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11. 发明授权

US07709491B2 Substituted quinazolines as antiviral agents, especially against cytomegaloviruses 有权
标题翻译：取代喹唑啉作为抗病毒剂，特别是针对巨细胞病毒
公开(公告)号：US07709491B2
公开(公告)日：2010-05-04
申请号：US10534138
申请日：2003-10-25
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Susanne Nikolic , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Susanne Nikolic , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Tse-I Lin
IPC分类号： A61K31/517 , C07D239/74 , C07D405/10
CPC分类号： C07D239/74
摘要： The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译：本发明涉及取代喹唑啉及其生产方法，除了其用于生产用于治疗和/或预防疾病的药物，特别是用作抗病毒剂，特别是抗巨细胞病毒的药物。

12. 发明申请

US20060235032A1 Substituted quinazolines as antiviral agents, especially against cytomegaloviruses 有权
标题翻译：取代喹唑啉作为抗病毒剂，特别是针对巨细胞病毒
公开(公告)号：US20060235032A1
公开(公告)日：2006-10-19
申请号：US10534138
申请日：2003-10-25
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Susanne Nikolic , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Susanne Nikolic , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Tse-I Lin
IPC分类号： A61K31/517 , C07D239/72 , C07D405/02
CPC分类号： C07D239/74
摘要： The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译：本发明涉及取代喹唑啉及其生产方法，除了其用于生产用于治疗和/或预防疾病的药物，特别是用作抗病毒剂，特别是抗巨细胞病毒的药物中。

13. 发明授权

US08198282B2 Substituted azaquinazolines having an antiviral action 有权
标题翻译：取代的具有抗病毒作用的氮杂喹啉
公开(公告)号：US08198282B2
公开(公告)日：2012-06-12
申请号：US12647210
申请日：2009-12-24
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Suessmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Suessmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： A61K31/497 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

14. 发明申请

US20100179174A1 SUBSTITUTED AZAQUINAZOLINES HAVING AN ANTIVIRAL ACTION 有权
标题翻译：具有抗病毒活性的取代的氨基脲
公开(公告)号：US20100179174A1
公开(公告)日：2010-07-15
申请号：US12647210
申请日：2009-12-24
申请人： Tobias WUNBERG , Judith Baumeister , Mario Jeske , Frank Sûssmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias WUNBERG , Judith Baumeister , Mario Jeske , Frank Sûssmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： A61K31/519 , C07D487/04 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

15. 发明申请

US20080132515A1 Substituted Azaquinazolines Having an Antiviral Action 有权
标题翻译：具有抗病毒作用的取代的氮杂喹啉
公开(公告)号：US20080132515A1
公开(公告)日：2008-06-05
申请号：US11579919
申请日：2005-04-23
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Sussmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Sussmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

16. 发明授权

US07662822B2 Substituted azaquinazolines having an antiviral action 有权
标题翻译：取代的具有抗病毒作用的氮杂喹啉
公开(公告)号：US07662822B2
公开(公告)日：2010-02-16
申请号：US11579919
申请日：2005-04-23
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： C07D471/04 , A61K31/497 , C07D213/75 , C07D213/73 , C07F9/06 , C07F9/28 , C07C265/12 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

17. 发明申请

US20070099929A1 Substituted thiophenes 审中-公开
标题翻译：取代的噻吩
公开(公告)号：US20070099929A1
公开(公告)日：2007-05-03
申请号：US11455253
申请日：2006-06-16
申请人： Kai Thede , Tobias Wunberg , Timothy Lowinger , Diana Koletzki , Andreas Urban , Judith Baumeister , Kerstin Henninger
发明人： Kai Thede , Tobias Wunberg , Timothy Lowinger , Diana Koletzki , Andreas Urban , Judith Baumeister , Kerstin Henninger
IPC分类号： A61K31/496 , A61K31/453 , A61K31/4436 , A61K31/4025 , A61K31/381 , C07D409/02
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D417/04
摘要： The invention relates to substituted thiophenes and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular for hepatitis C viruses.
摘要翻译：本发明涉及取代的噻吩及其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病，特别是用作抗病毒剂的药物的用途特别适用于丙型肝炎病毒。

18. 发明授权

US06500817B1 Thiazolyl urea derivatives and their utilization as antiviral agents 失效
标题翻译：噻唑脲衍生物及其作为抗病毒剂的利用
公开(公告)号：US06500817B1
公开(公告)日：2002-12-31
申请号：US09914554
申请日：2001-08-31
申请人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
发明人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
IPC分类号： A61K31426
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07D487/04
摘要： The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.
摘要翻译：本发明涉及噻唑基脲衍生物，其制备方法及其作为药物，特别是作为抗病毒药物的用途。

19. 发明授权

US07105553B2 Thiazolyl amide derivatives 有权
标题翻译：噻唑基酰胺衍生物
公开(公告)号：US07105553B2
公开(公告)日：2006-09-12
申请号：US10168197
申请日：2000-12-12
申请人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
发明人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07F7/1804 , C07F9/6539
摘要： The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
摘要翻译：本发明涉及新化合物，其制备方法及其用作药物，特别是抗病毒药物。

20. 发明申请

US20140199295A1 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
标题翻译：涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术
公开(公告)号：US20140199295A1
公开(公告)日：2014-07-17
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
摘要翻译：本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法测定（例如在ADA免疫测定中）。这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; - 用于修饰和/或改善ISV的方法以消除或减少其引起这种蛋白质干扰或这种信号的倾向; - 可以引入到ISV中的改变，其去除或减少其引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。

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