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11. 发明授权

US5387575A Pyrimidine derivatives, process for preparing the same and herbicide using the same 失效
标题翻译：嘧啶衍生物，其制备方法和使用其的除草剂
公开(公告)号：US5387575A
公开(公告)日：1995-02-07
申请号：US894557
申请日：1992-06-05
申请人： Katsumasa Harada , Takaaki Abe , Yuji Akiyoshi , Akio Matsushita , Mikio Kojima , Ikuo Shiraishi , Kaoru Yamamoto , Takashi Hayama , Shohei Fukuda
发明人： Katsumasa Harada , Takaaki Abe , Yuji Akiyoshi , Akio Matsushita , Mikio Kojima , Ikuo Shiraishi , Kaoru Yamamoto , Takashi Hayama , Shohei Fukuda
IPC分类号： A01N43/54 , A01N43/66 , C07D239/60 , C07D251/30 , C07D251/38 , C07D521/00 , C07D239/52 , A01N73/54
CPC分类号： C07D231/12 , A01N43/54 , A01N43/66 , C07D233/56 , C07D239/60 , C07D249/08 , C07D251/30 , C07D251/38
摘要： Disclosed are a pyrimidine or triazine compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents cyano group, a halogen atom, hydroxy group or --O--R.sup.7 where R.sup.7 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; R.sup.2 represents hydrogen atom or a lower alkyl group; R.sup.3 represents hydrogen atom or a lower alkyl group; R.sup.4 represents a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 represents a lower alkyl group or a phenyl group which may have a substituent, hydroxy group, a lower alkoxy group or a benzyloxy group when Z is nitrogen atom; or a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 has the same meaning as defined above, hydroxy group, OK, a lower alkoxy group which may have a substituent, a lower alkenyloxy group, a lower alkynyloxy group, a cycloalkoxy group which may have a substituent, a phenoxy group, a benzyloxy group, a lower alkylthio group, a phenylthio group or an alkylsulfonylamino group when Z is --CH.dbd. group; R.sup.5 represents a lower alkoxy group; R.sup.6 represents a lower alkoxy group or a lower alkyl group; X represents oxygen atom or sulfur atom; and Z represents nitrogen atom or --CH.dbd. group. processes for preparing the same and a herbicide containing the same as an active ingredient(s).
摘要翻译：公开了由下式（I）表示的嘧啶或三嗪化合物：其中R 7表示低级烷基，低级烯基，低级炔基，卤代烷基，低级烷基或氰基 - 低级烷基; R2代表氢原子或低级烷基; R3表示氢原子或低级烷基; R 4表示当Z为氮原子时，可以具有取代基，羟基，低级烷氧基或苄氧基的低级烷基或苯基，-NHSO 2 -R 8，或1-咪唑基，-NHSO 2 -R 8，其中R8具有与上述相同的含义，羟基，OK，可具有取代基的低级烷氧基，低级链烯氧基，低级炔氧基，环烷氧基当Z为-CH =基团时，可具有取代基，苯氧基，苄氧基，低级烷硫基，苯硫基或烷基磺酰基氨基; R5代表低级烷氧基; R6代表低级烷氧基或低级烷基; X表示氧原子或硫原子; Z表示氮原子或-CH =基团。其制备方法和含有其作为活性成分的除草剂。

12. 发明授权

US5362736A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US5362736A
公开(公告)日：1994-11-08
申请号：US840847
申请日：1992-02-25
申请人： Kiyofumi Ishikawa , Takashi Hayama , Masaru Nishikibe , Mitsuo Yano
发明人： Kiyofumi Ishikawa , Takashi Hayama , Masaru Nishikibe , Mitsuo Yano
IPC分类号： C07D217/20 , C07D401/06 , C07D401/12 , C07D417/12 , C07D491/056 , C07D491/00 , A01N43/42
CPC分类号： C07D401/06 , C07D217/20 , C07D401/12 , C07D417/12
摘要： Novel isoquinoline derivatives represented by formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X.sup.1 and X.sup.2 are as defined in the specification, have an anti-arrhythmic activity and bradycardiac activity and are effective for the treatment of arrhythmia, myocardiac infarction or angina pectoris.
摘要翻译：由式（I）表示的新型异喹啉衍生物：其中R1，R2，R3，R4，R5，X1和X2如说明书中所定义，具有抗心律不齐活性和心动过缓活性，并且对于治疗心律失常，心肌梗塞或心绞痛。

13. 发明申请

US20070027147A1 Biarylurea derivatives 失效
标题翻译：双芳脲衍生物
公开(公告)号：US20070027147A1
公开(公告)日：2007-02-01
申请号：US11002422
申请日：2004-12-03
申请人： Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
发明人： Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
IPC分类号： A61K31/538 , A61K31/4545 , A61K31/4439 , C07D413/14 , C07D403/14
CPC分类号： C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
摘要翻译：本发明涉及式（I）化合物及其制备方法及其用途：式（I）其中：Ar为含氮杂芳环; X和Z各自为碳原子，等等; Y是CO，等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子，等等; “img id =”custom-character-00001“he =”3.13mm“wi =”6.01mm“file =”US20070027147A1-20070201-P00001.TIF“alt =”custom character“img-content =”character“ img-format =“tif”/>是单键或双键。根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂，因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。

14. 发明授权

US06413979B1 Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative 失效
标题翻译：取代的5-（2,2-二氟-1,3-苯并间二氧杂环戊烯-5-基）环戊烯并吡啶衍生物
公开(公告)号：US06413979B1
公开(公告)日：2002-07-02
申请号：US09582225
申请日：2000-07-21
申请人： Takashi Hayama , Norikazu Otake , Masaru Nishikibe
发明人： Takashi Hayama , Norikazu Otake , Masaru Nishikibe
IPC分类号： A61F31435
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14
摘要： The present invention relates to a cyclopentenopyridine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl group or the like. R1 is a mono- or di-C1-C6 alkylamino group or the like, and R2 is a hydroxyl group or the like, a process for its production and its use.
摘要翻译：本发明涉及由通式（I）表示的环戊烯并吡啶衍生物或其药学上可接受的盐，其中Ar为苯基等。 R1是单或二C1-C6烷基氨基等，R2是羟基等，其制备方法及其用途。

15. 发明授权

US06310276B1 Plant which belongs to the genus limonium and a method for creating the same 失效
标题翻译：属于lim草的植物及其生产方法
公开(公告)号：US06310276B1
公开(公告)日：2001-10-30
申请号：US09144037
申请日：1998-08-31
申请人： Masahiro Nakagawa , Takashi Hayama
发明人： Masahiro Nakagawa , Takashi Hayama
IPC分类号： A01H500
CPC分类号： A01H6/30 , A01H5/02
摘要： A plant which belongs to the genus Limonium, having a characteristic of undergoing flower bud differentiation and flower stalk development within 50 days from seeding even without low temperatures of 25° C. or below; and a method for creating the plant are disclosed.
摘要翻译：属于Limonium属的植物，即使没有25℃或更低的低温，也能播种后的50天内进行花芽分化和花茎发育的特征; 并且公开了一种用于创建植物的方法。

16. 发明授权

US5529977A Triazine derivative, process for preparing the same and herbicide using the same 失效
标题翻译：三嗪衍生物，其制备方法和使用其的除草剂
公开(公告)号：US5529977A
公开(公告)日：1996-06-25
申请号：US326830
申请日：1994-10-21
申请人： Katsumasa Harada , Takaaki Abe , Yuji Akiyoshi , Akio Matsushita , Mikio Kojima , Ikuo Shiraishi , Kaoru Yamamoto , Takashi Hayama
发明人： Katsumasa Harada , Takaaki Abe , Yuji Akiyoshi , Akio Matsushita , Mikio Kojima , Ikuo Shiraishi , Kaoru Yamamoto , Takashi Hayama
IPC分类号： A01N43/54 , A01N43/66 , C07D239/60 , C07D251/30 , C07D251/38 , C07D521/00 , C07D251/34 , C07D251/16 , C07D403/12
CPC分类号： C07D231/12 , A01N43/54 , A01N43/66 , C07D233/56 , C07D239/60 , C07D249/08 , C07D251/30 , C07D251/38
摘要： Disclosed are a pyrimidine or triazine compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents cyano group, a halogen atom, hydroxy group or --O--R.sup.7 where R.sup.7 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a halo-lower alkyl group or a cyano-lower alkyl group; R.sup.2 represents hydrogen atom or a lower alkyl group; R.sup.3 represents hydrogen atom or a lower alkyl group; R.sup.4 represents a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 represents a lower alkyl group or a phenyl group which may have a substituent, hydroxy group, a lower alkoxy group or a benzyloxy group when Z is nitrogen atom; or a 1-imidazolyl group, --NHSO.sub.2 --R.sup.8 where R.sup.8 has the same meaning as defined above, hydroxy group, OK, a lower alkoxy group which may have a substituent, a lower alkenyloxy group, a lower alkynyloxy group, a cycloalkoxy group which may have a substituent, a phenoxy group, a benzyloxy group, a lower alkylthio group, a phenylthio group or an alkylsulfonylamino group when Z is --CH.dbd. group; R.sup.5 represents a lower alkoxy group; R.sup.6 represents a lower alkoxy group or a lower alkyl group; X represents oxygen atom or sulfur atom; and Z represents nitrogen atom or --CH.dbd. group.processes for preparing the same and a herbicide containing the same as an active ingredient(s).
摘要翻译：公开了由下式（I）表示的嘧啶或三嗪化合物：其中R 1表示氰基，卤素原子，羟基或-O-R 7，其中R 7表示低级烷基，低级烯基基，低级炔基，卤代低级烷基或氰基 - 低级烷基; R2表示氢原子或低级烷基; R3表示氢原子或低级烷基; R 4表示当Z为氮原子时，可以具有取代基，羟基，低级烷氧基或苄氧基的低级烷基或苯基，-NHSO 2 -R 8，或1-咪唑基，-NHSO 2 -R 8，其中R8具有与上述相同的含义，羟基，OK，可具有取代基的低级烷氧基，低级链烯氧基，低级炔氧基，环烷氧基当Z为-CH =基团时，可具有取代基，苯氧基，苄氧基，低级烷硫基，苯硫基或烷基磺酰基氨基; R5代表低级烷氧基; R6代表低级烷氧基或低级烷基; X表示氧原子或硫原子; Z表示氮原子或-CH =基团。其制备方法和含有其作为活性成分的除草剂。

17. 发明授权

US5114918A Endothelin antagonistic cyclic pentapeptides 失效
标题翻译：内皮素拮抗剂环糊精
公开(公告)号：US5114918A
公开(公告)日：1992-05-19
申请号：US630505
申请日：1990-12-20
申请人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Niiyama , Toshio Nagase , Toshiaki Mase , Kagari Fujita , Masaru Nishikibe , Masaki Ihara , Mitsuo Yano
发明人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Niiyama , Toshio Nagase , Toshiaki Mase , Kagari Fujita , Masaru Nishikibe , Masaki Ihara , Mitsuo Yano
IPC分类号： A61K38/00 , C07K7/64 , C07K14/575
CPC分类号： C07K14/57536 , A61K38/00 , Y10S514/826 , Y10S514/921 , Y10S514/922 , Y10S514/929 , Y10S530/80 , Y10S930/27
摘要： Cyclic pentapeptides of the formula:cyclo (-X.sup.1 -X.sup.2 -X.sup.3 -X.sup.4 -X.sup.5 -) (I)wherein X.sup.n (n=1-5) represents amino acid residues. These compounds are useful as hypotensive drugs.

18. 发明授权

US07354946B2 Biarylurea derivatives 失效
标题翻译：双芳脲衍生物
公开(公告)号：US07354946B2
公开(公告)日：2008-04-08
申请号：US11002422
申请日：2004-12-03
申请人： Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
发明人： Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
IPC分类号： C07D498/04 , C07D405/12 , A61K31/423 , A61K31/424
CPC分类号： C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof:Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
摘要翻译：本发明涉及式（I）化合物及其制备方法及其用途：式（I）其中：Ar为含氮杂芳环; X和Z各自为碳原子，等等; Y是CO，等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子，等等; “img id =”CUSTOM-CHARACTER-00001“he =”3.13mm“wi =”6.01mm“file =”US07354946-20080408-P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/>是单键或双键。根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂，因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。

19. 发明授权

US5714479A Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives 失效
标题翻译：内皮素拮抗杂芳环稠合环戊烯衍生物
公开(公告)号：US5714479A
公开(公告)日：1998-02-03
申请号：US596143
申请日：1996-02-20
申请人： Kiyofumi Ishikawa , Toshio Nagase , Toshiaki Mase , Takashi Hayama , Masaki Ihara , Masaru Nishikibe , Mitsuo Yano
发明人： Kiyofumi Ishikawa , Toshio Nagase , Toshiaki Mase , Takashi Hayama , Masaki Ihara , Masaru Nishikibe , Mitsuo Yano
IPC分类号： C07D221/04 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D419/04 , A61K31/435 , C07D471/04
CPC分类号： C07D221/04 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D419/04
摘要： A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP94 / 01357 Sec。 371日期1996年2月20日 102（e）日期1996年2月20日PCT 1994年8月16日PCT PCT。出版物WO95 / 05374 日期1995年2月23日一种下式的杂芳环稠合环戊烯衍生物：其中变量如说明书中所定义; 或其药学上可接受的盐。

20. 发明授权

US5691315A Endothelin antagonistic peptide derivatives 失效
标题翻译：内皮素拮抗肽衍生物
公开(公告)号：US5691315A
公开(公告)日：1997-11-25
申请号：US494818
申请日：1995-06-26
申请人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Niiyama , Toshio Nagase , Toshiaki Mase , Kagari Fujita , Masaki Ihara , Fumihiko Ikemoto , Mitsuo Yano
发明人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Niiyama , Toshio Nagase , Toshiaki Mase , Kagari Fujita , Masaki Ihara , Fumihiko Ikemoto , Mitsuo Yano
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/083 , C07K5/103 , C07K5/08 , C07K7/06
CPC分类号： C07K5/06156 , C07K5/0202 , C07K5/0205 , C07K5/06043 , C07K5/0808 , C07K5/1008 , A61K38/00
摘要： The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the treatment of hypertension, pulmonary hypertension, Reynaud's disease, myocardial infarction, angina pectoris, acute renal failure, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension.
摘要翻译：本发明涉及作为内皮素拮抗剂的化合物，其制备方法及其作为药物的用途。本发明化合物可用于治疗高血压，肺动脉高压，雷诺氏病，心肌梗塞，心绞痛，急性肾衰竭，脑梗塞，脑血管痉挛，动脉硬化，哮喘，内毒素休克，内毒素诱导的多器官功能衰竭或弥散性血管内凝血和/或环孢菌素诱导的肾衰竭或高血压。

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