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11. 发明申请

US20140039613A1 METHODS FOR REPLACING A CARDIAC VALVE 审中-公开
标题翻译：更换心脏瓣膜的方法
公开(公告)号：US20140039613A1
公开(公告)日：2014-02-06
申请号：US14048987
申请日：2013-10-08
申请人： The Cleveland Clinic Foundation
发明人： Jose L. Navia , Jose A. Navia , Carlos Oberti
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2418 , A61F2/2445 , A61F2/2457 , A61F2002/8483 , A61F2220/0016 , A61F2220/0075 , A61F2230/0013
摘要： A method for replacing a cardiac valve includes an expandable support member having oppositely disposed first and second ends, a main body portion extending between the ends, and a prosthetic valve within the main body portion. The main body portion has an annular shape for expanding into position in the annulus of the valve. The first and second ends include a plurality of upper and lower wing members movable from a collapsed condition into an extended condition for respectively engaging a first section of cardiac tissue surrounding the valve and for: engaging a portion of the native valve leaflets to pin the leaflets back against the annulus. The second end further includes at least two strut members spaced apart from each other. A respective one of the strut members is attached to at least one commissural section of the prosthetic valve to prevent prolapse of the valve leaflets.
摘要翻译：用于更换心脏瓣膜的方法包括具有相对设置的第一和第二端部的可扩张支撑构件，在端部之间延伸的主体部分和主体部分内的假体阀。主体部分具有用于扩展到阀的环形空间中的环形形状。第一端和第二端包括多个上部和下部翼构件，其可以从折叠状态移动到用于分别接合围绕所述阀的心脏组织的第一部分的延伸状态，并用于：接合一部分天然瓣膜以固定传单背对环。第二端还包括彼此间隔开的至少两个支柱构件。支柱构件中的相应一个附接到人工瓣膜的至少一个连合部分以防止瓣膜小叶脱垂。

12. 发明授权

US10939999B2 Apparatus and method for replacing a diseased cardiac valve 有权
公开(公告)号：US10939999B2
公开(公告)日：2021-03-09
申请号：US16025977
申请日：2018-07-02
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Ji-Feng Chen , Shengqiang Gao , Brian L. Davis , Samantha Stucke
IPC分类号： A61F2/24
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

13. 发明授权

US10537432B2 Apparatuses and methods for at least partially supporting a valve leaflet of a regurgitant heart valve 有权
公开(公告)号：US10537432B2
公开(公告)日：2020-01-21
申请号：US15677470
申请日：2017-08-15
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Samir Kapadia , Marwane Berrada
IPC分类号： A61F2/24
摘要： An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

14. 发明申请

US20190008632A1 APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE 审中-公开
公开(公告)号：US20190008632A1
公开(公告)日：2019-01-10
申请号：US16025977
申请日：2018-07-02
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Ji-Feng Chen , Shengqiang Gao , Brian L. Davis , Samantha Stucke
IPC分类号： A61F2/24
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

15. 发明授权

US10039644B2 Device, system, and method for treating a regurgitant heart valve 有权
公开(公告)号：US10039644B2
公开(公告)日：2018-08-07
申请号：US14737591
申请日：2015-06-12
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Samir Kapadia
IPC分类号： A61F2/24
摘要： In one aspect of the present disclosure, a device for treating a regurgitant heart valve in a subject can include a flexible, elongated body having a central chordae support portion disposed between first and second arms. The first and second arms can include first and second lumens, respectively, extending longitudinally therethrough. A method of treating a regurgitant heart valve in a subject is also provided.

16. 发明申请

US20150094803A1 APPARATUS AND METHOD FOR TREATING A REGURGITANT HEART VALVE 审中-公开
标题翻译：用于治疗心脏瓣膜的装置和方法
公开(公告)号：US20150094803A1
公开(公告)日：2015-04-02
申请号：US14502000
申请日：2014-09-30
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2454 , A61F2/2457 , A61F2230/0013 , A61F2230/0095
摘要： An apparatus is provided for treating regurgitation of blood flow through a diseased heart valve, which includes an annulus, anterior and posterior valve leaflets, and a subvalvular apparatus. The apparatus includes a substantially annular support member, at least one infra-annular support member securely connected thereto, and at least one anchoring element associated with the at least one infra-annular support member. The at least one anchoring element is configured to securely receive a prosthetic chordae tendineae for attachment to a papillary muscle. The posterior end portion is dimensioned for attachment to a posterior portion of the diseased heart valve annulus. The at least one infra-annular support member is securely connected to the substantially annular support member. The at least one infra-annular support member is dimensioned to extend below at least one of the posterior and anterior valve leaflets and across or behind at least one subvalvular structure.
摘要翻译：提供了一种用于治疗通过患病心脏瓣膜的血流量反流的装置，该心脏瓣膜包括环状，前后瓣叶和子瓣瓣装置。该装置包括基本上环形的支撑构件，至少一个牢固地连接到其上的基础环形支撑构件以及与至少一个基础环形支撑构件相关联的至少一个锚定元件。所述至少一个锚定元件构造成牢固地接收用于附着到乳头肌的假肢腱索。后端部的尺寸设计成用于附接到患病心脏瓣膜环的后部。至少一个基础环形支撑构件牢固地连接到大致环形的支撑构件上。所述至少一个基础环形支撑构件的尺寸被设计成在所述后瓣膜和所述前叶瓣中的至少一个下延伸并且在至少一个子瓣结构之上和之后延伸。

17. 发明申请

US20130304201A1 APPARATUS AND METHODS FOR REPAIR OF A CARDIAC VALVE 审中-公开
公开(公告)号：US20130304201A1
公开(公告)日：2013-11-14
申请号：US13947332
申请日：2013-07-22
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Jose L. Navia , Jose A. Navia , Mark S. Goodin
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2/91
摘要： An annuloplasty ring for repairing a cardiac valve includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion of the support member includes a plurality of wing members that extend from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and the valve annulus to secure the annuloplasty ring in the valve annulus. The annuloplasty ring may be expanded into full contact engagement with the annulus of the cardiac valve by an inflatable balloon. Methods for repairing a cardiac valve using the annuloplasty ring are also provided.

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