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11. 发明申请

US20060205817A1 Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof 失效
标题翻译：制备4-羟基异亮氨酸非对映异构体及其对映异构体及其衍生物的方法
公开(公告)号：US20060205817A1
公开(公告)日：2006-09-14
申请号：US10537293
申请日：2003-12-01
申请人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
发明人： Charles Mioskowski , Alain Wagner , Sandra De Lamo Marin , Cedric Catala , Jean-Michel Becht
IPC分类号： A61K31/198 , C07C227/02
CPC分类号： C07D307/66 , C07C227/32 , C07C229/22
摘要： The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine
摘要翻译：本发明涉及一种制备通式（I）的4-羟基异亮氨酸非对映异构体及其衍生物的方法，其特征在于其在直接得到式（I）衍生物的条件下还原式（II）的异恶唑衍生物，，或至少获得外消旋形式的结构（III）的内酯或对映异构体富集的混合物，然后在碱性条件下，在非质子或质子溶剂中，所需的内酯和任选的，分离所需的形式。本发明可用于特别制备（2S，3R，4S）-4-羟基异亮氨酸

12. 发明申请

US20050020660A1 Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors 失效
标题翻译：奎宁环衍生物的制备方法及其作为m2和/或m3毒蕈碱受体抑制剂的用途
公开(公告)号：US20050020660A1
公开(公告)日：2005-01-27
申请号：US10490436
申请日：2002-09-23
申请人： Michel Guyaux , Chimmanamada Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Mateo Zanda
发明人： Michel Guyaux , Chimmanamada Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Mateo Zanda
IPC分类号： A61K31/439 , A61K31/444 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/02 , A61P25/20 , A61P25/28 , C07D453/02 , C07F7/10 , C07D487/02 , A61K31/407
CPC分类号： C07D453/02
摘要： The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention_show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
摘要翻译：本发明涉及式I或II的奎宁环衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。本发明的化合物对于m 3和/或m 2毒蕈碱受体具有高亲和力，并且特别适用于治疗尿失禁。

13. 发明申请

US20090024575A1 METHODS FOR SIMILARITY SEARCHING OF CHEMICAL REACTIONS 有权
标题翻译：化学反应相似性检索方法
公开(公告)号：US20090024575A1
公开(公告)日：2009-01-22
申请号：US11779255
申请日：2007-07-17
申请人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
发明人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
IPC分类号： G06F7/00
CPC分类号： G06F19/702 , G06F19/707 , G06F19/708
摘要： A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.
摘要翻译：用于鉴定多个反应中的至少一对相似化学反应的基于计算机的方法，每个反应各自与来自至少一种试剂的至少一种产物的制备有关可包括为每个反应产生涉及动态和常规键的结构表示，基于该结构表示，为每个反应生成包括动态键的预定长度的一组片段描述符和相应的描述符向量。该方法还可以包括计算多个反应的描述符向量之间的相似性指数，并比较相似性指数以识别至少一对相似的反应。

14. 发明授权

US07871822B2 Method of use for characterizing the catalytic reactivity of catalyst(s) 失效
标题翻译：用于表征催化剂的催化反应性的方法
公开(公告)号：US07871822B2
公开(公告)日：2011-01-18
申请号：US10587177
申请日：2005-01-28
申请人： Alain Wagner , Cédric Catala
发明人： Alain Wagner , Cédric Catala
IPC分类号： G01N31/10
CPC分类号： C40B40/18 , B01J31/0235 , B01J31/0237 , B01J31/2239 , B01J31/2404 , B01J31/26 , B01J2219/00738 , B01J2231/005 , B01J2231/4266 , B01J2531/16 , B01J2531/26 , B01J2531/30 , B01J2531/40 , B01J2531/80 , B01J2531/824 , C40B30/08 , Y10T436/21 , Y10T436/212 , Y10T436/214 , Y10T436/216 , Y10T436/24
摘要： A method for selecting at least one catalyst from a catalyst library on the basis of the reactivity thereof in a chemical conversion process includes: (a) testing the catalytic activity of a first catalyst from said catalyst library with respect to a reaction medium containing, as the compounds to be converted, at least one reactivity probe having a labeling system and including at least one reaction unit capable of reacting in said chemical conversion; (b) analyzing the reaction medium after said catalytic test for the purpose of qualitatively and/or qualitatively characterizing the resulting compounds; (c) repeating steps (a) and (b) for at least one other catalyst in said library; and (d) comparing the analysis results for each catalyst in order to characterize at least one catalyst having the required reactivity in said chemical conversion.
摘要翻译：基于化学转化方法的反应性，从催化剂文库中选择至少一种催化剂的方法包括：（a）测定第一催化剂从所述催化剂文库相对于反应介质的催化活性，所述反应介质含有待转化的化合物，至少一种具有标记系统的反应性探针，并且包括能够在所述化学转化中反应的至少一个反应单元; （b）在所述催化试验之后分析反应介质，以定性和/或定性地表征所得化合物; （c）对所述文库中的至少一种其它催化剂重复步骤（a）和（b）; 和（d）比较每种催化剂的分析结果，以便表征在所述化学转化中具有所需反应性的至少一种催化剂。

15. 发明申请

US20050058587A1 Heterogeneous catalyst consisting of an aggregate of metal-coated nanoparticles 审中-公开
标题翻译：由金属包覆的纳米颗粒的聚集体组成的非均相催化剂
公开(公告)号：US20050058587A1
公开(公告)日：2005-03-17
申请号：US10495872
申请日：2002-11-19
申请人： Alain Wagner
发明人： Alain Wagner
IPC分类号： B01J37/00 , B01J31/22 , B01J31/24 , B01J35/00 , B01J35/02 , C01B33/12
CPC分类号： B01J35/0013 , B01J35/023
摘要： The invention concerns mainly an aggregate of nanoparticles based on at least an inorganic material, functionalized at the surface with at least a metallic derivative, said functionalized nanoparticles being organized in said aggregate so as to form a three-dimensional porous structure comprising channels. The invention also concerns the use of said aggregate as heterogeneous catalyst.
摘要翻译：本发明主要涉及至少基于至少一种在至少一种金属衍生物的表面官能化的无机材料的纳米颗粒聚集体，所述官能化纳米颗粒被组织在所述聚集体中，从而形成包括通道的三维多孔结构。本发明还涉及所述骨料作为多相催化剂的用途。

16. 发明授权

US07991730B2 Methods for similarity searching of chemical reactions 有权
标题翻译：化学反应相似性检索方法
公开(公告)号：US07991730B2
公开(公告)日：2011-08-02
申请号：US11779255
申请日：2007-07-17
申请人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
发明人： Alain Wagner , Frank Hoonakker , Alexandre Varnek
IPC分类号： G06F17/30 , G06F7/00 , G06F19/00
CPC分类号： G06F19/702 , G06F19/707 , G06F19/708
摘要： A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.
摘要翻译：用于鉴定多个反应中的至少一对相似化学反应的基于计算机的方法，每个反应各自与来自至少一种试剂的至少一种产物的制备有关可包括为每个反应产生涉及动态和常规键的结构表示，基于该结构表示，为每个反应生成包括动态键的预定长度的一组片段描述符和相应的描述符向量。该方法还可以包括计算多个反应的描述符向量之间的相似性指数，并比较相似性指数以识别至少一对相似的反应。

17. 发明授权

US6142424A Method of steering a vehicle and vehicle allowing implementation of the method 失效
标题翻译：转向车辆和车辆的方法允许实施该方法
公开(公告)号：US6142424A
公开(公告)日：2000-11-07
申请号：US583481
申请日：1996-01-05
申请人： Alain Wagner
发明人： Alain Wagner
IPC分类号： B64G1/64 , F42B15/36 , B64G1/40
CPC分类号： F42B15/36 , B64G1/641
摘要： The invention relates to a method of steering a vehicle, as well as to said vehicle allowing the method to be implemented.The method of steering such a vehicle including a propulsion system (2) and a jettisonable nose cone (8) containing a payload is noteworthy, according to the invention, in that, during the trajectory of said vehicle, the propulsion thrust of said vehicle (1) is temporarily interrupted in order to allow said jettisonable nose cone (8) to be ejected.
摘要翻译：本发明涉及一种转向车辆的方法，以及允许该方法实施的所述车辆。值得注意的是，根据本发明，引导包括推进系统（2）和可喷射鼻锥（8）的这种车辆的方法是，在所述车辆的轨迹期间，所述车辆的推进推力（ 1）被暂时中断以便允许所述可喷射鼻锥（8）被弹出。

18. 发明申请

US20070161039A1 Method for creating a database enabling the selection of at least one reaction-capable catalyst 审中-公开
标题翻译：用于创建能够选择至少一种具有反应性的催化剂的数据库的方法
公开(公告)号：US20070161039A1
公开(公告)日：2007-07-12
申请号：US10587336
申请日：2005-01-28
申请人： Alain Wagner , Cedric Catala
发明人： Alain Wagner , Cedric Catala
IPC分类号： C40B30/02 , C40B40/04
CPC分类号： C40B30/08 , B01J2219/00702
摘要： The invention relates to a method for creating a database enabling, in particular, the selection of at least one reaction-capable catalyst, comprising the following steps: a) preparing a number of different reaction media containing the same reactivity probe and each having at least one catalyst; b) analyzing, by means of an analytic method, each reaction medium after reaction, and; c) assigning, in the database, an analysis result according to step b) to the reactivity probe, this result characterizing different reaction products obtained from said reactivity probe. The database is a relational database containing: a first entity in which items of information relative to the reaction patterns listed in the data base are recorded; a second entity containing items of information relative to the state of bindings of at least one reaction pattern listed in the first entity; a third entity in which items of information associated with different reaction media are stored, and; at least one fourth entity in which items of information are stored that are linked to the analysis results of the reaction media at the end of a reaction.
摘要翻译：本发明涉及一种用于创建数据库的方法，其特别是选择至少一种具有反应能力的催化剂，其包括以下步骤：a）制备包含相同反应性探针的多种不同的反应介质，一种催化剂; b）通过分析方法分析反应后各反应介质; c）在数据库中将根据步骤b）的分析结果分配给反应性探针，该结果表征从所述反应性探针获得的不同反应产物。数据库是一个关系数据库，它包含：第一个实体，其中记录了相对于数据库中列出的反应模式的信息项; 第二实体，其包含相对于在第一实体中列出的至少一个反应模式的绑定状态的信息项; 存储与不同反应介质相关联的信息项目的第三实体; 至少一个第四实体，其中在反应结束时存储与反应介质的分析结果相关联的信息项。

19. 发明授权

US06182928B2 Method for placing an artificial satellite on a geostationary orbit 失效
标题翻译：将人造卫星放置在地球静止轨道上的方法
公开(公告)号：US06182928B2
公开(公告)日：2001-02-06
申请号：US09297180
申请日：1999-04-27
申请人： Alain Wagner
发明人： Alain Wagner
IPC分类号： B64G110
CPC分类号： B64G1/242 , B64G1/007 , B64G1/24
摘要： The invention concerns a method for placing an artificial satellite on a geostationary orbit injected on said orbit by a launch vehicle. The method is characterised in that the assembly consisting of the last stage (L) of said launch vehicle and satellite (S) be injected on the geostationary orbit (G) is first directly sent on a circular orbit (C), called extinction orbit, near the geostationary orbit, but sufficiently distant therefrom to avoid possible interferene with space objects already on the geostationary orbit (G), the satellite (S) is separated from said last stage (L), which stays on said extinction orbit (C), and the satellite (S) reaches the geostationary orbit (G) from said extinction orbit (C).
摘要翻译：本发明涉及一种将人造卫星放置在由运载火箭在所述轨道上注入的地球静止轨道上的方法。该方法的特征在于，由所述运载火箭的最后一级（L）和卫星（S）组成的组件被注入对地静止轨道（G）首先被直接发送在被称为消光轨道的圆形轨道（C）上，在距地球静止轨道近的地方，但距离地球静止轨道足够远，以避免与已经在地球静止轨道（G）上的空间物体的可能干扰，卫星（S）与停留在所述消光轨道（C）上的最后一级（L）分离，卫星（S）从所述灭绝轨道（C）到达地球静止轨道（G）。

20. 发明申请

US20070161038A1 Method of use for characterizing the catalytic reactivity of catalyst(s) 失效
标题翻译：用于表征催化剂的催化反应性的方法
公开(公告)号：US20070161038A1
公开(公告)日：2007-07-12
申请号：US10587177
申请日：2005-01-28
申请人： Alain Wagner , Cedric Catala
发明人： Alain Wagner , Cedric Catala
IPC分类号： C40B40/04
CPC分类号： C40B40/18 , B01J31/0235 , B01J31/0237 , B01J31/2239 , B01J31/2404 , B01J31/26 , B01J2219/00738 , B01J2231/005 , B01J2231/4266 , B01J2531/16 , B01J2531/26 , B01J2531/30 , B01J2531/40 , B01J2531/80 , B01J2531/824 , C40B30/08 , Y10T436/21 , Y10T436/212 , Y10T436/214 , Y10T436/216 , Y10T436/24
摘要： A method for selecting at least one catalyst from a catalyst library on the basis of the reactivity thereof in a chemical conversion process includes: (a) testing the catalytic activity of a first catalyst from said catalyst library with respect to a reaction medium containing, as the compounds to be converted, at least one reactivity probe having a labeling system and including at least one reaction unit capable of reacting in said chemical conversion; (b) analyzing the reaction medium after said catalytic test for the purpose of qualitatively and/or qualitatively characterizing the resulting compounds; (c) repeating steps (a) and (b) for at least one other catalyst in said library; and (d) comparing the analysis results for each catalyst in order to characterize at least one catalyst having the required reactivity in said chemical conversion.
摘要翻译：基于化学转化方法的反应性，从催化剂文库中选择至少一种催化剂的方法包括：（a）测定第一催化剂从所述催化剂文库相对于反应介质的催化活性，所述反应介质含有待转化的化合物，至少一种具有标记系统的反应性探针，并且包括能够在所述化学转化中反应的至少一个反应单元; （b）在所述催化试验之后分析反应介质，以定性和/或定性地表征所得化合物; （c）对所述文库中的至少一种其它催化剂重复步骤（a）和（b）; 和（d）比较每种催化剂的分析结果，以便表征在所述化学转化中具有所需反应性的至少一种催化剂。

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