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1. 发明申请

US20130131750A1 METHOD AND APPARATUS FOR ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY EMPLOYING A MULTIPOLAR LEFT VENTRICULAR LEAD 有权
标题翻译：自适应心脏再生治疗方法和装置采用多孔左心室导联
公开(公告)号：US20130131750A1
公开(公告)日：2013-05-23
申请号：US13301012
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译：医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。响应于激活时间确定选择第一起搏站点。该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。

2. 发明授权

US08639333B2 Method and apparatus for adaptive cardiac resynchronization therapy employing a multipolar left ventricular lead 有权
标题翻译：使用多极左心室导联的自适应心脏再同步治疗的方法和装置
公开(公告)号：US08639333B2
公开(公告)日：2014-01-28
申请号：US13301012
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili , Vincent E. Splett
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译：医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。响应于激活时间确定选择第一起搏站点。该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。

3. 发明授权

US09199087B2 Apparatus and method for selecting a preferred pacing vector in a cardiac resynchronization device 有权
标题翻译：用于在心脏再同步装置中选择优选起搏载体的装置和方法
公开(公告)号：US09199087B2
公开(公告)日：2015-12-01
申请号：US13301043
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili
IPC分类号： A61N1/368
CPC分类号： A61N1/3684 , A61N1/3686
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy including selecting left ventricular pacing sites for delivering the therapy. The left ventricular pacing sites are selected by delivering pacing pulses to a patient's left ventricle at multiple pacing sites one at a time and determining right ventricular activation times in response to the pacing pulses being delivered at each of the pacing sites. A left ventricular pacing site is selected in response to the determined right ventricular activation times.
摘要翻译：医疗设备和相关方法控制心脏起搏疗法的递送，包括选择用于递送治疗的左心室起搏部位。通过在多个起搏部位一次一个地向患者的左心室递送起搏脉冲来选择左心室起搏部位，并且响应于在每个起搏部位递送的起搏脉冲来确定右心室激活时间。响应于确定的右心室激活时间来选择左心室起搏部位。

4. 发明申请

US20130131751A1 APPARATUS AND METHOD FOR SELECTING A PREFERRED PACING VECTOR IN A CARDIAC RESYNCHRONIZATION DEVICE 有权
标题翻译：在心脏再生装置中选择优选的载体矢量的装置和方法
公开(公告)号：US20130131751A1
公开(公告)日：2013-05-23
申请号：US13301043
申请日：2011-11-21
申请人： Robert W. Stadler , Aleksandre T. Sambelashvili
发明人： Robert W. Stadler , Aleksandre T. Sambelashvili
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61N1/3686
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy including selecting left ventricular pacing sites for delivering the therapy. The left ventricular pacing sites are selected by delivering pacing pulses to a patient's left ventricle at multiple pacing sites one at a time and determining right ventricular activation times in response to the pacing pulses being delivered at each of the pacing sites. A left ventricular pacing site is selected in response to the determined right ventricular activation times.
摘要翻译：医疗设备和相关方法控制心脏起搏疗法的递送，包括选择用于递送治疗的左心室起搏部位。通过在多个起搏部位一次一个地向患者的左心室递送起搏脉冲来选择左心室起搏部位，并且响应于在每个起搏部位递送的起搏脉冲来确定右心室激活时间。响应于确定的右心室激活时间来选择左心室起搏部位。

5. 发明授权

US09180300B2 Left-ventricular pacing site selection guided by electrogram morphology analysis 有权
标题翻译：通过电描记图形态分析指导左心室起搏部位选择
公开(公告)号：US09180300B2
公开(公告)日：2015-11-10
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/362 , A61B5/00 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

6. 发明申请

US20130053918A1 LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 审中-公开
标题翻译：电子形态分析指导的左心室选择选择
公开(公告)号：US20130053918A1
公开(公告)日：2013-02-28
申请号：US13598815
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device system and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A control unit is operatively coupled with a plurality of electrodes for controlling the delivery of the pacing pulses, and a sensing module senses a cardiac signal generated in response to the delivered pacing pulses. A processor is configured to deliver a first pacing pulse at a first timing interval to a first pacing site, determine the cardiac signal sensed in response to the delivered first pacing pulse and determine a first morphology corresponding to the determined sensed cardiac signal, compare the first morphology to a threshold morphology and adjust the first timing interval to a second timing interval different from the first timing interval in response to the comparing, and determine the optimal pacing site in response to the adjusting.
摘要翻译：医疗器械系统和相关方法对候选起搏电极部位进行分类，以将起搏脉冲输送到患者的心脏。控制单元与多个电极可操作地耦合，用于控制起搏脉冲的传送，并且感测模块感测响应于所输送的起搏脉冲而产生的心脏信号。处理器被配置为以第一定时间隔将第一起搏脉冲传送到第一起搏位置，确定响应于所传送的第一起搏脉冲而感测的心脏信号，并且确定对应于所确定的感测到的心脏信号的第一形态，比较第一起搏脉冲形态到阈值形态，并且响应于比较将第一定时间隔调整到与第一定时间隔不同的第二定时间隔，并且响应于调整确定最佳起搏位置。

7. 发明申请

US20130053916A1 LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 有权
标题翻译：电子形态分析指导的左心室选择选择
公开(公告)号：US20130053916A1
公开(公告)日：2013-02-28
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

8. 发明授权

US08954160B2 Detection of extracardiac stimulation by a cardiac rhythm management device 有权
标题翻译：心律管理装置检测心外刺激
公开(公告)号：US08954160B2
公开(公告)日：2015-02-10
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/36 , A61N1/365 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

9. 发明申请

US20130060298A1 DETECTION OF EXTRACARDIAC STIMULATION BY A CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：通过CARDIAC RHYTHM管理设备检测提取物刺激
公开(公告)号：US20130060298A1
公开(公告)日：2013-03-07
申请号：US13600282
申请日：2012-08-31
申请人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
发明人： Vincent E. Splett , Robert W. Stadler , Nathan A. Grenz
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译：用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。

10. 发明申请

US20130030492A1 METHOD FOR DISCRIMINATING ANODAL AND CATHODAL CAPTURE 有权
标题翻译：用于分析阳极和阴极捕获的方法
公开(公告)号：US20130030492A1
公开(公告)日：2013-01-31
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

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