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11. 发明申请

US20100160290A1 PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US20100160290A1
公开(公告)日：2010-06-24
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/554 , C07D417/02 , A61K31/541 , C07D279/06 , C07D277/18 , A61K31/426 , C07D239/02 , A61K31/506 , C07D281/02 , A61P25/28
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

12. 发明授权

US4721703A Sublimation transfer system color hard copy printing paper 失效
标题翻译：升华转印系统彩色硬拷贝打印纸
公开(公告)号：US4721703A
公开(公告)日：1988-01-26
申请号：US589090
申请日：1984-02-07
申请人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
IPC分类号： B41M5/382 , B41M5/50 , B41M5/52 , B41M5/26
CPC分类号： B41M5/5254 , Y10S428/913 , Y10S428/914 , Y10T428/31511 , Y10T428/31739 , Y10T428/3179 , Y10T428/31982 , Y10T428/31986 , Y10T428/31993
摘要： The present invention relates to a sublimation transfer system color hard copy printing paper particularly to prevent effectively the printing paper from being adhered by melt with a dye carrier ribbon when a color hard copying is carried out, transfer dye satisfactorily and present excellent color. To this end, the sublimation transfer system color hard copy printing paper of the present invention has formed, on the surface of a base material, a layer formed of thermo-plastic resin having a transferring property relative to a dispersing dye and a compound having two or more radically polymerizable unsaturated double bonds in one molecule and the sublimation dye is transferred on this resin layer to thereby present color.
摘要翻译： PCT No.PCT / JP83 / 00184 Sec。 371日期1984年2月7日 102（e）日期1984年2月7日PCT Filed June 6，1983 PCT Pub。公开号WO83 / 04395 日本1983年12月22日。本发明涉及一种升华转印系统彩色硬拷贝印刷纸，特别是当进行彩色硬拷贝时，有效地防止印刷纸与染料载体带熔融粘合，令人满意地转印染料并呈现优异的色彩。为此，本发明的升华转印系统彩色硬拷贝印刷纸在基材的表面上形成了由相对于分散染料具有转印性的热塑性树脂形成的层和具有两个或更多的可自由基聚合的不饱和双键，并且升华染料转移到该树脂层上，从而呈现出颜色。

13. 发明授权

US4668560A Sublimation transfer type color hard-copy printing paper 失效
标题翻译：升华转印型彩色复印纸
公开(公告)号：US4668560A
公开(公告)日：1987-05-26
申请号：US802993
申请日：1985-11-29
申请人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
IPC分类号： B41M5/382 , B41M5/392 , B41M5/50 , B41M5/52 , B41M5/26
CPC分类号： B41M5/5218 , Y10S428/913 , Y10S428/914 , Y10S430/146 , Y10T428/24802 , Y10T428/31511 , Y10T428/31739 , Y10T428/31783 , Y10T428/31786 , Y10T428/3179 , Y10T428/31986
摘要： The present invention relates to a sublimation transfer system color hard-copy printing paper and its object is to present an optimum coloring when the color hard-copying according to the subtractive color mixing process is carried out. To this end, the sublimation transfer system color hard-copy printing paper according to the present invention is provided at least on its surface with a resin layer containing a metal compound selected from Al, Mg, Ca and Sn wherein the sublimation dye is transferred and then colored on this resin layer.
摘要翻译：本发明涉及一种升华转印系统彩色硬拷贝印刷纸，其目的是在进行根据减色混合处理的彩色硬拷贝时呈现最佳着色。为此，根据本发明的升华转印系统彩色硬拷贝打印纸至少在其表面上提供含有选自Al，Mg，Ca和Sn的金属化合物的树脂层，其中升华染料被转移，然后在该树脂层上着色。

14. 发明授权

US4522881A Cover film for color hard copy printing paper 失效
标题翻译：彩色复印纸盖纸
公开(公告)号：US4522881A
公开(公告)日：1985-06-11
申请号：US552037
申请日：1983-10-31
申请人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Yoshio Fujiwara
IPC分类号： G03C11/08 , B41M5/34 , B41M5/382 , B41M5/46 , B41M7/00 , G03C11/10 , B41M5/26
CPC分类号： B41M5/46 , B41M7/0027 , G03C11/10 , B41M5/345 , Y10S428/913 , Y10S428/914 , Y10S430/162 , Y10T428/265 , Y10T428/31786 , Y10T428/3179 , Y10T428/31906 , Y10T428/31935 , Y10T428/31993
摘要： The present invention relates to a cover film for a color hard copy printing paper by which a colorless and transparent protective layer can be formed on a surface of a printing paper on which a color-print is made. The cover film for a color hard copy printing paper according to the present invention comprises a heat-resistant base and a cover material layer including a colorless and transparent ultraviolet ray shielding layer which is formed on the heat-resistant base, has no adhesive property for the heat-resistant base and is melted and transferred to a surface of a printing paper by heating. According to the cover film for a color hard copy printing paper, it is possible to form with ease a protective layer having small curl and high color fading protection property on a surface of a color-copied printing paper.
摘要翻译： PCT No.PCT / JP83 / 00064 Sec。 371日期：1983年10月31日 102（e）日期1983年10月31日PCT提交1983年3月1日PCT公布。出版物WO83 / 03080 1983年9月15日。本发明涉及一种用于彩色硬拷贝印刷纸的覆盖膜，通过该覆盖膜可以在其上形成彩色印刷品的印刷纸的表面上形成无色透明的保护层。根据本发明的彩色硬拷贝打印纸的覆盖膜包括耐热基底和覆盖材料层，该覆盖材料层包括形成在耐热基底上的无色透明的紫外线屏蔽层，对于耐热基底并通过加热熔化并转印到打印纸的表面上。根据用于彩色复印打印纸的覆盖膜，可以在彩色复印的打印纸的表面上容易地形成具有小卷曲和高褪色保护性能的保护层。

15. 发明申请

US20150246938A1 NOVEL OLEFIN DERIVATIVE 审中-公开
标题翻译：新奥尔芬衍生物
公开(公告)号：US20150246938A1
公开(公告)日：2015-09-03
申请号：US14343992
申请日：2012-09-07
申请人： Akira Matsumura , Naotake Kobayashi , Yuji Nishiura , Sachie Tagashira , Shiro Kida , Kana Kurahashi , Mitsuhiro Yonehara
发明人： Akira Matsumura , Naotake Kobayashi , Yuji Nishiura , Sachie Tagashira , Shiro Kida , Kana Kurahashi , Mitsuhiro Yonehara
IPC分类号： C07F7/18 , C07D213/643 , C07D401/12 , C07D417/04 , C07D213/40 , C07D401/06 , C07D239/34 , C07D237/14 , C07D277/34 , C07D213/69
CPC分类号： C07F7/1804 , A61K9/1623 , A61K9/2018 , A61K9/4858 , C07C217/62 , C07C233/18 , C07C271/16 , C07C271/22 , C07C275/64 , C07D213/40 , C07D213/643 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/80 , C07D213/81 , C07D213/84 , C07D231/12 , C07D231/18 , C07D231/20 , C07D233/70 , C07D237/14 , C07D239/34 , C07D261/12 , C07D277/34 , C07D285/06 , C07D309/10 , C07D309/12 , C07D319/06 , C07D333/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07F7/0812
摘要： The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound.A compound of formula (I′): wherein R1 is substituted or unsubstituted aryl etc., R2 is each independently hydrogen, substituted or unsubstituted alkyl etc., R3 is each independently hydrogen, substituted or unsubstituted alkyl etc., n is an integer from 0 to 3, R12 is hydrogen, substituted or unsubstituted alkyl etc., Ring A is aromatic carbocycle or aromatic heterocycle, R9 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., m is an integer from 0 to 4, R4 and R5 is each independently hydrogen, substituted or unsubstituted alkyl etc., R6 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., R13 is hydrogen, substituted or unsubstituted alkyl etc., X5 is bond etc., R7 is hydrogen or substituted or unsubstituted alkyl, R8 is substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl etc.
摘要翻译：本发明的目的是提供具有ACC2抑制活性的新化合物。此外，本发明的目的是提供一种包含该化合物的药物组合物。式（I'）的化合物：其中R 1为取代或未取代的芳基等，R 2各自独立地为氢，取代或未取代的烷基等，R 3各自独立地为氢，取代或未取代的烷基等，n为 0〜3，R 12为氢，取代或未取代的烷基等，环A为芳香族碳环或芳香族杂环，R9为取代或未取代的烷基，取代或未取代的链烯基等，m为0〜4的整数，R4和R5 各自独立地为氢，取代或未取代的烷基等，R 6为取代或未取代的烷基，取代或未取代的烯基等，R 13为氢，取代或未取代的烷基等，X 5为键等，R 7为氢或取代或未取代的烷基，R8是取代或未取代的烷基羰基，取代或未取代的烯基羰基等

16. 发明授权

US08633188B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08633188B2
公开(公告)日：2014-01-21
申请号：US13243874
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/535 , A61K31/541 , C07D279/00 , C07D265/00
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

17. 发明授权

US08173642B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08173642B2
公开(公告)日：2012-05-08
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

18. 发明申请

US20090082560A1 AMINODIHYDROTHIAZINE DERIVATIVES 有权
标题翻译：氨基酸衍生物
公开(公告)号：US20090082560A1
公开(公告)日：2009-03-26
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D267/06 , C07D417/12 , C07D279/06 , C07D277/18
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

19. 发明授权

US4241198A Releasing agent 失效
标题翻译：卸货代理
公开(公告)号：US4241198A
公开(公告)日：1980-12-23
申请号：US973419
申请日：1978-12-26
申请人： Naotake Kobayashi
发明人： Naotake Kobayashi
IPC分类号： C10M169/04 , C08F8/00 , C08F8/42 , C09J7/02 , C10N40/36 , C10N50/08 , C08F26/12 , C08C19/42 , C08F220/18
CPC分类号： C09J7/0228 , C08F8/42 , C09J2433/005 , Y10T428/1443 , Y10T428/1452 , Y10T428/2839 , Y10T442/2754
摘要： A releasing agent containing:(A) a copolymer which is produced by copolymerization of:(a) a monomer mixture comprising 70 to 40 percent by weight (hereafter represented by "wt. %") stearyl acrylate and/or stearyl methacrylate and 30 to 60 wt. % acrylonitrile; and(b) an ethylenically unsaturated compound being copolymerizable with the monomer mixture and having functional groups reactive with metal alcoholate, the ethylenically unsaturated compound being used in an amount of 0.5 to 30 part by weight (hereafter represented by "wt.part") per 100 wt. part of the monomer mixture; and(B) a metal alcoholate being represented by the following general formula: ##STR1## wherein R is a hydrocarbon group having 1 to 20 carbon atoms or this hydrocarbon group further having oxygen atom, nitrogen atom, sulfur atom or halogen atom, including the case R being identical or not identical with each other in the general formula and R being combined with each other, n is an integer from 1 to 4, m is an integer from zero to 10, and M is a metal element belonging to III, IV and V groups of the periodic table. Another releasing agent containing a copolymer of the above monomer mixture, the above ethylenically unsaturated compound and further at least one monomer being selected from the group consisting of cyclohexyl group-containing ethylenically unsaturated compound in an amount of 2 to 30 wt.part per 100 wt.part of the monomer mixture, and imidazole compound with ethylenically unsaturated group in an amount of 0.5 to 15 wt.part per 100 wt. part of the monomer mixture, wherein the functional groups in the copolymerizable compound monomer are also at least partially cross-linked with the above metal alcoholate.
摘要翻译：一种脱模剂，其含有：（A）共聚物，其通过以下方式共聚制备：（a）单体混合物，其包含70〜40重量％（以下，以重量％表示），丙烯酸硬脂基酯和/或甲基丙烯酸硬脂酯，30〜 60重量％％丙烯腈; 和（b）可与单体混合物共聚并具有与金属醇化物反应的官能团的烯属不饱和化合物，烯属不饱和化合物的用量为0.5〜30重量份（以下以“wt.part”表示） 100重量部分单体混合物; 和（B）金属醇盐由以下通式表示：其中R是具有1至20个碳原子的烃基，或该烃基还含有氧原子，氮原子，硫原子或卤素原子，包括情况R在通式中相同或不相同，R相互结合，n为1〜4的整数，m为0〜10的整数，M为属于III的金属元素， IV和V组的周期表。含有上述单体混合物的共聚物，上述烯键式不饱和化合物和至少一种选自含有环己基的烯属不饱和化合物的单体的另一种脱模剂，其含量为每100重量份2-30重量份单体混合物的一部分和具有烯属不饱和基团的咪唑化合物，其量为每100重量份0.5至15重量份。单体混合物的一部分，其中可共聚合化合物单体中的官能团也至少部分地与上述金属醇化物交联。

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