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11. 发明授权

US4711896A .alpha., .omega.-dicarboxylic acids and medicaments which contain these compounds 失效
标题翻译： α，ω-二羧酸和含有这些化合物的药物
公开(公告)号：US4711896A
公开(公告)日：1987-12-08
申请号：US840563
申请日：1986-02-21
申请人： Jacob Bar-Tana , Ernst-Christian Witte , Bernd Hagenbruch , Johannes Pill , Karlheinz Stegmeier
发明人： Jacob Bar-Tana , Ernst-Christian Witte , Bernd Hagenbruch , Johannes Pill , Karlheinz Stegmeier
IPC分类号： C07C55/02 , A61K31/19 , A61P3/06 , A61P3/08 , C07C51/00 , C07C55/28 , C07C55/32 , C07C57/13 , C07C57/30 , C07C57/34 , C07C57/38 , C07C57/42 , C07C57/52 , C07C59/245 , C07C59/305 , C07C59/84 , C07C67/00 , C07C121/48 , C07C121/50
CPC分类号： C07C57/42 , C07C55/28 , C07C55/32 , C07C57/13 , C07C57/34 , C07C57/38 , C07C59/245 , C07C59/305 , C07C59/84
摘要： ##STR1## α, ω-dicarboxylic acids having the general formula (I') in which: R
1 and R
2 , which may be different or the same, represent a lower alkyl group which can be substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl being capable of substitution one or several times by hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C
3 -C
7 -cyclo-alkyl group or a phenyl group possibly substituted by hydroxy, halogen, lower alkyl or lower alkoxy, and X and Y, which may be different or the same, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxycarbonyl or carbamoyl, and Q represents non-ramified, saturated or unsaturated alkyl chain with 8-14 C atoms, which can be substituted, interrupted by hetero-atoms, and form part of a cyclic system, as well as their carboxylic acid derivatives in vivo, provided that when Q represents an unramified, saturated alkyl chain with 8-14 C atoms, and R
1 and R
2 represent methyl and Y represents hydrogen, X may not represent hydrogen, ethoxy-carbonyl, bromine, cyano or methyl, and if R
1 and R
2 represent methyl and X and Y hydrogen, then Q may not represent any formula (II) group. Process for their preparation and medicines containing these compounds, which have an anti-diabetic action and lower the level of lipids.
摘要翻译： PCT No.PCT / EP85 / 00288 Sec。 371日期1986年2月21日 102（e）日期1986年2月21日PCT归档1985年6月15日PCT公布。公开号WO86 / 00298 日本1月16日，1986年1月16日，具有通式（I'）的α，ω-二羧酸，其中：R1和R2可以不同或相同，表示可被羟基，低级烷氧基，卤素或苯基取代的低级烷基，苯基能够被羟基，低级烷氧基，低级烷基或卤素取代一次或几次; 低级烯基或炔基; 可以被羟基，卤素，低级烷基或低级烷氧基取代的C 3 -C 7 - 环烷基或苯基，X和Y可以不同或相同，表示氢，低级烷基，低级烷氧基，羟基，氰基，卤素，羧基，低级烷氧基羰基或氨基甲酰基，Q表示具有8-14个C原子的非分支，饱和或不饱和的烷基链，其可被取代，被杂原子间隔并形成环系的一部分，如以及它们的体内羧酸衍生物，条件是当Q表示具有8-14个C原子的未饱和的饱和烷基链时，R 1和R 2表示甲基且Y表示氢，X可以不表示氢，乙氧羰基，溴，氰基或甲基，并且如果R 1和R 2表示甲基且X和Y氢，则Q可以不表示任何式（II）基团。其制备方法和含有这些化合物的药物，其具有抗糖尿病作用并降低脂质水平。

12. 发明授权

US5145611A Carboxylic acid derivatives, and pharmaceutical compositions containing them 失效
标题翻译：羧酸衍生物和含有它们的药物组合物
公开(公告)号：US5145611A
公开(公告)日：1992-09-08
申请号：US143456
申请日：1988-01-12
申请人： Hans P. Wolff , Ernst-Christian Witte , Hans-Frieder Kuehnle
发明人： Hans P. Wolff , Ernst-Christian Witte , Hans-Frieder Kuehnle
IPC分类号： C07C69/708 , A61K20060101 , A61K31/095 , A61K31/16 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/255 , A61P3/00 , A61P3/08 , A61P3/10 , C07C20060101 , C07C51/00 , C07C51/06 , C07C51/09 , C07C51/367 , C07C53/126 , C07C59/00 , C07C59/125 , C07C59/13 , C07C59/58 , C07C59/64 , C07C59/68 , C07C59/70 , C07C67/00 , C07C69/712 , C07C69/734 , C07C69/736 , C07C229/22 , C07C233/00 , C07C233/01 , C07C309/00 , C07C313/00 , C07C315/02 , C07C317/00 , C07C317/02 , C07C317/04 , C07C317/06 , C07C317/14 , C07C317/16 , C07C317/44 , C07C317/46 , C07C317/48 , C07C319/14 , C07C321/00 , C07C321/02 , C07C323/02 , C07C323/09 , C07C323/12 , C07C323/15 , C07C323/16 , C07C323/19 , C07C323/25 , C07C323/30 , C07C323/52 , C07C323/54 , C07C323/56 , C07C323/65
CPC分类号： C07C317/00 , Y10S514/866
摘要： Carboxylic acid derivatives of the formula ##STR1## R.sub.1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamino. R.sub.2 is optionally substituted aryl or, when B is alkylene also a hydrogen atom. A is a straight-chained or branched, saturated or unsaturated alkylene containing 3 to 10 carbon atoms which is optionally interrupted by a heteratom attached to a saturated carbon and has a chain length of at least 3 atoms. Y is S(O).sub.n group or oxygen, n being 0, 1 or 2. B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene containing 1 to 18 carbon atoms. Physiologically acceptable salts, esters and amides thereof are also included. The compounds are useful in the treatment of metabolic diseases.
摘要翻译：式R1的羧酸衍生物是烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基，环烷基或环烷氧基或任选取代的芳基，芳氧基，芳硫基，芳基亚磺酰基，芳基磺酰基或芳基氨基。 R2是任选取代的芳基，或当B是亚烷基也是氢原子时。 A是含有3至10个碳原子的直链或支链，饱和或不饱和的亚烷基，其任选被连接到饱和碳上的杂原子中断并具有至少3个原子的链长度。 Y是S（O）n基或氧，n是0,1或2.B是价键或含有1至18个碳原子的直链或支链，饱和或不饱和的亚烷基。还包括其生理上可接受的盐，酯和酰胺。该化合物可用于治疗代谢性疾病。

13. 发明授权

US06258832B1 Method for producing thiazolidinediones, and new thiazolidinediones 失效
标题翻译：噻唑烷二酮的制备方法，新的噻唑烷二酮类
公开(公告)号：US06258832B1
公开(公告)日：2001-07-10
申请号：US09381247
申请日：1999-09-14
申请人： Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
发明人： Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
IPC分类号： A61K31427
CPC分类号： C07D417/12 , C07D417/14
摘要： Improved process of compound of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminium in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
摘要翻译：式III化合物的改进方法，其中A表示CH = CH或SW表示OX表示其中残基R 2为氢或C 1 -C 6烷基，Y表示CH或NR的S，O或NR 2表示萘基，噻吩基或任选被单取代的苯基或被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴二取代，R 1表示氢或C 1 -C 6烷基，并且n表示1-3，通过还原通式IV的化合物，其中A，W，X ，Y，R，R 1和n在质子溶剂中具有上述活化的铝，以及新的式III化合物和含有这些化合物的药物制剂。

14. 发明授权

US4670439A 2H-1-benzopyran-2-one derivatives, processes for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译： 2H-1-苯并吡喃-2-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4670439A
公开(公告)日：1987-06-02
申请号：US755496
申请日：1985-07-16
申请人： Ernst-Christian Witte , Peter Neubert , Androniki Roesch
发明人： Ernst-Christian Witte , Peter Neubert , Androniki Roesch
IPC分类号： A61K31/495 , A61P37/08 , C07D311/16 , C07D311/18 , C07D311/54 , C07D405/12
CPC分类号： C07D311/18 , C07D311/16 , C07D311/54
摘要： The present invention provides 2H-1-benzopyran-2-one derivatives of the general formula: ##STR1## wherein either R.sub.1 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.2 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl; or R.sub.1 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl, and R.sub.2 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.3 is a phenyl or benzyl radical which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these 2H-1-benzopyran-2-one derivatives and pharmaceutical compositions containing them.
摘要翻译：本发明提供通式如下的1H-1-苯并吡喃-2-酮衍生物：其中R 1是任选被苯基取代的低级烷基，其可以被低级烷基，低级烷氧基，羟基或卤素，R2是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单取代或二取代; 或R 1是三氟甲基，氰基，羟甲基，烷氧基甲基，酰氧基甲基，卤代甲基，氨基甲基，一烷基氨基甲基或二烷基氨基甲基，酰基，羧基，烷氧基羰基或氨基甲酰基，其可以被低级烷基单或二取代，并且R 2是低级烷基，被苯基取代，其可以被低级烷基，低级烷氧基，羟基或卤素取代，R3是可被低级烷基，低级烷氧基，羟基或卤素取代的苯基或苄基; 及其药理学上可接受的盐。本发明还提供制备这些2H-1-苯并吡喃-2-酮衍生物的方法和含有它们的药物组合物。

15. 发明授权

US4933367A Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds 失效
标题翻译：羧酸衍生物，其制备方法，用途及含有这些化合物的药物组合物
公开(公告)号：US4933367A
公开(公告)日：1990-06-12
申请号：US27229
申请日：1987-03-12
申请人： Hans P. Wolff , Ernst-Christian Witte , Hans-Frieder Kuhnle
发明人： Hans P. Wolff , Ernst-Christian Witte , Hans-Frieder Kuhnle
IPC分类号： C07C69/736 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/49 , C07C20060101 , C07C51/00 , C07C59/125 , C07C59/215 , C07C59/64 , C07C59/68 , C07C59/76 , C07C59/88 , C07C67/00 , C07C69/65 , C07C69/708 , C07C69/738 , C07C227/00 , C07C227/08 , C07C227/16 , C07C229/22 , C07C229/30 , C07C229/36 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/45 , C07C233/47 , C07C233/51 , C07C233/63 , C07C233/65 , C07C233/81 , C07C235/20 , C07C237/06 , C07C237/22 , C07C253/00 , C07C255/32 , C07C309/29 , C07C309/63 , C07C309/65 , C07C309/77 , C07C311/00 , C07C311/02 , C07C311/03 , C07C311/06 , C07C311/15 , C07C311/19 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/14 , C07C317/44 , C07C317/46 , C07C323/52 , C07C323/56
CPC分类号： C07C317/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , C07C309/00 , C07C323/00 , C07C59/64 , C07C59/68 , C07C59/88
摘要： This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.
摘要翻译： PCT No.PCT / EP86 / 00406 Sec。 371日期1987年3月12日 102（e）日期1987年3月12日PCT申请1986年7月10日PCT公布。公开号WO87 / 00521 日本1987年1月29日。本发明涉及羧酸衍生物及其用途。该化合物可用于治疗各种疾病如糖尿病，糖尿病前期，脂肪性疾病或动脉粥样硬化。

16. 发明授权

US4278680A Hypoglycaemically and hypolipidaemically active derivatives of phenylacetic acid 失效
标题翻译：低血糖和降血糖活性的苯乙酸衍生物
公开(公告)号：US4278680A
公开(公告)日：1981-07-14
申请号：US101978
申请日：1979-12-10
申请人： Manfred Hubner , Hans Kuhnle , Ernst-Christian Witte , Ruth Heerdt , Rudi Weyer , Volker Hitzel
发明人： Manfred Hubner , Hans Kuhnle , Ernst-Christian Witte , Ruth Heerdt , Rudi Weyer , Volker Hitzel
IPC分类号： A61K31/17 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/27 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/47 , A61K31/495 , A61P3/06 , A61P3/08 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/87 , C07C235/52 , C07C279/26 , C07D209/42 , C07D213/82 , C07D215/48 , C07D241/28 , C07D307/79 , C07D311/22 , C07D333/38 , C07D213/56 , A61K31/455 , C07D215/40
CPC分类号： C07D213/82 , C07C279/26 , C07D209/42 , C07D215/48 , C07D307/79 , C07D311/22 , C07D333/38 , Y10S514/866
摘要： Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy,Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, andR.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical,or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.
摘要翻译：其中A是任选被卤素，三氟甲基，烷基，烷氧基，烯氧基，烷氧基烷氧基，烷基取代的氨基或芳氧基取代的芳基，或任选被卤素，烷基或烷氧基取代的杂环体系 Y是价态键或含有至多3个碳原子的任意支化的亚烷基，R 1和R 2各自独立地为氢或低级烷基或其生理上相容的盐或酯，表现出显着的低血糖和降血脂活性。

17. 发明授权

US06441185B2 Method for producing thiazolidinediones, and new thiazolidinediones 失效
标题翻译：噻唑烷二酮的制备方法，新的噻唑烷二酮类
公开(公告)号：US06441185B2
公开(公告)日：2002-08-27
申请号：US09783494
申请日：2001-02-14
申请人： Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
发明人： Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
IPC分类号： C07D41714
CPC分类号： C07D417/12 , C07D417/14
摘要： Improved process of compounds of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminum in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
摘要翻译：式III化合物的改进方法，其中A表示CH = CH或SW表示OX表示其中残基R2为氢或C1-C6烷基，Y表示CH或NR的S，O或NR2表示萘基，噻吩基或任选单取代的苯基或被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴二取代，R 1表示氢或C 1 -C 6烷基，并且n表示1-3，通过还原通式IV的化合物，其中A，W，X ，Y，R，R 1和n在质子溶剂中具有上述活化的铝，以及新的式III化合物和含有这些化合物的药物制剂。

18. 发明授权

US4616086A Piperazine-substituted aryl and aralkyl carboxylic acids useful for treating infirmaties caused by excess lipids or thrombocyte 失效
标题翻译：哌嗪取代的芳基和芳烷基羧酸，可用于治疗由过量脂质或血小板细胞引起的体温
公开(公告)号：US4616086A
公开(公告)日：1986-10-07
申请号：US657032
申请日：1984-10-01
申请人： Ernst-Christian Witte , Hans P. Wolff , Bernd Hagenbruch , Karlheinz Stegmeir , Johannes Pill
发明人： Ernst-Christian Witte , Hans P. Wolff , Bernd Hagenbruch , Karlheinz Stegmeir , Johannes Pill
IPC分类号： C07D295/02 , A61K31/495 , A61P7/00 , C07D295/06 , C07D295/08 , C07D295/096 , C07D295/112 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/194 , C07D295/20 , C07D295/205 , C07D295/26 , C07D241/04
CPC分类号： C07D295/185 , C07D295/096 , C07D295/112 , C07D295/15 , C07D295/155 , C07D295/192 , C07D295/194 , C07D295/205 , C07D295/26
摘要： The present invention is concerned with new carboxylic acid derivatives, with processes for the preparation thereof and with pharmaceutical compositions for lipid depression and thrombocyte aggregation, containing them, and to methods for treating infirmaties caused by excess lipids or thrombocyte aggregation.The new carboxylic acid derivatives according to the present invention are compounds of the general formula: ##STR1## wherein A is a valency bond or a lower alkylene chain, B is a valency bond or a saturated or unsaturated lower alkylene chain, R is hydrogen, an alkyl group which can be substituted by hydroxyl, carboxyl, sulphonic acid or optionally substituted phenoxy group, or R is an aralkyl radical, the aryl moiety of which can be substituted and the alkyl moiety of which is optionally unsaturated and can contain up to 4 carbon atoms, or R is a phenacyl radical, the phenyl moiety optionally substituted, or R is an acyl radical derived from aliphatic, araliphatic or aromatic carboxylic or sulphonic acid, or R is an aryl radical optionally substituted with the proviso that when A is a valency bond, R cannot be hydrogen, methyl, ethyl, hydroxyethyl, benzyl or phenyl, and the physiologically acceptable salts, esters and amides thereof.
摘要翻译：本发明涉及新的羧酸衍生物，其制备方法和含有它们的脂质抑制和血小板聚集的药物组合物，以及用于治疗由过量脂质或凝血细胞聚集引起的不孕症的方法。根据本发明的新的羧酸衍生物是下列通式的化合物：其中A是价键或低级亚烷基链，B是价键或饱和或不饱和的低级亚烷基链，R 是氢，可以被羟基，羧基，磺酸或任选取代的苯氧基取代的烷基，或R是芳烷基，其芳基部分可以被取代，并且其烷基部分任选是不饱和的并且可以含有最多4个碳原子，或R是苯甲酰基，苯基部分任选被取代，或R是衍生自脂族，芳脂族或芳族羧酸或磺酸的酰基，或R是任选被取代的芳基，条件是当 A是价键，R不能是氢，甲基，乙基，羟乙基，苄基或苯基，以及它们的生理上可接受的盐，酯和酰胺。

19. 发明授权

US4153728A Phenoxyalkylcarboxylic acid compounds and therapeutic compositions 失效
标题翻译：苯氧基烷基羧酸化合物和治疗组合物
公开(公告)号：US4153728A
公开(公告)日：1979-05-08
申请号：US733542
申请日：1976-10-18
申请人： Hans P. Wolff , Ernst-Christian Witte , Max Thiel , Harald Stork , Egon Roesch
发明人： Hans P. Wolff , Ernst-Christian Witte , Max Thiel , Harald Stork , Egon Roesch
IPC分类号： A61K31/215 , A61K20060101 , A61K31/16 , A61K31/19 , A61K31/22 , A61P3/06 , A61P7/02 , C07C20060101 , C07C51/00 , C07C59/68 , C07C67/00 , C07C69/734 , C07C69/76 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/34 , C07C235/48 , C07C101/42 , A01N9/20
CPC分类号： C07C2101/14 , Y10S514/824
摘要： Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein B is a valency bond or a straight-chained or branched, saturated or unsaturated hydrocarbon radical containing up to 3 carbon atoms;N is 1 or 2 andR.sub.1, r.sub.2 and R.sub.3 are hydrogen or lower alkyl; and the pharmacologically compatible salts thereof; have been found to be outstandingly effective in lowering the serum lipid level and the cholesterol level in mammals without inducing undesired side effects and to possess excellent thrombocyte-aggregation inhibiting activity.
摘要翻译：式（I）的新型苯氧基烷基羧酸化合物，其中B是含有至多3个碳原子的价键或直链或支链，饱和或不饱和的烃基; N 1 OR 2，R 1，R 2和R 3为氢或低级烷基; 和其药理学上相容的盐; 已被发现在降低哺乳动物血清脂质水平和胆固醇水平而没有诱导不期望的副作用并且具有优异的血小板聚集抑制活性方面是非常有效的。

20. 发明授权

US3997666A 1-[3-(Naphth-1-yloxy)-2-hydroxypropvl]-piperazine compounds and therapeutic compositions 失效
标题翻译： 1- {8- 3-（萘-1-基氧基）-2-羟基丙基{9-哌嗪化合物和治疗组合物
公开(公告)号：US3997666A
公开(公告)日：1976-12-14
申请号：US544719
申请日：1975-01-28
申请人： Ernst-Christian Witte , Kurt Stach , Max Thiel , Gisbert Sponer , Egon Roesch
发明人： Ernst-Christian Witte , Kurt Stach , Max Thiel , Gisbert Sponer , Egon Roesch
IPC分类号： C07D295/08 , A61K31/495 , A61P9/12 , C07D295/088 , C07D295/092 , C07D295/096
CPC分类号： C07D295/088
摘要： New 1-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine compounds of the formula: ##STR1## and the pharmacologically compatible salts thereof are outstandingly effective in lowering blood pressure and are thus useful as anti-hypertensive agents.
摘要翻译：具有下式的新的1- [3-（萘-1-基氧基）-2-羟丙基] - 哌嗪化合物及其药理学相容的盐在降低血压方面显着有效，因此可用作抗 - 高血压药物

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