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11. 发明申请

US20130005002A1 AMIDASE AND USE THEREOF FOR PRODUCING 3-AMINOCARBOXYLIC ACID ESTERS 审中-公开
标题翻译：用于生产3-氨基羧酸酯的氨基酸及其用途
公开(公告)号：US20130005002A1
公开(公告)日：2013-01-03
申请号：US13497985
申请日：2010-09-24
申请人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
发明人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
IPC分类号： C12P13/00 , C12N9/80
CPC分类号： C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
摘要： Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
摘要翻译：制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到根据权利要求1的通过加入多肽的对映选择性脱酰作用。

12. 发明授权

US08008051B2 Butynol I esterase 有权
标题翻译：丁醇I酯酶
公开(公告)号：US08008051B2
公开(公告)日：2011-08-30
申请号：US12422785
申请日：2009-04-13
申请人： Bernhard Hauer , Thomas Friedrich , Christoph Nübling , Rainer Stürmer , Wolfgang Ladner
发明人： Bernhard Hauer , Thomas Friedrich , Christoph Nübling , Rainer Stürmer , Wolfgang Ladner
IPC分类号： C12P7/64 , C12P7/62 , C12N9/18
CPC分类号： C12N9/16 , C12P41/00
摘要： The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译：本发明涉及具有酯酶活性，特别是丁酸酯酶活性的来自假单胞菌的新型蛋白质，涉及编码的核酸序列，表达盒，载体和重组微生物; 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。

13. 发明授权

US07888080B2 Enzymatic reduction for producing optically active alcohols 有权
标题翻译：用于制备光学活性醇的酶还原
公开(公告)号：US07888080B2
公开(公告)日：2011-02-15
申请号：US12158390
申请日：2006-12-13
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer , Hartwig Schröder
IPC分类号： C12P17/00 , C12N9/14
CPC分类号： C07D333/16 , C07D333/20 , C12P7/02 , C12P11/00 , C12P41/002
摘要： A process for preparing optically active alkanols of the formula I in which n is an integer from 0 to 5; Cyc is an optionally substituted, mono- or polynuclear, saturated or unsaturated, carbocyclic or heterocyclic ring, and R1 is halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, with R2, R3 and R4 independently of one another being hydrogen or a lower alkyl or lower alkoxy radical and X− being a counterion, which process comprises incubating in a medium comprising alkanone of the formula II in which n, Cyc and R1 are as defined above, an enzyme having a polypeptide sequence (i) SEQ ID NO: 1 or (ii) in which, compared to SEQ ID NO:1, up to 25% of the amino acid radicals have been altered by deletion, insertion, substitution or a combination thereof and which retains at least 50% of the enzymic activity of SEQ ID NO:1, with the compound of the formula II being enzymically reduced to give the compound of the formula I, and isolating the product formed.
摘要翻译：一种制备式I的光学活性链烷醇的方法，其中n为0至5的整数; Cyc是任选取代的单或多核饱和或不饱和的碳环或杂环，R1是卤素，SH，OH，NO2，NR2R3或NR2R3R4 + X-，R2，R3和R4彼此独立地是氢或低级烷基或低级烷氧基，X是抗衡离子，该方法包括在包含式II的烷酮的培养基中孵育，其中n，Cyc和R 1如上定义，具有多肽序列（i）SEQ ID NO： SEQ ID NO：1或（ii）其中与SEQ ID NO：1相比，通过缺失，插入，取代或其组合改变多达25％的氨基酸基团，并且其保留至少50％的酶活性为SEQ ID NO：1，其中式II化合物被酶还原，得到式I化合物，并分离形成的产物。

14. 发明授权

US07498448B2 Methods for the production of 3-methylamino-1-(thiene-2-yl)-propane-1-ol 有权
标题翻译： 3-甲基氨基-1-（噻吩-2-基） - 丙-1-醇的制备方法
公开(公告)号：US07498448B2
公开(公告)日：2009-03-03
申请号：US10573130
申请日：2004-09-30
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer
IPC分类号： C07D333/12
CPC分类号： C07D333/16
摘要： The present invention relates to enzymic and nonenzymic processes for preparing 3-methylamino-1-(thien-2-yl)propan-1-ol; as well as to enzymes for implementing these processes; and to nucleic acid sequences encoding these enzymes, to expression cassettes containing these nucleic acid sequences, to vectors and to recombinant hosts.
摘要翻译：本发明涉及制备3-甲基氨基-1-（噻吩-2-基）丙-1-醇的酶和非酶法; 以及用于实施这些过程的酶; 以及编码这些酶的核酸序列，含有这些核酸序列的表达盒，载体和重组宿主。

15. 发明授权

US07314739B2 Lipase variants 失效
标题翻译：脂肪酶变体
公开(公告)号：US07314739B2
公开(公告)日：2008-01-01
申请号：US10493210
申请日：2002-10-17
申请人： Markus Matuschek , Rainer Stürmer , Bernhard Hauer , Gerhard Klebe , Marco Bocola
发明人： Markus Matuschek , Rainer Stürmer , Bernhard Hauer , Gerhard Klebe , Marco Bocola
IPC分类号： C12P7/62 , C12P7/40 , C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/20
摘要： The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
摘要翻译：本发明涉及脂酶变体，其可通过在选自脂肪酶同源家族I.1或I.2的起始脂肪酶的氨基酸序列上进行至少一个氨基酸取代而制备，原型脂肪酶序列SEQ ID NO：1中的位置17,29,30,25,66,117,122,160,163,167,265,266,286,289。

16. 发明授权

US08012725B2 Method for the production of optically-active alcohols 有权
标题翻译：光学活性醇的制造方法
公开(公告)号：US08012725B2
公开(公告)日：2011-09-06
申请号：US11667721
申请日：2005-11-15
申请人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/16 , C12P7/02 , C12P7/04 , C12Q1/26 , C12Q1/32 , C12N1/00 , C12N1/20 , C12N9/02 , C07H21/04
CPC分类号： C12P7/16 , Y02E50/10
摘要： The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
摘要翻译：本发明涉及制备S-丁-2-醇的酶法; 和用于进行所述方法的酶; 编码所述酶的核酸序列，含有所述核酸序列的表达盒，载体和重组宿主。

17. 发明申请

US20100009421A1 Method For The Enzymatic Reduction Of Alkyne Derivates 有权
标题翻译：酶催化还原炔烃衍生物的方法
公开(公告)号：US20100009421A1
公开(公告)日：2010-01-14
申请号：US12439427
申请日：2007-08-30
申请人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
发明人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , C12N9/0036
摘要： The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.
摘要翻译：本发明涉及一种用于酶还原式（1）的炔衍生物的方法，其中R 1表示H，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基或任选取代的碳环或杂环，芳族或非芳族基团，R2表示H，C1-C6-烷基，C2-C6-烯基，通过在特殊的还原酶存在下反应。

18. 发明授权

US08399225B2 Process for preparing urethane-containing (meth)acrylic esters 有权
标题翻译：制备含氨基甲酸酯（甲基）丙烯酸酯的方法
公开(公告)号：US08399225B2
公开(公告)日：2013-03-19
申请号：US12776670
申请日：2010-05-10
申请人： Rainer Stürmer , Dejana Drew , Bernhard Hauer , Jürgen Däuwel , Uwe Meisenburg
发明人： Rainer Stürmer , Dejana Drew , Bernhard Hauer , Jürgen Däuwel , Uwe Meisenburg
IPC分类号： C12P7/60
CPC分类号： C12P13/02 , C12P7/62
摘要： The invention relates to a process for preparing urethane-containing acrylic- and (meth)acrylic esters by reacting a urethane-containing alcohol with a reactant acrylic- or (meth)acrylic ester of a saturated alcohol in the presence of at least one polymerization inhibitor and an enzyme as a catalyst within a reactor, wherein the saturated alcohol released in the process and optionally an entraining agent form an azeotrope with an excess of the reactant (meth)acrylic ester, such that the azeotrope is removed by distillation under reduced pressure and at least one substream from the bottom of the reactor is circulated through the top of the distillation column. Using this process, urethane-containing acrylic- and (meth)acrylic esters are prepared in high yields and high purities under mild conditions from economically obtainable reactants with no significant polymer formation.
摘要翻译：本发明涉及通过使含氨基甲酸酯的醇与饱和醇的反应性丙烯酸或（甲基）丙烯酸酯在至少一种聚合抑制剂的存在下反应来制备含氨基甲酸酯的丙烯酸和（甲基）丙烯酸酯的方法和作为反应器内的催化剂的酶，其中在该方法中释放的饱和醇和任选的夹带剂与过量的反应物（甲基）丙烯酸酯形成共沸物，使得通过减压蒸馏除去共沸物，来自反应器底部的至少一个子流通过蒸馏塔的顶部循环。使用该方法，在温和条件下从经济可获得的反应物中以高产率和高纯度制备含氨基甲酸酯的丙烯酸酯和（甲基）丙烯酸酯，没有显着的聚合物形成。

19. 发明授权

US08227218B2 Method for the enzymatic reduction of alkyne derivates 有权
标题翻译：炔烃衍生物的酶还原方法
公开(公告)号：US08227218B2
公开(公告)日：2012-07-24
申请号：US12439427
申请日：2007-08-30
申请人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
发明人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , C12N9/0036
摘要： The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.
摘要翻译：本发明涉及一种用于酶还原式（1）的炔衍生物的方法，其中R 1表示H，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基或任选取代的碳环或杂环，芳族或非芳族基团，R2表示H，C1-C6-烷基，C2-C6-烯基，通过在特殊的还原酶存在下反应。

20. 发明授权

US07795004B2 Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases 有权
标题翻译：使用两种醇脱氢酶使光学活性仲醇外消旋化的方法
公开(公告)号：US07795004B2
公开(公告)日：2010-09-14
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P41/00
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译：通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。类。

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