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11. 发明申请

US20090076557A1 Closed Loop Cardiac Resynchronization Therapy Using Cardiac Activation Sequence Information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20090076557A1
公开(公告)日：2009-03-19
申请号：US12276070
申请日：2008-11-21
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/39 , A61N1/368
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

12. 发明授权

US09993205B2 Cardiac response classification using retriggerable classification windows 有权
公开(公告)号：US09993205B2
公开(公告)日：2018-06-12
申请号：US12818066
申请日：2010-06-17
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/08 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

13. 发明申请

US20130013020A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20130013020A1
公开(公告)日：2013-01-10
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

14. 发明申请

US20120165895A1 Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification 审中-公开
标题翻译：心脏起搏反应分类中不被捕获的内在歧视
公开(公告)号：US20120165895A1
公开(公告)日：2012-06-28
申请号：US13411852
申请日：2012-03-05
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.
摘要翻译：心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

15. 发明授权

US08116870B2 Capture detection for multi-chamber pacing 有权
标题翻译：捕获检测多腔起搏
公开(公告)号：US08116870B2
公开(公告)日：2012-02-14
申请号：US12214852
申请日：2008-06-23
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61N1/3684
摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.
摘要翻译：多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。描述了在多室起搏期间检测各种捕获条件的方法。在心动周期期间，起搏脉冲被传送到左心室和右心室。在起搏脉冲输送之后感测心电图信号。仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。将心电图信号特征与检测窗口进行比较以确定捕获条件。

16. 发明授权

US07979113B2 Multi channel approach to capture verification 有权
标题翻译：捕获验证的多渠道方法
公开(公告)号：US07979113B2
公开(公告)日：2011-07-12
申请号：US12435896
申请日：2009-05-05
申请人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
发明人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264
摘要： Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.
摘要翻译：方法和系统包括使用多通道方法对心脏起搏应答进行分类。通过多个感测通道感测多个心脏反应信号。每个感测通道包括电极和感测电路的不同组合。基于心脏反应信号的形态对起搏脉搏的心脏反应进行分类。分类心脏反应包括区分捕获，融合，非捕获和非捕获与内在活动。

17. 发明申请

US20090240301A1 Multi Channel Approach to Capture Verfication 有权
标题翻译：多通道捕获检测方法
公开(公告)号：US20090240301A1
公开(公告)日：2009-09-24
申请号：US12435896
申请日：2009-05-05
申请人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
发明人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
IPC分类号： A61N1/08
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264
摘要： Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.
摘要翻译：方法和系统包括使用多通道方法对心脏起搏应答进行分类。通过多个感测通道感测多个心脏反应信号。每个感测通道包括电极和感测电路的不同组合。基于心脏反应信号的形态对起搏脉搏的心脏反应进行分类。分类心脏反应包括区分捕获，融合，非捕获和非捕获与内在活动。

18. 发明申请

US20080228093A1 Systems and methods for enhancing cardiac signal features used in morphology discrimination 审中-公开
标题翻译：用于增强形态学鉴别中使用的心脏信号特征的系统和方法
公开(公告)号：US20080228093A1
公开(公告)日：2008-09-18
申请号：US11717482
申请日：2007-03-13
申请人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
发明人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
IPC分类号： A61B5/0464
CPC分类号： A61B5/04525 , A61B5/0464 , A61B5/7203 , A61B5/7264 , A61N1/371
摘要： Methods and devices used to classify cardiac events based on morphological analysis of sensed signals are described. A signal comprising a cardiac signal component and a noise signal component is sensed. The sensed signal is processed to preferentially alter morphology of the cardiac signal component. The altered morphology of the cardiac signal component enhances detection of one or more features of the cardiac signal component. The features of the cardiac signal component are detected and the cardiac event is classified using the detected features. Processing the sensed signal may involve the use of adaptable signal processing parameters. For example, the signal processing parameters may be selected to accentuate one or more desirable features of the cardiac signal component or to mitigate one or more undesirable features of the cardiac signal component.
摘要翻译：描述了基于感测信号的形态学分析来分类心脏事件的方法和装置。检测包括心脏信号分量和噪声信号分量的信号。处理感测到的信号以优先改变心脏信号分量的形态。心脏信号分量改变的形态增强了对心脏信号分量的一个或多个特征的检测。检测心脏信号分量的特征，并使用检测到的特征对心脏事件进行分类。处理感测信号可能涉及使用适应性信号处理参数。例如，可以选择信号处理参数以强调心脏信号分量的一个或多个期望特征或减轻心脏信号分量的一个或多个不期望的特征。

19. 发明申请

US20080140145A1 Selection of cardiac signal features detected in multiple classification intervals for cardiac pacing response classification 有权
公开(公告)号：US20080140145A1
公开(公告)日：2008-06-12
申请号：US12070004
申请日：2008-02-14
申请人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
发明人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/7264 , A61N1/362 , A61N1/371
摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.

20. 发明授权

US08831727B2 Methods and systems for managing fusion and noise in cardiac pacing response classification 有权
标题翻译：用于管理心脏起搏反应分类中的融合和噪声的方法和系统
公开(公告)号：US08831727B2
公开(公告)日：2014-09-09
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/362 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

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