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11. 发明授权

US08552168B2 Nucleic acids for inducing expression of transcripts and proteins and methods for making and using them 有权
标题翻译：用于诱导转录物和蛋白质表达的核酸及其制备和使用方法
公开(公告)号：US08552168B2
公开(公告)日：2013-10-08
申请号：US12599577
申请日：2008-05-08
申请人： Steven P. Briggs , Kiyoshi Tachikawa
发明人： Steven P. Briggs , Kiyoshi Tachikawa
IPC分类号： C07H21/04 , C12N15/00 , C12N15/82 , C12N15/74 , C12N1/20 , C12N1/00 , C12N1/12 , C12P21/06
CPC分类号： C12N15/8216 , C12N15/63 , C12N15/70 , C12N2800/101 , C12N2830/00
摘要： The invention provides nucleic acids and polypeptides for enhanced expression of nucleic acids and proteins. In one aspect, the sequences serve as transcription and translation enhancers or stabilizers, and can be incorporated in expression constructs at or near the translation control elements. The invention provides methods of producing mRNA (transcripts) and proteins. The invention provides methods of discovering new enhancer elements.
摘要翻译：本发明提供用于增强核酸和蛋白质表达的核酸和多肽。在一个方面，该序列用作转录和翻译增强子或稳定剂，并且可以并入翻译控制元件中或其附近的表达构建体中。本发明提供了产生mRNA（转录物）和蛋白质的方法。本发明提供了发现新的增强子元件的方法。

12. 发明授权

US07071307B2 Nucleic acids and proteins with thioredoxin reductase activity 失效
公开(公告)号：US07071307B2
公开(公告)日：2006-07-04
申请号：US10141531
申请日：2002-05-06
申请人： Bipin K. Dalmia , Steven P. Briggs , Greg del Val , John R. Desjarlais , Peter Heifetz , Peter Luginbuhl , Umesh Muchhal
发明人： Bipin K. Dalmia , Steven P. Briggs , Greg del Val , John R. Desjarlais , Peter Heifetz , Peter Luginbuhl , Umesh Muchhal
IPC分类号： C07K1/00
CPC分类号： C12N9/0036 , C07K2319/00 , C12N15/8242 , C12N15/8257 , C12Y108/01009 , Y02A90/26
摘要： The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.

13. 发明授权

US06287843B1 Maize histone deacetylases and their use 有权
标题翻译：玉米组蛋白脱乙酰酶及其用途
公开(公告)号：US06287843B1
公开(公告)日：2001-09-11
申请号：US09282305
申请日：1999-03-31
申请人： Donald Adelphi Baldwin , Steven P. Briggs , Virginia C. Crane
发明人： Donald Adelphi Baldwin , Steven P. Briggs , Virginia C. Crane
IPC分类号： C12N120
CPC分类号： C12N15/8279 , C12N9/16 , C12N15/8216
摘要： Histone deacetylases and nucleotide sequences encoding said histone deacetylases are provided. The sequences as well as corresponding antisense constructs are useful for modulating gene activity in plants. Additionally, the sequences are useful for enhancing disease resistance in transformed plants.
摘要翻译：提供组蛋白脱乙酰酶和编码所述组蛋白脱乙酰酶的核苷酸序列。序列以及相应的反义构建体可用于调节植物中的基因活性。此外，该序列可用于增强转化植物中的抗病性。

14. 发明授权

US5853991A PCR-based cDNA subtractive cloning method 失效
公开(公告)号：US5853991A
公开(公告)日：1998-12-29
申请号：US863028
申请日：1997-05-23
申请人： Xun Wang , Jonathan P. Duvick , Steven P. Briggs
发明人： Xun Wang , Jonathan P. Duvick , Steven P. Briggs
IPC分类号： C07K14/415 , C12N15/10 , C12Q1/68 , C07H21/04 , C12N15/00 , C12P19/34
CPC分类号： C12Q1/6809 , C07K14/415 , C12N15/1096
摘要： A process is described in which PCR-based cDNA libraries with anchored ends are made, a PCR-based cDNA subtracted (PCSUB) library is produced therefrom, and the ends of a cDNA clone are isolated, via PCR, from an anchored-ends library.

15. 发明授权

US06479629B2 Maize histone deacetylases and their use 有权
标题翻译：玉米组蛋白脱乙酰酶及其用途
公开(公告)号：US06479629B2
公开(公告)日：2002-11-12
申请号：US09883720
申请日：2001-06-18
申请人： Donald Adelphi Baldwin , Steven P. Briggs , Virginia C. Crane
发明人： Donald Adelphi Baldwin , Steven P. Briggs , Virginia C. Crane
IPC分类号： A61K3800
CPC分类号： C12N15/8279 , C12N9/16 , C12N15/8216
摘要： Histone deacetylases and nucleotide sequences encoding said histone deacetylases are provided. The sequences as well as corresponding antisense constructs are useful for modulating gene activity in plants. Additionally, the sequences are useful for enhancing disease resistance in transformed plants.
摘要翻译：提供组蛋白脱乙酰酶和编码所述组蛋白脱乙酰酶的核苷酸序列。序列以及相应的反义构建体可用于调节植物中的基因活性。此外，该序列可用于增强转化植物中的抗病性。

16. 发明授权

US06455297B1 Methods and compositions for regulating cell death and enhancing disease resistance to plant pathogens 有权
标题翻译：用于调节细胞死亡并增强对植物病原体的抗病性的方法和组合物
公开(公告)号：US06455297B1
公开(公告)日：2002-09-24
申请号：US09923654
申请日：2001-08-07
申请人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
发明人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
IPC分类号： C12N988
CPC分类号： C12N15/8261 , C12N9/88 , C12N15/8242 , C12N15/8243 , C12N15/8263 , C12N15/8282 , C12N15/8289 , Y02A40/146
摘要： Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking said antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.
摘要翻译：提供了用于提高植物中对病原体的抗病性的组合物和方法。本发明的方法包括用编码C-5卟啉代谢途径中的酶的基因的反义核苷酸序列稳定转化植物，并将所述反义序列可操作地连接到病原体诱导型启动子，使得病原体侵入细胞引起过敏反应，导致病原体与初始接触细胞的限制。提供了转化的植物和种子。提供了编码本发明中有用的野生型玉米urod基因的核苷酸序列和由此编码的蛋白质的氨基酸序列。这些组合物也可用于调节特异性靶向组织中的细胞死亡。还提供了玉米病变模拟物，显性突变体表型，命名为Les22，以及其表现的分子基础。

17. 发明授权

US06211437B1 Nucleic acids from maize encoding proteins which suppress plant cell death 失效
标题翻译：来自玉米编码蛋白质的核酸抑制植物细胞死亡
公开(公告)号：US06211437B1
公开(公告)日：2001-04-03
申请号：US08810009
申请日：1997-03-04
申请人： Steven P. Briggs , Gurmukh S. Johal , John Gray
发明人： Steven P. Briggs , Gurmukh S. Johal , John Gray
IPC分类号： A01H500
CPC分类号： C12N9/0071 , C12N15/8207 , C12N15/8282 , C12N15/8289
摘要： The present invention is drawn to genes from maize encoding proteins which suppress plant cell death and methods of plant transformation therewith.
摘要翻译：本发明涉及抑制植物细胞死亡的玉米编码蛋白质的基因及其植物转化方法。

18. 发明申请

US20110318830A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING AND RE-DIFFERENTIATING CELLS 审中-公开
标题翻译：用于重新编程和重新分化细胞的组合物和方法
公开(公告)号：US20110318830A1
公开(公告)日：2011-12-29
申请号：US13126703
申请日：2009-11-12
申请人： Steven P. Briggs , Kiyoshi Tackihawa , Robert O'brien
发明人： Steven P. Briggs , Kiyoshi Tackihawa , Robert O'brien
IPC分类号： C12N5/071 , C07K14/00 , C07H21/04
CPC分类号： C07K14/4702 , C12N2506/00
摘要： The invention provides compositions and in vitro and ex vivo methods for de-differentiating or re-programming mammalian cells. In alternative embodiments, the invention provides compositions comprising mixtures of Designed Regulatory Proteins (DRPs) or Reprogramming DRP protein (ReD) for de-differentiating or re-programming mammalian cells. The invention also provides compositions and methods for direct reprogramming of a first differentiated phenotype of a cell to a second differentiated phenotype.
摘要翻译：本发明提供用于解离或重新编程哺乳动物细胞的组合物和体外和离体方法。在替代实施方案中，本发明提供包含用于解离或重新编程哺乳动物细胞的设计调节蛋白（DRP）或重编程DRP蛋白（ReD）的混合物的组合物。本发明还提供用于将细胞的第一分化表型直接重编程为第二分化表型的组合物和方法。

19. 发明申请

US20100306880A1 NUCLEIC ACIDS FOR INDUCING EXPRESSION OF TRANSCRIPTS AND PROTEINS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：用于诱导转录和蛋白质表达的核酸及其制备和使用它们的方法
公开(公告)号：US20100306880A1
公开(公告)日：2010-12-02
申请号：US12599577
申请日：2008-05-08
申请人： Steven P. Briggs , Kiyoshi Tachikawa
发明人： Steven P. Briggs , Kiyoshi Tachikawa
IPC分类号： A01H13/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C07K7/06 , C12P21/02 , C12N9/00
CPC分类号： C12N15/8216 , C12N15/63 , C12N15/70 , C12N2800/101 , C12N2830/00
摘要： The invention provides nucleic acids and polypeptides for enhanced expression of nucleic acids and proteins. In one aspect, the sequences serve as transcription and translation enhancers or stabilizers, and can be incorporated in expression constructs at or near the translation control elements. The invention provides methods of producing mRNA (transcripts) and proteins. The invention provides methods of discovering new enhancer elements.
摘要翻译：本发明提供用于增强核酸和蛋白质表达的核酸和多肽。在一个方面，该序列用作转录和翻译增强子或稳定剂，并且可以并入翻译控制元件中或附近的表达构建体中。本发明提供了产生mRNA（转录物）和蛋白质的方法。本发明提供了发现新的增强子元件的方法。

20. 发明授权

US07612256B2 Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifying growth in plants transformed therewith 有权
标题翻译：编码玉米的Br2P-糖蛋白的分离的核酸分子以及用其转化的植物中改变生长的方法
公开(公告)号：US07612256B2
公开(公告)日：2009-11-03
申请号：US11338356
申请日：2006-01-24
申请人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
发明人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
IPC分类号： C12N15/82 , C12N15/29 , A01H5/00 , A01H5/10
CPC分类号： C07K14/415 , C12N15/8261 , Y02A40/146
摘要： The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modifying the growth of plants.
摘要翻译：本发明涉及植物的遗传修饰，特别涉及转化植物中P-糖蛋白基因的表达。提供了编码玉米P-糖蛋白的Br2基因的核苷酸序列及其使用方法。这些序列用于修饰植物的生长。

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