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1. 发明申请

US20050153391A1 Ligand to gpr8 and dna thereof 有权
标题翻译：配体到gpr8和dna
公开(公告)号：US20050153391A1
公开(公告)日：2005-07-14
申请号：US10311019
申请日：2001-06-20
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , A61P1/14 , A61P3/04 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/08 , A01K67/00 , A61K38/17 , C07H21/04 , C07K14/705
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.
摘要翻译：本发明旨在提供GPR8，其DNA等的配体，更具体地说，可以与GPR8或其酰胺或酯或其盐，以及其DNA等结合的多肽。GPR8的配体本发明可用于开发使用GPR8表达系统的受体结合测定系统，筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素，催乳素产生抑制剂等。

2. 发明授权

US07671174B2 Ligand to GPR8 失效
标题翻译：配体到GPR8
公开(公告)号：US07671174B2
公开(公告)日：2010-03-02
申请号：US11699352
申请日：2007-01-26
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as the DNA encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing receptor-binding assay systems with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.
摘要翻译：本发明提供了GPR8的配体，特别是能够结合GPR8或其酰胺或酯或其盐的多肽以及编码这些多肽的DNA。本发明的GPR8的配体可用于开发使用GPR8表达系统的受体结合测定系统，用于筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素和催乳素生成抑制剂。

3. 发明申请

US20080305998A1 Ligand to GPR8 and DNA thereof 失效
标题翻译：配体与GPR8及其DNA
公开(公告)号：US20080305998A1
公开(公告)日：2008-12-11
申请号：US11699352
申请日：2007-01-26
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto nee Mika Kurihara , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto nee Mika Kurihara , Chieko Kitada , Takuya Watanabe
IPC分类号： A61K38/00 , C07K14/00 , C12N15/11 , C12N15/00 , G01N33/566 , A61P43/00 , G01N33/53 , C12N1/20 , C12P21/04 , C07K16/18
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc.The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.
摘要翻译：本发明旨在提供GPR8，其DNA等的配体，更具体地说，可以与GPR8或其酰胺或酯或其盐，以及其DNA等结合的多肽。GPR8的配体本发明可用于开发使用GPR8表达系统的受体结合测定系统，筛选用于药物的候选化合物，例如用于肥胖的预防/治疗剂，食欲激素，催乳素产生抑制剂等。

4. 发明授权

US07193033B2 Peptide having appetite stimulating activity 有权
标题翻译：具有食欲刺激活性的肽
公开(公告)号：US07193033B2
公开(公告)日：2007-03-20
申请号：US10311019
申请日：2001-06-20
申请人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
发明人： Masaaki Mori , Yukio Shimomura , Mioko Harada , Taiji Asami , Yoshio Matsumoto , Yuka Adachi , Tsukasa Sugo , Michiko Abe , Mika Goto , Chieko Kitada , Takuya Watanabe
IPC分类号： C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , G01N2333/726 , G01N2500/04
摘要： The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as DNA, encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.
摘要翻译：本发明提供了GPR8的配体，特别是能够结合GPR8或其酰胺或酯或其盐的多肽以及编码这些多肽的DNA。本发明的GPR8的配体可用于开发使用GPR8表达系统的受体结合测定系统，用于筛选用于药物的候选化合物，例如用于肥胖症的预防/治疗剂，食欲刺激剂和催乳素生成抑制剂。

5. 发明申请

US20070232538A1 Uses of polypeptides 审中-公开
标题翻译：多肽的用途
公开(公告)号：US20070232538A1
公开(公告)日：2007-10-04
申请号：US11647076
申请日：2006-12-27
申请人： Yoshio Matsumoto , Takuya Watanabe , Hideki Takahashi , Masaaki Mori
发明人： Yoshio Matsumoto , Takuya Watanabe , Hideki Takahashi , Masaaki Mori
IPC分类号： A61K48/00 , A61K38/17
CPC分类号： C07D223/16 , A61K31/4025 , A61K31/4375 , A61K31/4745 , A61K31/55 , A61K38/00 , A61K48/00 , C07D295/13 , C07D471/04 , C07K14/47
摘要： The present invention provides uses of a polypeptide having a ligand activity to a sensory epithelium neuropeptide-like receptor (SENR) which is a G protein-coupled receptor protein, and a DNA encoding the same. More specifically, the present invention provides an anti-attention-deficit-disorder or anti-narcolepsy agent, which comprises a polypeptide having a ligand activity for SENR or a salt thereof, as well as a method for screening compounds having an anti-attention-deficit-disorder or anti-narcolepsy activity or compounds having an anti-anxiety, anti-depression, anti-insomnia, anti-schizophrenia or anti-fear activity or salts thereof, which comprises using the above polypeptide or a precursor protein of the polypeptide or a salt thereof.
摘要翻译：本发明提供了作为G蛋白偶联受体蛋白质的感觉上皮神经肽样受体（SENR）具有配体活性的多肽及其编码的DNA的用途。更具体地，本发明提供了包含对SENR具有配体活性的多肽或其盐的抗注意力缺陷障碍或抗发作性睡病剂，以及用于筛选具有抗注意力缺陷型或抗发作性睡病的化合物的方法，包括使用上述多肽或该多肽的前体蛋白，或者，具有抗焦虑，抗抑郁，抗失眠，抗精神分裂症或抗恐惧活性的化合物或抗发作性睡病活动，其盐。

6. 发明授权

US06367963B2 Food mixing apparatus 失效
标题翻译：食品搅拌机
公开(公告)号：US06367963B2
公开(公告)日：2002-04-09
申请号：US09771231
申请日：2001-01-26
申请人： Keiichi Sanpei , Yoshio Matsumoto , Sadao Fukushima
发明人： Keiichi Sanpei , Yoshio Matsumoto , Sadao Fukushima
IPC分类号： B01F902
CPC分类号： A47J43/04 , A47J27/14
摘要： A food mixing apparatus includes a main housing, a mixing container for receiving food, and having a central axis: Y, a rotor ring surrounding the mixing container, the rotor ring being fixed to the mixing container and having a central axis: X extending at an angle to the central axis: Y of the mixing container, and a support roller mechanism attached to the main housing, the support roller mechanism supporting the rotor ring at two points only from below to rotate the rotor ring about the axis: X. An aerating tube communicating with an opening formed in a bottom surface of the mixing container extends coaxially with the axis: X of the rotor ring. The aerating tube communicates with a blast duct mounted in the main housing.
摘要翻译：食品混合装置包括主壳体，用于接收食物的混合容器，并具有中心轴线：Y，围绕混合容器的转子环，转子环固定到混合容器并具有中心轴线：X延伸到与混合容器的中心轴线Y成角度;以及安装在主壳体上的支承辊机构，支承辊机构仅在下方的两点处支承转子环，以使转子环绕轴线旋转：X 与形成在混合容器的底面中的开口连通的充气管与转子环的轴线X同轴地延伸。充气管与安装在主壳体中的鼓风管连通。

7. 发明授权

US6012419A Rotational phase adjusting apparatus having seat for drill-machining 失效
标题翻译：具有用于钻孔加工的座的旋转相位调节装置
公开(公告)号：US6012419A
公开(公告)日：2000-01-11
申请号：US907482
申请日：1997-08-08
申请人： Kazutoshi Iwasaki , Yoshio Matsumoto
发明人： Kazutoshi Iwasaki , Yoshio Matsumoto
IPC分类号： F01L1/344 , F01L1/34
CPC分类号： F01L1/3442 , F01L2103/00 , F01L2103/01 , F01L2820/01 , Y10T29/49231
摘要： In a rotational phase adjusting apparatus used for adjusting opening/closing timings of an intake valve or an exhaust valve of an internal combustion engine, a shoe housing driven by a driving shaft has a circumferential wall and a front plate which are integrally formed by aluminum die-casting. Each shoe has a distortion-absorbing hole, and a fan-shaped chamber for accommodating a vane for driving a driven shaft is formed between adjacent two of the shoes. The outer circumferential wall of each shoe has a recess which has an arch shape in section and extends in an axial direction. A clamp seat is formed on a front plate side. When the clamp seat is pressed by a draw claw, a portion of each shoe on the outer circumferential side of the distortion-absorbing hole is resiliently deformed, but a portion of each shoe on the inner circumferential side of the distortion-absorbing hole is deformed less. Thus, this improves the machining accuracy of working surfaces of the shoe housing which affects on sealability and sliding wear between component parts.
摘要翻译：在用于调节内燃机的进气门或排气门的打开/关闭定时的旋转相位调节装置中，由驱动轴驱动的鞋壳具有由铝模具一体形成的周壁和前板 -铸件。每个鞋具有变形吸收孔，并且在相邻的两个鞋之间形成用于容纳用于驱动从动轴的叶片的扇形室。每个鞋的外周壁具有凹部，该凹部具有拱形并且沿轴向延伸。在前板侧形成夹座。当夹持座被拉爪按压时，变形吸收孔的外周侧的每个鞋的部分弹性变形，但是变形吸收孔的内周侧的各鞋的一部分变形减。因此，这提高了鞋壳的工作表面的加工精度，这影响了组件之间的密封性和滑动磨损。

8. 发明授权

US5836276A Rotational phase adjusting apparatus having fluid reservoir 失效
标题翻译：具有流体储存器的旋转相位调节装置
公开(公告)号：US5836276A
公开(公告)日：1998-11-17
申请号：US907483
申请日：1997-08-08
申请人： Kazutoshi Iwasaki , Michio Adachi , Masayasu Ushida , Yoshio Matsumoto
发明人： Kazutoshi Iwasaki , Michio Adachi , Masayasu Ushida , Yoshio Matsumoto
IPC分类号： F01L1/344
CPC分类号： F01L1/3442 , F01L1/16 , F01L2001/34436 , F01L2810/02 , Y10T74/2102
摘要： In a vane-type rotational phase adjusting apparatus used for adjusting opening/closing timings of an intake valve or an exhaust valve of an engine, a housing unit driven by a driving shaft has a fan-shaped accommodating chamber between adjacent two of a plurality of shoes arranged circumferentially. A vane unit for driving a driven shaft is disposed in the housing unit with its vanes being disposed in the corresponding one of the accommodating chamber so that the rotational phase of the driven shaft is adjusted by the pressure of fluid in the accommodating chamber. Recesses are formed as fluid reservoirs in a cross-sectionally half circle shape on the circumferential end walls of the shoes to hold the operating fluid therein when the housing unit and the vane unit are at rest because of engine stop.
摘要翻译：在用于调节发动机的进气门或排气门的开/关定时的叶片式旋转相位调节装置中，由驱动轴驱动的壳体单元在多个相邻的两个相邻的两个之间具有扇形容纳室鞋周排列布置。用于驱动从动轴的叶片单元设置在壳体单元中，其叶片设置在相应的一个容纳室中，使得从动轴的旋转相位通过容纳室中的流体的压力来调节。当壳体单元和叶片单元由于发动机停止而处于静止状态时，凹槽在鞋的周向端壁上形成为横截面半圆形的流体储存器，以将工作流体保持在其中。

9. 发明授权

US5357439A Custom-made manufacturing system and custom-made manufacturing method 失效
标题翻译：定制制造系统和定制制造方法
公开(公告)号：US5357439A
公开(公告)日：1994-10-18
申请号：US666927
申请日：1991-03-11
申请人： Kichie Matsuzaki , Kaoru Imai , Hideaki Suzuki , Hideaki Matoba , Masahiro Watanabe , Hidetoshi Inaba , Hisashi Onari , Masahito Uno , Toru Mita , Ichiro Taniguchi , Koichi Sugimoto , Yoshio Matsumoto
发明人： Kichie Matsuzaki , Kaoru Imai , Hideaki Suzuki , Hideaki Matoba , Masahiro Watanabe , Hidetoshi Inaba , Hisashi Onari , Masahito Uno , Toru Mita , Ichiro Taniguchi , Koichi Sugimoto , Yoshio Matsumoto
IPC分类号： B23Q41/00 , G05B15/02 , G05B19/418 , G06Q50/00 , G06Q50/04 , G06F15/46
CPC分类号： G05B19/41865 , G05B2219/31389 , G05B2219/32024 , Y02P90/20 , Y02P90/265
摘要： The present invention relates to a manufacturing system which accepts a custom order of product from a customer and custom manufactures a product without sacrificing manufacturing efficiency. The manufacturing system includes the featuring steps of inputting the required specification of a product, creating the product design based on the design information of the product transmitted from a designing department, status data from the production department, and the input required specification, showing the created product design to the customer, selectively indicating a product to be purchased, transmitting the specification of the selected product to the production department, and producing a product based on the selected product specification.
摘要翻译：本发明涉及一种接受来自客户的定制产品订单的制造系统，并定制制造产品而不牺牲制造效率。制造系统包括以下步骤：输入产品所需的规格，根据从设计部门传送的产品的设计信息，生产部门的状态数据和输入要求的规格，创建产品设计，显示所创建的产品设计给客户，选择性地指示要购买的产品，将所选产品的规格传输给生产部门，并根据所选产品规格生产产品。

10. 发明授权

US4477636A Hot-melt adhesive and method 失效
标题翻译：热熔胶及方法
公开(公告)号：US4477636A
公开(公告)日：1984-10-16
申请号：US392699
申请日：1982-06-28
申请人： Soichi Muroi , Shigetoshi Seta , Yoshio Matsumoto , Koichi Yasui , Kazuyoshi Imamura
发明人： Soichi Muroi , Shigetoshi Seta , Yoshio Matsumoto , Koichi Yasui , Kazuyoshi Imamura
IPC分类号： C08G63/00 , C08G63/52 , C08G63/676 , C08G63/682 , C09J167/06 , C09J183/00 , C08L67/02 , C08L67/06
CPC分类号： C08G63/676 , C08G63/52 , C08G63/6828 , C09J167/06
摘要： A hot-melt adhesive comprising a self-curing unsaturated polyester resin having an air-drying functional group and an average polymerization degree of 8 or more has been found to have an excellent heat resistance and a high bonding strength when it is bonding-cured under heat and pressure. If an additive selected from a polymerization initiator, a polymerization promotor and a photosensitizer is incorporated into the present air-drying, self-curing polyester resin, the curing speed is extremely increased to such an extent as cannot be expected from the conventional curing type adhesives. The incorporation of such an additive into the self-curing unsaturated polyester resin is advantageously realized in the form of composite structures of various forms, e.g., a laminate form, a core-in-sheath form and an islands-in-sea form. Such a composite hot-melt adhesive structure is useful for improving a pot life. If a thermoplastic polymer is incorporated, the resulting hot-melt adhesive is further improved with respect to bonding strength. Since the present hot-melt adhesive is solvent-free and does not contain as a cross-linking agent a vinyl monomer, it is easy to handle and environmental pollution can be advantageously avoided.
摘要翻译：已经发现包含具有空气干燥官能团和平均聚合度为8以上的自固化不饱和聚酯树脂的热熔性粘合剂在粘合固化下具有优异的耐热性和高的粘结强度热和压力。如果将选自聚合引发剂，聚合促进剂和光敏剂的添加剂引入到目前的空气干燥，自固化聚酯树脂中，则固化速度极大地增加到常规固化型粘合剂不能预期的程度。将这种添加剂并入自固化不饱和聚酯树脂中有利地以各种形式的复合结构的形式实现，例如层压形式，芯鞘形式和海岛形式。这种复合热熔粘合剂结构对于提高适用期是有用的。如果引入热塑性聚合物，则所得热熔粘合剂相对于粘接强度进一步提高。由于本发明的热熔粘合剂是无溶剂的，不含作为交联剂的乙烯基单体，因此易于处理，可以有效地避免环境污染。

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