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11. 发明申请

US20060104973A1 Reducing NgR-p75 mediated inhibition of axon regeneration 失效
公开(公告)号：US20060104973A1
公开(公告)日：2006-05-18
申请号：US11320192
申请日：2005-12-27
申请人： Zhigang He , Kevin Wang , Jieun Kim
发明人： Zhigang He , Kevin Wang , Jieun Kim
IPC分类号： A61K39/395 , G01N33/567 , G01N33/53
CPC分类号： C07K16/28 , A61K38/00 , C07K14/70571 , C07K16/2863 , C07K2317/55 , C07K2319/00 , C07K2319/30 , G01N33/6896 , G01N2500/02
摘要： Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration.

12. 发明授权

US07045967B2 Multi-lamp actuating facility 失效
标题翻译：多灯驱动设备
公开(公告)号：US07045967B2
公开(公告)日：2006-05-16
申请号：US10936328
申请日：2004-09-08
申请人： Mender Chen , Woody Chan , Kevin Wang
发明人： Mender Chen , Woody Chan , Kevin Wang
IPC分类号： H05B37/00
CPC分类号： H05B41/2824 , H05B41/392
摘要： A lamp actuating device includes a number of lamps each having an output terminal, an inverter circuit coupled to the lamps to energize the lamps, a low frequency control unit coupled to the inverter circuit, to set an average value for the level of the effective lamp current at the output terminals of the lamps and to control the inverter circuit, a number of current detecting devices coupled between the lamps and the low frequency control devices to obtain and send the average current value at the output terminals of the lamps to the low frequency control unit. A number of regulating devices are coupled between the lamps and the low frequency control unit, to maintain each lamp at the predetermined average value of the effective current.
摘要翻译：灯驱动装置包括多个灯，每个灯具有输出端子，反相器电路耦合到灯以激励灯，连接到逆变器电路的低频控制单元，以设置有效灯的电平的平均值在灯的输出端子处的电流并控制逆变器电路，耦合在灯和低频控制装置之间的多个电流检测装置，以获得并将灯的输出端处的平均电流值发送到低频控制单元多个调节装置耦合在灯和低频控制单元之间，以将每个灯保持在有效电流的预定平均值。

13. 发明申请

US20050260697A1 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining 有权
标题翻译：蛋白水解标记物作为癌症，器官损伤和肌肉康复/运动过度训练的诊断性生物标志物
公开(公告)号：US20050260697A1
公开(公告)日：2005-11-24
申请号：US11106932
申请日：2005-04-15
申请人： Kevin Wang , Ronald Hayes , Ming Liu , Monika Oli
发明人： Kevin Wang , Ronald Hayes , Ming Liu , Monika Oli
IPC分类号： C12Q1/37 , G01N33/68
CPC分类号： G01N33/6896 , C12Q1/37 , Y10T436/118339 , Y10T436/25375
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译：本发明鉴定诊断神经细胞损伤，器官损伤和/或神经元障碍的生物标志物。本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。

14. 发明授权

US06856099B2 Multi-lamp actuating facility 失效
标题翻译：多灯驱动设备
公开(公告)号：US06856099B2
公开(公告)日：2005-02-15
申请号：US10621996
申请日：2003-07-16
申请人： Mender Chen , Woody Chan , Kevin Wang
发明人： Mender Chen , Woody Chan , Kevin Wang
IPC分类号： H05B41/282 , H05B41/392 , H05B37/02
CPC分类号： H05B41/392 , H05B41/2824
摘要： A lamp actuating device includes a number of lamps each having an output terminal, an inverter circuit coupled to the lamps to convert electric power and to energize the lamps, a low frequency control unit coupled to the inverter circuit, to set an average current value at the output terminals of the lamps and to control the inverter circuit, a number of current detecting units coupled between the lamps and the low frequency control unit to obtain and send the average current value at the output terminals of the lamps to the low frequency control unit. A number of regulating devices are coupled between the lamps and the low frequency control unit respectively, to control electric power through the lamps, and to maintain each of the lamps at the average current value.
摘要翻译：灯致动装置包括多个灯，每个灯具有输出端子，反相器电路耦合到灯以转换电力并激励灯，连接到逆变器电路的低频控制单元，以将平均电流值设定在灯的输出端子并控制逆变器电路，耦合在灯和低频控制单元之间的多个电流检测单元，以获得并将灯的输出端处的平均电流值发送到低频控制单元。多个调节装置分别耦合在灯和低频控制单元之间，以控制通过灯的电力，并且将每个灯保持在平均电流值。

15. 发明授权

US06637546B1 Carpet cleaning machine 失效
标题翻译：地毯清洗机
公开(公告)号：US06637546B1
公开(公告)日：2003-10-28
申请号：US09665991
申请日：2000-09-20
申请人： Kevin Wang
发明人： Kevin Wang
IPC分类号： F01N108
CPC分类号： A47L11/4011 , A47L9/2805 , A47L9/2821 , A47L9/2831 , A47L9/2836 , A47L9/2842 , A47L9/2857 , A47L9/2889 , A47L9/2894 , A47L11/40 , A47L11/4016 , A47L11/4058 , A47L11/4069 , A47L11/4088 , A47L2201/00
摘要： A muffler for a steam cleaning apparatus comprising a housing having a first and a second inlet, and an outlet, a plurality of baffles disposed within, and coupled to the housing, wherein the plurality of baffles are covered with a foam; wherein the first inlet is pneumatically coupled to an air pump of the steam cleaning apparatus, and wherein the first inlet provides to the housing a stream of humid air from an application subsystem of the steam cleaning apparatus; and wherein the second inlet receives combustion exhaust from a combustion motor that drives an air pump that is operationally coupled to the application subsystem, and wherein the outlet releases air comprising combustion exhaust of the motor.
摘要翻译：一种用于蒸汽清洁设备的消声器，包括具有第一入口和第二入口的壳体，以及出口，设置在壳体内并联接到壳体上的多个挡板，其中多个挡板被泡沫覆盖; 其中所述第一入口气动地联接到所述蒸汽清洁设备的空气泵，并且其中所述第一入口向所述壳体提供来自所述蒸汽清洁设备的应用子系统的潮湿空气流; 并且其中所述第二入口接收来自驱动可操作地联接到所述应用子系统的空气泵的燃烧马达的燃烧排气，并且其中所述出口排出包括所述马达的燃烧排气的空气。

16. 发明授权

US08957194B2 1B20 PCSK9 antagonists 有权
标题翻译： 1B20 PCSK9拮抗剂
公开(公告)号：US08957194B2
公开(公告)日：2015-02-17
申请号：US13466433
申请日：2012-05-08
申请人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
发明人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC分类号： C12N15/13 , C12N5/10 , C12N15/63 , C07K16/40 , C12N9/64 , A61K39/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

17. 发明授权

US08276059B2 Displaying detailed information in the context of a condensed enumeration of information 有权
标题翻译：在浓缩的信息列举的上下文中显示详细信息
公开(公告)号：US08276059B2
公开(公告)日：2012-09-25
申请号：US11694020
申请日：2007-03-30
申请人： Daniela K. Busse , Ramshankar Venkatasubramanian , Kevin Wang
发明人： Daniela K. Busse , Ramshankar Venkatasubramanian , Kevin Wang
IPC分类号： G06F17/00 , G06F3/048
CPC分类号： G06F17/245
摘要： Systems and techniques for displaying detailed information in the context of a condensed enumeration of information. For example, in one aspect, in one aspect, a display includes a visual rendition of a table that systematically arranges condensed information in a collection of rows and columns for reference by a human user. The table includes information characterizing a collection of items. The visual rendition of the table comprises a region that renders additional detail regarding a first item in the collection. The region is disposed in the midst of the visual rendition of the table.
摘要翻译：系统和技术，用于在浓缩的信息列举的上下文中显示详细信息。例如，在一个方面，在一个方面，在一个方面，显示器包括系统地将集中的信息放置在行和列的集合中以供人类用户参考的表的视觉再现。该表包括表征项目集合的信息。该表的视觉再现包括一个区域，其呈现关于集合中的第一项的附加细节。该区域被放置在桌子的视觉再现之中。

18. 发明申请

US20060015959A1 Transgenic animals expressing transglutaminase II 审中-公开
标题翻译：表达转谷氨酰胺酶II的转基因动物
公开(公告)号：US20060015959A1
公开(公告)日：2006-01-19
申请号：US11167991
申请日：2005-06-27
申请人： Feng Bian , Rathna Iyer , Kevin Wang , Yuang Ye
发明人： Feng Bian , Rathna Iyer , Kevin Wang , Yuang Ye
IPC分类号： A01K67/027 , C07H21/04 , C12N5/06
CPC分类号： C07K14/70503 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N9/1044 , C12N15/85 , C12N2830/008 , C12N2830/85
摘要： The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a TGII (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (NFTs), composed predominantly of amyloid β peptides and hyperphosphorylated tau, respectively. While animal models for plaque formation exist, there is no animal model that recapitulates the formation of NFTs. This invention provides transgenic mice that overexpress human TGII, an activator of cdk5, resulting in tau that is hyperphosphorylated at AD-relevant epitopes. Deposition of tau is detected in the amygdala, thalamus and cortex. Increased phosphorylated neurofilament, silver-positive neurons and neuronal death are also observed in these regions. We conclude that the overexpression of TGII, an activator of cdk5, is sufficient to produce hyperphosphorylation of tau and neuronal death. The TGII transgenic mouse represents the first model for tau pathology in AD.
摘要翻译：本发明提供具有编码TGII（蛋白激酶cdk 5的激活物）多肽的转基因的转基因非人动物和转基因非人哺乳动物细胞。与阿尔茨海默氏病（AD）相关的两个神经病理学损伤分别是淀粉样蛋白斑和主要由淀粉样β肽组成的神经原纤维缠结（NFT）。虽然存在斑块形成的动物模型，但没有重现NFT形成的动物模型。本发明提供过表达人类TGII（cdk5的激活剂）的转基因小鼠，导致在AD相关表位上过度磷酸化的tau。在杏仁核，丘脑和皮质中检测到tau的沉积。在这些区域也观察到增加的磷酸化神经丝，银阳性神经元和神经元死亡。我们得出结论，cdk5的激活剂TGII的过度表达足以产生tau和神经元死亡的过度磷酸化。 TGII转基因小鼠代表AD中第一个tau病理模型。

19. 发明申请

US20050260654A1 Neural proteins as biomarkers for nervous system injury and other neural disorders 有权
标题翻译：神经蛋白作为神经系统损伤和其他神经障碍的生物标志物
公开(公告)号：US20050260654A1
公开(公告)日：2005-11-24
申请号：US11107248
申请日：2005-04-15
申请人： Kevin Wang , Ronald Hayes , Ming Liu , Monika Oli
发明人： Kevin Wang , Ronald Hayes , Ming Liu , Monika Oli
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： C12Q1/6883 , G01N33/6896 , G01N2800/28 , G01N2800/52
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译：本发明鉴定诊断神经细胞损伤和/或神经元疾病的生物标志物。本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。

20. 发明授权

US11241153B2 Method and apparatus for parallel optical coherence tomographic funduscope 有权
公开(公告)号：US11241153B2
公开(公告)日：2022-02-08
申请号：US16689928
申请日：2019-11-20
申请人： Kevin Wang
发明人： Kevin Wang
IPC分类号： A61B3/10 , A61B3/15 , A61B3/00 , A61B3/12
摘要： An apparatus for parallel optical coherence tomographic funduscope includes an illumination arm, a processing unit, and a retina imaging interferometer. The illumination arm includes a light source used for emitting incident lights; the processing unit is used for processing raw images from the retina imaging interferometer to obtain fundus images; and the retina imaging interferometer which includes a sample arm, a reference arm, a detection arm and a blocking unit to block unwanted back reflections from optical elements and eye, is used for acquiring the raw images by a camera in the detection arm. The illumination and the reference arms are located in a first light path and the sample and the detection arms are located in a second light path. The blocking unit include a detection pupil located at the intersection of the first and second light paths to block unwanted back reflections from optical elements and eye.

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