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11. 发明申请

US20090123546A1 Polymer-based, sustained release drug delivery system 审中-公开
标题翻译：基于聚合物的缓释药物递送系统
公开(公告)号：US20090123546A1
公开(公告)日：2009-05-14
申请号：US12082520
申请日：2008-04-11
申请人： Paul Ashton , Jianbing Chen , Hong Guo
发明人： Paul Ashton , Jianbing Chen , Hong Guo
IPC分类号： A61K9/10 , A61K31/513
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/7007 , A61K31/513 , A61K47/34 , A61K47/55 , A61K47/554 , A61L17/005 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer.
摘要翻译：公开了一种持续释放系统，其包括分散在聚合物中的聚合物和药物活性剂。试剂是颗粒状或颗粒形式，并且具有主要由试剂从颗粒溶解到聚合物基质中的速率受到系统释放的速率。有利地，聚合物对于试剂是可渗透的，并且相对于试剂从聚合物的释放速率而言是非释放速率限制的。

12. 发明申请

US20070098760A1 Method for treating and/or preventing retinal diseases with sustained release corticosteroids 审中-公开
标题翻译：用持续释放的皮质类固醇治疗和/或预防视网膜疾病的方法
公开(公告)号：US20070098760A1
公开(公告)日：2007-05-03
申请号：US11635161
申请日：2006-12-07
申请人： Hong Guo , Paul Ashton
发明人： Hong Guo , Paul Ashton
IPC分类号： A61K31/573 , A61F2/02
CPC分类号： A61K31/573 , A61K9/0051
摘要： The present invention relates to a method for administering a corticosteroid to a posterior segment of an eye. In the method, a sustained release device is implanted to deliver the corticosteroid to the eye. The aqueous corticosteroid concentration remains less than vitreous corticosteroid concentration during release of the corticosteroid from the device.
摘要翻译：本发明涉及向眼后段施用皮质类固醇的方法。在该方法中，植入持续释放装置以将皮质类固醇递送至眼睛。在皮质类固醇释放期间，皮质类固醇水溶液的浓度仍然低于玻璃体皮质类固醇浓度。

13. 发明申请

US20160075776A1 Compositions and Methods for Controlled Release of Agents 审中-公开
标题翻译：药剂控制释放的组成和方法
公开(公告)号：US20160075776A1
公开(公告)日：2016-03-17
申请号：US14855946
申请日：2015-09-16
申请人： Paul Ashton , Hong Guo , Leigh T. Canham , Dinesh Nadarassan
发明人： Paul Ashton , Hong Guo , Leigh T. Canham , Dinesh Nadarassan
IPC分类号： C07K16/24 , A61K9/00 , C07K16/22 , A61K38/22 , A61K9/16 , C07K14/715
CPC分类号： A61K38/22 , A61K9/0051 , A61K47/02 , C07K14/7151 , C07K2319/30
摘要： This invention discloses reservoirs, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies. The reservoirs may comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The reservoir may be used in vitro or in vivo to maintain an equilibrium concentration of a therapeutic agent over an intended period of time such as over multiple days, weeks, months, or years. Additionally, the reservoir may be reloaded with additional therapeutic agent. These reservoirs may be used for treating or preventing conditions of a subject such as chronic diseases.
摘要翻译：本发明公开了诸如用于递送治疗剂的植入物，特别是大分子如蛋白质和抗体的储库。储存器可以包含浸渍有治疗剂的多孔硅基载体材料。储存器可以在体外或体内使用以维持治疗剂在预期的时间段内的平衡浓度，例如超过几天，几周，几个月或几年。此外，储存器可以用另外的治疗剂重新装载。这些储存器可用于治疗或预防受试者例如慢性疾病的病症。

14. 发明授权

US08666190B1 Local black points in aerial imagery 有权
标题翻译：当地黑点在航空影像中
公开(公告)号：US08666190B1
公开(公告)日：2014-03-04
申请号：US13018986
申请日：2011-02-01
申请人： David Marwood , Hong Guo , Aaron Yonas
发明人： David Marwood , Hong Guo , Aaron Yonas
IPC分类号： G06K9/00
CPC分类号： G06T5/008 , G06K9/0063 , G06T2207/10032 , G06T2207/20021 , G06T2207/30181
摘要： The system and method of use are provided for correcting digital images based on the notions of local black points. The system and method are based on determining local black points in a digital image and correcting the intensities of nearby pixels so as to remove bias in the image introduced by atmospheric conditions. By sampling only localized land imagery the claimed method computes black points that are more robust against the localized effects of atmospheric and land reflection effects than black points computed from wider areas. The result of the method is that images corrected by this method are robust to atmospheric conditions that vary with time and viewing angle.
摘要翻译：提供了系统和使用方法，用于基于局部黑点的概念校正数字图像。该系统和方法基于确定数字图像中的局部黑点并校正附近像素的强度，以消除由大气条件引入的图像中的偏差。通过仅对局部地形图像进行采样，所要求的方法计算对于大面积和地面反射效应的局部效应比从较宽区域计算的黑点更强的黑点。该方法的结果是通过该方法校正的图像对随着时间和视角而变化的大气条件是鲁棒的。

15. 发明授权

US08574659B2 Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof 有权
公开(公告)号：US08574659B2
公开(公告)日：2013-11-05
申请号：US12688132
申请日：2010-01-15
申请人： Hong Guo , Paul Ashton
发明人： Hong Guo , Paul Ashton
IPC分类号： A61K9/50
CPC分类号： A61K9/20 , A61F9/0017 , A61K9/0051 , A61K9/0092 , A61K9/5089 , A61K31/58 , Y10T29/49888
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

16. 发明授权

US07998108B2 Injector apparatus and method of use 有权
标题翻译：注射装置及使用方法
公开(公告)号：US07998108B2
公开(公告)日：2011-08-16
申请号：US11900907
申请日：2007-09-12
申请人： Martin Nazzaro , Hong Guo , Ron LeBlanc , Josh York
发明人： Martin Nazzaro , Hong Guo , Ron LeBlanc , Josh York
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61M5/329 , A61M5/46 , A61M31/007 , A61M37/0069 , A61M2005/31508
摘要： Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery.
摘要翻译：本文公开了一种注射器装置，其包括插入元件，头元件，植入物和用于安全装置处理的一组可拆卸保护器元件。该装置包括在注射期间控制装置的穿透深度的止挡件。该装置可以包括可移除的捕获物，其防止植入物由于其插入元件的推进而离开装置。该装置可以包括防止植入物从其头部元件离开装置的可脱离块。该装置可以被配置用于眼内药物递送。

17. 发明申请

US20100234817A1 OCULAR TROCAR ASSEMBLY 有权
公开(公告)号：US20100234817A1
公开(公告)日：2010-09-16
申请号：US12703634
申请日：2010-02-10
申请人： Martin Nazzaro , Hong Guo , Ron LeBlanc , Josh York
发明人： Martin Nazzaro , Hong Guo , Ron LeBlanc , Josh York
IPC分类号： A61M5/32
CPC分类号： A61F9/0017 , A61B17/3468 , A61F9/007
摘要： The invention provides a trocar assembly for delivering a payload into tissue, such as an eye, comprising a primary housing, a cannula, a payload, an actuator and a trocar.
摘要翻译：本发明提供了一种套管针组件，用于将有效载荷递送到诸如眼睛的组织中，包括主壳体，套管，有效载荷，致动器和套管针。

18. 发明授权

US07214710B2 Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids 失效
标题翻译：化学治疗剂与氧杂烷酸的渗透性，水溶性，无刺激性前药
公开(公告)号：US07214710B2
公开(公告)日：2007-05-08
申请号：US10851096
申请日：2004-05-24
申请人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
发明人： Peter A. Crooks , Tadeusz Cynkowski , Grazyna Cynkowska , Hong Guo , Paul Ashton
IPC分类号： A61K31/215
CPC分类号： A61K47/542 , A61K47/54
摘要： The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.
摘要翻译：本发明涉及化学治疗剂的前药领域及其应用方法。

19. 发明申请

US20050196455A1 Suspension delivery system for the sustained and controlled local release of pharmaceuticals 审中-公开
标题翻译：持续和受控的药物暂停释放系统
公开(公告)号：US20050196455A1
公开(公告)日：2005-09-08
申请号：US10972750
申请日：2004-10-25
申请人： Jianbing Chen , Hong Guo , Paul Ashton
发明人： Jianbing Chen , Hong Guo , Paul Ashton
IPC分类号： A61K9/00 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20
CPC分类号： A61K9/1652 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/2054 , A61K9/2059
摘要： The invention relates to a novel suspension delivery system for the sustained and controlled release of pharmaceuticals. Methods of preparation and use are also disclosed.
摘要翻译：本发明涉及用于持续和控制释放药物的新型悬浮液输送系统。还公开了制备和使用方法。

20. 发明申请

US20050186279A1 Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof 审中-公开
标题翻译：缓释药物递送装置，使用方法及其制造方法
公开(公告)号：US20050186279A1
公开(公告)日：2005-08-25
申请号：US11081142
申请日：2005-03-15
申请人： Hong Guo , Paul Ashton
发明人： Hong Guo , Paul Ashton
IPC分类号： A61F9/007 , A61K9/00 , A61K9/22 , A61K31/4422 , A61K31/58 , A61M37/00 , A61P9/12 , A61P27/02 , A61P29/00 , A61K9/24
CPC分类号： A61K9/20 , A61F9/0017 , A61K9/0051 , A61K9/0092 , A61K9/5089 , A61K31/58 , Y10T29/49888
摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.
摘要翻译：提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

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