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11. 发明授权

US06605592B2 Protein HOFNF53 失效
标题翻译：蛋白质HOFNF53
公开(公告)号：US06605592B2
公开(公告)日：2003-08-12
申请号：US09800729
申请日：2001-03-08
申请人： Jian Ni , Kevin P. Baker , Charles E. Birse , Reinhard Ebner , Michele Fiscella , George A. Komatsoulis , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Ping Wei , Kimberly A. Florence
发明人： Jian Ni , Kevin P. Baker , Charles E. Birse , Reinhard Ebner , Michele Fiscella , George A. Komatsoulis , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Ping Wei , Kimberly A. Florence
IPC分类号： C07K1447
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application relates to a novel human protein, Protein HOFNF53. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。特别地，本申请涉及新的人蛋白质蛋白质HOFNF53。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

12. 发明授权

US06806351B2 Secreted protein HBJFE12 失效
标题翻译：分泌蛋白HBJFE12
公开(公告)号：US06806351B2
公开(公告)日：2004-10-19
申请号：US09774639
申请日：2001-02-01
申请人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
发明人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
IPC分类号： C07K14435
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

13. 发明授权

US06420526B1 186 human secreted proteins 失效
标题翻译： 186人分泌蛋白
公开(公告)号：US06420526B1
公开(公告)日：2002-07-16
申请号：US09149476
申请日：1998-09-08
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： C12Q168
CPC分类号： G01N33/68 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

14. 发明授权

US06919433B2 Antibodies to protein HPMBQ91 失效
标题翻译：蛋白质HPMBQ91的抗体
公开(公告)号：US06919433B2
公开(公告)日：2005-07-19
申请号：US09853161
申请日：2001-05-11
申请人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
发明人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , C07K1/00 , C12N5/06 , C12N5/16
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

15. 发明授权

US06548539B1 Agents for regulation of colon cancer gene expression 失效
标题翻译：用于调节结肠癌基因表达的药剂
公开(公告)号：US06548539B1
公开(公告)日：2003-04-15
申请号：US10090866
申请日：2002-03-05
申请人： Stanislaw Pikul , Daniel R. Soppet , Paul E. Young
发明人： Stanislaw Pikul , Daniel R. Soppet , Paul E. Young
IPC分类号： A61K3134
CPC分类号： C07C323/42 , C07C323/40 , C07C323/41 , C07C323/44 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D307/22
摘要： Compounds of the general structure according to Formula (I) wherein R1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl; R2 is selected from alkyl, alkenyl, alkyny, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; R3 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; W is selected from Ch2, O and S; n is 0 to about 3: X is selected from S or O; Y, if present, is selected from a bond, aryl, NH, NR, O or S, where R3 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; and Z, if present, can represent a bond or is selected from lower alkyl, O or S are disclosed. Also disclosed are uses of such compounds for treating a variety of disease conditions, including cancer.
摘要翻译：其中R 1选自烷基，烯基，炔基，杂烷基，卤代烷基，芳基，芳烷基，杂芳基，杂芳基烷基，环烷基和杂环烷基中的根据式（I）的通式结构的化合物; R 2选自烷基，烯基，炔基，杂烷基，卤代烷基，芳基烷基，杂芳基烷基，环烷基烷基和杂环烷基烷基; R 3选自芳基，杂芳基，环烷基和杂环烷基; W选自Ch2，O和S; n为0至约3：X选自S或O; Y如果存在，选自键，芳基，NH，NR，O或S，其中R 3选自氢，烷基，烯基，炔基，杂烷基，卤代烷基，芳基烷基，杂芳基烷基，环烷基烷基和杂环烷基烷基; 和Z如果存在，可以表示键或选自低级烷基，O或S。还公开了这些化合物用于治疗各种疾病状况（包括癌症）的用途。

16. 发明授权

US07335738B2 Heregulin-like factor 失效
标题翻译：类胰岛素样因子
公开(公告)号：US07335738B2
公开(公告)日：2008-02-26
申请号：US11354079
申请日：2006-02-15
申请人： Paul E. Young , Richter C. King , Mia Hijazi , Steven M. Ruben
发明人： Paul E. Young , Richter C. King , Mia Hijazi , Steven M. Ruben
IPC分类号： C07K1/00
CPC分类号： C07H21/04 , C07K14/4702 , C07K14/4756 , G01N33/574 , G01N33/57488 , G01N2333/475
摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
摘要翻译：本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。特别地，提供编码人HLF蛋白的分离的核酸分子。还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

17. 发明授权

US06951738B2 Human tumor necrosis factor receptors TR13 and TR14 失效
标题翻译：人肿瘤坏死因子受体TR13和TR14
公开(公告)号：US06951738B2
公开(公告)日：2005-10-04
申请号：US10046433
申请日：2002-01-16
申请人： Jian Ni , Kevin P. Baker , Steven M. Ruben , Paul E. Young
发明人： Jian Ni , Kevin P. Baker , Steven M. Ruben , Paul E. Young
IPC分类号： A61K38/00 , C07H21/04 , C07K14/705 , C07K14/715 , C07K16/28 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/7151
摘要： The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的两种新型蛋白质TR13和TR14。特别地，提供编码人TR13和TR14蛋白的分离的核酸分子。还提供TR13和TR14多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR13和TR14的激动剂和拮抗剂的筛选方法。

18. 发明授权

US08372948B2 12 human secreted proteins 有权
公开(公告)号：US08372948B2
公开(公告)日：2013-02-12
申请号：US12264040
申请日：2008-11-03
申请人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号： C07K5/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

19. 发明授权

US07368244B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07368244B2
公开(公告)日：2008-05-06
申请号：US11214796
申请日：2005-08-31
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07H21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

20. 发明授权

US07041802B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07041802B2
公开(公告)日：2006-05-09
申请号：US10180454
申请日：2002-06-27
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07K16/00 , C12P21/08 , C12N5/06 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

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