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11. 发明申请

US20120101064A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES 失效
标题翻译：咪唑衍生物及其作为细胞周期调节因子的调节剂
公开(公告)号：US20120101064A1
公开(公告)日：2012-04-26
申请号：US13266976
申请日：2010-04-30
申请人： Steven Howard , Paul Neil Mortenson , Steven Douglas Hiscock , Alison Jo-Anne Woolford , Andrew James Woodhead , Gianni Chessari , Marc O'reilly , Miles Stuart Congreve , Claudio Dagostin , Young Shin Cho , Fan Yang , Christine Hiu-Tung Chen , Christopher Thomas Brain , Bharat Lagu , Yaping Wang , Sunkyu Kim , John Grialdes , Michael Joseph Luzzio , Lawrence Blas Perez
发明人： Steven Howard , Paul Neil Mortenson , Steven Douglas Hiscock , Alison Jo-Anne Woolford , Andrew James Woodhead , Gianni Chessari , Marc O'reilly , Miles Stuart Congreve , Claudio Dagostin , Young Shin Cho , Fan Yang , Christine Hiu-Tung Chen , Christopher Thomas Brain , Bharat Lagu , Yaping Wang , Sunkyu Kim , John Grialdes , Michael Joseph Luzzio , Lawrence Blas Perez
IPC分类号： A61K31/675 , A61K31/4439 , A61K31/496 , A61K31/4545 , C07D413/06 , A61K31/5377 , C07D417/10 , A61K31/427 , C07D403/10 , A61K31/4178 , C07D409/10 , C07D401/06 , A61K31/4725 , A61K31/551 , C07D471/04 , A61K31/437 , C07F9/6561 , A61P35/00 , A61P35/02 , C07D401/14
CPC分类号： C07D471/04 , C07D233/22 , C07D233/24 , C07D235/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D487/04 , C07D519/00
摘要： The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+—O− or CR3; Y is N, N+—O− or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.
摘要翻译：本发明提供式（I）化合物及其盐，互变异构体，溶剂化物和N-氧化物; 其中Q是CH或N; X是N，N + -O-或CR 3; Y是N，N + -O-或CR3a; R1和R2独立地选自氢和权利要求中定义的各种取代基; 或R 1和R 2与它们所连接的原子一起连接以形成任选取代的4至7个成员的碳环或杂环芳族或非芳族环; R3选自氢和各种取代基; 并且R 3a选自氢和权利要求中定义的各种取代基。还提供含有式（I）化合物，制备化合物的方法和化合物的医疗用途的药物组合物。式（I）化合物具有作为CDK激酶抑制剂的活性，并且可用于治疗尤其是增殖性疾病如癌症。

12. 发明授权

US07989441B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US07989441B2
公开(公告)日：2011-08-02
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/44 , C07D223/12 , C07D211/76
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物。

13. 发明申请

US20090069294A1 Organic Compounds 失效
标题翻译：有机化合物
公开(公告)号：US20090069294A1
公开(公告)日：2009-03-12
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/55 , C07D243/02 , A61K31/551 , A61K31/407 , A61K31/435 , C07D221/04 , C07D487/04 , A61P35/00 , C07D495/04 , A61K31/4365 , A61K31/4412 , C07D211/76 , C07D223/14
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物。

14. 发明授权

US09346770B2 Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses 有权
标题翻译：对过氧化物酶体增殖物激活受体亚型具有活化作用的化合物及其制备方法和用途
公开(公告)号：US09346770B2
公开(公告)日：2016-05-24
申请号：US13704281
申请日：2011-06-18
申请人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
发明人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
IPC分类号： C07D263/32 , A61K31/421 , C07D413/10 , C07D277/24 , A61K31/439
CPC分类号： C07D263/32 , A61K31/439 , C07D277/24 , C07D413/10
摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).
摘要翻译：在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。

15. 发明授权

US07115596B2 Thiazole compounds as integrin receptor antagonists derivatives 失效
标题翻译：噻唑化合物作为整合素受体拮抗剂衍生物
公开(公告)号：US07115596B2
公开(公告)日：2006-10-03
申请号：US10741056
申请日：2003-12-19
申请人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
发明人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
IPC分类号： A61K31/55 , A61K31/5025 , A61K31/44 , A61K31/425 , A61K31/36 , C07D401/00 , C07D417/00 , C07D413/00 , C07D471/02 , C07D207/00 , C07D317/46
CPC分类号： C07D417/14 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin without significantly inhibiting the αvβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α5β5整联蛋白，而不显着抑制α3β6 整合素。

16. 发明授权

US06531494B1 Gem-substituted &agr;v&bgr;3 antagonists 失效
标题翻译：宝石取代的alphavbeta3拮抗剂
公开(公告)号：US06531494B1
公开(公告)日：2003-03-11
申请号：US09942214
申请日：2001-08-29
申请人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
发明人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/73 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白的方法。

17. 发明申请

US20130089613A1 Compounds Having Activating Effect on Subtypes of Peroxisome Proliferator-Activated Receptors and its Preparation Method and Uses 有权
标题翻译：对过氧化物酶体增殖物激活受体亚型具有活化作用的化合物及其制备方法和用途
公开(公告)号：US20130089613A1
公开(公告)日：2013-04-11
申请号：US13704281
申请日：2011-06-18
申请人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
发明人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
IPC分类号： C07D263/32 , C07D413/10
CPC分类号： C07D263/32 , A61K31/439 , C07D277/24 , C07D413/10
摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).
摘要翻译：在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。

18. 发明申请

US20100157548A1 FOLDABLE ELECTRICAL DEVICES 审中-公开
标题翻译：可折叠电气设备
公开(公告)号：US20100157548A1
公开(公告)日：2010-06-24
申请号：US12543719
申请日：2009-08-19
申请人： Yaping Wang , Yifeng Sun
发明人： Yaping Wang , Yifeng Sun
IPC分类号： H05K1/00
CPC分类号： H05K1/028 , H05K2201/051
摘要： A foldable electrical device (100) includes a first housing (110), a second housing (120) foldably connected to the first housing, and a flexible printed circuit board (140). The flexible printed circuit board includes a first portion (142), a second portion (144) and a curving portion (146) connecting the first portion and the second portion. The first portion is at least partially received within the first housing, the second portion is at least partially received within the second housing, and the curving portion winds around an axis which is substantially stationary with respect to the second housing for at least 360 degrees.
摘要翻译：可折叠电气装置（100）包括第一壳体（110），可折叠地连接到第一壳体的第二壳体（120）和柔性印刷电路板（140）。柔性印刷电路板包括连接第一部分和第二部分的第一部分（142），第二部分（144）和弯曲部分（146）。第一部分至少部分地被容纳在第一壳体内，第二部分至少部分地被容纳在第二壳体内，并且弯曲部分围绕相对于第二壳体基本上静止的轴至少360度旋转。

19. 发明申请

US20080114045A1 Process for the Production of Candesartan 审中-公开
标题翻译：坎地沙坦生产工艺
公开(公告)号：US20080114045A1
公开(公告)日：2008-05-15
申请号：US11793244
申请日：2005-12-15
申请人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li , Stefan Koecher
发明人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li , Stefan Koecher
IPC分类号： A61K31/4184 , C07D403/02
CPC分类号： C07C227/04 , C07C227/10 , C07C229/56 , C07C229/60 , C07D235/26 , C07D403/10
摘要： The present invention relates to novel processes for the preparation of candesartan or of a protected form of candesartan, of a candesartan salt or of a candesartan ester; compounds which can be used in processes according to the invention, processes for their preparation, their use in processes according to the invention; a novel polymorphic form of candesartan cilexetil, a process for its preparation and its use for the production of a medicament.
摘要翻译：本发明涉及制备坎地沙坦或坎地沙坦的坎地沙坦或坎地沙坦酯的坎地沙坦或其受体形式的新方法。可用于根据本发明的方法的化合物，其制备方法，它们在根据本发明的方法中的用途; 一种新型多态形式的坎地沙坦酯，其制备方法及其用于制备药物。

20. 发明申请

US20050043344A1 Heteroarylalkanoic acids as integrin receptor antagonists derivatives 审中-公开
标题翻译：杂芳基链烷酸作为整联蛋白受体拮抗剂衍生物
公开(公告)号：US20050043344A1
公开(公告)日：2005-02-24
申请号：US10743354
申请日：2003-12-22
申请人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
发明人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
IPC分类号： A61K31/4245 , A61K31/4745 , A61P19/02 , A61P19/10 , A61P27/00 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译：本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白而不显着抑制αVβ6整联蛋白的方法。

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