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1. 发明授权

US5223496A Cephalosporin antibiotics 失效
标题翻译：头孢菌素类抗生素
公开(公告)号：US5223496A
公开(公告)日：1993-06-29
申请号：US872866
申请日：1992-04-23
申请人： Alexander R. Cazers , K. Thomas Koshy , Prem S. Jaglan , Robert J. Yancey, Jr. , Terry J. Gilbertson , Thomas S. Arnold , David B. Johnson , Catherine L. Gatchell
发明人： Alexander R. Cazers , K. Thomas Koshy , Prem S. Jaglan , Robert J. Yancey, Jr. , Terry J. Gilbertson , Thomas S. Arnold , David B. Johnson , Catherine L. Gatchell
IPC分类号： C07D501/36
CPC分类号： C07D501/36
摘要： Cephalosporin compounds of Formulas II ##STR1## where R is hydrogen or a pharmaceutical cation, in which case R.sub.1 is not present, orR is hydrogen or a chemical bond when R.sub.1 is an acid addition salt anion, and R.sub.2 is (a) hydrogen, (b) a duplicate of the formula I compound to form a dimer, (c) an aminocarbonylmethyl, or (d) an --SR.sub.3 group where R.sub.3 is alkyl, cyclohexyl, phenyl, chloro-substituted phenyl, nitro-substituted phenyl, benzyl or furfuryl, have been found to be valuable as antibiotics for treating warm-blooded animals to combat pathogenic bacterial infections which cause diseases such as the commonly known "shipping fever".
摘要翻译：式II的头孢菌素化合物其中R是氢或药物阳离子，在这种情况下R1不存在，或当R 1是酸加成盐阴离子时，R是氢或化学键，R2是（a）氢，（b）式I化合物的副本以形成二聚体，（c）氨基羰基甲基或（d）-SR 3基团，其中R 3是烷基，环己基，苯基，氯取代的苯基，硝基取代的苯基，苄基或糠基已经被发现作为用于治疗温血动物的抗生素是有价值的，以对抗引起诸如常见的“发热”之类的疾病的致病细菌感染。

2. 发明申请

US20090324641A1 NOVEL ADJUVANT COMPOSITIONS 有权
标题翻译：新辅助组合物
公开(公告)号：US20090324641A1
公开(公告)日：2009-12-31
申请号：US12490767
申请日：2009-06-24
申请人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
发明人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
IPC分类号： A61K39/21 , A61K39/108
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
摘要翻译：本发明涉及包含三萜类，甾醇，免疫调节剂，聚合物和Th2刺激剂的各种组合的佐剂制剂; 制备佐剂组合物的方法; 以及在具有不同抗原的免疫原性和疫苗组合物中使用佐剂制剂。本发明还涉及该制剂在动物治疗中的用途。

3. 发明授权

US06485904B1 DNA encoding a plasminogen activating protein 失效
标题翻译：编码纤溶酶原激活蛋白的DNA
公开(公告)号：US06485904B1
公开(公告)日：2002-11-26
申请号：US09078091
申请日：1998-05-13
申请人： Everett L. Rosey , Robert J. Yancey, Jr. , James A. Leigh
发明人： Everett L. Rosey , Robert J. Yancey, Jr. , James A. Leigh
IPC分类号： C12Q168
CPC分类号： C07K14/3153 , A61K39/00 , C07K2319/00
摘要： The present invention provides polynucleotide molecules comprising nucleotide sequences encoding plasminogen activating (PauA) proteins from Streptococcus uberis, and substantially homologous polypeptides, peptide fragments, and fusion proteins thereof. The present invention further provides compositions and methods for recombinantly expressing the PauA proteins, substantially homologous polypeptides, peptide fragments and fusion proteins encoded by the polynucleotide molecules of the present invention. The present invention further provides a vaccine for protecting a member of a mammalian species against mastitis, comprising a PauA protein, substantially homologous polypeptide, peptide fragment, fusion protein, or polynucleotide molecule of the present invention.
摘要翻译：本发明提供了包含编码来自乳房链球菌的纤溶酶原激活（PauA）蛋白的核苷酸序列以及基本上同源的多肽，肽片段及其融合蛋白的多核苷酸分子。本发明还提供用于重组表达由本发明的多核苷酸分子编码的PauA蛋白，基本上同源的多肽，肽片段和融合蛋白的组合物和方法。本发明还提供了一种用于保护哺乳动物物种免受乳腺炎的疫苗，其包含本发明的PauA蛋白，基本上同源的多肽，肽片段，融合蛋白或多核苷酸分子。

4. 发明授权

US5134137A Cephalosporin antibiotics 失效
标题翻译： CEPHALOSPORIN抗生素
公开(公告)号：US5134137A
公开(公告)日：1992-07-28
申请号：US460346
申请日：1990-05-09
申请人： Alexander R. Cazers , K. Thomas Koshy , Prem S. Jaglan , Robert J. Yancey, Jr. , Terry J. Gilbertson , Thomas S. Arnold , David B. Johnson , Catherine L. Gatchell
发明人： Alexander R. Cazers , K. Thomas Koshy , Prem S. Jaglan , Robert J. Yancey, Jr. , Terry J. Gilbertson , Thomas S. Arnold , David B. Johnson , Catherine L. Gatchell
IPC分类号： C07D519/06 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D519/00
CPC分类号： C07D501/36
摘要： Cephalosporin compounds of Formulas II ##STR1## where R is hydrogen or a pharmaceutical cation, in which case R.sub.1 is not present, orR is hydrogen or a chemical bond when R.sub.1 is an acid addition salt anion, and R.sub.2 is (a) hydrogen, (b) a duplicate of the formula I compound to form a dimer, (c) an aminocarbonylmethyl, or (d) an --SR.sub.3 group where R.sub.3 is alkyl, cyclohexyl, phenyl, chloro-substituted phenyl, nitro-substituted phenyl, benzyl or furfuryl, have been found to be valuable as antibiotics for treating warm-blooded animals to combat pathogenic bacterial infections which cause diseases such as the commonly known "shipping fever".
摘要翻译： PCT No.PCT / US88 / 03435。 371日期1990年5月9日 102（e）日期1990年5月9日PCT提交1988年10月11日PCT公布。出版物WO89 / 04313 日本1989年5月18日。式II的头孢菌素化合物其中R是氢或药物阳离子，在这种情况下R1不存在，或当R 1是酸加成盐阴离子时，R是氢或化学键，并且R 2是（a）氢，（b）式I化合物的副本以形成二聚体，（c）氨基羰基甲基或（d）-SR 3基团，其中R 3是烷基，环己基，苯基，氯取代的苯基已经发现，硝基取代的苯基，苄基或糠基作为用于治疗温血动物的抗生素是有价值的，以对抗引起诸如常见的“发热”的疾病的致病细菌感染。

5. 发明授权

US08580280B2 Adjuvant compositions 有权
标题翻译：佐剂成分
公开(公告)号：US08580280B2
公开(公告)日：2013-11-12
申请号：US12490767
申请日：2009-06-24
申请人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
发明人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
IPC分类号： A61K45/00 , C07K2/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
摘要翻译：本发明涉及包含三萜类，甾醇，免疫调节剂，聚合物和Th2刺激剂的各种组合的佐剂制剂; 制备佐剂组合物的方法; 以及在具有不同抗原的免疫原性和疫苗组合物中使用佐剂制剂。本发明还涉及该制剂在动物治疗中的用途。

6. 发明授权

US06486161B1 Use of rifamycin derivative for treating mastitis in a domestic animal 失效
标题翻译：利福霉素衍生物用于治疗家畜中的乳腺炎
公开(公告)号：US06486161B1
公开(公告)日：2002-11-26
申请号：US09463580
申请日：2000-05-23
申请人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Robert J. Yancey, Jr. , Jeffrey L. Watts
发明人： Kenji Fujii , Katsuji Yamashita , Kazunori Hosoe , Robert J. Yancey, Jr. , Jeffrey L. Watts
IPC分类号： A61K3150
CPC分类号： A61K31/5383
摘要： A method for treating mastitis in a domestic animal in need of such a treatment, which comprises administering to the animal a pharmaceutical composition comprising a rifamycin derivative of the formula (1): wherein R is an alkyl group having 1 to 7 carbon atoms or a physiologically acceptable salt thereof as an active ingredient, and a physiologically acceptable carrier. The present invention provides a novel therapeutic method effective for treatment of mastitis caused by bacterial infection in a domestic animal.
摘要翻译：一种在需要这种治疗的家畜中治疗乳腺炎的方法，其包括向动物施用包含式（1）的利福霉素衍生物的药物组合物：其中R是具有1至7个碳原子的烷基或其生理学上可接受的盐作为活性成分，以及生理上可接受的载体。本发明提供了一种有效治疗家畜细菌感染引起的乳腺炎的新型治疗方法。

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