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11. 发明授权

US4294241A Collagen skin dressing 失效
标题翻译：胶原蛋白皮肤敷料
公开(公告)号：US4294241A
公开(公告)日：1981-10-13
申请号：US86547
申请日：1979-10-19
申请人： Teruo Miyata
发明人： Teruo Miyata
IPC分类号： A61L15/32 , A61L15/42 , A61L15/44 , A61L15/00
CPC分类号： A61L15/425 , A61L15/325 , A61L15/44 , A61L2300/404 , A61L2300/406 , Y10S128/08
摘要： Skin or wound dressings are prepared in gel or sheet form from enzyme-solubilized collagen and/or such chemically modified collagen. Improved sheet form dressing is prepared by tubular extrusion of such collagen gels.
摘要翻译：由酶溶解的胶原和/或这种化学改性的胶原蛋白以凝胶或片状形式制备皮肤或伤口敷料。通过这种胶原凝胶的管状挤出制备改进的片状敷料。

12. 发明授权

US4268131A Fiber collagen contact lens 失效
标题翻译：纤维胶原隐形眼镜
公开(公告)号：US4268131A
公开(公告)日：1981-05-19
申请号：US29091
申请日：1979-04-11
申请人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel , Michael W. Dunn
发明人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel , Michael W. Dunn
IPC分类号： C08L89/06 , G02B1/04 , G02C7/04 , C08H1/06 , C09H1/04
CPC分类号： G02B1/043 , C08L89/06 , G02C7/04
摘要： Soft contact lenses are made from purified fiber collagen and mixtures of such fiber with purified solubilized collagen.
摘要翻译：软性隐形眼镜由纯化的纤维胶原蛋白和这种纤维与纯化的溶解胶原蛋白的混合物制成。

13. 发明授权

US5840054A Method for obstructing lacrimal canaliculi with infusable solution or dispersion 失效
标题翻译：用输注溶液或分散液阻塞泪小管的方法
公开(公告)号：US5840054A
公开(公告)日：1998-11-24
申请号：US493282
申请日：1995-06-21
申请人： Takashi Hamano , Teruo Miyata , Takeshi Ogawara
发明人： Takashi Hamano , Teruo Miyata , Takeshi Ogawara
IPC分类号： A61K9/08 , A61F9/007 , A61K38/17 , A61L31/04 , A61L31/14 , A61P27/02 , A61F9/00
CPC分类号： A61L31/145 , A61F9/00772 , A61L31/041 , A61L31/043 , A61L31/044 , A61L2430/16
摘要： A method of obstructing the lacrimal canaliculi by infusing therein a solution or liquid dispersion containing a gel forming material, such having collagen as the main ingredient in the range of 1 mg/ml to 70 mg/ml for improving the symptoms of dry eye.
摘要翻译：通过在其中注入含有凝胶形成材料的溶液或液体分散体，例如以1mg / ml至70mg / ml的胶原作为主要成分，以改善干眼症状的方法来阻塞泪小管。

14. 发明授权

US5171261A Vascular prosthesis, manufacturing method of the same, and substrate for vascular prothesis 失效
标题翻译：血管生成，其制造方法和血管基质的基质
公开(公告)号：US5171261A
公开(公告)日：1992-12-15
申请号：US508618
申请日：1990-04-13
申请人： Yasuhara Noishiki , Teruo Miyata
发明人： Yasuhara Noishiki , Teruo Miyata
IPC分类号： A61F2/06 , A61L27/50
CPC分类号： A61L27/507 , A61F2/062 , Y10S623/901 , Y10S623/921
摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.

15. 发明授权

US4749689A Hemostatic agent composed of collagen/gelatin and protamine 失效
标题翻译：止血剂由胶原/明胶和鱼精蛋白组成
公开(公告)号：US4749689A
公开(公告)日：1988-06-07
申请号：US87966
申请日：1987-08-17
申请人： Teruo Miyata , Kazuhiko Kodaira , Masayasu Furuse , Yasuharu Noishiki
发明人： Teruo Miyata , Kazuhiko Kodaira , Masayasu Furuse , Yasuharu Noishiki
IPC分类号： A61K38/16 , A61K38/17 , A61K38/39 , A61L15/12 , A61L26/00 , A61K37/08 , A61L15/01 , A61L17/00 , C08L89/06
CPC分类号： A61L15/125 , A61K38/39 , A61L26/0052 , A61L2400/04 , Y10S128/08
摘要： This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.
摘要翻译：本发明涉及用于外科手术的止血剂，其可以以两种方式制备：一种将胶原蛋白/明胶与鱼精蛋白混合，另一种将胶原/明胶与鱼精蛋白混合和双功能交联剂混合制成所述胶原/明胶与所述鱼精蛋白具有共价键。所生产的止血剂可以在比由纯胶原制成的常规止血剂的时间更短的时间内止血。

16. 发明授权

US4592864A Aqueous atelocollagen solution and method of preparing same 失效
标题翻译：水性胶原纤维素溶液及其制备方法
公开(公告)号：US4592864A
公开(公告)日：1986-06-03
申请号：US634253
申请日：1984-07-25
申请人： Teruo Miyata , Toshio Taira
发明人： Teruo Miyata , Toshio Taira
IPC分类号： A61K35/36 , A61K38/17 , C07K14/78 , A61K37/00 , C07K15/20
CPC分类号： C07K14/78 , Y10S514/801
摘要： An aqueous atelocollagen solution, which can be injected into living bodies as a medical material, has a pH value in the range from about 6.5 to about 8.0 and an osmolality in the range from about 250 to about 320 mOsm/KgH.sub.2 O, and contains a phosphate buffer solution, or glucose and a phosphate buffer solution, as an agent to adjust pH and osmolality within the ranges specified above. This aqueous atelocollagen solution can be prepared by dissolving atelocollagen in an aqueous acidic solution and adding the above-mentioned pH- and osmolality-adjusting agent to the resulting solution in such an amount as to adjust pH and osmolality of the final solution within the ranges mentioned above.
摘要翻译：可以作为医疗材料注入生物体中的水溶性胶原蛋白溶液的pH值在约6.5至约8.0的范围内，重量克分子渗透压浓度在约250至约320mOsm / KgH2O范围内，并含有磷酸盐缓冲溶液或葡萄糖和磷酸盐缓冲溶液作为调节pH和重量摩尔渗透压浓度在上述范围内的试剂。这种水性胶原胶原溶液可以通过将胶原蛋白溶解在酸性水溶液中并将上述pH和渗透压浓度调节剂加入到所得溶液中，使得最终溶液的pH和重量克分子渗透浓度在所述范围内调节以上。

17. 发明授权

US4406853A Method of preparation of regenerated fiber collagen condom 失效
标题翻译：再生纤维胶原避孕套的制备方法
公开(公告)号：US4406853A
公开(公告)日：1983-09-27
申请号：US302335
申请日：1981-09-15
申请人： Teruo Miyata
发明人： Teruo Miyata
IPC分类号： A61F6/04 , B29C41/14 , B29C13/04
CPC分类号： A61F6/04 , B29C41/14
摘要： A novel collagen condom consists of isotropically-strong, crosslinked, regenerated fiber collagen. A method of preparation involves the steps of at least twice dipping a mandrel into an acidic collagen dispersion; slowly removing the mandrel under spinning conditions; neutralizing and drying the membrane between dippings; crosslinking the finally dried membrane while on the mandrel and removing the membrane from the mandrel.
摘要翻译：一种新型胶原蛋白避孕套由各向同性，交联，再生的纤维胶原组成。制备方法包括将心轴至少两次浸入酸性胶原分散体中的步骤; 在纺丝条件下慢慢取出心轴; 蘸液中和干燥膜; 在芯棒上交联最终干燥的膜，并从心轴上除去膜。

18. 发明授权

US4271070A Chemically-modified fiber collagen hemostatic agents 失效
标题翻译：化学修饰纤维胶原止血剂
公开(公告)号：US4271070A
公开(公告)日：1981-06-02
申请号：US147063
申请日：1980-05-05
申请人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel
发明人： Teruo Miyata , Albert L. Rubin , Kurt H. Stenzel
IPC分类号： A61K38/00 , A61L15/32 , C07K14/78 , C07G7/00 , C08L89/06
CPC分类号： C07K14/78 , A61L15/325 , A61K38/00 , A61L2400/04 , Y10S128/08 , Y10S530/84
摘要： Chemically-modified quaternary-structured fiber collagens of minimum molecular length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidinated, esterified, and guanidinated-esterified collagen fibers of the type described.
摘要翻译：作为止血剂要求具有最小分子长度，直径和周期性并且含有相对高的正静电电荷的化学修饰的四元结构纤维胶原。具体实例是所述类型的胍化，酯化和胍化 - 酯化的胶原纤维。

19. 发明授权

US4260228A Collagen gel contact lens and method of preparation 失效
标题翻译：胶原凝胶隐形眼镜及其制备方法
公开(公告)号：US4260228A
公开(公告)日：1981-04-07
申请号：US113856
申请日：1980-01-21
申请人： Teruo Miyata
发明人： Teruo Miyata
IPC分类号： C08K5/053 , C08L89/06 , C09H1/04 , G02C7/04
CPC分类号： C08K5/053
摘要： An improved collagen gel soft contact lens is prepared from an aldehyde-crosslinked, lens-shaped collagen gel containing a water-soluble, aliphatic, monomeric, polyhydroxy compound, e.g., glucose.
摘要翻译：由含有水溶性，脂肪族，单体，多羟基化合物（例如葡萄糖）的醛交联的晶状体胶原凝胶制备改进的胶原凝胶软性隐形眼镜。

20. 发明授权

US4223984A Collagen soft contact lens 失效
标题翻译：胶原柔软隐形眼镜
公开(公告)号：US4223984A
公开(公告)日：1980-09-23
申请号：US026945
申请日：1979-04-04
申请人： Teruo Miyata , Albert L. Rubin , Michael W. Dunn , Kurt H. Stenzel
发明人： Teruo Miyata , Albert L. Rubin , Michael W. Dunn , Kurt H. Stenzel
IPC分类号： A61F2/00 , A61L27/24 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , A61L27/24 , G02B1/043 , A61F2310/00365 , Y10S128/08
摘要： Soft contact lenses are made from solubilized, defatted, transparent, cross-linked collagen, and/or chemically-modified collagen.
摘要翻译：软性隐形眼镜由溶解，脱脂，透明，交联的胶原和/或化学改性的胶原蛋白制成。

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