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11. 发明授权

US07949411B1 Epicardial lead 有权
标题翻译：心外膜导联
公开(公告)号：US07949411B1
公开(公告)日：2011-05-24
申请号：US11626132
申请日：2007-01-23
申请人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
发明人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/057
摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.
摘要翻译：实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

12. 发明授权

US07448999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07448999B1
公开(公告)日：2008-11-11
申请号：US11053468
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/0422 , A61B5/6852 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B5/6859 , A61N1/057 , A61N1/0587
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

13. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

14. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

15. 发明授权

US07340288B1 Trans-septal intra-cardiac lead system 失效
公开(公告)号：US07340288B1
公开(公告)日：2008-03-04
申请号：US11053493
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/36514 , A61N2001/0585
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

16. 发明授权

US07274965B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07274965B1
公开(公告)日：2007-09-25
申请号：US11053373
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/00
CPC分类号： A61N1/00
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

17. 发明授权

US06968237B2 Implantable coronary sinus lead and lead system 失效
标题翻译：植入性冠状动脉窦引导系统
公开(公告)号：US06968237B2
公开(公告)日：2005-11-22
申请号：US10154893
申请日：2002-05-22
申请人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
发明人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.
摘要翻译：公开了一种植入式刺激引线，用于放置在冠状窦区及其相关联的冠状动脉血管，其覆盖在患者心脏的左侧。引线包括至少一个近端连接器; 至少一个组织刺激电极; 耦合在所述至少一个近端连接器和所述至少一个刺激电极之间的至少一个导体; 以及引线体，其包括围绕所述至少一个导体的绝缘材料的外壳，所述引线主体具有例如硅橡胶的相对柔性的远端部分，其长度对应于心脏的冠状窦区域，并且较硬例如聚氨酯的近端部分。包括引导体的远侧和近端部分的伸缩部分的鲁棒的过渡接头将引线体的两个部分相互连接。还提供了一种多功能引线输送系统，其包括设置在引线主体的远端部分内的探针止动器。探针止动器限定了通过导丝而不是通孔的扩大的远端的尺寸的孔。引线包括具有纵向延伸的孔的尖端电极，其尺寸允许引导线通过尖端电极。

18. 发明授权

US07056314B1 Steerable obturator 有权
标题翻译：导向闭孔器
公开(公告)号：US07056314B1
公开(公告)日：2006-06-06
申请号：US10452244
申请日：2003-05-30
申请人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
IPC分类号： A61M25/01
CPC分类号： A61M25/0152 , A61B17/3478 , A61B2017/003 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/015 , A61M2025/0161
摘要： An omnidirectionally steerable obturator facilitates the delivery of the distal tip of an introducer sheath into the coronary sinus of a heart. The steerable obturator comprises an obturator body extending longitudinally along a central axis, the obturator body being configured to be received by the introducer sheath. The obturator body further has a flexible, deflectable distal end section terminating in a rounded distal tip. An actuator, controllable from a proximal end of the obturator body, is operatively associated with the flexible distal end section of the obturator body to cause deflection of the flexible distal end section of the obturator body in at least one selected direction to facilitate passage of the distal end section of the obturator body and the distal tip of the introducer sheath into the coronary sinus of the heart.The obturator body is preferably configured to be received in a close fit within at least the tip of the introducer sheath. More preferably, the distal end of the obturator body has an outer surface and the fit between the outer surface of the obturator and at least the tip of the introducer sheath comprises substantially a line-to-line fit.
摘要翻译：全向可操纵的闭孔器有利于将导引鞘的远侧末端递送到心脏的冠状窦。可操纵的闭孔器包括沿着中心轴线纵向延伸的闭孔器，所述封闭器主体构造成由引导器护套容纳。闭孔体还具有终止于圆形远端尖端的柔性的，可偏转的远端部分。从闭塞体的近端可控制的致动器与闭塞体的柔性远端部分可操作地相关联，以使闭塞体的柔性远端部分沿至少一个选定的方向偏转，以便于通过闭塞体的远端部分和导引鞘的远侧末端插入心脏的冠状窦。闭孔体优选构造成在至少引导器护套的尖端内紧密配合。更优选地，闭孔体的远端具有外表面，并且填塞物的外表面与引导器护套的至少末端之间的配合基本上包括线对齐配合。

19. 发明授权

US06456890B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456890B2
公开(公告)日：2002-09-24
申请号：US09797531
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N100
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multi-lumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多腔管沿着导丝线前进，直到达到所需的位置，导线从主体和多管腔管中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

20. 发明授权

US06456889B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456889B2
公开(公告)日：2002-09-24
申请号：US09797281
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N1100
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multilumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多根管沿引导线前进，直到达到所需的位置，导线从主体和多管腔中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

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