专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20060051244A1 Device for the detection of at least one ligand contained in a sample that is to be analyzed 有权
标题翻译：用于检测待分析样品中所含的至少一种配体的装置
公开(公告)号：US20060051244A1
公开(公告)日：2006-03-09
申请号：US10528954
申请日：2003-09-26
申请人： Mirko Lehmann , Claas Muller , Holger Klapproth , Ingo Freund
发明人： Mirko Lehmann , Claas Muller , Holger Klapproth , Ingo Freund
IPC分类号： G01N33/50
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/6454 , G01N33/54373
摘要： Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.
摘要翻译：公开了一种用于检测待分析样品中所含的至少一种配体的装置。所述装置包括光波导，其表面上直接或间接固定至少一种配体特异性受体。配体在与其接触时与所述受体结合。本发明的装置包括至少一个用于将激发辐射注入到波导中的辐射光源，所述辐射用于根据配体与受体的结合激发发射辐射。至少一个辐射接收器被集成到半导体芯片的半导体衬底中，以便检测发光辐射。波导以单片方式集成到半导体衬底中或作为波导层施加在其上。

12. 发明申请

US20080138829A1 Method For Detecting and/or Determining the Concentration of at Least One Ligand 审中-公开
标题翻译：检测和/或确定最少一个配体浓度的方法
公开(公告)号：US20080138829A1
公开(公告)日：2008-06-12
申请号：US11665169
申请日：2005-10-12
申请人： Mirko Lehmann , Ingo Freund , Holger Klapproth , Sonja Mohry
发明人： Mirko Lehmann , Ingo Freund , Holger Klapproth , Sonja Mohry
IPC分类号： G01N21/76 , G01N33/543 , G01N33/53
CPC分类号： G01N33/54373
摘要： The invention relates to a method for detecting and/or determining the concentration of a ligand contained in a solution to be analyzed, during which a receptor, which can enter into a specific bond with the ligand, is immobilized on a semiconductor chip at a test location. In order to bind the ligand to the receptor, the solution is applied to the test location. A luminescence radiation or a color change is generated according to the binding of the ligand to the receptor. A radiation measurement signal is picked up with the aid of a radiation receiver integrated in the semiconductor chip, whereas the solution and/or an auxiliary liquid that does not contain the luminophore is in contact with the radiation receiver. While the generation of luminescence radiation is prevented and the radiation receiver is in contact with the auxiliary liquid and/or with a substitute liquid, a darkness measurement signal is measured for the radiation receiver. The radiation measurement signal is compensated for with the darkness measurement signal
摘要翻译：本发明涉及一种用于检测和/或确定待分析溶液中所含配体的浓度的方法，在该方法中，可以与配体进入特定键的受体在测试中固定在半导体芯片上位置。为了将配体结合到受体，将溶液施加到测试位置。根据配体与受体的结合产生发光辐射或颜色变化。借助于集成在半导体芯片中的辐射接收器拾取辐射测量信号，而不包含发光体的溶液和/或辅助液体与辐射接收器接触。虽然防止了发光辐射的产生并且辐射接收器与辅助液体和/或替代液体接触，但是对辐射接收器测量了暗度测量信号。用黑度测量信号补偿辐射测量信号

13. 发明申请

US20050155411A1 Method for producing a sensor or actuator arrangement, and corresponding sensor or actuator arrangement 失效
标题翻译：用于制造传感器或致动器装置的方法以及相应的传感器或致动器装置
公开(公告)号：US20050155411A1
公开(公告)日：2005-07-21
申请号：US10504738
申请日：2003-02-07
申请人： Markus Rogalla , Ingo Freund , Mirko Lehmann
发明人： Markus Rogalla , Ingo Freund , Mirko Lehmann
IPC分类号： G12B9/04 , B81B7/00 , G01N35/00 , H05K5/00 , H05K7/14 , G01N27/414
CPC分类号： B81B7/0061
摘要： In a method for producing a sensor arrangement and the resulting sensor arrangement, a sensor is provided on or in a chip and the chip is covered with a protective cover, the cover being an interface between the sensor and the environment. An adhesive layer is provided between the chip and the protective cover, the adhesive layer alone or together with the protective cover being an interface between the sensor and the environment. The protective cover and/or the adhesive layer may have a channel formed therein, the channel functioning as the reception channel for a sensor. In an alternative embodiment, the protective cover placed on a wafer with several chips, and the wafer is cut up to produce the individual chips with the protective cover. Thus, a sensor arrangement may have the protective cover applied to the individual chip after the chip is cut from the wafer, or the protective cover may be applied to the wafer, and the wafer and cover are then cut up into the individual chips and corresponding covers. The channel leading from one side of the arrangement to the sensor may be taken through the adhesive layer, through the protective cover, or through both. A hole may be formed in the protective cover above the sensor, with the sensor lying loosely in the hole. The reaction volume may be determined by the dimensions of the hole.
摘要翻译：在用于制造传感器装置和所得到的传感器装置的方法中，传感器设置在芯片上或芯片中，并且芯片被保护盖覆盖，盖是传感器和环境之间的接口。粘合剂层设置在芯片和保护盖之间，粘合剂层单独或与保护罩一起作为传感器和环境之间的界面。保护盖和/或粘合剂层可以具有形成在其中的通道，该通道用作传感器的接收通道。在替代实施例中，将保护盖放置在具有几个芯片的晶片上，并且切割晶片以用保护盖产生单独的芯片。因此，在从晶片切割芯片之后，传感器装置可以具有施加到单个芯片的保护盖，或者可以将保护盖施加到晶片，然后将晶片和盖切割成各个芯片，并且对应于盖子。从布置的一侧引导到传感器的通道可以穿过粘合剂层，通过保护盖，或者通过两者。可以在传感器上方的保护罩中形成孔，传感器松动地位于孔中。反应体积可以由孔的尺寸确定。

14. 发明授权

US08329104B2 Measurement device with at least one sensor 有权
标题翻译：至少有一个传感器的测量装置
公开(公告)号：US08329104B2
公开(公告)日：2012-12-11
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/00 , G01N33/53 , G01N33/566 , G01N33/543
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

15. 发明授权

US07777283B2 Electric component 有权
标题翻译：电气部件
公开(公告)号：US07777283B2
公开(公告)日：2010-08-17
申请号：US11791501
申请日：2004-11-26
申请人： Mirko Lehmann , Ingo Freund
发明人： Mirko Lehmann , Ingo Freund
IPC分类号： H01L29/00
CPC分类号： G01N27/4148
摘要： An electric component comprising a sensor and/or actuator chip with a substrate on which a passivating layer and a sensor and/or actuator structure consisting of an active surface area is arranged. The chip is surrounded by an encapsulation having an opening which forms an access to the at least one active surface area. A layer stack is arranged on the substrate, said stack of layers comprising from the passivating layer to the substrate at least one first strip conductor layer, a first electric insulating layer, a second strip conductor layer and a second electric insulating layer. The first conductor strip layer is fully arranged outside the area of the chip covered by the opening. At least one conductor strip of the second conductor strip layer is connected to the sensor and/or actuator structure.
摘要翻译：一种电气部件，包括具有衬底的传感器和/或致动器芯片，其上布置有由活性表面积组成的钝化层和传感器和/或致动器结构。芯片由具有开口的封装围绕，该开口形成对至少一个有源表面区域的访问。层叠在衬底上，层叠层包括至少一个第一带状导体层，第一电绝缘层，第二带状导体层和第二电绝缘层，从钝化层到衬底。第一导体带层完全布置在由开口覆盖的芯片的区域的外部。第二导体带层的至少一个导体条连接到传感器和/或致动器结构。

16. 发明申请

US20090175764A1 Measurement Device with At Least One Sensor 有权
标题翻译：具有至少一个传感器的测量装置
公开(公告)号：US20090175764A1
公开(公告)日：2009-07-09
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： B01J19/00
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

17. 发明授权

US08324913B2 Moisture sensor and method for measuring moisture of a gas-phase medium 有权
标题翻译：湿度传感器及气相介质湿度测定方法
公开(公告)号：US08324913B2
公开(公告)日：2012-12-04
申请号：US12594510
申请日：2008-04-02
申请人： Mirko Lehmann , Heinz-Peter Frerichs , Ingo Freund
发明人： Mirko Lehmann , Heinz-Peter Frerichs , Ingo Freund
IPC分类号： G01R27/08 , G01N19/00
CPC分类号： G01N27/414 , G01N25/56
摘要： The invention relates to a moisture sensor which comprises a receiving area on its surface for a moisture film, the layer thickness of which is dependent on the relative humidity in the surrounding of the receiving area. The moisture sensor has a signal source which is connected to at least one control electrode at at least one infeed, the electrode abutting the receiving area, for providing a control voltage to the moisture film. The moisture sensor comprises at least one potential sensor which has at least one sensor area, under the receiving area, which is spaced apart from the at least one infeed. The sensor area is electrically insulated from the receiving area by an insulation layer, located between the sensor area and the receiving area, in such a way that an electrical potential can be capacitively detected by means of the potential sensor, the potential being dependent on the layer thickness of the moisture film and the control voltage.
摘要翻译：本发明涉及一种水分传感器，其包括在其表面上的用于湿膜的接收区域，其层厚度取决于接收区域周围的相对湿度。水分传感器具有信号源，该信号源在至少一个进给处连接到至少一个控制电极，电极邻接接收区域，以提供对湿气膜的控制电压。湿度传感器包括至少一个在至少一个传感器区域的电位传感器，该传感器区域在与至少一个进料间隔开的接收区域下方。传感器区域通过位于传感器区域和接收区域之间的绝缘层与接收区域电绝缘，使得电位可以通过电位传感器电容性地检测，电位取决于水分膜的层厚度和控制电压。

18. 发明申请

US20100283087A1 Electric Component 有权
标题翻译：电气部件
公开(公告)号：US20100283087A1
公开(公告)日：2010-11-11
申请号：US12840597
申请日：2010-07-21
申请人： Mirko Lehmann , Ingo Freund
发明人： Mirko Lehmann , Ingo Freund
IPC分类号： H01L29/66
CPC分类号： G01N27/4148
摘要： An electric component comprising a sensor and/or actuator chip with a substrate on which a passivating layer and a sensor and/or actuator structure consisting of an active surface area is arranged. The chip is surrounded by an encapsulation having an opening which forms an access to the at least one active surface area. A layer stack is arranged on the substrate, said stack of layers comprising from the passivating layer to the substrate at least one first strip conductor layer, a first electric insulating layer, a second strip conductor layer and a second electric insulating layer. The first conductor strip layer is fully arranged outside the area of the chip covered by the opening. At least one conductor strip of the second conductor strip layer is connected to the sensor and/or actuator structure.
摘要翻译：一种电气部件，包括具有衬底的传感器和/或致动器芯片，其上布置有钝化层和由有源表面区域组成的传感器和/或致动器结构。芯片由具有开口的封装围绕，该开口形成对至少一个有源表面区域的访问。层叠在衬底上，层叠层包括至少一个第一带状导体层，第一电绝缘层，第二带状导体层和第二电绝缘层，从钝化层到衬底。第一导体带层完全布置在由开口覆盖的芯片的区域的外部。第二导体带层的至少一个导体条连接到传感器和/或致动器结构。

19. 发明授权

US07462326B2 Device for the detection of at least one ligand contained in a sample that is to be analyzed 有权
标题翻译：用于检测待分析样品中所含的至少一种配体的装置
公开(公告)号：US07462326B2
公开(公告)日：2008-12-09
申请号：US10528954
申请日：2003-09-26
申请人： Mirko Lehmann , Claas Müller , Holger Klapproth , Ingo Freund
发明人： Mirko Lehmann , Claas Müller , Holger Klapproth , Ingo Freund
IPC分类号： G01N21/76 , G01N21/00 , G01N33/543 , G01N21/41 , G02B6/12 , G02B6/00 , G02B6/10 , G01B9/02 , C12M1/34
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/6454 , G01N33/54373
摘要： Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.
摘要翻译：公开了一种用于检测待分析样品中所含的至少一种配体的装置。所述装置包括光波导，其表面上直接或间接固定至少一种配体特异性受体。配体在与其接触时与所述受体结合。本发明的装置包括至少一个用于将激发辐射注入到波导中的辐射光源，所述辐射用于根据配体与受体的结合激发发射辐射。至少一个辐射接收器被集成到半导体芯片的半导体衬底中，以便检测发光辐射。波导以单片方式集成到半导体衬底中或作为波导层施加在其上。

20. 发明申请

US20070243637A1 Process and device for determining the concentrations of ligands 审中-公开
标题翻译：用于测定配体浓度的方法和装置
公开(公告)号：US20070243637A1
公开(公告)日：2007-10-18
申请号：US11784768
申请日：2007-04-09
申请人： Sonja Mohry , Holger Klapproth , Mirko Lehmann , Ingo Freund
发明人： Sonja Mohry , Holger Klapproth , Mirko Lehmann , Ingo Freund
IPC分类号： G01N33/543 , C12M3/00
CPC分类号： G01N33/558 , G01N33/54306
摘要： In a process for determining the concentrations of ligands (9, 10) in a sample to be analyzed, ligands (9) of a first ligand type are bond-specific for receptors (6) of a first receptor type, and ligands (10) of a second ligand type are bond-specific for receptors (8) of a second receptor type. A first receptor (6) of the first receptor type is immobilized at least one first test site (5), and a second receptor (8) of the second receptor type is immobilized at a second test site (7) on a substrate (23). A third receptor (11) of the second receptor type is mixed with the sample in such a way that it is present in a specified concentration in the mixture that is obtained in this manner. The mixture is caused to contact the substrate in such a way that at least one ligand (9) of the first ligand type can bind to the first receptor (6) and ligands (10) of the second ligand type can bind to the second receptor (8) and to the third receptor (11). Thereupon components of the mixture that are not bound to an immobilized receptor (6, 8) are removed from the substrate. Thereupon a first measurement signal that is dependent on the concentration of the ligand (9) bound to the first receptor (6) and a second measurement signal that is dependent on the concentration of the ligand (10) bound to the second receptor (8) are generated. With the aid of the first measurement signal the concentration of the ligand (9) of the first ligand type in the sample is determined and, with the aid of the second measurement signal and of the concentration of the third receptor (11) in the mixture, the concentration of the ligands (10) of the second ligand type in the sample is determined.
摘要翻译：在用于测定待分析样品中配体（9,10）的浓度的方法中，第一配体类型的配体（9）对于第一受体类型的受体（6）是键特异性的，而配体（10）第二种配体类型是第二受体类型的受体（8）的键特异性。将第一受体类型的第一受体（6）固定在至少一个第一测试位点（5）上，并且将第二受体类型的第二受体（8）固定在基底（23）上的第二测试位点（7））。将第二受体类型的第三受体（11）与样品混合，使得其以以这种方式获得的混合物中以特定浓度存在。使混合物以这样的方式接触底物，使得第一配体型的至少一种配体（9）可以结合第一受体（6），并且第二配体型的配体（10）可以结合第二受体（8）和第三受体（11）。因此，从底物中除去不与固定化受体（6,8）结合的混合物的组分。因此，依赖于与第一受体（6）结合的配体（9）的浓度的第一测量信号和取决于与第二受体（8）结合的配体（10）的浓度的第二测量信号，被生成。借助于第一测量信号，测定样品中第一配体类型的配体（9）的浓度，借助于第二测量信号和混合物中第三受体（11）的浓度测定样品中第二配体类型的配体（10）的浓度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式