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11. 发明授权

US06632192B2 Apparatus and method for selective reduction of segmental intracellular and extracellular edema 失效
标题翻译：用于选择性还原细胞内和细胞外水肿的装置和方法
公开(公告)号：US06632192B2
公开(公告)日：2003-10-14
申请号：US09799466
申请日：2001-03-05
申请人： Reynolds G. Gorsuch , Kris Venkat
发明人： Reynolds G. Gorsuch , Kris Venkat
IPC分类号： A61M3700
CPC分类号： B01D63/024 , A61M1/1678 , A61M1/28 , A61M1/3472 , A61M1/3482 , B01D61/142 , B01D61/18 , B01D61/22 , B01D2313/243 , B01D2313/90
摘要： Segmental edema is treated by inserting a plasma extraction filter device in a major vein of a body segment or servicing the body segment containing the edemic tissues, and inserting a return catheter in a major artery of the body segment affected or feeding the body segment from which plasma is extracted. Blood plasma and plasma proteins extracted from the edemic body segment through the plasma extraction filter fluids are directed to an ultrafiltration apparatus where plasma water is separated from the plasma proteins. Plasma proteins are returned to the body segment from which the plasma was extracted via the return catheter in the major artery of the subject body segment.
摘要翻译：通过将血浆提取过滤装置插入体节段的主要静脉或维护含有血液组织的体节段，并将返回导管插入受影响的身体部分的主要动脉或者将其从其中提取血浆。通过血浆提取过滤液从血流体部分提取的血浆和血浆蛋白质被导向超滤装置，其中等离子体水与血浆蛋白质分离。血浆蛋白质返回到通过主体部分的主动脉中的返回导管从其中提取血浆的身体部分。

12. 发明授权

US5968004A Microporous membrane sheet plasma extraction catheter 失效
标题翻译：微孔膜片血浆提取导管
公开(公告)号：US5968004A
公开(公告)日：1999-10-19
申请号：US935399
申请日：1997-09-23
申请人： Reynolds G. Gorsuch
发明人： Reynolds G. Gorsuch
IPC分类号： A61M1/16 , A61M1/34 , A61M37/00 , A61F2/00
CPC分类号： A61M1/1678 , A61M1/3472 , A61M1/3496
摘要： An assembly for being implanted in a blood vessel for carrying out in vivo plasma separation incorporates a plasma extraction capsule formed of a microporous polymeric membrane sheet having a pore size capable of allowing diffusion of plasma, the capsule having one or more interior plasma flow channels and a catheter secured to the capsule and having at least one lumen in fluid communication with the one or more interior capsule channels.
摘要翻译：用于植入用于进行体内血浆分离的血管中的组件包括由具有能够允许等离子体扩散的孔径的微孔聚合物膜片形成的等离子体提取胶囊，所述胶囊具有一个或多个内部等离子体流动通道，以及导管，其固定到所述胶囊并且具有与所述一个或多个内部胶囊通道流体连通的至少一个内腔。

13. 发明授权

US06234991B1 Method and apparatus for continuous peritoneal cascade dialysis and hemofiltration (CPCD/H) 失效
标题翻译：连续腹膜透析和血液滤过（CPCD / H）的方法和装置
公开(公告)号：US06234991B1
公开(公告)日：2001-05-22
申请号：US09382237
申请日：1999-08-24
申请人： Reynolds G. Gorsuch
发明人： Reynolds G. Gorsuch
IPC分类号： A61M100
CPC分类号： B01D63/084 , A61M1/1625 , A61M1/1678 , A61M1/1696 , A61M1/28 , A61M1/281 , A61M1/284 , A61M1/3673 , A61M2205/04 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2209/088 , B01D61/28 , B01D63/02 , B01D2313/23 , B01D2313/243
摘要： A continuous peritoneal dialysis is carried out by providing a dialyzer element having a filter membrane for being exposed within the peritoneal cavity and an interior dialysate passageway, the membrane having pores sufficient to allow diffusion of blood toxins, implanting the dialyzer element in the peritoneal cavity of a patient, infusing a transfer fluid into the patient's peritoneal cavity and continuously supplying substantially fresh dialysate fluid into interior dialysate passageway of the dialyzer element, directing the fluid along the passageway whereby it is exposed to the transfer fluid by diffusion through the membrane and whereby toxins from said transfer fluid are diffused into the dialysate in the dialyzer element to form toxic dialysate fluid, and continuously removing the toxic dialysate from said dialyzer element.
摘要翻译：通过提供具有用于暴露于腹膜腔内的过滤膜的透析器元件和内部透析液通道进行连续腹膜透析，该膜具有足以允许血液毒素扩散的孔，将透析器元件植入腹膜腔内患者将输送流体输入到患者的腹膜腔中，并将基本上新鲜的透析液连续供应到透析器元件的内部透析液通道中，引导流体沿着通道，由此通过扩散通过膜而暴露于转移流体，由此毒素从所述转移流体扩散到透析器元件中的透析液中以形成有毒透析液，并且从所述透析器元件连续地除去有毒透析液。

14. 发明授权

US07195711B2 Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration 失效
标题翻译：专用中空纤维膜，用于体内血浆置换和超滤
公开(公告)号：US07195711B2
公开(公告)日：2007-03-27
申请号：US10959918
申请日：2004-10-06
申请人： Reynolds G. Gorsuch , Henry Grage , Harold Handley, Jr. , Harold Peters , Jacob C. Kearns
发明人： Reynolds G. Gorsuch , Henry Grage , Harold Handley, Jr. , Harold Peters , Jacob C. Kearns
IPC分类号： B01D69/08 , B01D71/68 , B01D63/02
CPC分类号： B01D67/0016 , A61M1/1678 , A61M1/34 , A61M1/3403 , B01D69/02 , B01D69/04 , B01D69/08 , B01D69/12 , B01D71/68 , B01D2325/022
摘要： An in-vivo plasmapheresis and/or in-vivo ultrafiltration membrane comprises elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface. The fiber is further characterized by having an average elongation breaking force strength of at least about 0.2 lbs. and an average elongation of at least about 45%.
摘要翻译：体内血浆置换术和/或体内超滤膜包括细长的中空纤维，每个纤维具有沿着纤维长度延伸的内腔，纤维壁在内壁和外壁之间具有多个区域，每个区域具有质量密度不同于相邻区域的质量密度。纤维壁的特征在于在内壁表面具有较低的质量密度区域，并且在外壁表面具有较高的质量密度区域。纤维的进一步特征在于具有至少约0.2磅的平均伸长断裂力强度。平均伸长率至少约45％。

15. 发明授权

US06607501B2 Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications 失效
公开(公告)号：US06607501B2
公开(公告)日：2003-08-19
申请号：US09858029
申请日：2001-05-14
申请人： Reynolds G. Gorsuch
发明人： Reynolds G. Gorsuch
IPC分类号： A61M3700
CPC分类号： A61M1/3679 , A61M1/1678 , A61M1/3489 , A61M2202/0415
摘要： The present invention is directed to a method of treating cells, tissues or organs using in vivo plasma separation by implanting a plasma separation filter device within a blood vessel of a patient, or allogenic, or xenogenic donor, continuously separating blood plasma from whole blood in vivo, directing the plasma from the plasma separation filter device to a bioreactor, and exposing the plasma to cells, tissue or an organ within the bioreactor utilizing immune separation membranes where necessary.

16. 发明授权

US5980481A Method and apparatus for continuous peritoneal cascade dialysis and hemofiltration (CPCD/H) 失效
标题翻译：连续腹膜透析和血液滤过（CPCD / H）的方法和装置
公开(公告)号：US5980481A
公开(公告)日：1999-11-09
申请号：US853051
申请日：1997-05-08
申请人： Reynolds G. Gorsuch
发明人： Reynolds G. Gorsuch
IPC分类号： A61M1/16 , A61M1/28 , A61M1/36 , B01D61/28 , B01D63/02 , B01D63/08 , A61M1/00
CPC分类号： B01D63/084 , A61M1/1625 , A61M1/1678 , A61M1/28 , A61M1/281 , A61M1/3673 , B01D61/28 , B01D63/02 , A61M1/1696 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , B01D2313/23 , B01D2313/243
摘要： A continuous peritoneal dialysis is carried out by providing a dialyzer element having a filter membrane for being exposed within the peritoneal cavity and an interior dialysate passageway, the membrane having pores sufficient to allow diffusion of blood toxins, implanting the dialyzer element in the peritoneal cavity of a patient, infusing a transfer fluid into the patient's peritoneal cavity and continuously supplying substantially fresh dialysate fluid into interior dialysate passageway of the dialyzer element, directing the fluid along the passageway whereby it is exposed to the transfer fluid by diffusion through the membrane and whereby toxins from said transfer fluid are diffused into the dialysate in the dialyzer element to form toxic dialysate fluid, and continuously removing the toxic dialysate from said dialyzer element.
摘要翻译：通过提供具有用于暴露于腹膜腔内的过滤膜的透析器元件和内部透析液通道进行连续腹膜透析，该膜具有足以允许血液毒素扩散的孔，将透析器元件植入腹膜腔内患者将输送流体输入到患者的腹膜腔中，并将基本上新鲜的透析液连续供应到透析器元件的内部透析液通道中，引导流体沿着通道，由此通过扩散通过膜而暴露于转移流体，由此毒素从所述转移流体扩散到透析器元件中的透析液中以形成有毒透析液，并且从所述透析器元件连续地除去有毒透析液。

17. 发明授权

US5218972A Biomedical force measuring apparatus 失效
标题翻译：生物医用力测量仪
公开(公告)号：US5218972A
公开(公告)日：1993-06-15
申请号：US754960
申请日：1991-09-04
申请人： Reynolds G. Gorsuch , John Atkins
发明人： Reynolds G. Gorsuch , John Atkins
IPC分类号： A61B5/03
CPC分类号： A61B5/033
摘要： A force transducer usable tokodynamometer for measuring intrauterine pressure and motion, and for measuring other force exerted by human body or other organisms. The tokodynamometer has a cavity filled with an incompressible fluid and closed by a flexible diaphragm disposed for contacting the body portion being studied. A zero-displacement fluid-pressure transducer is in the cavity and provides an electrical signal responsive to pressure in the fluid, as body force acts through the flexible diaphragm to induce pressure in the fluid. Changes in intrauterine pressure or other body forces are thus measured with no significant physical displacement of a transducer or other force-measuring element. The fluid-filled cavity has the shape of a truncated cone with the diaphragm at the larger end and the transducer at the smaller end, increasing the sensitivity of the transducer.
摘要翻译：用于测量宫内压力和运动的力传感器，用于测量人体或其他生物施加的其他力的力传感器。该动力计具有填充有不可压缩流体的空腔，并且被设置成用于接触所研究的主体部分的柔性隔膜封闭。零位移流体压力传感器位于空腔中，并且响应于流体中的压力而提供响应于体力的电信号，因为体力通过柔性隔膜作用以引起流体中的压力。因此，测量宫内压力或其他身体力的变化，没有传感器或其他力测量元件的显着物理位移。流体填充的空腔具有截头圆锥体的形状，隔膜在较大的端部，传感器在较小端部，增加了传感器的灵敏度。

18. 发明授权

US06949078B2 Apparatus and method for selective reduction of segmental intracellular and extracellular edema 失效
标题翻译：用于选择性还原细胞内和细胞外水肿的装置和方法
公开(公告)号：US06949078B2
公开(公告)日：2005-09-27
申请号：US10357068
申请日：2003-01-31
申请人： Reynolds G. Gorsuch , Kris Venkat
发明人： Reynolds G. Gorsuch , Kris Venkat
IPC分类号： A61M1/00 , A61M1/16 , A61M1/34 , A61M1/36 , B01D61/14 , B01D61/18 , B01D61/22 , B01D63/02 , A61M37/00 , A61M5/00
CPC分类号： B01D63/024 , A61M1/1678 , A61M1/28 , A61M1/3472 , A61M1/3482 , B01D61/142 , B01D61/18 , B01D61/22 , B01D2313/243 , B01D2313/90
摘要： Segmental edema is treated by inserting a plasma extraction filter device in a major vein of a body segment or servicing the body segment containing the edemic tissues, and inserting a return catheter in a major artery of the body segment affected or feeding the body segment from which plasma is extracted. Blood plasma and plasma proteins extracted from the edemic body segment through the plasma extraction filter fluids are directed to an ultrafiltration apparatus where plasma water is separated from the plasma proteins. Plasma proteins are returned to the body segment from which the plasma was extracted via the return catheter in the major artery of the subject body segment.
摘要翻译：通过将血浆提取过滤装置插入体节段的主要静脉或维护含有血液组织的体节段，并将返回导管插入受影响的身体部分的主要动脉或者将其从其中提取血浆。通过血浆提取过滤液从血流体部分提取的血浆和血浆蛋白质被导向超滤装置，其中等离子体水与血浆蛋白质分离。血浆蛋白质返回到通过主体部分的主动脉中的返回导管从其中提取血浆的身体部分。

19. 发明授权

US06659973B2 Apparatus and method for in-vivo plasmapheresis using periodic backflush 失效
公开(公告)号：US06659973B2
公开(公告)日：2003-12-09
申请号：US09754773
申请日：2001-01-04
申请人： Reynolds G. Gorsuch , Tommy Cooper
发明人： Reynolds G. Gorsuch , Tommy Cooper
IPC分类号： A61M3700
CPC分类号： A61M1/1678 , A61M1/1682 , A61M1/1688 , A61M1/3413 , A61M2205/7554
摘要： Apparatus and method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed.

20. 发明授权

US06561996B1 Apparatus and method for in vivo hemodialysis 失效
标题翻译：用于体内血液透析的装置和方法
公开(公告)号：US06561996B1
公开(公告)日：2003-05-13
申请号：US09081883
申请日：1998-05-19
申请人： Reynolds G. Gorsuch
发明人： Reynolds G. Gorsuch
IPC分类号： A61M3700
CPC分类号： A61M1/1678 , A61M1/1696 , A61M1/3417 , A61M1/342 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355
摘要： A method of removing toxins from a patient's blood comprises implanting a filter device having a dialysis membrane with an exterior surface exposed to the patient's blood and a dialysate cavity exposed to an interior surface of the dialysate membrane within a blood vessel of a patient, continuously directing substantially uncontaminated or substantially decontaminated dialysate into the dialysate cavity and in diffusive communication with the patient's blood, dialysing the patient's blood with the dialysate, and continuously removing toxin contaminated dialysate from the filter device.
摘要翻译：从患者血液中除去毒素的方法包括：植入具有透析膜的过滤装置，其具有暴露于患者血液的外表面和暴露于患者血管内透析液膜内表面的透析液腔，连续引导基本上未被污染或基本上净化的透析液进入透析液腔并与患者的血液扩散连通，用透析液透析患者的血液，并从过滤器装置连续地去除毒素污染的透析液。

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