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11. 发明授权

US5494917A Cognition enhancing quinuclidine compound 失效
标题翻译：认知增强奎宁环化合物
公开(公告)号：US5494917A
公开(公告)日：1996-02-27
申请号：US313118
申请日：1994-10-12
申请人： Yoshihide Fuse , Kozo Yamamoto , Hideyuki Kishida , Toshiaki Miwa , Takayoshi Hidaka , Ikuo Katsumi
发明人： Yoshihide Fuse , Kozo Yamamoto , Hideyuki Kishida , Toshiaki Miwa , Takayoshi Hidaka , Ikuo Katsumi
IPC分类号： A61K31/435 , A61K31/55 , A61P25/28 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/44 , C07D211/72
CPC分类号： C07D453/02
摘要： A cognition enhancer comprising, as an effective ingredient, a bicyclic compound containing nitrogen atom having the general formula (I): ##STR1## or a physiologically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP94 / 00218 Sec。 371日期：1994年10月12日 102（e）日期1994年10月12日PCT 1994年2月4日PCT PCT。 WO94 / 19348 PCT公开号 1994年9月1日。一种认知增强剂，其包含作为有效成分的含有通式（I）的氮原子的双环化合物或其生理学上可接受的盐。

12. 发明授权

US5137407A Head drive for threaded fastener 失效
标题翻译：螺丝紧固件头驱动
公开(公告)号：US5137407A
公开(公告)日：1992-08-11
申请号：US615574
申请日：1990-11-19
申请人： Kozo Yamamoto
发明人： Kozo Yamamoto
IPC分类号： F16B23/00
CPC分类号： F16B23/003 , Y10S411/919
摘要： A threaded fastener having a recess or projection in a head for engagement with a jointing equipment is disclosed. The recess or projection is composed of a center portion and radial portions extending radially outward of circumference of the center portion. Each of the radial portions includes a pair of straight line section and a rounded corner to prevent stress concentration for providing substantial strength against press-molding and applied torque.
摘要翻译：公开了一种螺纹紧固件，其具有用于与接合设备接合的头部中的凹部或突起。凹部或突起由中心部分和径向部分构成，径向部分沿中心部分的圆周径向向外延伸。每个径向部分包括一对直线部分和圆角，以防止应力集中以提供相对于压模和施加转矩的强度。

13. 发明授权

US08376864B2 Damper mechanism 有权
标题翻译：阻尼机制
公开(公告)号：US08376864B2
公开(公告)日：2013-02-19
申请号：US12710915
申请日：2010-02-23
申请人： Kozo Yamamoto , Keisuke Fujioka , Tomoki Hada
发明人： Kozo Yamamoto , Keisuke Fujioka , Tomoki Hada
IPC分类号： F16F15/121
CPC分类号： F16F15/1392
摘要： A damper mechanism has a first rotating body, a second rotating body, at least one first elastic member, and at least one second elastic member. The second rotating body is disposed rotatably with respect to the first rotating body. The first elastic member is disposed so as to link elastically the first rotating body and the second rotating body in the rotation direction, and to operate only on the positive side of the torsional characteristics. The second elastic member is disposed so as to link elastically the first rotating body and the second rotating body in the rotation direction, and operate only on the negative side of the torsional characteristics.
摘要翻译：阻尼机构具有第一旋转体，第二旋转体，至少一个第一弹性构件和至少一个第二弹性构件。第二旋转体相对于第一旋转体可旋转地设置。第一弹性构件被布置成在旋转方向上弹性地连接第一旋转体和第二旋转体，并且仅在扭转特性的正侧上操作。第二弹性构件被设置成在旋转方向上弹性地连接第一旋转体和第二旋转体，并且仅在扭转特性的负侧进行操作。

14. 发明授权

US08008058B2 Ketose 3-epimerase, its preparation and uses 有权
标题翻译：酮基3-差向异构酶，其制备和用途
公开(公告)号：US08008058B2
公开(公告)日：2011-08-30
申请号：US12093902
申请日：2006-11-06
申请人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
发明人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
IPC分类号： C12N9/90 , C07K14/00 , C12P19/24 , C12P21/00
CPC分类号： C12N9/90 , C12P19/02
摘要： An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects by providing a ketose 3-epimerase which is obtainable from a microorganism of the genus Rhizobium, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for converting D- or L-ketohexose into corresponding D- or L-ketohexose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketohexose; and D- or L-ketopentose into corresponding D- or L-ketopentose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketopentose; by using the enzyme.
摘要翻译：本发明的目的是提供一种新的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，以及使用该酶制备酮糖酮的方法。本发明通过提供可从根瘤菌属微生物获得的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，解决上述目的，以及方法通过使D-或L-酮基己糖的C-3位的羟基差向异构化将D-或L-酮己糖转化为相应的D-或L-己酮; 和D-或L-酮戊糖转化成相应的D-或L-酮戊糖，通过差异化D-或L-酮戊糖的C-3位的羟基; 通过使用酶。

15. 发明申请

US20100129865A1 KETOSE 3-EPIMERASE, ITS PREPARATION AND USES 有权
标题翻译： KETOSE 3-EPIMERASE，其制备和用途
公开(公告)号：US20100129865A1
公开(公告)日：2010-05-27
申请号：US12093902
申请日：2006-11-06
申请人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
发明人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
IPC分类号： C12P21/04 , C12N9/90 , C12N15/11 , C12P19/24 , C12N15/00 , C12N1/21
CPC分类号： C12N9/90 , C12P19/02
摘要： An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects by providing a ketose 3-epimerase which is obtainable from a microorganism of the genus Rhizobium, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for converting D- or L-ketohexose into corresponding D- or L-ketohexose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketohexose; and D- or L-ketopentose into corresponding D- or L-ketopentose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketopentose; by using the enzyme.
摘要翻译：本发明的目的是提供一种新的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，以及使用该酶制备酮糖酮的方法。本发明通过提供可从根瘤菌属微生物获得的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，解决上述目的，以及方法通过使D-或L-酮基己糖的C-3位的羟基差向异构化将D-或L-酮己糖转化为相应的D-或L-己酮; 和D-或L-酮戊糖转化成相应的D-或L-酮戊糖，通过差异化D-或L-酮戊糖的C-3位的羟基; 通过使用酶。

16. 发明授权

US06903116B2 Methods of treating cancer using a heat shock factor activity inhibitor 失效
标题翻译：使用热休克因子活性抑制剂治疗癌症的方法
公开(公告)号：US06903116B2
公开(公告)日：2005-06-07
申请号：US10339063
申请日：2003-01-09
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： C07D405/06 , A61K31/445 , A61K31/40
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

17. 发明授权

US5979623A Dynamic damper and coupling mechanism 失效
标题翻译：动力阻尼器和联轴器机构
公开(公告)号：US5979623A
公开(公告)日：1999-11-09
申请号：US111707
申请日：1998-07-08
申请人： Kozo Yamamoto
发明人： Kozo Yamamoto
IPC分类号： F16F15/12 , F16F15/126 , F16F15/134 , F16F15/139 , F16F15/14 , F16F15/30 , F16F15/315 , F16D3/14
CPC分类号： F16F15/1442 , F16F15/139
摘要： A dynamic damper 70 allows for a stable operation of a sub-clutch without complicating a structure of the sub-clutch. The dynamic damper 70 of a coupling mechanism 91 for coupling a crankshaft 90 of an engine and an input shaft 9 of a transmission includes a mass member 71, a sub-clutch 73 and an annular rubber member 72. The mass member 71 can rotate in accordance with rotation of the input shaft 9. The sub-clutch 73 has a release member 86 for release, and releases interlocking between the input shaft 9 and the mass member 71 when the crankshaft 90 and the input shaft 9 are released from each other by releasing the biasing state of a pressure plate 4c. The release member 86 is in contact with the pressure plate 4c and moves in accordance with an axial movement of the pressure plate 4c. The annular rubber member 72 elastically couples the input shaft 9 and the mass member 71 in the rotating direction when they are in the interlocked state.
摘要翻译：动态阻尼器70允许副离合器的稳定操作而不会使副离合器的结构复杂化。用于联接发动机的曲轴90和变速器的输入轴9的联接机构91的动力阻尼器70包括质量构件71，副离合器73和环形橡胶构件72.质量构件71可以在副离合器73具有用于释放的释放构件86，并且当曲轴90和输入轴9彼此分离时，输入轴9和质量构件71之间的互锁释放释放压板4c的偏压状态。释放构件86与压板4c接触并且根据压板4c的轴向移动而移动。当环状橡胶构件处于互锁状态时，环形橡胶构件72将旋转方向弹性地连接输入轴9和质量构件71。

18. 发明授权

US5803441A Damper mechanism with undulated ribbon-like spring having means for restricting radial movement of the spring 失效
标题翻译：具有波纹带状弹簧的阻尼机构具有用于限制弹簧的径向移动的装置
公开(公告)号：US5803441A
公开(公告)日：1998-09-08
申请号：US631197
申请日：1996-04-12
申请人： Kozo Yamamoto
发明人： Kozo Yamamoto
IPC分类号： F16F1/02 , F16F15/133 , F16D3/12 , F16D3/80
CPC分类号： F16F1/025 , F16F15/1335
摘要： To reduce a frictional resistance generated between undulated ribbon-like springs and outer circumferential walls, a flywheel assembly is composed of a first flywheel 1, a second flywheel 3 and ribbon-like springs 18. A fluid chamber 17 is formed between the second flywheel 3 and the first flywheel 1. The undulated ribbon-like spring 18 is disposed within the fluid chamber 17. In one embodiment, a projecting ring portion 20a that projects beyond the other ring portions 20 is provided so as to contact with an outer circumferential portion 7a of the fluid chamber 17 in order to prevent the remainder of the spring from contacting the portion 7a of the chamber 17. In another embodiment, a mid-portion of the undulated ribbon-like spring is confined to restrict radially outward movement by a plate and axially aligned pins which prevent radial movement of portions of the spring.
摘要翻译：为了减少波状带状弹簧和外周壁之间产生的摩擦阻力，飞轮组件由第一飞轮1，第二飞轮3和带状弹簧18组成。流体室17形成在第二飞轮3 和第一飞轮1.布置的带状弹簧18设置在流体室17内。在一个实施例中，突出超过其它环部20的突出环部分20a设置成与外周部分7a 以防止弹簧的其余部分接触腔室17的部分7a。在另一个实施例中，波纹带状弹簧的中部被限制以通过板限制径向向外运动，并且轴向对齐的销，其防止弹簧的部分的径向移动。

19. 发明授权

US5731193A Recombinant DNA and transformant containing the same 失效
标题翻译：重组DNA和含有其的转化体
公开(公告)号：US5731193A
公开(公告)日：1998-03-24
申请号：US828511
申请日：1997-03-31
申请人： Tetsuya Mori , Kozo Yamamoto , Tsunetaka Ohta
发明人： Tetsuya Mori , Kozo Yamamoto , Tsunetaka Ohta
IPC分类号： C12N15/09 , C07K14/505 , C07K14/56 , C12N5/10 , C12N15/85 , C07H21/04 , C12N15/67 , C12P21/02
CPC分类号： C12N15/85 , C07K14/505 , C07K14/56 , C12N2830/00 , C12N2830/42 , C12N2830/85
摘要： Insertion of IFN-alpha promoters in recombinant DNAs improves their expression efficiencies for useful polypeptides. Expression of such a recombinant DNA in host cells of mammalian origin is artificially controllable by the presence and absence of external stimuli using IFN-alpha inducers. Thus, transformants with such a recombinant DNA readily increase to a maximized cell density with causing neither damages nor extinction due to polypeptides they produce, and subsequent exposure to IFN-alpha inducers allows the proliferated cells to efficiently produce polypeptides with significant glycosylations.
摘要翻译：在重组DNA中插入IFN-α启动子改善了其对有用多肽的表达效率。这种重组DNA在哺乳动物来源的宿主细胞中的表达可以通过使用IFN-α诱导物的外部刺激的存在和不存在来人为可控。因此，具有这种重组DNA的转化体容易增加到最大化的细胞密度，由于它们产生的多肽而不造成损伤或消灭，随后暴露于IFN-α诱导物允许增殖的细胞有效地产生具有显着糖基化的多肽。

20. 发明授权

US5401106A Bearing assembly with inner race bearing support means 失效
标题翻译：带内圈轴承支承装置的轴承总成
公开(公告)号：US5401106A
公开(公告)日：1995-03-28
申请号：US18708
申请日：1993-02-17
申请人： Kozo Yamamoto
发明人： Kozo Yamamoto
IPC分类号： F16C33/78 , F16C35/063 , F16F15/12 , F16F15/131 , F16F15/134 , F16F15/16 , F16F15/30
CPC分类号： F16F15/13171 , F16C33/7843 , F16C19/06 , F16C2361/55
摘要： The invention includes a bearing assembly having concentric inner and outer races and roller elements disposed therebetween. Seal members are disposed on either side of the races, flanking the roller elements. The outer race is provided with circumferential grooves adjacent to each axial face of the outer race. Annular urging members are fitted between the races, adjoining the seal members on the outer sides thereof, urging the seals into contact with the races. The outer circumferential edge of each urging member extends into one of the grooves in the outer race. The urging members are biased such that the inner circumferential edge of each engages the adjacent seal and retains the inner race within the outer race in order to reduce wobble and vibration between the inner and outer races.
摘要翻译：本发明包括具有同心的内圈和外圈以及设置在它们之间的辊元件的轴承组件。密封构件设置在赛车的两侧，侧面是滚子元件。外圈设有与外圈的每个轴向面相邻的圆周槽。环形推动构件安装在邻接其外侧上的密封构件的种族之间，迫使密封件与种族接触。每个推动构件的外周缘延伸到外圈中的一个凹槽中。推动构件被偏置，使得每个的内周边缘接合相邻的密封件并且将内座圈保持在外座圈内，以便减少内座圈和外座圈之间的摆动和振动。

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