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11. 发明授权

US07641785B2 Method of measuring blood component and sensor used in the method 有权
标题翻译：方法测量血液成分和传感器的方法
公开(公告)号：US07641785B2
公开(公告)日：2010-01-05
申请号：US10954020
申请日：2004-09-28
申请人： Teppei Shinno , Shin Ikeda
发明人： Teppei Shinno , Shin Ikeda
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , C12Q1/006 , G01N27/3274 , G01N33/66 , G01N33/721
摘要： A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.
摘要翻译：提供了可以容易地校正血细胞比容的影响的用于血液成分分析的传感器。传感器包括分析部分，其包括工作电极，对电极和试剂部分。试剂部分包括与血液成分和介体反应的氧化还原酶，并且通过在介体存在下引起血液成分和氧化还原酶之间的氧化还原反应来测定血液成分，并检测由氧化还原反应产生的氧化还原电流通过工作电极和对电极。在该传感器中，试剂部还含有用于溶血红细胞的溶血剂（例如胆酸钠），当检测到氧化还原电流时，红细胞用溶血剂溶血，使血红蛋白释放到红细胞外与介体反应，并且检测由该反应产生的电流以校正血细胞比容的影响。

12. 发明申请

US20050145490A1 Method of measuring blood component and sensor used in the method 有权
标题翻译：方法测量血液成分和传感器的方法
公开(公告)号：US20050145490A1
公开(公告)日：2005-07-07
申请号：US10954020
申请日：2004-09-28
申请人： Teppei Shinno , Shin Ikeda
发明人： Teppei Shinno , Shin Ikeda
IPC分类号： G01N33/483 , C12M1/34 , C12Q1/00 , C12Q1/26 , C12Q1/32 , G01N27/327 , G01N27/416 , G01N33/487 , G01N33/66 , G01N33/72 , C12M1/00 , C12N11/00 , C25B9/00 , C25B13/00 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , G01N27/3274 , G01N33/66 , G01N33/721
摘要： A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.
摘要翻译：提供了可以容易地校正血细胞比容的影响的用于血液成分分析的传感器。传感器包括分析部分，其包括工作电极，对电极和试剂部分。试剂部分包括与血液成分和介体反应的氧化还原酶，并且通过在介体存在下引起血液成分和氧化还原酶之间的氧化还原反应来测定血液成分，并检测由氧化还原反应产生的氧化还原电流通过工作电极和对电极。在该传感器中，试剂部还含有用于溶血红细胞的溶血剂（例如胆酸钠），当检测到氧化还原电流时，红细胞用溶血剂溶血，使血红蛋白释放到红细胞外与介体反应，并且检测由该反应产生的电流以校正血细胞比容的影响。

13. 发明授权

US08163962B2 Method for producing alkoxyindanone derivative 失效
标题翻译：制备烷氧基茚满酮衍生物的方法
公开(公告)号：US08163962B2
公开(公告)日：2012-04-24
申请号：US12742873
申请日：2008-11-14
申请人： Tetsuya Ooyama , Takashi Onozawa , Shin Ikeda , Yoshinobu Suzuki
发明人： Tetsuya Ooyama , Takashi Onozawa , Shin Ikeda , Yoshinobu Suzuki
IPC分类号： C07C45/61
CPC分类号： C07C45/80 , C07C2602/08 , C07C49/67
摘要： [Problems to be Solved]The present invention aims to provide a method for efficiently producing a high-purity alkoxyindanone derivative while maintaining an industrially superior volumetric efficiency.[Solution]Provided is a method for producing an alkoxyindanone derivative represented by a general formula in FIG. 2 (wherein R represents an alkoxy group containing 1 to 6 carbon atoms and n represents an integer of 1 to 4), comprising reacting an alkoxyphenylpropionic acid derivative represented by a general formula in FIG. 1 (wherein R and n are as defined above) with a condensing agent, adding an organic solvent to the resulting reaction mixture, and subsequently decomposing the condensing agent with an aqueous alkaline solution.
摘要翻译： [待解决的问题]本发明的目的在于提供一种有效地制造高纯度烷氧基茚满酮衍生物的方法，同时保持了工业上优异的体积效率。 [解决方案]提供一种制备图1中通式所示的烷氧基茚满酮衍生物的方法。 2（其中R表示含有1至6个碳原子的烷氧基，n表示1至4的整数），包括使由图1中的通式表示的烷氧基苯基丙酸衍生物反应。 1（其中R和n如上定义）与缩合剂反应，向所得反应混合物中加入有机溶剂，随后用碱性水溶液分解缩合剂。

14. 再颁专利

USRE39390E1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：USRE39390E1
公开(公告)日：2006-11-14
申请号：US10924334
申请日：2002-05-17
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with which is obtained by filtering out hemocytes therein filtered in blood can rapidly reach an electrode system. In a biosensor where plasma with which is obtained by filtering out hemocytes therein filtered with by a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其测量对象为全血，等离子体<？delete-start id =“DEL-S-00001”date =“20061114”？>与<？delete -end id =“DEL-S-00001”？> <？insert-start id =“INS-S-00001”date =“20061114”？>通过过滤出<？insert-end id =“INS- S-00001“？>血细胞<？delete-start id =”DEL-S-00002“date =”20061114“？>其中过滤的<？delete-end id =”DEL-S-00002“？> 在血液中开始id =“INS-S-00002”date =“20061114”？> <？insert-end id =“INS-S-00002”？>可以快速到达电极系统。在等离子体<？delete-start id =“DEL-S-00003”date =“20061114”？>与<？delete-end id =“DEL-S-00003”？> <？insert-start id = 通过滤出<？insert-end id =“INS-S-00003”？>血细胞<？delete-start id =“DEL-S-00004”获得的“INS-S-00003”date =“20061114”？ “date =”20061114“？>用<？delete-end id =”DEL-S-00004“？> <？insert-start id =”INS-S-00004“date =”20061114“？> ？insert-end id =“INS-S-00004”？>由于毛细作用，将过滤器吸入样品溶液供给路径，形成有：从底部保持过滤器的初级侧部的第一按压部，用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

15. 发明授权

US06969450B2 Biosensor and measuring apparatus for biosensor 有权
标题翻译：用于生物传感器的生物传感器和测量装置
公开(公告)号：US06969450B2
公开(公告)日：2005-11-29
申请号：US10616305
申请日：2003-07-10
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka , Yoshinobu Tokuno
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka , Yoshinobu Tokuno
IPC分类号： A61B5/00 , G01N27/30 , G01N33/487 , C12M1/00
CPC分类号： G01N33/4875 , A61B5/1486 , A61B2562/0295
摘要： In biosensor system 1, biosensor 2 is mounted in measuring apparatus 3 for quantifying or detecting existence of a targeted substrate in a sample solution. Mounting end portion 20 of biosensor 2 to be mounted in measuring apparatus 3 has an extension of one base plate in the length direction, and further extensions of the other base plate in the width direction. Sensor mounting portion 30 of measuring apparatus 3 has a shape matching up with the shape of mounting end portion 20. Thereby wrong insertion of biosensor 2 in measuring apparatus 3 can be prevented.Further, varying shapes of plural biosensors 5 and 6 to have a common part and a non-common part, such biosensors can be handily measured by one measuring apparatus 7.
摘要翻译：在生物传感器系统1中，将生物传感器2安装在用于定量或检测样品溶液中目标基板的存在的测量装置3中。安装在测量装置3中的生物传感器2的安装端部20在长度方向上具有一个基板的延伸部，另一个底板在宽度方向上延伸。测量装置3的传感器安装部30具有与安装端部20的形状相匹配的形状。从而可以防止生物传感器2在测量装置3中错误插入。此外，多个生物传感器5和6的不同形状具有公共部分和非共同部分，可以通过一个测量装置7轻松测量这样的生物传感器。

16. 发明申请

US20050175509A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050175509A1
公开(公告)日：2005-08-11
申请号：US10515602
申请日：2003-12-19
申请人： Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka
发明人： Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： C12Q1/00 , G01N27/30
CPC分类号： C12Q1/006 , C12Q1/004 , G01N2333/904
摘要： The present invention relates to a biosensor which comprises an electrode system including at least one pair of electrodes, at least one insulating base plate for supporting the electrode system, a first reaction layer provided at least on a working electrode of the electrode system, including an organic compound having a functional group capable of bonding or being adsorbed to an electrode and a hydrophobic hydrocarbon group, a second reaction layer provided on the first reaction layer, including an amphiphilic lipid capable of bonding or being adsorbed to a hydrophobic portion of the first reaction layer, and a reagent system carried in a two-component membrane composed of the first and second reaction layers, including at least membrane-binding type pyrroquinoline quinone-dependent glucose dehydrogenase and an electron mediator.
摘要翻译：本发明涉及一种生物传感器，其包括电极系统，该电极系统包括至少一对电极，至少一个用于支撑电极系统的绝缘基板，至少设置在电极系统的工作电极上的第一反应层，具有能够键合或吸附到电极和疏水性烃基的官能团的有机化合物，设置在第一反应层上的第二反应层，包括能够键合或吸附到第一反应的疏水部分的两亲性脂质以及由第一反应层和第二反应层构成的双组分膜中携载的至少包含膜结合型吡喹啉醌依赖性葡萄糖脱氢酶和电子介体的试剂系统。

17. 发明授权

US06599407B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06599407B2
公开(公告)日：2003-07-29
申请号：US09747975
申请日：2000-12-27
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004
摘要： The present invention provides a biosensor having a favorable response characteristic up to a high concentration range, a low blank response and a high storage stability. This sensor comprises an electrode system including a working electrode and a counter electrode, for forming an electrochemical measurement system by coming in contact with a supplied solution; an electrically insulating supporting member for supporting the electrode system; a first reagent layer formed on the working electrode; and a second reagent layer formed on the counter electrode, wherein the first reagent layer comprises an enzyme as the main component, and the second reagent layer comprises an electron mediator as the main component.
摘要翻译：本发明提供一种生物传感器，其具有高浓度范围，低空白响应和高储存稳定性的良好响应特性。该传感器包括电极系统，其包括工作电极和对电极，用于通过与所提供的溶液接触形成电化学测量系统; 用于支撑电极系统的电绝缘支撑构件; 形成在工作电极上的第一试剂层; 以及形成在对电极上的第二试剂层，其中第一试剂层包含酶作为主要成分，第二试剂层包含电子介体作为主要成分。

18. 发明授权

US06451372B2 Biosensor and method of producing the same 失效
标题翻译：生物传感器及其生产方法
公开(公告)号：US06451372B2
公开(公告)日：2002-09-17
申请号：US09770946
申请日：2001-01-26
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： B05D300
CPC分类号： C12Q1/002
摘要： The present invention provides a biosensor that has a reaction reagent system easily dissolved even in a sample solution containing a high concentration of a substrate and ensures rapid and highly accurate measurement. The method of forming a target reaction layer according to the present invention dissolves a material constituting the target reaction layer in a solvent of a sublimable substance to prepare a solution, applies the solution in a desired area to form the target reaction layer, freezes the applied solution, and sublimates the solvent included in a solid matter of the frozen solution under reduced pressure for removal. The resultant reaction layer has a large surface area and is easily dissolved in the sample solution to enable rapid measurement.
摘要翻译：本发明提供了一种生物传感器，其具有即使在含有高浓度基板的样品溶液中也容易溶解的反应试剂体系，并且确保快速且高精度的测量。根据本发明的形成目标反应层的方法将构成目标反应层的材料溶解在可升华物质的溶剂中以制备溶液，将溶液施加到所需区域以形成目标反应层，冻结所施加的溶液，并在减压下升华包含在冷冻溶液的固体物质中的溶剂以除去。所得反应层的表面积大，容易溶解在样品溶液中，能够快速测定。

19. 发明授权

US06258254B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06258254B1
公开(公告)日：2001-07-10
申请号：US09122628
申请日：1998-07-27
申请人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Yoshiko Miyamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01F164
CPC分类号： C12Q1/004
摘要： A method using a biosensor is disclosed which facilitates high accuracy quantitation of a substrate by best eliminating adverse effects of red blood cell existing in blood together with the substrate. The biosensor comprises an electrode system including a working electrode and a counter electrode formed on an electrically insulating base plate, and a reaction layer containing at least an oxidoreductase and an electron acceptor, wherein the electron acceptor is a sodium salt.
摘要翻译：公开了一种使用生物传感器的方法，其通过最好地消除血液中存在于血液中的红细胞与基质一起的不良影响，促进了基质的高精度定量。生物传感器包括电极系统，其包括在电绝缘基板上形成的工作电极和对电极，以及至少包含氧化还原酶和电子受体的反应层，其中电子受体是钠盐。

20. 发明授权

US6051392A Method for quantitating a substrate and measurement device used therefor 有权
标题翻译：用于定量基板的方法和用于其的测量装置
公开(公告)号：US6051392A
公开(公告)日：2000-04-18
申请号：US328510
申请日：1999-06-09
申请人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , A61B5/15 , A61B5/155 , A61B5/157 , G01N27/28 , G01N27/30 , G01N33/487 , C12Q1/26 , C12Q1/54
CPC分类号： A61B5/1486 , A61B5/150022 , A61B5/150435 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15142 , A61B5/15151 , A61B5/15171 , A61B5/6848 , A61B5/14532 , Y10S435/817
摘要： The present invention provides a measurement device facilitating accurate quantitation of a substrate from a trace amount of sample and a highly reliable quantitating method of a substrate. The method uses an analysis element comprising a pair of electrodes for electrochemically quantitating reaction between a substrate in a sample and an oxidoreductase. One of the electrodes of the analysis element is a membrane formed on an inner wall of a cylindrical hollow space having an opening and the other is a needle. The needle electrode is projected temporarily external to the hollow space to puncture a subject and the resultant sample is collected from the subject.
摘要翻译：本发明提供了一种测量装置，其有助于从微量样品和基板的高可靠性定量方法对衬底的精确定量。该方法使用包括一对电极的分析元件，用于电化学定量样品中的底物与氧化还原酶之间的反应。分析元件的一个电极是形成在具有开口的圆柱形中空空间的内壁上的膜，另一个是针。针状电极暂时投射到中空空间的外部，以刺破被检体，并从被检体收集所得样品。

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