T. On the basis of the intensity I of the fluorescent light beam f, information Z on the position of the detection-subject substance T and information Δz on the displacement of the detection-subject substance T can be acquired. In addition, by making use of the information Z and the information Δz, it is possible to obtain information on the structure of the detection-subject substance T, its structural change, a base sequence of a nucleic acid chain serving as the detection-subject substance T, the existence/non-existence of substance interactions and the state of progress of the interactions.
摘要翻译：关于检测对象物质T的位置和位移的信息可以通过采用ev逝光照明技术来呈现。瞬逝光束PE具有随着距离能够产生ev逝光束PE的边界面S的距离Z的增加而根据指数函数突然衰减的强度的性质。固定在边界面S上的检测对象物质T被具有所述特性的ev逝光束PE激发，产生检测对象物质T的原始荧光光束f。基于荧光的强度I 光束f，关于检测对象物质T的位置的信息Z和关于检测对象物质T的位移的信息＆Dgr; z。此外，通过利用信息Z和信息＆Dgr; z，可以获得关于检测对象物质T的结构及其结构变化的信息，作为检测用的核酸链的碱基序列 - 物质T，物质相互作用的存在/不存在以及相互作用的进展状态。

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