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11. 发明申请

US20060068447A1 Directed assembly of functional heterostructures 失效
标题翻译：定向组装功能异质结构
公开(公告)号：US20060068447A1
公开(公告)日：2006-03-30
申请号：US11253452
申请日：2005-10-19
申请人： Sukanta Banerjee , Kairali Podual , Michael Seul
发明人： Sukanta Banerjee , Kairali Podual , Michael Seul
IPC分类号： G01N33/567 , G01N33/53 , B05D3/00
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)-microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention. also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films. Provides a simple set-up to synthesize thin films of tailored composition and morphology.
摘要翻译：本发明涉及一种用于产生功能组织的空间图案化聚合物 - 聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和有机（聚合） - 微粒复合膜的交流电场介导组装定制组合和形态; 本发明还涉及将所述组件结合到其它结构中。本发明。还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜，微反应器，智能材料。用于生成多功能薄膜的小型化格式。提供简单的设置来合成定制组合和形态的薄膜。

12. 发明授权

US06964747B2 Production of dyed polymer microparticles 有权
标题翻译：染色聚合物微粒的生产
公开(公告)号：US06964747B2
公开(公告)日：2005-11-15
申请号：US10348123
申请日：2003-01-21
申请人： Sukanta Banerjee , Cecilia Georgescu , Eric S. Daniels , Victoria L. Dimonie , Michael Seul
发明人： Sukanta Banerjee , Cecilia Georgescu , Eric S. Daniels , Victoria L. Dimonie , Michael Seul
IPC分类号： B01J13/02 , D06P3/52
CPC分类号： D06P1/90 , C08J3/215 , D06P1/908 , D06P1/92 , D06P1/922 , D06P1/924 , D06P1/926 , D06P1/928 , Y10T428/2987 , Y10T428/2989
摘要： A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or only weakly soluble, and a third solvent in which the dye and the microparticle polymer are not or only weakly soluble. The first and second solvents are immiscible with each other, or at most partially miscible. The third solvent is miscible with the first and second solvents. The formulation provides substantially complete partitioning of the dye to the microparticles. The method may be used to obtain dyed polymer microparticle formed of cross-linked or non-cross-linked polymers. Libraries are provided comprising two or more sets of microparticles of different dye loadings. Fluorescent core-shell microparticles are produced from a mixture of microparticle cores incorporating one or more fluorescent dyes, a polymerization mixture comprising at least one polymerizable shell monomer, at least one free radical polymerization initiator comprising a water-insoluble oxidizing agent, and at least one water-soluble reducing agent.
摘要翻译：使用由可溶于染料和微粒聚合物的第一溶剂构成的溶剂体系将染料，例如荧光染料引入聚合物微粒中，染料和微粒聚合物不是或仅仅是弱的第二溶剂和其中染料和微粒聚合物不是或仅仅是弱溶解的第三溶剂。第一和第二溶剂彼此不混溶，或最多部分混溶。第三溶剂与第一溶剂和第二溶剂混溶。该制剂提供染料基本上完全分配到微粒。该方法可用于获得由交联或非交联聚合物形成的染色聚合物微粒。提供包括两组或更多组不同染料负载的微粒子的文库。荧光核壳微粒由掺入一种或多种荧光染料的微粒核心，包含至少一种可聚合壳单体的聚合混合物，至少一种包含水不溶性氧化剂的自由基聚合引发剂和至少一种水溶性还原剂。

13. 发明申请

US20050246844A1 Method for controlling solute loading of polymer microparticles 有权
标题翻译：控制聚合物微粒溶质负载的方法
公开(公告)号：US20050246844A1
公开(公告)日：2005-11-10
申请号：US11179135
申请日：2005-07-12
申请人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
发明人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
IPC分类号： C08J3/215 , A61K7/021 , A61K9/16 , A61K9/50
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
摘要翻译：通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。第二溶剂是用于溶质和聚合物（调谐溶剂）的弱溶剂或非溶剂。第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂，但是作为相对于第一和第二溶剂的共溶剂，因为其可与第一溶剂和第二溶剂混溶。通过调节溶质相对于微粒聚合物的比例，调节三元溶剂体系的组成，主要是调谐溶剂的量来控制掺入到微粒中的溶质的量。该方法对于提供包含可区分的染料负载，特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。

14. 发明授权

US08486720B2 Arrays of magnetic particles 有权
标题翻译：磁性粒子阵列
公开(公告)号：US08486720B2
公开(公告)日：2013-07-16
申请号：US10910460
申请日：2004-08-03
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li
IPC分类号： G01N33/553
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了一种通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库生成新的编码磁性颗粒文库的方法。子库根据需要进行功能化在数组的形成中是有用的。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

15. 发明申请

US20120220715A1 Method For Selecting Desired Level Of Dye Loading And Controlling Loading Of Polymer Microparticles 审中-公开
标题翻译：选择染料加载和控制聚合物微粒负载水平的方法
公开(公告)号：US20120220715A1
公开(公告)日：2012-08-30
申请号：US13417791
申请日：2012-03-12
申请人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
发明人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
IPC分类号： C08L25/08
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
摘要翻译：通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。第二溶剂是用于溶质和聚合物（调谐溶剂）的弱溶剂或非溶剂。第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂，但是作为相对于第一和第二溶剂的共溶剂，因为其可与第一溶剂和第二溶剂混溶。通过调节溶质相对于微粒聚合物的比例，调节三元溶剂体系的组成，主要是调谐溶剂的量来控制掺入微粒中的溶质量。该方法对于提供包含可区分的染料负载，特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。

16. 发明授权

US07892854B2 Multianalyte molecular analysis using application-specific random particle arrays 有权
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US07892854B2
公开(公告)日：2011-02-22
申请号：US10204799
申请日：2001-06-21
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
IPC分类号： G01N33/553 , C12Q1/68
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

17. 发明授权

US07255895B2 Method for controlling solute loading of polymer microparticles 有权
标题翻译：控制聚合物微粒溶质负载的方法
公开(公告)号：US07255895B2
公开(公告)日：2007-08-14
申请号：US10348165
申请日：2003-01-21
申请人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
发明人： Sukanta Banerjee , Cecilia Georgescu , Michael Seul
IPC分类号： B05D7/00
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
摘要翻译：通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。第二溶剂是用于溶质和聚合物（调谐溶剂）的弱溶剂或非溶剂。第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂，但是作为相对于第一和第二溶剂的共溶剂，因为其可与第一溶剂和第二溶剂混溶。通过调节溶质相对于微粒聚合物的比例，调节三元溶剂体系的组成，主要是调谐溶剂的量来控制掺入微粒的溶质量。该方法对于提供包含可区分的染料负载，特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。

18. 发明申请

US20060035240A1 Optimization of gene expression analysis using immobilized capture probes 有权
公开(公告)号：US20060035240A1
公开(公告)日：2006-02-16
申请号：US10974036
申请日：2004-10-26
申请人： Michael Seul , Sukanta Banerjee , Jiacheng Yang , Tatiana Vener
发明人： Michael Seul , Sukanta Banerjee , Jiacheng Yang , Tatiana Vener
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

19. 发明授权

US09436088B2 Un-supported polymeric film with embedded microbeads 有权
标题翻译：具有嵌入微珠的未负载的聚合物膜
公开(公告)号：US09436088B2
公开(公告)日：2016-09-06
申请号：US11761789
申请日：2007-06-12
申请人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
发明人： Michael Seul , Sukanta Banerjee , Kairali Podual , Ye Hong
IPC分类号： G01N33/553 , G03F7/16 , G03F7/004
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to polymer-bead composites having a single layer planar, crystalline assembly of encoded beads embedded in a hydrophilic polymeric matrix. The composite may be unattached to a solid support. The encoded beads have different biomolecules attached to their surfaces, and the encoding permits distinguishing beads having different biomolecules attached thereto. The present invention also relates to a systematic process for the creation of functionally organized, spatially patterned assemblies of polymer-microparticle composites, including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films.
摘要翻译：本发明涉及具有嵌入亲水性聚合物基质中的编码珠粒的单层平面结晶组合物的聚合物 - 珠复合物。复合材料可能不附着在固体支撑物上。编码的珠粒具有连接到其表面的不同生物分子，并且编码允许区分附着有不同生物分子的珠粒。本发明还涉及一种用于创建聚合物 - 微粒复合材料的功能组织的空间图案化组件的系统方法，包括图案化的自支撑有机（聚合物）膜和有机 - 聚合物 - 微粒的AC电场介导装配定制组合和形态的复合材料。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜和微反应器以及用于产生多功能薄膜的小型化形式。

20. 发明申请

US20130040840A1 NUCLEIC ACID AMPLIFICATION WITH INTEGRATED MULTIPLEX DETECTION 审中-公开
标题翻译：具有集成多重检测的核酸扩增
公开(公告)号：US20130040840A1
公开(公告)日：2013-02-14
申请号：US13540211
申请日：2012-07-02
申请人： Hui Huang , Sukanta BANERJEE , Michael Seul , Nataliya Korzheva , Jiacheug Yang , Yi Zhang
发明人： Hui Huang , Sukanta BANERJEE , Michael Seul , Nataliya Korzheva , Jiacheug Yang , Yi Zhang
IPC分类号： C40B30/04 , C40B60/12 , C40B40/06
CPC分类号： C12Q1/6804 , G01N33/6803 , G01N33/6854 , G01N2333/705 , G01N2458/10 , C12Q2563/179
摘要： Compositions and methods of detecting multiple proteins of interest in a sample using arrays are provided herein.
摘要翻译：本文提供了使用阵列检测样品中感兴趣的多种蛋白质的组合物和方法。

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