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1. 发明申请

US20080114045A1 Process for the Production of Candesartan 审中-公开
标题翻译：坎地沙坦生产工艺
公开(公告)号：US20080114045A1
公开(公告)日：2008-05-15
申请号：US11793244
申请日：2005-12-15
申请人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li , Stefan Koecher
发明人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li , Stefan Koecher
IPC分类号： A61K31/4184 , C07D403/02
CPC分类号： C07C227/04 , C07C227/10 , C07C229/56 , C07C229/60 , C07D235/26 , C07D403/10
摘要： The present invention relates to novel processes for the preparation of candesartan or of a protected form of candesartan, of a candesartan salt or of a candesartan ester; compounds which can be used in processes according to the invention, processes for their preparation, their use in processes according to the invention; a novel polymorphic form of candesartan cilexetil, a process for its preparation and its use for the production of a medicament.
摘要翻译：本发明涉及制备坎地沙坦或坎地沙坦的坎地沙坦或坎地沙坦酯的坎地沙坦或其受体形式的新方法。可用于根据本发明的方法的化合物，其制备方法，它们在根据本发明的方法中的用途; 一种新型多态形式的坎地沙坦酯，其制备方法及其用于制备药物。

2. 发明申请

US20090111994A1 Method for The Production of Losartan 审中-公开
标题翻译：氯沙坦生产方法
公开(公告)号：US20090111994A1
公开(公告)日：2009-04-30
申请号：US11883972
申请日：2006-02-02
申请人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li
发明人： Yaping Wang , Yonggang Li , Yulin Li , Guojun Zheng , Yi Li
IPC分类号： C07D257/04
CPC分类号： C07C257/14 , C07D233/64 , C07D257/04 , C07D403/10 , Y02P20/55
摘要： The present invention relates to a novel process for preparing losartan, an imidazole derivative with the chemical name 2-n-butyl-4-chloro-5-hydroxymethyl-1-{[2′-(1H-tetrazol-5-yl)biphenyl-4-]methyl}imidazole, and pharmacologically active salts thereof. The invention further relates to novel intermediates which are suitable for preparing losartan and to novel processes for preparing intermediate compounds which are suitable for preparing losartan.One aspect of the invention is a process for preparing a compound of the general formula I which can form as an intermediate in an inventive preparation of losartan.
摘要翻译：本发明涉及一种制备氯沙坦的新方法，该化合物名为2-正丁基-4-氯-5-羟甲基-1 - {[2' - （1H-四唑-5-基）联苯 -4-]甲基}咪唑及其药理学活性盐。本发明还涉及适用于制备氯沙坦的新型中间体和适用于制备氯沙坦的中间体化合物的新方法。本发明的一个方面是制备可在本发明氯沙坦制剂中形成中间体的通式Ⅰ化合物的方法。

3. 发明授权

US09346770B2 Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses 有权
标题翻译：对过氧化物酶体增殖物激活受体亚型具有活化作用的化合物及其制备方法和用途
公开(公告)号：US09346770B2
公开(公告)日：2016-05-24
申请号：US13704281
申请日：2011-06-18
申请人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
发明人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
IPC分类号： C07D263/32 , A61K31/421 , C07D413/10 , C07D277/24 , A61K31/439
CPC分类号： C07D263/32 , A61K31/439 , C07D277/24 , C07D413/10
摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).
摘要翻译：在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。

4. 发明申请

US20130089613A1 Compounds Having Activating Effect on Subtypes of Peroxisome Proliferator-Activated Receptors and its Preparation Method and Uses 有权
标题翻译：对过氧化物酶体增殖物激活受体亚型具有活化作用的化合物及其制备方法和用途
公开(公告)号：US20130089613A1
公开(公告)日：2013-04-11
申请号：US13704281
申请日：2011-06-18
申请人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
发明人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
IPC分类号： C07D263/32 , C07D413/10
CPC分类号： C07D263/32 , A61K31/439 , C07D277/24 , C07D413/10
摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).
摘要翻译：在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。

5. 发明授权

US08081300B2 Apparatus and method for laser ranging 有权
标题翻译：用于激光测距的装置和方法
公开(公告)号：US08081300B2
公开(公告)日：2011-12-20
申请号：US12538122
申请日：2009-08-08
申请人： Tian Jin , Guojun Zheng , Chongqiu Liu , Yi Qun Fan
发明人： Tian Jin , Guojun Zheng , Chongqiu Liu , Yi Qun Fan
IPC分类号： G01C3/08
CPC分类号： G01S7/489 , G01S7/4873 , G01S17/105
摘要： The present invention relates to a method for laser ranging with high precision and high efficient, a method for identifying distance mode automatically during laser ranging process, and a laser ranger with high precision, high efficient and low power waste. The accuracy of ranging is increased through multi classes of receiving process; the accuracy of ranging is further increased through the selection of distance mode and the adjustment of receiving sensitivity before the measuring steps are executed; the accuracy of ranging is further increased through executing jitter judgment on obtained distance measured values to discard the distance measured values that do not satisfy the setting conditions and judge whether the number of remaining distance measured values satisfies the setting quantity requirement; and the present invention is also of simple structure, high measurement efficiency, and low power waste.
摘要翻译：本发明涉及一种高精度，高效率的激光测距方法，一种在激光测距过程中自动识别距离模式的方法，以及具有高精度，高效率，低功耗的激光雷达。通过多类接收过程提高测距的准确性; 在执行测量步骤之前，通过距离模式的选择和接收灵敏度的调整进一步提高测距精度; 通过对所获得的距离测量值执行抖动判断，放弃不满足设定条件的距离测量值，并判断剩余距离测量值是否满足设定量要求，进一步提高测距精度; 本发明结构简单，测量效率高，浪费低。

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