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11. 发明授权

US08725255B2 Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
标题翻译：心脏再同步治疗优化使用心脏激活序列信息
公开(公告)号：US08725255B2
公开(公告)日：2014-05-13
申请号：US11601216
申请日：2006-11-17
申请人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
发明人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

12. 发明申请

US20080004667A1 Selection of pacing sites to enhance cardiac performance 有权
标题翻译：选择起搏部位以增强心脏性能
公开(公告)号：US20080004667A1
公开(公告)日：2008-01-03
申请号：US11479877
申请日：2006-06-30
申请人： Shantha Arcot-Krishnamurthy , Michael John Stucky , Yinghong Yu , Jiang Ding
发明人： Shantha Arcot-Krishnamurthy , Michael John Stucky , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/36514 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36578 , A61N1/36592
摘要： Systems and methods for selection of electrodes and related pacing configuration parameters used to pace a heart chamber are described. A change in the hemodynamic state of a patient is detected. Responsive to the detected change, a distribution of an electrical, mechanical, or electromechanical parameter related to contractile function of a heart chamber with respect to locations of multiple electrodes disposed within the heart chamber is determined. A pacing output configuration, including one or more electrodes of the multiple electrodes, is selected and the heart chamber is paced using the selected pacing output configuration.
摘要翻译：描述了用于选择电极的系统和方法以及用于调节心室的相关起搏配置参数。检测患者的血液动力学状态的变化。响应于检测到的变化，确定与心室的收缩功能相关的电，机械或机电参数相对于设置在心室内的多个电极的位置的分布。选择包括多个电极中的一个或多个电极的起搏输出配置，并且使用所选择的起搏输出配置来起搏心室。

13. 发明申请

US20130158621A1 ECTOPIC-TRIGGERED PARA-HIS STIMULATION 审中-公开
公开(公告)号：US20130158621A1
公开(公告)日：2013-06-20
申请号：US13716810
申请日：2012-12-17
申请人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
发明人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02152 , A61B5/0464 , A61B5/0468 , A61N1/365 , A61N1/37 , A61N1/371
摘要： Ectopic cardiac activity can be detected, such as in the absence of a diagnosed tachyarrhythmia episode. In response to the detected ectopic activity, electrostimulation can be provided to a para-Hisian region, such as to activate natural cardiac contraction mechanisms or to interrupt re-entrant cardiac activity. Subsequent ectopic cardiac activity can be detected, and subsequent electrostimulation can be provided to the para-Hisian region, such as according to one or more adjustable electrostimulation parameters.
摘要翻译：可以检测异位心脏活动，例如在没有诊断的快速性心律失常发作时。响应于检测到的异位活动，可以向对等神经区域提供电刺激，例如激活自然心脏收缩机制或中断再入心脏活动。可以检测随后的异位心脏活动，并且可以根据一个或多个可调节的电刺激参数来向对 - Hisian区域提供随后的电刺激。

14. 发明授权

US08565880B2 His-bundle capture verification and monitoring 有权
标题翻译： His-bundle捕获验证和监控
公开(公告)号：US08565880B2
公开(公告)日：2013-10-22
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/36
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

15. 发明申请

US20110264158A1 HIS-BUNDLE CAPTURE VERIFICATION AND MONITORING 有权
标题翻译：验证和监控
公开(公告)号：US20110264158A1
公开(公告)日：2011-10-27
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

16. 发明授权

US08295927B2 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US08295927B2
公开(公告)日：2012-10-23
申请号：US12254631
申请日：2008-10-20
申请人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
发明人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

17. 发明授权

US08214026B2 Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US08214026B2
公开(公告)日：2012-07-03
申请号：US12976397
申请日：2010-12-22
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

18. 发明授权

US07966066B2 Apparatus and method for optimizing atrioventricular delay 有权
标题翻译：用于优化房室延迟的装置和方法
公开(公告)号：US07966066B2
公开(公告)日：2011-06-21
申请号：US11126490
申请日：2005-05-11
申请人： Yinghong Yu , Jiang Ding , Jeffrey E. Stahmann
发明人： Yinghong Yu , Jiang Ding , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/3706
摘要： Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.
摘要翻译：在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。各种系统和方法的组合也是可能的。

19. 发明申请

US20110071588A1 CARDIAC PACING USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜
公开(公告)号：US20110071588A1
公开(公告)日：2011-03-24
申请号：US12955218
申请日：2010-11-29
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

20. 发明授权

US07869873B2 Method and system for setting cardiac resynchronization therapy parameters 有权
标题翻译：设置心脏再同步治疗参数的方法和系统
公开(公告)号：US07869873B2
公开(公告)日：2011-01-11
申请号：US11681244
申请日：2007-03-02
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

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