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11. 发明授权

US5801147A Polypeptides and use thereof 失效
标题翻译：多肽及其用途
公开(公告)号：US5801147A
公开(公告)日：1998-09-01
申请号：US766725
申请日：1996-12-13
申请人： Chieko Kitada , Takuya Watanabe
发明人： Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K1/00 , C07K14/575 , C07K14/00
CPC分类号： C07K1/006 , C07K14/57563 , A61K38/00
摘要： Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO:13 (I) wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO:20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.
摘要翻译：公开了（1）式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐：His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr -Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO：13（I）其中X是氢原子; 或可以被选自羟基，取代或未取代的氨基，羧基，氨基甲酰基和取代或未取代的芳基的成员取代的低级烷基; Y是从Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val的N-末端计数的1至16个氨基酸残基组成的氨基酸或肽之一 -Lys-Asn-Lys SEQ ID NO：20，和（2）包含由式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐的药物组合物，其具有显着的c-AMP活性并且是有用的作为神经活化剂。

12. 发明授权

US07671174B2 Ligand to GPR8 失效
标题翻译：配体到GPR8
公开(公告)号：US07671174B2
公开(公告)日：2010-03-02
申请号：US11699352
申请日：2007-01-26
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as the DNA encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing receptor-binding assay systems with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.
摘要翻译：本发明提供了GPR8的配体，特别是能够结合GPR8或其酰胺或酯或其盐的多肽以及编码这些多肽的DNA。本发明的GPR8的配体可用于开发使用GPR8表达系统的受体结合测定系统，用于筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素和催乳素生成抑制剂。

13. 发明申请

US20080305998A1 Ligand to GPR8 and DNA thereof 失效
标题翻译：配体与GPR8及其DNA
公开(公告)号：US20080305998A1
公开(公告)日：2008-12-11
申请号：US11699352
申请日：2007-01-26
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto nee Mika Kurihara , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto nee Mika Kurihara , Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K14/00 , C12N15/11 , C12N15/00 , G01N33/566 , A61P43/00 , G01N33/53 , C12N1/20 , C12P21/04 , C07K16/18
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc.The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.
摘要翻译：本发明旨在提供GPR8，其DNA等的配体，更具体地说，可以与GPR8或其酰胺或酯或其盐，以及其DNA等结合的多肽。GPR8的配体本发明可用于开发使用GPR8表达系统的受体结合测定系统，筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素，催乳素产生抑制剂等。

14. 发明授权

US07193033B2 Peptide having appetite stimulating activity 有权
标题翻译：具有食欲刺激活性的肽
公开(公告)号：US07193033B2
公开(公告)日：2007-03-20
申请号：US10311019
申请日：2001-06-20
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as DNA, encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.
摘要翻译：本发明提供了GPR8的配体，特别是能够结合GPR8或其酰胺或酯或其盐的多肽以及编码这些多肽的DNA。本发明的GPR8的配体可用于开发使用GPR8表达系统的受体结合测定系统，用于筛选用于药物的候选化合物，例如用于肥胖症的预防/治疗剂，食欲刺激剂和催乳素生成抑制剂。

15. 发明授权

US5623050A Stable polypeptides having c-AMP production enhancing activity and the use thereof 失效
标题翻译：具有c-AMP产生增强活性的稳定多肽及其用途
公开(公告)号：US5623050A
公开(公告)日：1997-04-22
申请号：US932455
申请日：1992-08-18
申请人： Chieko Kitada , Takuya Watanabe
发明人： Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K1/00 , C07K14/575 , C07K14/00
CPC分类号： C07K1/006 , C07K14/57563 , A61K38/00
摘要： Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof:His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO: 13 (I)wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO: 20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.
摘要翻译：公开了（1）式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐：His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr -Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO：13（I）其中X是氢原子; 或可以被选自羟基，取代或未取代的氨基，羧基，氨基甲酰基和取代或未取代的芳基的成员取代的低级烷基; Y是从Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val的N-末端计数的1至16个氨基酸残基组成的氨基酸或肽之一 -Lys-Asn-Lys SEQ ID NO：20，和（2）包含由式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐的药物组合物，其具有显着的c-AMP活性并且是有用的作为神经活化剂。

16. 发明申请

US20050153391A1 Ligand to gpr8 and dna thereof 有权
标题翻译：配体到gpr8和dna
公开(公告)号：US20050153391A1
公开(公告)日：2005-07-14
申请号：US10311019
申请日：2001-06-20
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , A61P1/14 , A61P3/04 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/08 , A01K67/00 , A61K38/17 , C07H21/04 , C07K14/705
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.
摘要翻译：本发明旨在提供GPR8，其DNA等的配体，更具体地说，可以与GPR8或其酰胺或酯或其盐，以及其DNA等结合的多肽。GPR8的配体本发明可用于开发使用GPR8表达系统的受体结合测定系统，筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素，催乳素产生抑制剂等。

17. 发明授权

US5208320A Polypeptide having c-AMP-producing activity 失效
标题翻译：具有C-AMP生产活性的多肽
公开(公告)号：US5208320A
公开(公告)日：1993-05-04
申请号：US732059
申请日：1991-07-18
申请人： Chieko Kitada , Takuya Watanabe
发明人： Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/57563 , A61K38/00
摘要： A polypeptide or a pharmaceutically acceptable salt thereof having c-AMP-producing activity is disclosed, the polypeptide being represented by the following general formula:X-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Y (X-SEQ ID NO:2-Y)wherein X represents any amino acid residue or an acyl group, and Y represents NH.sub.2, OH, Ala-NH.sub.2, Ala-OH, Ala-Ala-NH.sub.2, Ala-Ala-OH, Ala-Ala-Val-NH.sub.2 or Ala-Ala-Val-OH.

18. 发明授权

US08716709B2 Display device 有权
标题翻译：显示设备
公开(公告)号：US08716709B2
公开(公告)日：2014-05-06
申请号：US13701117
申请日：2011-05-18
申请人： Atsuhito Murai , Yoshiharu Kataoka , Takuya Watanabe , Yuhko Hisada , Satoshi Horiuchi
发明人： Atsuhito Murai , Yoshiharu Kataoka , Takuya Watanabe , Yuhko Hisada , Satoshi Horiuchi
IPC分类号： G01N27/414 , H01L23/64 , H01L31/08
CPC分类号： G01N27/4141 , G02F1/133 , G02F1/13306 , H01L2924/0002 , H01L2924/00
摘要： The present invention provides an inexpensive display device that includes an ion sensor portion and a display and that can be miniaturized. The present invention is a display device that includes an ion sensor portion including an ion sensor circuit and a display including a display-driving circuit. The display device has a substrate, and at least one portion of the ion sensor circuit and at least one portion of the display-driving circuit are formed on the same main surface of the substrate.
摘要翻译：本发明提供了一种廉价的显示装置，其包括离子传感器部分和显示器，并且可以小型化。本发明是包括离子传感器部分的离子传感器部分和包括显示驱动电路的显示器的显示装置。显示装置具有基板，离子传感器电路的至少一部分和显示驱动电路的至少一部分形成在基板的同一主面上。

19. 发明申请

US20130240746A1 ION SENSOR AND DISPLAY DEVICE 审中-公开
标题翻译：离子传感器和显示器件
公开(公告)号：US20130240746A1
公开(公告)日：2013-09-19
申请号：US13701123
申请日：2011-05-18
申请人： Atsuhito Murai , Yoshiharu Kataoka , Takuya Watanabe , Yuhko Hisada , Satoshi Horiuchi
发明人： Atsuhito Murai , Yoshiharu Kataoka , Takuya Watanabe , Yuhko Hisada , Satoshi Horiuchi
IPC分类号： G01T1/24
CPC分类号： G01T1/24 , G01N27/4148
摘要： The present invention provides an ion sensor and a display device which are capable of detecting positive ions and negative ions with high precision, at low cost. The ion sensor includes: a field effect transistor; an ion sensor antenna; and a capacitor, the ion sensor antenna and one terminal of the capacitor connected to a gate electrode of the field effect transistor, the other terminal of the capacitor receiving voltage.
摘要翻译：本发明提供了能够以低成本高精度地检测正离子和负离子的离子传感器和显示装置。离子传感器包括：场效应晶体管; 离子传感器天线; 和电容器，离子传感器天线和电容器的一端连接到场效应晶体管的栅电极，电容器的另一端接受电压。

20. 发明授权

US08487552B2 Lighting controlling method, lighting apparatus and lighting system 有权
标题翻译：照明控制方法，照明装置和照明系统
公开(公告)号：US08487552B2
公开(公告)日：2013-07-16
申请号：US13228587
申请日：2011-09-09
申请人： Takuya Watanabe , Namjin Kim , Hyunha Kim
发明人： Takuya Watanabe , Namjin Kim , Hyunha Kim
IPC分类号： H05B37/02
CPC分类号： H05B33/0818 , H05B33/0848
摘要： A lighting apparatus, a lighting system and a lighting control method are disclosed. The lighting apparatus includes an LED module, a heat sink for emitting heat generated from the LED module, a rectifier for rectifying an input commercial AC power, a transformer including a main coil and an auxiliary coil to transform the rectified power, and an electronic module for biasing a current used to drive the LED module based on the input voltage transported via the auxiliary coil.
摘要翻译：公开了一种照明装置，照明系统和照明控制方法。照明装置包括LED模块，用于发射从LED模块产生的热量的散热器，用于整流输入商用AC电力的整流器，包括主线圈和辅助线圈的变压器以变换整流后的电力;以及电子模块用于基于经由辅助线圈传送的输入电压来偏置用于驱动LED模块的电流。

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