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    • 14. 发明授权
    • Peptidoglycan recognition proteins
    • 肽聚糖识别蛋白
    • US06444790B1
    • 2002-09-03
    • US09469242
    • 1999-12-22
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • Paul E. YoungSteven M. RubenCraig A. RosenHenrik S. Olsen
    • C07K100
    • C07K14/47A61K38/00
    • The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
    • 本发明涉及由角质形成细胞,伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地,提供分离的核酸分子,其编码人胶原聚糖识别蛋白相关蛋白(本文称为PGRP-K(角质形成细胞),PGRP-W(伤口愈合)和PGRP-C(软骨肉瘤))。 图1A-B, 图2A-C, 3,分别与人肽聚糖识别蛋白(PGRP)以及鼠Tag-7都具有同源性。 还提供了PGRP-K,PGRP-W和PGRP-C多肽。 进一步提供载体,宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K,PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K,PGRP-W和PGRP-C基因表达的诊断方法。