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11. 发明授权

US08954160B2 Detection of extracardiac stimulation by a cardiac rhythm management device 有权
标题翻译：心律管理装置检测心外刺激
公开(公告)号：US08954160B2
公开(公告)日：2015-02-10
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/36 , A61N1/365 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

12. 发明申请

US20130060298A1 DETECTION OF EXTRACARDIAC STIMULATION BY A CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：通过CARDIAC RHYTHM管理设备检测提取物刺激
公开(公告)号：US20130060298A1
公开(公告)日：2013-03-07
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

13. 发明申请

US20130131750A1 METHOD AND APPARATUS FOR ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY EMPLOYING A MULTIPOLAR LEFT VENTRICULAR LEAD 有权
标题翻译：自适应心脏再生治疗方法和装置采用多孔左心室导联
公开(公告)号：US20130131750A1
公开(公告)日：2013-05-23
申请号：US13301012
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译：医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。响应于激活时间确定选择第一起搏站点。该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。

14. 发明授权

US08639333B2 Method and apparatus for adaptive cardiac resynchronization therapy employing a multipolar left ventricular lead 有权
标题翻译：使用多极左心室导联的自适应心脏再同步治疗的方法和装置
公开(公告)号：US08639333B2
公开(公告)日：2014-01-28
申请号：US13301012
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译：医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。响应于激活时间确定选择第一起搏站点。该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。

15. 发明授权

US07181268B2 Ischemia detection 失效
标题翻译：缺血检测
公开(公告)号：US07181268B2
公开(公告)日：2007-02-20
申请号：US10304112
申请日：2002-11-25
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/0402
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36585
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart that are sensed by an accelerometer sensor. The heart acceleration signal can be obtained from an single- or multiple-axis accelerometer and/or a pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及由加速度计传感器感测到的心脏的动态机械活动的变化来检测心肌缺血的发生。心脏加速度信号可以从部署在心脏内部或附近的单轴或多轴加速度计和/或压力传感器获得。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

16. 发明授权

US06937899B2 Ischemia detection 有权
标题翻译：缺血检测
公开(公告)号：US06937899B2
公开(公告)日：2005-08-30
申请号：US09945179
申请日：2001-08-30
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/11 , A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61B5/4839 , A61B5/04011 , A61B5/0452 , A61B5/1107 , A61B5/6869 , A61B5/7203 , A61B2562/028 , A61B2562/222 , A61N1/36542 , A61N1/368
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart. Dynamic mechanical activity can be represented, for example, by a heart acceleration signal or pressure signal. The electrical signal can be obtained from a set of implanted or external electrodes. The heart acceleration signal can be obtained from an accelerometer or pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及心脏的动态机械活动的变化来检测心肌缺血的发生。动态机械活动可以例如通过心脏加速度信号或压力信号来表示。电信号可以从一组植入电极或外部电极获得。可以从部署在心脏内部或附近的加速度计或压力传感器获得心脏加速度信号。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

17. 发明授权

US09480844B2 Method and apparatus for reducing noise in a medical device 有权
标题翻译：减少医疗装置噪音的方法和装置
公开(公告)号：US09480844B2
公开(公告)日：2016-11-01
申请号：US12915093
申请日：2010-10-29
申请人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
发明人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
IPC分类号： A61N1/37 , A61N1/36 , A61N1/362
CPC分类号： A61N1/3702 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing a cardiac signal, detecting a cardiac event in response to the sensed signal, determining whether an interval associated with the cardiac signal is less than an interval threshold, determining a noise metric in response to an interval associated with the cardiac signal being less than the interval threshold, determining whether the noise metric is greater than a noise metric threshold, and determining whether to inhibit detecting in response to determining whether an interval associated with the cardiac signal is less than the interval threshold and determining whether the noise metric is greater than the noise metric threshold.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测心脏信号，响应于感测信号检测心脏事件，确定与心脏信号相关联的间隔是否小于间隔阈值，确定噪声响应于与所述心脏信号相关联的间隔小于所述间隔阈值的度量，确定所述噪声度量是否大于噪声度量阈值，以及响应于确定与所述心脏信号相关联的间隔是否是禁止检测小于间隔阈值并确定噪声度量是否大于噪声度量阈值。

18. 发明授权

US09180300B2 Left-ventricular pacing site selection guided by electrogram morphology analysis 有权
标题翻译：通过电描记图形态分析指导左心室起搏部位选择
公开(公告)号：US09180300B2
公开(公告)日：2015-11-10
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/362 , A61B5/00 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

19. 发明授权

US09174062B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US09174062B2
公开(公告)日：2015-11-03
申请号：US11687094
申请日：2007-03-16
申请人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
发明人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
IPC分类号： A61B5/00 , A61N1/362 , A61N1/39 , A61B5/0464 , A61B5/0468 , A61B5/046 , A61N1/05
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, determining a relationship between a plurality of characteristics associated with a morphology of the cardiac signals sensed during a predetermined sensing window, generating a threshold in response to the determined relationship, comparing a first characteristic of the plurality of characteristics with the threshold, and determining whether the sensed cardiac signals are associated with the cardiac event in response to the comparing of the first characteristic.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，确定与在预定感测窗口期间感测到的心脏信号的形态有关的多个特征之间的关系，产生阈值响应于所确定的关系，将所述多个特征的第一特征与所述阈值进行比较，并且响应于所述第一特征的比较，确定所感测的心脏信号是否与心脏事件相关联。

20. 发明授权

US08983585B2 Method and apparatus for detecting and discriminating tachycardia 有权
标题翻译：用于检测和辨别心动过速的方法和装置
公开(公告)号：US08983585B2
公开(公告)日：2015-03-17
申请号：US12768944
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler
发明人： Xusheng Zhang , Robert W. Stadler
IPC分类号： A61B5/04 , A61N1/362 , A61B5/0464 , A61N1/39 , A61B5/00
CPC分类号： A61N1/3622 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for monitoring a patient's heart rhythm sensing a cardiac signal determine whether a cardiac signal is noise corrupted by obtaining cardiac signal pulses and generating a pulse amplitude threshold in response to the plurality of signal pulses. The number of signal sample points exceeding the pulse amplitude threshold in each of the of signal pulses is computed. The cardiac signal is determined to be noise corrupted or non-corrupted in response to the computed number of signal sample points.
摘要翻译：用于监测感测心脏信号的患者心律的医疗装置和相关方法通过获得心脏信号脉冲并响应于多个信号脉冲产生脉冲幅度阈值来确定心脏信号是否被噪声破坏。计算每个信号脉冲中超过脉冲振幅阈值的信号采样点数。响应于所计算的信号采样点数，心脏信号被确定为噪声损坏或未被破坏。

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