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11. 发明授权

US07085351B2 Method and apparatus for controlling electron beam current 有权
公开(公告)号：US07085351B2
公开(公告)日：2006-08-01
申请号：US10358160
申请日：2003-02-05
申请人： Jianping Lu , Otto Zhou , Yuan Cheng
发明人： Jianping Lu , Otto Zhou , Yuan Cheng
IPC分类号： H01J35/32
CPC分类号： H01J35/06 , A61B6/032 , A61B6/4021 , A61B6/4028 , A61B6/405 , A61B6/4488 , A61B6/482 , B82Y10/00 , H01J3/021 , H01J35/065 , H01J35/08 , H01J35/105 , H01J35/14 , H01J35/22 , H01J35/28 , H01J35/30 , H01J2201/30469 , H01J2235/06 , H01J2235/062 , H01J2235/064 , H01J2235/068 , H05G1/34
摘要： An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.

12. 发明申请

US20050236443A1 Multifunction pouring spout and removable lid 有权
标题翻译：多功能倾倒口和可拆卸盖
公开(公告)号：US20050236443A1
公开(公告)日：2005-10-27
申请号：US10830275
申请日：2004-04-22
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B44D3/12 , B65D5/72
CPC分类号： B44D3/128 , B44D3/127
摘要： An inventive pouring spout for containers of liquid, having a removable lid and a strip with magnets located thereon. The spout is selectively attachable and is fitted to the diameter of an opening of a particular container. In a preferred embodiment, the spout is fitted to the diameter of a paint can opening, where it may replace the typical lid of a paint can for the duration of its use. Essentially, the spout effectively prevents the entry of paint in the sealing groove of the paint can or on the sides of the can.
摘要翻译：一种用于液体容器的创新性倾倒嘴，其具有可移除的盖和位于其上的磁体的带。喷嘴可选择性地附接并且被安装到特定容器的开口的直径上。在一个优选实施例中，喷嘴适合于油漆罐开口的直径，其中可以在其使用期间替换油漆罐的典型盖。基本上，喷口有效地防止油漆在油漆罐的密封槽或罐的侧面上的进入。

13. 发明申请

US20050156290A1 Concealable chip leadframe unit structure 失效
标题翻译：可控芯片引线框单元结构
公开(公告)号：US20050156290A1
公开(公告)日：2005-07-21
申请号：US10959207
申请日：2004-10-07
申请人： Jeffrey Lien , Yuan Cheng
发明人： Jeffrey Lien , Yuan Cheng
IPC分类号： H01L21/58 , H01L23/31 , H01L23/495
CPC分类号： H01L23/49551 , H01L23/3114 , H01L23/4951 , H01L24/48 , H01L24/49 , H01L2224/32245 , H01L2224/451 , H01L2224/48091 , H01L2224/4826 , H01L2224/49171 , H01L2224/73215 , H01L2924/00014 , H01L2924/00 , H01L2924/00015 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A concealable chip leadframe unit structure is disclosed which is made up of multiple lead units arranged in order, each lead in the lead unit is formed by pressing and comprising of a piece body with upper placement plane, the lower surface of the piece body is pressed to form at least an inner conducting plane which can be connected to the chip, and at least one protruding bump is formed adjacent to the inner conducting plane, the end surface of the protruding bump is used as an out-conducting plane to be connected to outside; in this structure, chip can be attached to the upper placement plane of the lead structure, and the inner conducting plane can be connected to the chip through metallic wire.
摘要翻译：公开了一种可隐藏的芯片引线框单元结构，其由依次布置的多个引线单元构成，引线单元中的每个引线通过压制形成，并且包括具有上放置平面的片体，片体的下表面被按压至少形成能够连接到芯片的内部导电平面，并且与内部导电平面相邻地形成至少一个突出凸块，突出凸起的端面用作与外部导电平面连接的导电平面外; 在该结构中，芯片可以安装在引线结构的上部放置平面上，并且内部导电平面可以通过金属线连接到芯片。

14. 发明授权

US09552955B2 Electron source 有权
标题翻译：电子源
公开(公告)号：US09552955B2
公开(公告)日：2017-01-24
申请号：US13291080
申请日：2011-11-07
申请人： Moritz Beckmann , Walter Beyerlein , Andreas Böhme , Yuan Cheng , Jens Fürst , Markus Hemmerlein , Houman Jafari , Jürgen Oelschlegel , Qi Qiu , Frank Sprenger
发明人： Moritz Beckmann , Walter Beyerlein , Andreas Böhme , Yuan Cheng , Jens Fürst , Markus Hemmerlein , Houman Jafari , Jürgen Oelschlegel , Qi Qiu , Frank Sprenger
IPC分类号： H05B41/36 , H01J35/06 , H01J3/02 , H05G1/26 , H05G1/32 , H05G1/48 , H05G1/58 , H05G1/70
CPC分类号： H01J35/065 , H01J3/021 , H01J2235/068 , H05G1/265 , H05G1/32 , H05G1/48 , H05G1/58 , H05G1/70
摘要： An electron source includes a plurality of electron emission cathodes and at least one control electrode. A gate current regulator is provided for regulation of current flowing through the at least one control electrode.
摘要翻译：电子源包括多个电子发射阴极和至少一个控制电极。提供了栅极电流调节器，用于调节流经至少一个控制电极的电流。

15. 发明授权

US08497264B2 Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use 有权
公开(公告)号：US08497264B2
公开(公告)日：2013-07-30
申请号：US13047693
申请日：2011-03-14
申请人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
发明人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
IPC分类号： C07D513/10 , C07D498/20 , A61K31/547 , A61K31/5386
CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

16. 发明申请

US20130018064A1 Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use 有权
标题翻译：氨基杂芳基化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US20130018064A1
公开(公告)日：2013-01-17
申请号：US13511360
申请日：2010-11-19
申请人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
发明人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
IPC分类号： A61K31/506 , A61P25/28 , A61K31/4709 , C07D401/08 , C07D401/06
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

17. 发明授权

US08155262B2 Methods, systems, and computer program products for multiplexing computed tomography 有权
标题翻译：用于复用计算机断层扫描的方法，系统和计算机程序产品
公开(公告)号：US08155262B2
公开(公告)日：2012-04-10
申请号：US11526217
申请日：2006-09-22
申请人： Otto Z. Zhou , Jianping Lu , Jian Zhang , Guang Yang , Yueh Lee , Qi Qiu , Yuan Cheng
发明人： Otto Z. Zhou , Jianping Lu , Jian Zhang , Guang Yang , Yueh Lee , Qi Qiu , Yuan Cheng
IPC分类号： A61B6/03
CPC分类号： G01N23/04 , G01N2223/204 , G01N2223/419
摘要： Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object with a plurality of x-ray beams from a plurality of viewing angles, wherein each x-ray beam has a distinct waveform; detecting the x-ray intensities of the plurality of pulsed x-ray beams as a function of time, and extracting individual projection image data from the detected x-ray intensities based on the distinct waveforms of the x-ray beams for combining the projection image data to generate three-dimensional tomographic image data of the object.
摘要翻译：公开了用于复用计算机断层摄影的方法，系统和计算机程序产品。根据一个方面，本文描述的主题可以包括用多个视角对多个X射线束照射物体，其中每个X射线束具有不同的波形; 检测作为时间的函数的多个脉冲X射线束的x射线强度，并且基于用于组合投影图像的x射线束的不同波形从检测到的x射线强度中提取各个投影图像数据数据以产生对象的三维断层图像数据。

18. 发明申请

US20110118250A1 BETA-SECRETASE MODULATORS AND METHODS OF USE 有权
标题翻译： BETA-SECRETASE调制器和使用方法
公开(公告)号：US20110118250A1
公开(公告)日：2011-05-19
申请号：US12909566
申请日：2010-10-21
申请人： Brian K. Albrecht , Denise Lyn Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart C. Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod F. Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang , Wenge Zhong
发明人： Brian K. Albrecht , Denise Lyn Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart C. Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod F. Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang , Wenge Zhong
IPC分类号： A61K31/538 , C07D405/12 , A61K31/4433 , A61K31/444 , C07D405/14 , A61K31/4439 , A61K31/506 , A61K31/497 , C07D413/12 , A61K31/5377 , A61K31/4178 , A61K31/4545 , A61K31/453 , C07D311/96 , A61K31/352 , C07D407/12 , A61K31/4709 , C07D401/12 , C07D409/12 , A61K31/422 , A61K31/4025 , C07D471/04 , A61K31/501 , A61P25/28 , A61P25/00 , A61P25/16
CPC分类号： C07D405/12 , C07D413/12
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j在本文中定义。本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

19. 发明授权

US07652009B2 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US07652009B2
公开(公告)日：2010-01-26
申请号：US11289659
申请日：2005-11-29
申请人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron C. Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
发明人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron C. Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
IPC分类号： A61K31/506 , C07D401/02 , C07D239/22
CPC分类号： C07D401/14 , C07D215/233 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

20. 发明申请

US20090157741A1 DATA OBJECT COPY/PASTE TRANSFER METHOD AND APPARATUS 审中-公开
标题翻译：数据对象复制/浆料转移方法和装置
公开(公告)号：US20090157741A1
公开(公告)日：2009-06-18
申请号：US12332667
申请日：2008-12-11
申请人： Yuan Cheng , Yue Ma , Min Qu , Hai F. Zhang
发明人： Yuan Cheng , Yue Ma , Min Qu , Hai F. Zhang
IPC分类号： G06F17/30
CPC分类号： G06F9/543
摘要： The present invention provides a solution of transferring a data object between files through copy/paste, in which not only the filtered data object which is adapted to the format and/or function of a destination file is explicitly written to the destination file, but also the original data object information is implicitly written to the destination file, and the map relationship between them is established, so that the whole original information of the transferred data object is reserved during the transfer between files. In subsequent copy/paste operations, the user may choose to use the original data object corresponding to the data object in the transfer of the data object or not based on the actual situation and particular needs, so that the problem of information loss in the process of transferring a data object between files through copy/paste operation is solved effectively.
摘要翻译：本发明提供了通过复制/粘贴在文件之间传送数据对象的解决方案，其中不仅将适用于目的地文件的格式和/或功能的经过滤的数据对象明确地写入目的地文件，而且将原始数据对象信息隐含地写入到目的地文件中，并且建立它们之间的映射关系，使得在文件之间传送期间预留所传送的数据对象的整个原始信息。在随后的复制/粘贴操作中，用户可以根据实际情况和特殊需要，选择使用与数据对象相对应的原始数据对象进行数据对象的传送，从而使流程中的信息丢失问题通过复制/粘贴操作在文件之间传输数据对象得到有效解决。

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