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11. 发明授权

US06632920B1 36 human secreted proteins 失效
标题翻译： 36人分泌蛋白
公开(公告)号：US06632920B1
公开(公告)日：2003-10-14
申请号：US09716129
申请日：2000-11-17
申请人： Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
发明人： Henrik S. Olsen , Steven M. Ruben , Craig A. Rosen , Laurie A. Brewer , Reinhard Ebner , Roxanne Duan , Kimberly Florence
IPC分类号： A61K3800
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。

12. 发明授权

US06590075B2 Secreted protein HODAZ50 失效
标题翻译：分泌蛋白HODAZ50
公开(公告)号：US06590075B2
公开(公告)日：2003-07-08
申请号：US09148545
申请日：1998-09-04
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K100
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

13. 发明授权

US06525174B1 Precerebellin-like protein 失效
标题翻译：类似前脑苷脂的蛋白质
公开(公告)号：US06525174B1
公开(公告)日：2003-02-25
申请号：US09205258
申请日：1998-12-04
申请人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号： C07K1447
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

14. 发明授权

US06444790B1 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US06444790B1
公开(公告)日：2002-09-03
申请号：US09469242
申请日：1999-12-22
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

15. 发明申请

US20120122762A1 186 Human Secreted Proteins 审中-公开
标题翻译： 186人类分泌蛋白
公开(公告)号：US20120122762A1
公开(公告)日：2012-05-17
申请号：US13359199
申请日：2012-01-26
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

16. 发明申请

US20090011983A1 186 Human Secreted Proteins 失效
标题翻译： 186人类分泌蛋白
公开(公告)号：US20090011983A1
公开(公告)日：2009-01-08
申请号：US11745580
申请日：2007-05-08
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/63 , C12N5/06 , C12Q1/00 , A61P43/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

17. 发明申请

US20090005301A1 207 Human Secreted Proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：US20090005301A1
公开(公告)日：2009-01-01
申请号：US11759448
申请日：2007-06-07
申请人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
发明人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
IPC分类号： C07K14/47 , C12N15/12 , C12N15/85 , C07K16/18 , C12Q1/68 , A61K38/14 , A61K31/7088 , G01N33/68 , C12P21/02 , C12N15/00 , C12N5/10
CPC分类号： C07K14/47 , A61K48/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

18. 发明授权

US06806351B2 Secreted protein HBJFE12 失效
标题翻译：分泌蛋白HBJFE12
公开(公告)号：US06806351B2
公开(公告)日：2004-10-19
申请号：US09774639
申请日：2001-02-01
申请人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
发明人： Steven M. Ruben , Daniel R. Soppet , Reinhard Ebner , Henrik S. Olsen , Paul E. Young , John M. Greene , Ann M. Ferrie , Guo-Liang Yu , Jian Ni , Craig A. Rosen , Laurie A. Brewer , Fouad Janat
IPC分类号： C07K14435
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

19. 发明授权

US06566325B2 49 human secreted proteins 失效
公开(公告)号：US06566325B2
公开(公告)日：2003-05-20
申请号：US09904615
申请日：2001-07-16
申请人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
发明人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
IPC分类号： C07K1400
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

20. 发明申请

US20110003383A1 ANTIBODIES TO HT5GJ57 失效
标题翻译：抗体HT5GJ57
公开(公告)号：US20110003383A1
公开(公告)日：2011-01-06
申请号：US12268263
申请日：2008-11-10
申请人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
发明人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
IPC分类号： C12N5/07 , G01N33/53 , C12P21/06 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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