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11. 发明授权

US4830488A Measuring instrument for intracardial acquisition of blood oxygen saturation 失效
标题翻译：测量仪器用于血氧饱和度的心内采集
公开(公告)号：US4830488A
公开(公告)日：1989-05-16
申请号：US51857
申请日：1987-05-20
申请人： Roland Heinze , Hakan Elmqvist
发明人： Roland Heinze , Hakan Elmqvist
IPC分类号： A61B5/145 , A61B5/1459 , A61N1/365
CPC分类号： A61N1/36557
摘要： A measuring instrument for obtaining an intracardial signal indicative of blood oxygen saturation, which may be used to control the stimulation frequency of a heart pacemaker, has a measuring probe which contains a light transmitter and a light receiver. The light receiver receives light from the light transmitter reflected by the blood. The light transmitter and the light receiver are connected in parallel to an evaluation circuit via two leads. A constant current source is connected in series with the light transmitter. The current generated by the light receiver, indicative of blood oxygen saturation, can be identified by forming the difference between current flowing in the measuring probe and the constant current. A reference measurement to compensate for factors in the total current resulting from the lead resistances and the measuring probe temperature is not necessary.
摘要翻译：可用于控制心脏起搏器的刺激频率的用于获得指示血氧饱和度的心内信号的测量仪器具有包含光发射器和光接收器的测量探针。光接收器接收来自由血液反射的光发射器的光。光发射器和光接收器通过两根引线并联连接到评估电路。恒流源与光发射器串联连接。由光接收器产生的指示血氧饱和度的电流可以通过形成测量探头中流动的电流与恒定电流之间的差异来识别。用于补偿由导通电阻和测量探头温度导致的总电流中的因素的参考测量不是必需的。

12. 发明授权

US4807632A Measuring instrument for intracardial acquisition of the blood oxygen saturation of a patient for controlling the pacing rate of a heart pacemaker 失效
标题翻译：用于心脏内采集患者血氧饱和度的测量仪器，用于控制心脏起搏器的起搏速率
公开(公告)号：US4807632A
公开(公告)日：1989-02-28
申请号：US52032
申请日：1987-05-19
申请人： Hans D. Liess , Roland Heinze
发明人： Hans D. Liess , Roland Heinze
IPC分类号： G01N33/49 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61N1/365 , G01D18/00
CPC分类号： A61B5/1459 , A61N1/36557
摘要： A measuring instrument for the intracardial acquistion of the blood oxygen saturation of a patient for use in controlling a heart pacemaker implanted in the patient has a measuring probe with a measuring current path which includes a light transmitter and a light receiver which receives light emitted by the light transmitter and reflected by the blood. The measuring probe is connected to an evaluation circuit via two lines. A useful signal measurement and a reference measurement, independent of the blood reflection, are made and the blood oxygen saturation is identified by comparing the two signals. A separate evaluation of the useful signal measurement and the reference signal measurement is enabled by making the useful signal measurement chronologically offset with respect to the reference measurement in one embodiment, or by using the amplitude of the current from the light receiver to make one measurement, and using the voltage amplitude to make the other measurement in another embodiment.
摘要翻译：用于心脏采集患者的血氧饱和度用于控制植入患者的心脏起搏器的测量仪器具有测量电流路径的测量探头，该测量电流路径包括光发射器和接收由光发射器和血液反射。测量探头通过两条线连接到评估电路。进行独立于血液反射的有用的信号测量和参考测量，并通过比较两个信号来识别血氧饱和度。通过使有用信号测量在一个实施例中相对于参考测量按时间顺序偏移，或者通过使用来自光接收器的电流的振幅进行一次测量，可以对有用信号测量和参考信号测量进行单独的评估，并且在另一实施例中使用电压幅度进行另一测量。

13. 发明授权

US4727879A Measurement device for intracardial acquisition of blood oxygen saturation 失效
标题翻译：用于血氧饱和度的心内采集的测量装置
公开(公告)号：US4727879A
公开(公告)日：1988-03-01
申请号：US915675
申请日：1986-10-06
申请人： Hans-Dieter Liess , Roland Heinze
发明人： Hans-Dieter Liess , Roland Heinze
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61N1/365
CPC分类号： A61N1/36557 , A61B5/1459
摘要： A measurement device for frequency control of a heart pacemaker based on the level of blood oxygen saturation contains a measuring probe which includes a light transmitter and a light receiver. The light receiver receives the light emitted by the light transmitter and reflected by the blood. The light transmitter and the light receiver are connected in parallel to an evaluation circuit via two common lines, this evaluation circuit charging the measuring probe with a constant current or with a constant voltage. A resistor is arranged in series with the light receiver. A transistor is arranged parallel to this series circuit, the base thereof being connected to the junction of the resistor and the light receiver. By means of this arrangement, the measurement sensitivity given deposits on the probe is maintained at a higher level. In an alternative embodiment, this can also be achieved using a resistor in series with the light transmitter with a transistor controlled by the light receiver connected in parallel therewith.
摘要翻译：用于基于血氧饱和度的心脏起搏器的频率控制的测量装置包括测量探头，其包括光发射器和光接收器。光接收器接收由光发射器发射并被血液反射的光。光发射器和光接收器通过两条公共线与评估电路并联连接，该评估电路用恒定电流或恒定电压对测量探头充电。电阻器与光接收器串联布置。晶体管被平行于该串联电路设置，其基极连接到电阻器和光接收器的结。通过这种布置，探头上给定的沉积物的测量灵敏度保持在更高的水平。在替代实施例中，这也可以使用与光发射器串联的电阻器来实现，其中晶体管由与其并联连接的光接收器控制。

14. 发明授权

US5645575A Cardiac pacemaker and pacing method using detection of physical stress for adjusting stimulation rate 失效
标题翻译：心脏起搏器和起搏方法使用物理应激检测来调整刺激速率
公开(公告)号：US5645575A
公开(公告)日：1997-07-08
申请号：US576755
申请日：1995-12-21
申请人： Karl Stangl , Michael Laule , Roland Heinze
发明人： Karl Stangl , Michael Laule , Roland Heinze
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36585 , A61N1/36521
摘要： In a method and apparatus for operating an implantable cardiac pacemaker, the stimulation rate is modulated, while a patient in whom the pacemaker is implanted is experiencing a number of different levels of physical stress, and a number of signal sequences corresponding to a non-mechanical physiological characteristic are obtained, one sequence being obtained for each physical stress level. These signal sequences form a reference field, which is stored in the pacemaker. A current signal sequence of the non-mechanical physiological characteristic is subsequently obtained, and this signal sequence is compared to all of the signal sequences in the stored reference field, and one of the reference field signal sequences having the highest correlation with the current signal sequence is selected. The stimulation rate is then set at a rate equal to the basic stimulation rate for the modulation which produced the highest correlating sequence in the reference field.
摘要翻译：在用于操作可植入心脏起搏器的方法和装置中，刺激速率被调制，而其中植入起搏器的患者经历多个不同水平的物理应力，并且多个信号序列对应于非机械获得生理特征，为每个物理应力水平获得一个序列。这些信号序列形成参考场，其存储在起搏器中。随后获得非机械生理特性的当前信号序列，并将该信号序列与存储的参考场中的所有信号序列进行比较，并且与当前信号序列具有最高相关性的参考场信号序列之一被选中。然后将刺激速率设定为等于在参考场中产生最高相关序列的调制的基本刺激速率的速率。

15. 发明授权

US5514171A Pressure and heart movement sensor for heart stimulators 失效
标题翻译：用于心脏刺激器的压力和心脏运动传感器
公开(公告)号：US5514171A
公开(公告)日：1996-05-07
申请号：US271522
申请日：1994-07-07
申请人： Kurt Hoegnelid , Kenth-Ake-Sune Nilsson , Nils Holmstroem , Roland Heinze , Karin Ljungstroem , Pierre Westin
发明人： Kurt Hoegnelid , Kenth-Ake-Sune Nilsson , Nils Holmstroem , Roland Heinze , Karin Ljungstroem , Pierre Westin
IPC分类号： A61N1/365 , A61B5/03 , A61N1/37 , A61N1/05
CPC分类号： A61B5/03 , A61N1/3702
摘要： A pressure and heart movement sensor for a heart stimulator, includes an electrode system for implantation with an electrode cable containing at least two electrical conductors leading to electrode poles. A measurement device is arranged to measure an electrical quantity between the electrical conductors, which quantity varying according to the pressure applied to the electrode cable. Alternately, the electrode cable contains at least one electrical conductor, and the measurement device is arranged to measure the impedance between the conductor and ambient medium and to deliver an output signal, which varies according to the impedance measured, when the electrode cable is subjected to pressure.
摘要翻译：用于心脏刺激器的压力和心脏运动传感器包括用于注入电极电缆的电极系统，该电极电缆包含至少两个通向电极极的电导体。测量装置被布置成测量电导体之间的电量，该电量根据施加到电极电缆的压力而变化。替代地，电极电缆包含至少一个电导体，并且测量装置被布置成测量导体和环境介质之间的阻抗，并且当电极电缆经受时，传递根据测量的阻抗而变化的输出信号压力。

16. 发明授权

US5076271A Rate-responsive pacing method and system employing minimum blood oxygen saturation as a control parameter and as a physical activity indicator 失效
标题翻译：使用最小血氧饱和度作为对照参数和作为体能活动指标的反应性PACING方法和系统
公开(公告)号：US5076271A
公开(公告)日：1991-12-31
申请号：US555965
申请日：1990-07-19
申请人： Anders Lekholm , Roland Heinze
发明人： Anders Lekholm , Roland Heinze
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61N1/365
CPC分类号： A61N1/36557 , A61B5/1459
摘要： A rate-responsive pacing method and system senses the minimum blood oxygen saturation in the right atrium of a patient's heart and uses such minimum blood oxygen saturation as a control parameter for indicating the muscular activity of a patient. Because the oxygen content of the venous blood in the right atrium varies significantly as venous blood from all parts of the body is introduced therein, evidencing differing levels of oxygen demand throughout the patient's body, the minimum oxygen content of the venous blood provides an accurate and reliable measure of those portions of the patient's body experiencing the greatest oxygen demand, i.e., experiencing muscular activity. A rate-responsive pacing system includes means for sensing the minimum oxygen content in the right atrium over a prescribed time interval, and using such minimum oxygen content as a control parameter for adjusting the rate of the pacemaker.

17. 发明授权

US4877032A Sensor arrangement for the control of implantable devices 失效
标题翻译：用于控制可植入装置的传感器装置
公开(公告)号：US4877032A
公开(公告)日：1989-10-31
申请号：US333805
申请日：1989-04-06
申请人： Roland Heinze , Hans-Dieter Liess
发明人： Roland Heinze , Hans-Dieter Liess
IPC分类号： G08C15/06 , A61N1/365
CPC分类号： A61N1/36585
摘要： A sensor arrangement for controlling an implantable device, such as a heart pacemaker, has a number of individual sensors connected to an evaluation circuit through a catheter having at least two leads. The sensors are respectively activated in chronological succession by a shared control circuit, with both the sensors and the control circuit being arranged in the catheter. The corresponding measured signals are transmitted via the same leads, and also being offset chronologically. The arrangement permits a number of sensors to be connected to a catheter while maintaining only two lines in the catheter, so that the flexibility and reliability of the catheter, which are best with the fewest possible leads, remain unimpaired.
摘要翻译：用于控制诸如心脏起搏器的可植入装置的传感器装置具有通过具有至少两个引线的导管连接到评估电路的多个单独的传感器。传感器分别通过共享控制电路以时间顺序依次启动，传感器和控制电路都布置在导管中。相应的测量信号通过相同的引线传输，并且也按时间顺序偏移。该装置允许多个传感器连接到导管，同时仅在导管中保持两条线，使得导管的灵活性和可靠性尽可能地以最少可能的引线保持不受损害。

18. 发明授权

US4870968A System and method for controlling the stimulation frequency of heart pacemakers 失效
标题翻译：控制心脏起搏器刺激频率的系统和方法
公开(公告)号：US4870968A
公开(公告)日：1989-10-03
申请号：US33883
申请日：1987-04-02
申请人： Alexander Wiertzfeld , Roland Heinze
发明人： Alexander Wiertzfeld , Roland Heinze
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36557
摘要： A follower control matches the stimulation frequency of a heart pacemaker to patient load condition by obtaining measurement values S.sub.02 corresponding to the central venous blood oxygen saturation in the heart according to the principle of reflection oximetry, by forming control values B.sub.S1 according to the quotient .DELTA.S.sub.02 /.DELTA.S.sub.02max where the numerator is the difference between the current measurement value and a stored reference value (e.g. S.sub.02max or S.sub.02min) and the denominator serves to standardize the control value based on the maximum change of the measurement value over a relatively long time interval, and by changing the stimulation frequency by an amount dependent on the magnitude of the control value. Preferably, the stimulation frequency f.sub.p is set directly as a function of the control value B.sub.S1 and most preferably according to the function ##EQU1## where f.sub.min is a prescribed minimum frequency, .DELTA.f.sub.max is the maximum frequency difference, c.sub.w is a programmable constant and .DELTA.f.sub.opt is a frequency change introduced by a concurrently operating optimizing control. Artifacts are avoided by obtaining measurement values at sampling intervals distributed in the time span between heart beats and varying in phase during each measurement cycle, and then selecting the minimum measurement value occurring in each measurement cycle.
摘要翻译：跟随器控制器通过根据反射血氧仪的原理获得对应于心脏中心静脉血氧饱和度的测量值S02，通过根据商DELTA S02形成控制值BS1，将心脏起搏器的刺激频率与患者负荷状况相匹配 / DELTA S02max，其中分子是当前测量值和存储的参考值（例如S02max或S02min）之间的差异，分母用于根据测量值在相对长的时间间隔上的最大变化来标准化控制值，并且通过将刺激频率改变取决于控制值的大小的量。优选地，刺激频率fp被直接设置为控制值BS1的函数，最优选地根据函数fp = fmin + DELTA fmaxe-cwB2S1 + DELTA fopt设定，其中fmin是规定的最小频率，DELTA fmax是最大频率差，cw是可编程常数，DELTA fopt是由同时运行的优化控制引入的频率变化。通过在每个测量周期内通过心跳和时间间隔分布的采样间隔获得测量值，然后选择在每个测量循环中出现的最小测量值来避免伪影。

19. 发明授权

US4763655A Frequency-controlled heart pacemaker 失效
标题翻译：频率控制的心脏起搏器
公开(公告)号：US4763655A
公开(公告)日：1988-08-16
申请号：US62707
申请日：1987-06-16
申请人： Alexander Wirtzfeld , Karl Stangl , Roland Heinze
发明人： Alexander Wirtzfeld , Karl Stangl , Roland Heinze
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/15 , A61B5/157 , A61N1/365 , A61N1/36
CPC分类号： A61B5/1459 , A61N1/3655 , A61N1/36557
摘要： The stimulation frequency of a heart pacemaker is controlled dependent on a signal representative of the blood oxygen content of the patient. The blood oxygen dependent signal is generated by a blood oxygen sensor. A temperature sensor generates a separate signal dependent on blood temperature. The blood oxygen and blood temperature signals are combined such that the blood oxygen signal is lowered, i.e., the value thereof is reduced, in ranges of higher physical load indicated by an increase in the temperature dependent signal. The combined signal is used to control the stimulation frequency of a heart pacemaker so that the stimulation frequency is increased, if blood oxygen saturation is decreasing and/or blood temperature is increasing.
摘要翻译：心脏起搏器的刺激频率由代表患者血氧含量的信号控制。血氧依赖信号由血氧传感器产生。温度传感器根据血液温度生成独立的信号。组合血氧信号和血液温度信号，使得在依赖于温度的信号的增加指示的较高物理负荷的范围内，血氧信号降低，即其值降低。组合信号用于控制心脏起搏器的刺激频率，使得如果血氧饱和度降低和/或血液温度升高，则刺激频率增加。

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