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11. 发明申请

US20060106116A1 Composition for lessening oxidative stress 审中-公开
标题翻译：用于减轻氧化应激的组合物
公开(公告)号：US20060106116A1
公开(公告)日：2006-05-18
申请号：US11315201
申请日：2005-12-23
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/12 , A61K31/075
CPC分类号： A61K31/085 , A61K31/122
摘要： A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q and an oxidized coenzyme of Q.
摘要翻译：一种用于减轻有需要的受试者体内氧化应激的方法，包括向所述受试者施用含有还原型辅酶Q和Q的氧化型辅酶的组合物。

12. 发明申请

US20050113459A1 Compositions for diabetes 审中-公开
标题翻译：糖尿病组合
公开(公告)号：US20050113459A1
公开(公告)日：2005-05-26
申请号：US10505523
申请日：2003-03-20
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A23K1/16 , A23L1/29 , A23L1/30 , A61K31/09 , A61K31/122 , A61P3/10 , A61K31/12 , A61K31/075 , A61K38/43
CPC分类号： A61K31/09 , A23K20/111 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/122 , A23V2250/314
摘要： The present invention provides a composition for improving glucose tolerance to patients having diabetic hyperglycemia and people having pre-diabetes, i.e., abnormal glucose tolerance. The composition helps control the blood glucose level, prevents diabetic complications, and can be administered over a long term due to its high safety. The composition containing a coenzyme Q, in particular, a reduced coenzyme Q10, as the main component improves the impaired glucose tolerance of diabetes patients, satisfactorily controls the blood glucose level, and decreases the blood glycosylated hemoglobin level.
摘要翻译：本发明提供了一种用于改善具有糖尿病性高血糖症患者和患有糖尿病前期即葡萄糖耐量异常的患者的葡萄糖耐量的组合物。该组合物有助于控制血糖水平，预防糖尿病并发症，并且由于其高度的安全性，可以长期施用。含有辅酶Q，特别是还原型辅酶Q 10作为主要成分的组合物改善了糖尿病患者的葡萄糖耐量受损，令人满意地控制了血糖水平，降低了血糖水平的血红蛋白水平。

13. 发明申请

US20070122400A1 Composition having liver function protecting effect 审中-公开
标题翻译：具有肝功能保护作用的组合物
公开(公告)号：US20070122400A1
公开(公告)日：2007-05-31
申请号：US10580403
申请日：2004-10-29
申请人： Hiroshi Kubo , Kenji Fujii , Kazunori Hosoe
发明人： Hiroshi Kubo , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K38/43 , A61K31/075
CPC分类号： A61K9/1623 , A23K20/111 , A23K20/30 , A23L33/10 , A23L33/16 , A23V2002/00 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K31/075 , A61K31/09 , A23V2200/32 , A23V2250/314
摘要： The present invention provides a highly safe composition which is effective for protecting liver functions and preventing liver dysfunctions in the case where liver dysfunctions rise by various causes. The present inventors found that oxidized coenzyme Q is effective for protecting liver functions in the absence of selenium and that reduced coenzyme Q has a higher efficacy for protecting liver functions. The composition containing, as the main components, oxidized coenzyme Q and less than 0.01 percent by weight of selenium, or reduced coenzyme Q can be used to protect liver functions. The present invention can provide a highly safe composition which is highly effective for maintaining health.
摘要翻译：本发明提供了一种高度安全的组合物，其在肝功能障碍由各种原因升高的情况下对于保护肝功能和预防肝功能障碍是有效的。本发明人发现，氧化型辅酶Q在不存在硒的情况下对肝功能的保护有效，还原型辅酶Q具有较高的肝功能保护功能。作为主要成分的含有氧化型辅酶Q和小于0.01重量％的硒或还原型辅酶Q的组合物可用于保护肝功能。本发明可以提供高度安全的用于维持健康的组合物。

14. 发明授权

US07754205B2 Composition for transmucosal administration containing conenzyme Q as the active ingredient 有权
标题翻译：用于经粘膜给药的组合物，其含有辅酶Q作为活性成分
公开(公告)号：US07754205B2
公开(公告)日：2010-07-13
申请号：US10476208
申请日：2002-05-08
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43
CPC分类号： A61K31/122 , A23L33/10 , A23V2002/00 , A61K9/0031 , A61K9/0048 , A61K9/02 , A61K31/047 , A61K31/09 , Y10S514/882 , A61K2300/00 , A23V2250/314
摘要： The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.
摘要翻译：本发明涉及能够维持人体健康的辅酶Q的供给，提供可以将辅酶Q有效地供给口服给药困难的患者，患有吞咽困难的老年患者以及由局部疾病。通过使用含有氧化型辅酶Q和/或还原型辅酶Q作为活性成分的经粘膜给药用组合物，可以提高血液或局部粘膜中的辅酶Q浓度，其中氧化型辅酶Q和还原型辅酶Q占整个组合物的0.0001-99重量％。

15. 发明申请

US20070293572A1 Anti-Fatigue Composition 审中-公开
标题翻译：抗疲劳成分
公开(公告)号：US20070293572A1
公开(公告)日：2007-12-20
申请号：US11596059
申请日：2005-05-09
申请人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
发明人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
IPC分类号： A61K31/05 , A61K31/205 , A61P25/26
CPC分类号： A61K31/205 , A23L33/10 , A23V2002/00 , A61K31/09 , A61K31/122 , A61K45/06 , A61K2300/00 , A23V2200/31 , A23V2250/314 , A23V2250/0612
摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.
摘要翻译：疲劳显着地涉及到今天人们的生活方式。虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。根据本发明，可以提供具有可靠效果的抗疲劳组合物。

16. 发明申请

US20070259908A1 Mitochondria Activators 审中-公开
标题翻译：线粒体激活剂
公开(公告)号：US20070259908A1
公开(公告)日：2007-11-08
申请号：US11661419
申请日：2005-08-25
申请人： Kenji Fujii , Shuka Matsumoto , Kazunori Hosoe
发明人： Kenji Fujii , Shuka Matsumoto , Kazunori Hosoe
IPC分类号： A61K31/437 , A61P25/00 , A61P3/10 , C07D471/04
CPC分类号： A61K31/047 , A61K31/122 , A61K31/4745
摘要： The present invention provides a mitochondrial activator containing pyrroloquinoline quinone, preferably pyrroloquinoline quinone and coenzyme Q (particularly reduced coenzyme Q) as active ingredients. In addition, the present invention provides a mitochondrial activator containing citric acid, preferably citric acid and coenzyme Q (particularly reduced coenzyme Q), as active ingredients. Since pyrroloquinoline quinone or citric acid exhibits a synergistic mitochondria activating effect with coenzyme Q (particularly reduced coenzyme Q), a high effect can be obtained even at a low dose. According to the present invention, therefore, a safer and practical mitochondrial activator is provided. The present invention further provides an agent for the prophylaxis or treatment of a disease caused by mitochondrial dysfunction.
摘要翻译：本发明提供了含有吡咯并喹啉醌，优选吡咯并喹啉醌和辅酶Q（特别是还原型辅酶Q）作为活性成分的线粒体活化剂。此外，本发明提供了含有柠檬酸，优选柠檬酸和辅酶Q（特别是还原型辅酶Q）的线粒体活化剂作为活性成分。由于吡咯喹啉醌或柠檬酸与辅酶Q（特别是还原型辅酶Q）具有协同的线粒体活化作用，因此即使在低剂量下也能获得高效果。因此，根据本发明，提供了更安全和实用的线粒体激活剂。本发明还提供了用于预防或治疗由线粒体功能障碍引起的疾病的药剂。

17. 发明申请

US20060165672A1 Fatigue reducing agent 有权
公开(公告)号：US20060165672A1
公开(公告)日：2006-07-27
申请号：US10541020
申请日：2004-01-19
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43 , A01N31/14
CPC分类号： A61K31/09 , A61K31/122
摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

18. 发明授权

US07015252B2 Compositions for lessening oxidative stress 有权
标题翻译：用于减轻氧化应激的组合物
公开(公告)号：US07015252B2
公开(公告)日：2006-03-21
申请号：US10492164
申请日：2002-10-15
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/12
CPC分类号： A61K31/085 , A61K31/122
摘要： The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.
摘要翻译：本发明提供了具有高安全性的抗氧化组合物，其能够在体内减少由活性氧，自由基等引起的氧化应激，从而防止疾病的发生或恶化。确认通过使用含有氧化型辅酶Q和/或还原型辅酶Q的组合物，在正常或糖尿病动物中尿8-羟基脱氧奎诺糖的量可以降低。此外，在糖尿病大鼠脾脏的组织病理学研究中，证实可以预防由氧化应激引起的脾脏组织变性。因此发现体内的氧化应激可以减轻。根据本发明，通过使用含有辅酶Q作为有效成分的组合物，可以减轻体内的氧化应激。

19. 发明申请

US20050070610A1 Dermal compositions containing coenzyme q as the active ingredient 审中-公开
标题翻译：含有辅酶q作为活性成分的皮肤组合物
公开(公告)号：US20050070610A1
公开(公告)日：2005-03-31
申请号：US10275882
申请日：2001-05-09
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K8/34 , A61K8/35 , A61K8/86 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/122 , A61K47/10 , A61L15/44 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P37/08 , A61Q19/00 , A61Q19/10
CPC分类号： A61Q19/00 , A61K8/347 , A61K8/355 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/122 , A61K47/10 , A61K2800/70 , A61L15/44 , A61L2300/216 , A61Q19/10
摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application. The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.
摘要翻译：本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法，对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂，皮肤病。

20. 发明授权

US06486161B1 Use of rifamycin derivative for treating mastitis in a domestic animal 失效
标题翻译：利福霉素衍生物用于治疗家畜中的乳腺炎
公开(公告)号：US06486161B1
公开(公告)日：2002-11-26
申请号：US09463580
申请日：2000-05-23
申请人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Robert J. Yancey, Jr. , Jeffrey L. Watts
发明人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Robert J. Yancey, Jr. , Jeffrey L. Watts
IPC分类号： A61K3150
CPC分类号： A61K31/5383
摘要： A method for treating mastitis in a domestic animal in need of such a treatment, which comprises administering to the animal a pharmaceutical composition comprising a rifamycin derivative of the formula (1): wherein R is an alkyl group having 1 to 7 carbon atoms or a physiologically acceptable salt thereof as an active ingredient, and a physiologically acceptable carrier. The present invention provides a novel therapeutic method effective for treatment of mastitis caused by bacterial infection in a domestic animal.
摘要翻译：一种在需要这种治疗的家畜中治疗乳腺炎的方法，其包括向动物施用包含式（1）的利福霉素衍生物的药物组合物：其中R是具有1至7个碳原子的烷基或其生理学上可接受的盐作为活性成分，以及生理上可接受的载体。本发明提供了一种有效治疗家畜细菌感染引起的乳腺炎的新型治疗方法。

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