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1. 发明授权

US08855755B2 Distinguishing between treatable and non-treatable heart rhythms 有权
标题翻译：区分可治疗和不可治疗的心律
公开(公告)号：US08855755B2
公开(公告)日：2014-10-07
申请号：US12430301
申请日：2009-04-27
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0468 , A61N1/365 , A61N1/362 , A61B5/0464 , A61B5/046 , A61B5/00 , A61N1/39 , A61B5/0452
CPC分类号： A61N1/3621 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/726 , A61B5/7264 , A61N1/36507 , A61N1/3962 , G06F19/00
摘要： Techniques are described for distinguishing between treatable and non-treatable heart rhythms. A medical device that operates in accordance with the techniques analyzes characteristics over several cardiac event intervals to detect initiation of a sudden rate onset. After detection of the initiation of the sudden rate onset, the IMD analyzes a morphology of an EGM associated with a selected cardiac event within the first several beats after the initiation of sudden rate onset. In one example, the IMD analyzes the morphology of the EGM associated with the first cardiac event immediately subsequent to the initiation of the sudden rate onset. If the morphology of the EGM of the selected cardiac event is abnormal compared to template EGM, the rhythm is classified as treatable. Otherwise, the rhythm is classified as non-treatable.
摘要翻译：描述了用于区分可治疗和不可治疗的心脏节律的技术。根据该技术操作的医疗装置分析几个心脏事件间隔的特征，以检测突然发生率的起始。在检测到突发性发作起始之后，IMD分析在突然发病起始之后的前几次心跳中与所选心脏事件相关的EGM的形态。在一个实例中，IMD分析与突然发病起始之后紧接着的第一次心脏事件相关的EGM的形态。如果所选心脏事件的EGM的形态与模板EGM相比异常，则将节律分类为可治疗的。否则，节奏被分类为不可治疗。

2. 发明授权

US08315699B2 Method and apparatus for detecting and discriminating tachycardia 有权
标题翻译：用于检测和辨别心动过速的方法和装置
公开(公告)号：US08315699B2
公开(公告)日：2012-11-20
申请号：US12768850
申请日：2010-04-28
申请人： Robert W. Stadler , Xusheng Zhang , Jeffrey M. Gillberg
发明人： Robert W. Stadler , Xusheng Zhang , Jeffrey M. Gillberg
IPC分类号： A61B5/04
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/04011 , A61B5/0464 , A61B5/0468 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for monitoring a patient's heart rhythm sense cardiac events and detect a sudden change in the heart rhythm in response to the sensed cardiac events. Detecting the sudden change includes determining a variability of intervals between the sensed cardiac events and switching between a low variability mode of operation and a high variability mode of operation in response to the variability of intervals. During the low variability mode, detecting the sudden change includes detecting an increase in the rate of cardiac events. During the high variability mode, detecting the sudden change includes detecting a sudden decrease in the variability of the cardiac event intervals. A concerning cardiac rhythm is detected in response to detecting the sudden change.
摘要翻译：用于监测患者心律的医疗装置和相关联的方法感测心脏事件并且响应于感测到的心脏事件来检测心律的突然变化。检测突然变化包括响应于间隔的可变性来确定所感测的心脏事件之间的间隔的可变性和低变异性操作模式与高变异性操作模式之间的切换。在低变异性模式期间，检测突然变化包括检测心脏事件发生率的增加。在高可变性模式期间，检测突然变化包括检测心脏事件间隔的变异性的突然降低。响应于检测到突然变化而检测到关于心律的A。

3. 发明授权

US08306618B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08306618B2
公开(公告)日：2012-11-06
申请号：US12763499
申请日：2010-04-20
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/37
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

4. 发明申请

US20120095520A1 SEQUENTIAL DISCRIMINATION APPROACH FOR DETECTING TREATABLE CARDIAC RHYTHMS 有权
标题翻译：用于检测可治疗性心脏病的顺序分析方法
公开(公告)号：US20120095520A1
公开(公告)日：2012-04-19
申请号：US12903325
申请日：2010-10-13
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61N1/36
CPC分类号： A61B5/7267 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/686 , A61B5/7239 , A61N1/3624 , A61N1/3962
摘要： A system and method for use in a medical device for discriminating cardiac events establishes population-based thresholds corresponding to cardiac signal morphology metrics for discriminating between a first cardiac event and a second cardiac event. A population-based threshold criterion for discriminating cardiac events is established. The population-based threshold criterion is applied to a cardiac signal segment and the segment is classified if the criterion is satisfied. A patient-specific threshold is established in response to the sensed cardiac signal segment not being classified after applying the population-based threshold criterion. The sensed signal segment is classified in response to the patient-specific threshold comparison.
摘要翻译：用于辨别心脏事件的医疗装置中的系统和方法建立了对应于心脏信号形态度量的基于群体的阈值，用于区分第一心脏事件和第二心脏事件。建立了基于人群的阈值判别标准，用于辨别心脏事件。基于人群的阈值标准被应用于心脏信号段，并且如果满足标准，则对该段进行分类。响应于在应用基于群体的阈值标准之后未被分类的感测到的心脏信号段建立患者特异性阈值。感测的信号段根据患者特异性阈值比较进行分类。

5. 发明申请

US20120053477A1 METHOD AND APPARATUS FOR ENHANCING TREATABLE ARRHYTHMIA DETECTION SPECIFICITY BY USING ACCUMULATED PATIENT ACTIVITY 有权
标题翻译：通过使用累积患者活动来增强可治疗性脑膜炎检测特异性的方法和装置
公开(公告)号：US20120053477A1
公开(公告)日：2012-03-01
申请号：US12869180
申请日：2010-08-26
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
IPC分类号： A61B5/04
CPC分类号： A61B5/1118 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61N1/36542 , A61N1/3962
摘要： A method and apparatus for detecting a cardiac event in a medical device determine an activity level count from an activity sensor signal for each of a number of time segments, store an activity level count for each of the time segments in a histogram, and accumulate the stored activity level counts to determine a percentage of time segments having an activity level count above a given activity level count.
摘要翻译：用于检测医疗装置中的心脏事件的方法和装置根据多个时间段中的每一个的活动传感器信号确定活动水平计数，将每个时间段的活动水平计数存储在直方图中，并且累积存储的活动级别计数以确定具有高于给定活动级别计数的活动级别计数的时间段的百分比。

6. 发明授权

US08095206B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08095206B2
公开(公告)日：2012-01-10
申请号：US11742618
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for adjusting a sensing parameter in a medical device that includes a sensing electrode sensing cardiac signals, a processor to determine an adjusting characteristic associated with the cardiac signals sensed over a predetermined sensing window, and a control unit to update the sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于调整包括感测心脏信号的感测电极的医疗装置中的感测参数的方法和装置，用于确定与在预定感测窗口上感测到的心脏信号相关联的调整特性的处理器以及用于更新感测参数的控制单元响应于确定的调整特性。

7. 发明申请

US20110270107A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270107A1
公开(公告)日：2011-11-03
申请号：US12768835
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0464 , A61B5/0452
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3621 , A61N1/3624 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. In response to the first match score being within one of the first and second match zones, a determination is made whether consecutive match scores are within the first match zone and whether a break in the treatable cardiac event has occurred. Cardiac evidence is accumulated in response to determining whether a break has occurred and utilized to discriminate cardiac events.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。响应于第一匹配分数在第一和第二匹配区域之一内，确定连续匹配分数是否在第一匹配区域内，以及是否发生了可治疗心脏事件中断。响应于确定是否发生休息并利用心脏事件来积累心脏证据。

8. 发明授权

US08050751B2 Periodic beat detection to detect artifacts in a cardiac electrogram 有权
标题翻译：定期拍摄检测心脏电图中的伪影
公开(公告)号：US08050751B2
公开(公告)日：2011-11-01
申请号：US12183950
申请日：2008-07-31
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
IPC分类号： A61B5/0464
CPC分类号： A61N1/3621 , A61B5/0464 , A61B5/7221 , A61B5/7239 , A61N1/36507 , A61N1/3925 , A61N1/3962
摘要： Techniques for determining whether artifacts are present in a cardiac electrogram are described. According to one example, a medical device senses a cardiac electrogram via electrodes. The medical device determines a derivative, e.g., a second order derivative, the electrogram. The medical device detects beats within the derivative, e.g., by comparing a rectified version of the derivative to one or more thresholds determined based on a maximum of the rectified derivative. The medical device determines whether the beats are periodic, and determines whether artifacts are present in the cardiac electrogram based on the determination of whether the beats are periodic. The medical device may further determine whether tachyarrhythmia is present and/or whether the cardiac rhythm of the patient is treatable based on the determination of whether the beats are periodic. For example, the medical device may determine that an electrogram is not treatable when the beats are periodic.
摘要翻译：描述了用于确定伪像是否存在于心电图中的技术。根据一个示例，医疗装置通过电极感测心电图。医疗设备确定导数，例如二阶导数，电描记图。医疗设备检测导数内的跳动，例如通过将导数的整流版本与基于校正导数的最大值确定的一个或多个阈值进行比较。医疗器械确定节拍是否是周期性的，并且基于确定节拍是否是周期性的确定来确定心脏电图中是否存在假象。医疗装置可以基于是否是周期性的确定来进一步确定是否存在快速性心律失常和/或患者的心律是否可治疗。例如，当节拍是周期性的时，医疗装置可以确定电描记图是不可治疗的。

9. 发明授权

US07991471B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US07991471B2
公开(公告)日：2011-08-02
申请号：US11461269
申请日：2006-07-31
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/368
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

10. 发明授权

US07734333B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07734333B2
公开(公告)日：2010-06-08
申请号：US11380815
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing a cardiac signal from a plurality of electrodes, determining amplitudes of the sensed cardiac signal during a predetermined sensing window, determining a noise to signal ratio corresponding to the determined amplitudes, and determining the sensed cardiac signal during the predetermined sensing window is corrupted by noise in response to the determined noise to signal ratio being greater than a noise to signal ratio threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括感测来自多个电极的心脏信号，确定在预定感测窗口期间检测到的心脏信号的幅度，确定对应于所确定的幅度的噪声信号比，以及确定响应于所确定的噪声信号比大于噪声信号比阈值，在预定感测窗口期间感测到的心脏信号被噪声破坏。

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