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11. 发明申请

US20120143623A1 RULE BASED DECISION SUPPORT AND PATIENT-SPECIFIC VISUALIZATION SYSTEM FOR OPTIMAL CANCER STAGING 审中-公开
标题翻译：基于规则的决策支持和患者特异性可视化系统，用于最佳癌症分期
公开(公告)号：US20120143623A1
公开(公告)日：2012-06-07
申请号：US13382013
申请日：2010-06-15
申请人： Roland Johannes Opfer , Cristian Lorenz , Rafael Wiemker , Lothar Spies , Guy Shechter
发明人： Roland Johannes Opfer , Cristian Lorenz , Rafael Wiemker , Lothar Spies , Guy Shechter
IPC分类号： G06Q50/22
CPC分类号： G06T7/0012 , G06Q50/22 , G06T2200/24 , G06T2207/30061
摘要： A system including a display and a processor and a corresponding method for identifying a tumor in a patient image, classifying the tumor based on a predetermined classification system and determining a recommendation regarding a lymph node biopsy based on the tumor identified in the patient image, the classification of the tumor and a predetermined rule.
摘要翻译：一种包括显示器和处理器的系统以及用于识别患者图像中的肿瘤的相应方法，基于预定分类系统对肿瘤进行分类，并基于在患者图像中识别的肿瘤确定关于淋巴结活检的建议，肿瘤分类和预定规则。

12. 发明授权

US08107707B2 Visualizing a vascular structure 有权
标题翻译：可视化血管结构
公开(公告)号：US08107707B2
公开(公告)日：2012-01-31
申请号：US12516670
申请日：2007-11-27
申请人： Rafael Wiemker , Roland Opfer , Thomas Buelow
发明人： Rafael Wiemker , Roland Opfer , Thomas Buelow
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/032 , A61B6/12 , A61B6/481 , A61B6/503 , G06T7/0012 , G06T2207/10081 , G06T2207/30104
摘要： A system (500) for visualizing a vascular structure represented by a three-dimensional angiography dataset is disclosed. Respective voxel values are associated with respective voxels. The dataset represents a vascular structure. The system comprises means (502) for establishing respective filling values; means (504) for identifying respective minimum filling values; means (506) for computing respective deficiency values; and an output (514) for providing a visualization in dependence on the deficiency values. A respective filling value is indicative of an amount of blood flow at the respective position in the vascular structure. A respective minimum filling value is a minimum of the filling values associated with the positions upstream of the respective position. A respective deficiency value is indicative of a difference between the filling value associated with the respective position and the minimum filling value associated with the respective position.
摘要翻译：公开了一种用于可视化由三维血管造影数据集表示的血管结构的系统（500）。各个体素值与相应的体素相关联。数据集表示血管结构。该系统包括用于建立相应填充值的装置（502）用于识别相应的最小填充值的装置（504）; 用于计算各个不足值的装置（506）; 以及用于根据不足值提供可视化的输出（514）。相应的填充值表示血管结构中各个位置处的血流量。相应的最小填充值是与相应位置的上游位置相关联的填充值的最小值。相应的缺陷值表示与各个位置相关联的填充值与与各个位置相关联的最小填充值之间的差异。

13. 发明申请

US20100246910A1 METHOD OF AUTOMATICALLY CORRECTING MIS-ORIENTATION OF MEDICAL IMAGES 审中-公开
标题翻译：自动校正医学影像的方法
公开(公告)号：US20100246910A1
公开(公告)日：2010-09-30
申请号：US12741838
申请日：2008-11-10
申请人： Rafael Wiemker , Thomas Buelow , Hans Barschdorf , Kirsten Meetz , Heinrich Schulz
发明人： Rafael Wiemker , Thomas Buelow , Hans Barschdorf , Kirsten Meetz , Heinrich Schulz
IPC分类号： G06K9/00
CPC分类号： G06T3/0068
摘要： This invention relates to a method and image processing apparatus for automatically correcting mis-orientation of medical images. One or more image processing software modules are used to extract (101) anatomical areas from the medical images. It is determined (103) whether the extracted anatomical areas correspond to reference anatomical areas, but the reference anatomical areas have associated thereto data indicating the orientation of the reference anatomical areas. If the extracted anatomical areas correspond with the reference anatomical areas, the true orientation of the extracted anatomical areas is determined (105) by realigning the medical image until the orientation of the extracted anatomical areas corresponds to the orientation of the reference anatomical areas.
摘要翻译：本发明涉及一种用于自动校正医学图像的错误取向的方法和图像处理装置。使用一个或多个图像处理软件模块从医学图像中提取（101）解剖区域。确定（103）所提取的解剖区域是否对应于参考解剖区域，但是参考解剖区域与其相关联地指示参考解剖区域的取向的数据。如果提取的解剖区域与参考解剖区域相对应，则通过重新对准医学图像来确定提取的解剖区域的真实取向（105），直到提取的解剖区域的取向对应于参考解剖区域的取向。

14. 发明申请

US20100128940A1 METHOD OF AUTOMATIC EXTRACTION OF THE PULMONARY ARTERY TREE FROM 3D MEDICAL IMAGES 有权
标题翻译：从三维医学图像中自动提取脉络膜的方法
公开(公告)号：US20100128940A1
公开(公告)日：2010-05-27
申请号：US11815662
申请日：2006-02-06
申请人： Thomas Buelow , Rafael Wiemker , Thomas Blaffert , Cristian Lorenz , Steffen Renisch
发明人： Thomas Buelow , Rafael Wiemker , Thomas Blaffert , Cristian Lorenz , Steffen Renisch
IPC分类号： G06K9/62
CPC分类号： G06T7/155 , G06T7/11 , G06T7/149 , G06T2200/04 , G06T2207/10081 , G06T2207/20044 , G06T2207/20156 , G06T2207/30061 , G06T2207/30101
摘要： An automated method (1) for the automatic extraction of a pulmonary vessel tree from a 3D medical image, such as multi-slice CT data, is disclosed. A segmented pulmonary vessel is identified as either an artery or a vein by determining a measure for arterialness for the vessel. The measure is based on a relation of the orientation of a local bronchus to the orientation of the segmented pulmonary vessel of the local bronchus. When a vessel is identified as a pulmonary artery, it is added to the pulmonary artery tree. Radii of the pulmonary artery and bronchus are measured automatically and positions where a ratio of these radii exhibits unusual values are presented in a display, preferably for suggesting further assessment by a radiologist, which for instance is useful for pulmonary embolism detection.
摘要翻译：公开了一种用于从诸如多层CT数据的3D医学图像自动提取肺血管树的自动化方法（1）。通过确定血管动脉的测量，将分段的肺血管识别为动脉或静脉。该措施基于局部支气管的取向与局部支气管的分段肺血管的取向的关系。当血管被识别为肺动脉时，将其加入肺动脉树。自动测量肺动脉和支气管的半径，并且在显示中呈现这些半径的比率显示出异常值的位置，优选用于暗示例如用于肺栓塞检测的放射科医师的进一步评估。

15. 发明申请

US20090147001A1 COMPUTER PROGRAM TO OUTPUT CONTRAST ENHANCED MEDICAL IMAGE DATA 审中-公开
标题翻译：计算机程序到输出对比度增强的医学图像数据
公开(公告)号：US20090147001A1
公开(公告)日：2009-06-11
申请号：US12300536
申请日：2007-05-14
申请人： Thomas Buelow , Rafael Wiemker , Lina Arbash Meinel
发明人： Thomas Buelow , Rafael Wiemker , Lina Arbash Meinel
IPC分类号： G06T17/00 , G06K9/00
CPC分类号： G06T7/12 , G06T7/11 , G06T2207/10081 , G06T2207/20161 , G06T2207/30068 , G06T2207/30101
摘要： A string of computer instructions is presented to output medical image data containing voxels representative of contrast enhanced material, and arranged to operate on a first object data set comprising voxels depicting contrast enhancement, whereby it segments a sub-set of voxels in the first object data set which voxels describe contrast enhanced vessels, and uses the results of the segmentation to partition the voxels depicting contrast enhancement into a first group of voxels describing the segmented vessels and a second group of voxels describing the remaining contrast enhanced voxels, and uses the partition to output a second object data set comprising voxels depicting contrast enhancement in which the difference between the voxels of the first group and the voxels of the second group is identifiable. It is particularly advantageously applied to dynamic contrast enhanced breast imaging.
摘要翻译：呈现一串计算机指令以输出包含代表对比度增强材料的体素的医学图像数据，并且被布置成对包含描绘对比度增强的体素的第一对象数据集进行操作，由此在第一对象数据中分割体素的子集设置哪些体素描述对比增强血管，并使用分割结果将描绘对比度增强的体素分成描述分割血管的第一组体素和描述剩余的对比度增强体素的第二组体素，并使用分区输出第二对象数据集，其包括描绘对比度增强的体素，其中第一组的体素与第二组的体素之间的差异是可识别的。特别有利地应用于动态对比度增强的乳房成像。

16. 发明授权

US10531815B2 User-steered on-the-fly path planning 有权
公开(公告)号：US10531815B2
公开(公告)日：2020-01-14
申请号：US14115709
申请日：2012-05-04
申请人： Kongkuo Lu , Rafael Wiemker
发明人： Kongkuo Lu , Rafael Wiemker
IPC分类号： A61B5/06 , A61B1/00 , A61B1/267 , A61B6/03 , A61B10/02
摘要： A method, system, and program product are provided for user-steered, on-the fly path planning in an image-guided endoscopic procedure, comprising: presenting, on a display, a 2D sectional image showing a region of interest from a preoperative CT scan; defining a control point on the 2D sectional image within a patient's body lumen responsive to a first user input; centering the control point; adjusting a viewing angle about the control point to show a longitudinal section of the body lumen responsive to a second user input; identifying a second point on a planned path within the body lumen responsive to a third user input; extending a planned path connecting the control point and the second point; redefining the second point as a new control point; and repeating the presenting adjusting, identifying, extending, and the redefining steps until the planned path reaches a procedure starting point within the patient's body.

17. 发明授权

US09757588B2 Deformable registration of images for image guided radiation therapy 有权
公开(公告)号：US09757588B2
公开(公告)日：2017-09-12
申请号：US12300339
申请日：2007-05-01
申请人： Michael Kaus , Vladimir Pekar , Rafael Wiemker
发明人： Michael Kaus , Vladimir Pekar , Rafael Wiemker
IPC分类号： G06Q10/00 , A61N5/10 , A61B6/00 , G06Q50/22 , G06T7/33 , G06T7/38 , A61B5/00 , A61B6/03 , A61B8/00 , G06F19/00
CPC分类号： A61N5/103 , A61B5/7285 , A61B6/03 , A61B6/466 , A61B6/541 , A61B8/543 , A61N5/1037 , A61N2005/1061 , G06F19/00 , G06F19/321 , G06F19/3481 , G06Q50/22 , G06T7/33 , G06T7/38 , G06T2207/30004 , G16H50/50
摘要： A system and method for developing radiation therapy plans and a system and method for developing a radiation therapy plan to be used in a radiation therapy treatment is disclosed. A radiation therapy plan is developed using a registration of medical images. The registration is based on identifying landmarks located within inner body structures.

18. 发明授权

US09269141B2 Interactive live segmentation with automatic selection of optimal tomography slice 有权
标题翻译：交互式实时分割，自动选择最佳断层扫描切片
公开(公告)号：US09269141B2
公开(公告)日：2016-02-23
申请号：US14342553
申请日：2012-09-03
申请人： Rafael Wiemker , Harald Sepp Heese , Andre Goossen , Klaus Erhard
发明人： Rafael Wiemker , Harald Sepp Heese , Andre Goossen , Klaus Erhard
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/187 , G06T2200/24 , G06T2207/20101 , G06T2207/30068
摘要： An apparatus for automatic selection of optimal tomography slices by executing a number of tentative segmentations using the same interactively provided in-slice seed point on some or all available tomography slices. The appropriate segmentation boundaries are then marked and the slice with the best segmentation goodness value (figure of merit) is presented to the user via a viewer. The steps are repeated when the user changes the seed point. The optimal segmentation boundary is displayed on top of a single simulated mammography image, fused from all tomography slice images.
摘要翻译：一种用于通过在一些或所有可用的断层摄影切片上使用相同交互式提供的切片种子点执行多个临时分割来自动选择最佳断层摄影切片的装置。然后标记适当的分割边界，并且经由观察者向用户呈现具有最佳分割优点值（品质因数）的切片。当用户更改种子点时，重复这些步骤。最佳分割边界显示在单个模拟乳房X射线摄影图像的顶部，融合于所有断层摄影切片图像。

19. 发明申请

US20150363080A1 DISPLAYING A PLURALITY OF REGISTERD IMAGES 有权
标题翻译：显示注册图像的多样性
公开(公告)号：US20150363080A1
公开(公告)日：2015-12-17
申请号：US14128668
申请日：2012-06-27
申请人： Thomas Buelow , Martin Bergtholdt , Kirsten Regina Meetz , Ingwer-Curt Carlsen , Rafael Wiemker
发明人： Thomas Buelow , Martin Bergtholdt , Kirsten Regina Meetz , Ingwer-Curt Carlsen , Rafael Wiemker
IPC分类号： G06F3/0484 , G06F19/00 , G06F3/0488 , G06T19/20 , G06F3/0482
CPC分类号： G06F3/04845 , G06F3/0482 , G06F3/04842 , G06F3/0488 , G06F19/00 , G06F19/321 , G06T19/20 , G06T2219/028 , G06T2219/2004
摘要： A system for displaying a plurality of registered images is disclosed. A first viewport unit (1) displays a representation of a first image dataset (4) in a first viewport (201). A second viewport unit (2) displays a representation of a second image dataset (5) in a second viewport (202). A position indication unit (7) enables a user to indicate a position in the first dataset (4) displayed in the first viewport (201), to obtain a user-indicated position. A corresponding position determining unit (8) determines a position in the second image dataset (5) corresponding to the user-indicated position, to obtain a corresponding position in the second image dataset (5), based on correspondence information (9) mapping positions in the first image dataset (4) to corresponding positions in the second image dataset (5). The second viewport unit (2) displays an indication of the corresponding position in the second viewport (202).
摘要翻译：公开了一种用于显示多个登记图像的系统。第一视口单元（1）在第一视口（201）中显示第一图像数据集（4）的表示。第二视口单元（2）在第二视口（202）中显示第二图像数据集（5）的表示。位置指示单元（7）使得用户能够指示在第一视口（201）中显示的第一数据集（4）中的位置，以获得用户指示的位置。对应位置确定单元（8）基于对应信息（9）确定第二图像数据集（5）中与用户指示位置相对应的位置，以获得第二图像数据集（5）中的相应位置，在第一图像数据集（4）中的第二图像数据集（5）中的对应位置。第二视口单元（2）显示第二视口（202）中对应位置的指示。

20. 发明授权

US09196030B2 System and method for determining a property of blur in a blurred image 有权
标题翻译：用于确定模糊图像中的模糊属性的系统和方法
公开(公告)号：US09196030B2
公开(公告)日：2015-11-24
申请号：US13496496
申请日：2010-09-15
申请人： Rafael Wiemker , Thomas Buelow , Steffen Renisch
发明人： Rafael Wiemker , Thomas Buelow , Steffen Renisch
IPC分类号： G06K9/00 , G06T7/00 , G06T5/00
CPC分类号： G06T7/0002 , G06T5/003 , G06T7/70 , G06T2207/10104 , G06T2207/20201 , G06T2207/30004
摘要： A system and a method of determining a property of blur in an image are provided. According to other aspects a medical image acquisition apparatus, a medical workstation and a computer program product are provided. The system (100) comprises a receiver (102) for receiving the image of an object-of-interest of a body. The image comprises blur. Further, the system comprises a determining subsystem (122) for determining a value of a characteristic of the blur in the image on individual lines of a plurality of lines intersecting with the object-of-interest at different angles. Thus, the lines extend in different directions. The determination of the value comprises analyzing the image along the respective lines. The system further comprises an obtaining subsystem (126) for obtaining a direction in which the value of the characteristic of the blur is maximal, based on the determined values on the individual lines of the plurality of lines, which lines extend in different directions.
摘要翻译：提供了一种确定图像中的模糊属性的系统和方法。根据其他方面，提供医学图像采集装置，医疗工作站和计算机程序产品。系统（100）包括用于接收身体感兴趣物体的图像的接收器（102）。图像包括模糊。此外，该系统包括确定子系统（122），用于确定与不同角度的与感兴趣物体相交的多条线上的各行上的图像中的模糊特征的值。因此，线在不同的方向延伸。该值的确定包括分析沿着各行的图像。该系统还包括获取子系统（126），用于根据在多条线路上的各条线路上确定的值来获得模糊特征值最大的方向，这些线路在不同方向上延伸。

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